Alberto R Kornblihtt

Summary

Affiliation: Universidad de Buenos Aires
Country: Argentina

Publications

  1. ncbi request reprint Shortcuts to the end
    Alberto R Kornblihtt
    Nat Struct Mol Biol 11:1156-7. 2004
  2. ncbi request reprint On intelligent design, cognitive relativism, vitalism and the mystery of the real world
    Alberto R Kornblihtt
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
    IUBMB Life 59:235-7. 2007
  3. doi request reprint Control of alternative splicing through siRNA-mediated transcriptional gene silencing
    Mariano Allo
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
    Nat Struct Mol Biol 16:717-24. 2009
  4. pmc CTCF: from insulators to alternative splicing regulation.
    Alberto R Kornblihtt
    Cell Res 22:450-2. 2012
  5. doi request reprint A long noncoding way to alternative splicing in plant development
    Alberto R Kornblihtt
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina Electronic address
    Dev Cell 30:117-9. 2014
  6. pmc RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing
    Manuel De la Mata
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular, y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
    Genet Res Int 2011:309865. 2011
  7. doi request reprint Alternative splicing: a pivotal step between eukaryotic transcription and translation
    Alberto R Kornblihtt
    Departamento de Fisiologia, Biología Molecular y Celular e Instituto de Fisiología, Biología Molecular y Neurociencias, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
    Nat Rev Mol Cell Biol 14:153-65. 2013
  8. ncbi request reprint Coupling transcription and alternative splicing
    Alberto R Kornblihtt
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
    Adv Exp Med Biol 623:175-89. 2007
  9. ncbi request reprint Promoter usage and alternative splicing
    Alberto R Kornblihtt
    Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, 2 Piso, C1428EHA Buenos Aires, Argentina
    Curr Opin Cell Biol 17:262-8. 2005
  10. pmc Multiple links between transcription and splicing
    Alberto R Kornblihtt
    Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, Ciudad Universitaria, Pabellón II C1428EHA Buenos Aires, Argentina
    RNA 10:1489-98. 2004

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Shortcuts to the end
    Alberto R Kornblihtt
    Nat Struct Mol Biol 11:1156-7. 2004
  2. ncbi request reprint On intelligent design, cognitive relativism, vitalism and the mystery of the real world
    Alberto R Kornblihtt
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
    IUBMB Life 59:235-7. 2007
  3. doi request reprint Control of alternative splicing through siRNA-mediated transcriptional gene silencing
    Mariano Allo
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
    Nat Struct Mol Biol 16:717-24. 2009
    ....
  4. pmc CTCF: from insulators to alternative splicing regulation.
    Alberto R Kornblihtt
    Cell Res 22:450-2. 2012
  5. doi request reprint A long noncoding way to alternative splicing in plant development
    Alberto R Kornblihtt
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina Electronic address
    Dev Cell 30:117-9. 2014
    ..2014) elucidate how long, highly structured noncoding RNAs control alternative splicing regulators that specifically mediate the action of the hormone auxin in the promotion of lateral root growth in Arabidopsis...
  6. pmc RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing
    Manuel De la Mata
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular, y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
    Genet Res Int 2011:309865. 2011
    ..This paper focuses on the multiple processes that take place during transcription elongation which ultimately regulate the outcome of alternative splicing decisions...
  7. doi request reprint Alternative splicing: a pivotal step between eukaryotic transcription and translation
    Alberto R Kornblihtt
    Departamento de Fisiologia, Biología Molecular y Celular e Instituto de Fisiología, Biología Molecular y Neurociencias, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
    Nat Rev Mol Cell Biol 14:153-65. 2013
    ....
  8. ncbi request reprint Coupling transcription and alternative splicing
    Alberto R Kornblihtt
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
    Adv Exp Med Biol 623:175-89. 2007
    ....
  9. ncbi request reprint Promoter usage and alternative splicing
    Alberto R Kornblihtt
    Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, 2 Piso, C1428EHA Buenos Aires, Argentina
    Curr Opin Cell Biol 17:262-8. 2005
    ..These mechanisms involve the recruitment of factors with dual functions in transcription and splicing (i.e. that contain both functional domains and hence link the two processes) and the control of RNA polymerase II elongation...
  10. pmc Multiple links between transcription and splicing
    Alberto R Kornblihtt
    Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, Ciudad Universitaria, Pabellón II C1428EHA Buenos Aires, Argentina
    RNA 10:1489-98. 2004
    ....
  11. ncbi request reprint A polar mechanism coordinates different regions of alternative splicing within a single gene
    Juan P Fededa
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
    Mol Cell 19:393-404. 2005
    ....
  12. ncbi request reprint A slow RNA polymerase II affects alternative splicing in vivo
    Manuel De la Mata
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, Buenos Aires, Argentina
    Mol Cell 12:525-32. 2003
    ..These results provide a direct proof for the elongation control of alternative splicing in vivo...
  13. doi request reprint Alternative Splicing of G9a Regulates Neuronal Differentiation
    Ana Fiszbein
    Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Fisiología, Biología Molecular y Neurociencias IFIBYNE CONICET, Ciudad Universitaria Pabellon II, C1428EHA Buenos Aires, Argentina
    Cell Rep 14:2797-808. 2016
    ..Overall, our findings indicate that by regulating its own alternative splicing, G9a promotes neuron differentiation and creates a positive feedback loop that reinforces cellular commitment to differentiation. ..
  14. ncbi request reprint An early ancestor in the evolution of splicing: a Trypanosoma cruzi serine-arginine-rich protein (TcSR) is functional in cis-splicing
    Daniel Portal
    Facultad de Ciencias Exactas y Naturales, Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Universidad de Buenos Aires, Buenos Aires, Argentina
    Mol Biochem Parasitol 127:37-46. 2003
    ..These results indicate that TcSR is a member of the SR splicing network and that some components common to the trans- and cis-splicing machineries evolved from the early origins of the eukaryotic lineage...
  15. ncbi request reprint RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20
    Manuel De la Mata
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Argentina
    Nat Struct Mol Biol 13:973-80. 2006
    ..These results suggest that the CTD promotes exon skipping by recruiting SRp20 and that this contributes independently of elongation to the transcriptional control of alternative splicing...
  16. doi request reprint How slow RNA polymerase II elongation favors alternative exon skipping
    Gwendal Dujardin
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, C1428EHA Buenos Aires, Argentina Inserm U1078 ECLA Team, Faculty of Medicine, 22 avenue Camille Desmoulins, 29238 Brest Cedex 3, France
    Mol Cell 54:683-90. 2014
    ..This indicates that a delay in the cotranscriptional emergence of the 5' ss promotes ETR-3 recruitment and subsequent inhibition of E9 inclusion. ..
  17. pmc Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation
    Ignacio E Schor
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIByNE UBA CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
    EMBO J 32:2264-74. 2013
    ....
  18. doi request reprint DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation
    Manuel J Munoz
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Argentina
    Cell 137:708-20. 2009
    ....
  19. ncbi request reprint Cross-talk between signaling pathways regulates alternative splicing: a novel role for JNK
    Federico Pelisch
    Biología Molecular y Neurociencias Consejo Nacional de Investigaciones Científicas y Técnicas, Departamento de Fisiologia, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
    J Biol Chem 280:25461-9. 2005
    ....
  20. ncbi request reprint Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT
    Matias Blaustein
    Instituto de Fisiologia, Biología Molecular y Neurociencias, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Departamento de Fisiologia, Biologia Molecular y Celular, Universidad de Buenos Aires, Ciudad Universitaria, Argentina
    Nat Struct Mol Biol 12:1037-44. 2005
    ..These results show how SR protein activity is modified in response to extracellular stimulation, leading to a concerted regulation of splicing and translation...
  21. doi request reprint Transcriptional elongation and alternative splicing
    Gwendal Dujardin
    Departamento de Fisiologia, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
    Biochim Biophys Acta 1829:134-40. 2013
    ..This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation...
  22. ncbi request reprint Control of alternative pre-mRNA splicing by RNA Pol II elongation: faster is not always better
    Guadalupe Nogues
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II C1428EHA Buenos Aires, Argentina
    IUBMB Life 55:235-41. 2003
    ..The model is supported by findings that cis- and trans- acting factors that modulate pol II elongation on a particular template also provoke changes in the alternative splicing balance of the encoded mRNAs...
  23. ncbi request reprint Transcriptional activators differ in their abilities to control alternative splicing
    Guadalupe Nogues
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II, C1428EHA Buenos Aires, Argentina
    J Biol Chem 277:43110-4. 2002
    ..Rapid, highly processive transcription favors EDI exon skipping, whereas slower, less processive transcription favors inclusion...
  24. ncbi request reprint Influence of polymerase II processivity on alternative splicing depends on splice site strength
    Guadalupe Nogues
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Biol Chem 278:52166-71. 2003
    ....
  25. pmc Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing
    Ignacio E Schor
    Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE UBA Consejo Nacional de Investigaciones Científicas y Técnicas of Argentina, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
    Proc Natl Acad Sci U S A 106:4325-30. 2009
    ....
  26. pmc Perturbation of chromatin structure globally affects localization and recruitment of splicing factors
    Ignacio E Schor
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Instituto de Fisiologia, Biología Molecular y Neurociencias, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    PLoS ONE 7:e48084. 2012
    ..All together, the combined imaging and biochemical approaches support a model where chromatin structure is essential for efficient co-transcriptional recruitment of general and regulatory splicing factors to pre-mRNA...
  27. ncbi request reprint Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via phosphatidylinositol 3-kinase
    Matias Blaustein
    Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II C1428EHA Buenos Aires, Argentina
    J Biol Chem 279:21029-37. 2004
    ..These results shed light on how extracellular stimuli are converted into changes in splicing patterns...
  28. doi request reprint Connections between chromatin signatures and splicing
    Luciana I Gómez Acuña
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
    Wiley Interdiscip Rev RNA 4:77-91. 2013
    ..These links between chromatin configuration and splicing raise the intriguing possibility of the existence of a memory for splicing patterns to be inherited through epigenetic modifications...
  29. doi request reprint The RNA Response to DNA Damage
    Luciana E Giono
    Instituto de Fisiologia, Biología Molecular y Neurociencias IFIBYNE UBA CONICET, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, C1428EHA Buenos Aires, Argentina Departamento de Fisiología, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, C1428EHA Buenos Aires, Argentina
    J Mol Biol 428:2636-51. 2016
    ..This review aims to present a comprehensive overview of the current knowledge on the many interactions between the DNA damage and RNA fields. ..
  30. doi request reprint Effects of airborne particulate matter on alternative pre-mRNA splicing in colon cancer cells
    Valeria Buggiano
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, C1428EHA Buenos Aires, Argentina
    Environ Res 140:185-90. 2015
    ..We also show that the underlying mechanism might involve changes in transcriptional elongation. This is the first study to demonstrate that particulate matter causes non-pleiotropic changes in alternative splicing. ..
  31. pmc Progesterone receptor induces bcl-x expression through intragenic binding sites favoring RNA polymerase II elongation
    Paola Y Bertucci
    IFIBYNE CONICET, Buenos Aires C1428EGA, Argentina
    Nucleic Acids Res 41:6072-86. 2013
    ..These results suggest a novel mechanism by which PR regulates gene expression by facilitating the proper passage of the polymerase along hormone-dependent genes. ..
  32. doi request reprint The carboxy terminal domain of RNA polymerase II and alternative splicing
    Manuel J Munoz
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires Ciudad Universitaria, Pabellon 2, C1428EHA Buenos Aires, Argentina
    Trends Biochem Sci 35:497-504. 2010
    ..Here, we discuss various examples of involvement of the CTD in alternative splicing regulation as well as the current methodological limitations in deciphering the detailed mechanisms of this process...
  33. pmc Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells
    Mariano Allo
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, Instituto de Fisiologia, Biología Molecular y Neurociencias Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
    Proc Natl Acad Sci U S A 111:15622-9. 2014
    ....
  34. pmc Alternative splicing at the right time
    Sabrina E Sanchez
    Instituto Leloir, IIBBA CONICET, C1405BWE, Buenos Aires, Argentina
    RNA Biol 8:954-9. 2011
    ....
  35. ncbi request reprint Regulation of fibronectin alternative splicing by a basement membrane-like extracellular matrix
    Anabella Srebrow
    Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II C1428EHA, Buenos Aires, Argentina
    FEBS Lett 514:285-9. 2002
    ....
  36. pmc A chloroplast retrograde signal regulates nuclear alternative splicing
    Ezequiel Petrillo
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, C1428EHA Buenos Aires, Argentina
    Science 344:427-30. 2014
    ....
  37. ncbi request reprint Fibronectin transcription in liver cells: promoter occupation and function in sinusoidal endothelial cells and hepatocytes
    Claudio R Alonso
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Ciencias Biologicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    Biochem Biophys Res Commun 295:1077-84. 2002
    ..These results establish the starting point to investigate the molecular basis of changes in transcriptional regulation of the FN gene involved in liver pathology...
  38. pmc Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
    Sebastian Kadener
    Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II C1428EHA, Buenos Aires, Argentina
    Proc Natl Acad Sci U S A 99:8185-90. 2002
    ....
  39. doi request reprint Chromatin, DNA structure and alternative splicing
    Nicolás Nieto Moreno
    Instituto de Fisiologia, Biología Molecular y Neurociencias IFIBYNE UBA CONICET and Departamento de Fisiología, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, C1428EHA Buenos Aires, Argentina
    FEBS Lett 589:3370-8. 2015
    ..Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non-B DNA conformations on the regulation of alternative splicing. ..
  40. doi request reprint Coupling between transcription and alternative splicing
    Ignacio E Schor
    Laboratorio de Fisiologia y Biologia Molecular, Departmento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab II, 20 Piso, Buenos Aires, 1428, Argentina
    Cancer Treat Res 158:1-24. 2013
    ....
  41. doi request reprint Gene silencing: small RNAs control RNA polymerase II elongation
    Mariano Allo
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, Buenos Aires, Argentina
    Curr Biol 20:R704-7. 2010
    ..The Argonaute protein NRDE-3, along with NRDE-2, are needed for TGS in C. elegans. TGS also inhibits elongation and controls alternative splicing in mammalian cells...
  42. ncbi request reprint The connection between splicing and cancer
    Anabella Srebrow
    Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, C1428EHA Buenos Aires, Argentina
    J Cell Sci 119:2635-41. 2006
    ..Mutations in splicing elements, for example, have been found in genes such as LKB1, KIT, CDH17, KLF6 and BRCA1, and changes in trans-acting regulators can affect the expression of genes such as Ron, RAC1 and CD44...
  43. pmc Histone methylation, alternative splicing and neuronal differentiation
    Ana Fiszbein
    Instituto de Fisiologia, Biología Molecular y Neurociencias IFIBYNE CONICET and Departamento de Fisiología, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    Neurogenesis (Austin) 3:e1204844. 2016
    ..All together, these results illustrate the importance of alternative splicing in the generation of a proper equilibrium between methylation and demethylation of histones for the regulation of neuron-specific transcriptional programs. ..
  44. ncbi request reprint Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential
    Alejandro J Urtreger
    Area Investigacion, Instituto de Oncologia Angel H Roffo, Universidad de Buenos Aires, C1417DTB Buenos Aires, Argentina
    Oncol Rep 16:1403-10. 2006
    ..The fact that FN was one of the only two genes significantly down-regulated out of the 1,176 genes analyzed stresses the hypothesis that FN may behave as an important metastasis suppressor gene in mammary cancer...
  45. pmc Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells
    Leticia Labriola
    Instituto de Biologia y Medicina Experimental, Universidad de Buenos Aires, Buenos Aires 1428, Argentina
    Mol Cell Biol 23:1095-111. 2003
    ..Finally, we demonstrate here for the first time that HRG-activated MAPK can phosphorylate both human and mouse PR in vitro...
  46. ncbi request reprint Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases
    Daniel Portal
    Facultad de Ciencias Exactas y Naturales, Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Universidad de Buenos Aires, Buenos Aires, Argentina
    Mol Biochem Parasitol 127:9-21. 2003
    ..This work constitutes the first report of a member of this family of proteins and the existence of an SR-network in a protozoan organism. The implications in the origins and control of splicing are discussed...
  47. doi request reprint A splicing regulator promotes transcriptional elongation
    Juan Pablo Fededa
    Nat Struct Mol Biol 15:779-81. 2008
  48. doi request reprint Identification of the cellular targets of the transcription factor TCERG1 reveals a prevalent role in mRNA processing
    James L Pearson
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 283:7949-61. 2008
    ..These findings provide the strongest support to date for a role of TCERG1 in mRNA processing and are consistent with proposals that TCERG1 couples transcription and processing...
  49. pmc The pathology of pre-mRNA splicing: a meeting in the Italian Alps. Workshop on pre-mRNA processing and disease
    Javier F Caceres
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    EMBO Rep 8:730-4. 2007
  50. ncbi request reprint Chromatin, transcript elongation and alternative splicing
    Alberto R Kornblihtt
    Nat Struct Mol Biol 13:5-7. 2006
    ..A recent study reveals that the chromatin-remodeling factor SWI/SNF regulates alternative splicing by creating internal 'roadblocks' to transcriptional elongation where the phosphorylation status of RNA pol II is qualitatively changed...
  51. pmc Regulation of fibronectin splicing in sinusoidal endothelial cells from normal or injured liver
    Ming Ling Chang
    Liver Center and Department of Medicine and Fetal Treatment Center, Department of Surgery, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:18093-8. 2004
    ..The data suggest that TGFbeta modifies the spliceosome, if not through its known signaling intermediates, then through the products of genes regulated by this cytokine...
  52. ncbi request reprint Alternative splicing: multiple control mechanisms and involvement in human disease
    Javier F Caceres
    MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Trends Genet 18:186-93. 2002
    ..We also focus on the role of the transcriptional machinery in the regulation of alternative splicing, and on those alterations of alternative splicing that lead to human disease...
  53. pmc Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells
    Cecilia Proietti
    Instituto de Biología y Medicina Experimental IBYME, CONICET, Buenos Aires 1428, Argentina
    Mol Cell Biol 25:4826-40. 2005
    ..Our results have for the first time demonstrated that progestins are able to induce Stat3 transcriptional activation, which is in turn an obligatory requirement for progestin stimulation of both in vitro and in vivo breast cancer growth...
  54. ncbi request reprint Promoter architecture modulates CFTR exon 9 skipping
    Franco Pagani
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste 34012, Italy
    J Biol Chem 278:1511-7. 2003
    ....