Bulus Adzu

Summary

Publications

  1. doi request reprint Effect of NIPRISAN® on CYP3A4 activity in vitro
    Bulus Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, PMB 21, Abuja, Nigeria
    Eur J Drug Metab Pharmacokinet 40:115-8. 2015
  2. doi request reprint Evaluation of antinociceptive and anti-inflammatory activities of standardised rootbark extract of Xeromphis nilotica
    Bulus Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, Abuja, Nigeria Electronic address
    J Ethnopharmacol 158:271-5. 2014
  3. ncbi request reprint Effect of Annona senegalensis rootbark extracts on Naja nigricotlis nigricotlis venom in rats
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, PMB 21 Abuja, Nigeria
    J Ethnopharmacol 96:507-13. 2005
  4. ncbi request reprint The efficacy of Sphaeranthus senegalensis Vaill extract against diarrhoea in rats
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, PMB 21 Abuja, Nigeria
    J Ethnopharmacol 95:173-6. 2004
  5. ncbi request reprint Studies on the use of Cassia singueana in malaria ethnopharmacy
    Bulus Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, PMB 21, Abuja, Nigeria
    J Ethnopharmacol 88:261-7. 2003
  6. ncbi request reprint Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, PMB 21, Garki, Abuja, Nigeria
    J Ethnopharmacol 84:169-73. 2003
  7. ncbi request reprint Neuropharmacological screening of Diospyros mespiliformis in mice
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, PMB 21, Abuja, Nigeria
    J Ethnopharmacol 83:139-43. 2002
  8. ncbi request reprint Pharmacological evidence favouring the folkloric use of Diospyros mespiliformis Hochst in the relief of pain and fever
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, PMB 21, Abuja, Nigeria
    J Ethnopharmacol 82:191-5. 2002
  9. ncbi request reprint Evaluation of the antidiarrhoeal effects of Zizyphus spina-christi stem bark in rats
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P M B 21 Abuja, FCT, Nigeria
    Acta Trop 87:245-50. 2003
  10. ncbi request reprint Antinociceptive activity of Zizyphus spina-christi root bark extract
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P.M.B. 21, Garki, Abuja, Nigeria
    Fitoterapia 72:344-50. 2001

Collaborators

Detail Information

Publications16

  1. doi request reprint Effect of NIPRISAN® on CYP3A4 activity in vitro
    Bulus Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, PMB 21, Abuja, Nigeria
    Eur J Drug Metab Pharmacokinet 40:115-8. 2015
    ....
  2. doi request reprint Evaluation of antinociceptive and anti-inflammatory activities of standardised rootbark extract of Xeromphis nilotica
    Bulus Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, Abuja, Nigeria Electronic address
    J Ethnopharmacol 158:271-5. 2014
    ..This study is aimed to evaluate the analgesic and anti-inflammatory efficacy of standardised aqueous extract of the plant using in vivo models of pain and inflammation in mice and rats...
  3. ncbi request reprint Effect of Annona senegalensis rootbark extracts on Naja nigricotlis nigricotlis venom in rats
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, PMB 21 Abuja, Nigeria
    J Ethnopharmacol 96:507-13. 2005
    ..It, however, failed to restore the biochemical functions (sGOT and sGPT) of the liver. The extract exhibited an LC(50) of 232.7 microg/ml in the brine shrimp test...
  4. ncbi request reprint The efficacy of Sphaeranthus senegalensis Vaill extract against diarrhoea in rats
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, PMB 21 Abuja, Nigeria
    J Ethnopharmacol 95:173-6. 2004
    ..These results suggest that the plant contain active constituents that may be useful against diarrhoea...
  5. ncbi request reprint Studies on the use of Cassia singueana in malaria ethnopharmacy
    Bulus Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, PMB 21, Abuja, Nigeria
    J Ethnopharmacol 88:261-7. 2003
    ..The observed pharmacological activities might be the scientific basis for the folkloric use of the plant in treating acute malaria attack. The study also paves way for the possible development of it, as a phytodrug against malaria...
  6. ncbi request reprint Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, PMB 21, Garki, Abuja, Nigeria
    J Ethnopharmacol 84:169-73. 2003
    ..05) when compared with the saline control group. The results suggest the presence of a potent anti-inflammatory and anti-nociceptive principle in the extract, which support the folkloric use of the plant in relieving rheumatic pains...
  7. ncbi request reprint Neuropharmacological screening of Diospyros mespiliformis in mice
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, PMB 21, Abuja, Nigeria
    J Ethnopharmacol 83:139-43. 2002
    ..It also failed to affect the motor coordination test. These results suggest that the extract contained an agent with neuropharmacological activity that may be sedative in nature...
  8. ncbi request reprint Pharmacological evidence favouring the folkloric use of Diospyros mespiliformis Hochst in the relief of pain and fever
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, PMB 21, Abuja, Nigeria
    J Ethnopharmacol 82:191-5. 2002
    ..05) against all the analgesic and anti-inflammatory models used. The LD(50) of the extract was estimated to be 513.80+/-33.92 mg/kg i.p. in mice. These results provide support for the use of the plant in relieving pain and fever...
  9. ncbi request reprint Evaluation of the antidiarrhoeal effects of Zizyphus spina-christi stem bark in rats
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P M B 21 Abuja, FCT, Nigeria
    Acta Trop 87:245-50. 2003
    ..It is suggested that the extract may contain biologically active components that may be useful against diarrhoea, thereby justifying its use in ethnomedical practice as an antidiarrhoeal agent...
  10. ncbi request reprint Antinociceptive activity of Zizyphus spina-christi root bark extract
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P.M.B. 21, Garki, Abuja, Nigeria
    Fitoterapia 72:344-50. 2001
    ..Acetic acid-induced writhing, formalin and thermal (hot plate) tests were used. The extract (50 and 100 mg/kg, i.p.) showed a dose-dependent analgesic effect in all the tests used. Its i.p. LD50 in mice was 2236.07 mg/kg...
  11. ncbi request reprint Neuropharmacological effect of the aqueous extract of Sphaeranthus senegalensis in mice
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, PMB 21, Garki, Abuja, Nigeria
    J Ethnopharmacol 78:33-7. 2001
    ..The i.p. LD(50) in mice was 2735.61 and 5000 mg/kg orally. The results suggest that the aqueous extract of S. senegalensis contains some active principles, which may be sedative in nature...
  12. doi request reprint The analgesic and antiplasmodial activities and toxicology of Vernonia amygdalina
    Anoka A Njan
    Department of Pharmacology and Therapeutics, Mbarara University of Science and Technology, Mbarara, Uganda
    J Med Food 11:574-81. 2008
    ..This study supports the traditional use of V. amygdalina as an alternative therapy for malaria and the symptomatic relief of pain usually associated with malaria...
  13. ncbi request reprint Effect of Zizyphus spina-christi Willd aqueous extract on the central nervous system in mice
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P M B 21, Garki, Abuja, Nigeria
    J Ethnopharmacol 79:13-6. 2002
    ..These results suggest that the extract contained some constituents that depress the central nervous system, which may not be due to neuromuscular blockade...
  14. ncbi request reprint Antinociceptive and antipyretic activities of the Zizyphus oxyphylla Edgew. leaves
    M Nisar
    Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan
    Phytother Res 21:693-5. 2007
    ..In conclusion, the present study suggests that the methanol extract of Zizyphus oxyphylla Edgew leaves possesses potent antipyretic and antinociceptive activities and thus validates its use in the treatment of pain and fever...
  15. ncbi request reprint Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P M B 21, Garki, Abuja, Nigeria
    J Ethnopharmacol 97:53-7. 2005
    ..These results indicate the presence of psychoactive substances in the aqueous extract of the root bark of Nauclea latifolia...
  16. ncbi request reprint Effect of niprisan on single oral dose pharmacokinetics of paracetamol in rats
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Garki, Abuja, Nigeria
    Eur J Drug Metab Pharmacokinet 26:201-4. 2001
    ..19% reduction in AUC(0-infinity) and Cmax respectively for paracetamol (20 mg/kg) + NIPRISAN (500 mg/kg). It was thus concluded that the gastric presence of NIPRISAN did not significantly reduce the absorption of paracetamol in rats...