Assam El-Osta

Summary

Affiliation: Baker Heart Research Institute
Country: Australia

Publications

  1. ncbi request reprint DNA damage detection and repair, and the involvement of epigenetic states
    Sahar Bassal
    Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Prahran, Australia
    Hum Mutat 25:101-9. 2005
  2. ncbi request reprint Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy
    Josephine M Forbes
    Address correspondence to Dr Josephine Forbes, Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute, P O Box 6492, St Kilda Road, Melbourne, Victoria, 8008, Australia
    J Am Soc Nephrol 16:2363-72. 2005
  3. doi request reprint Epigenetic regulation and fetal programming
    Christine Gicquel
    Epigenetics in Human Health and Disease, Baker Medical Research Institute, 75 Commercial Road, Melbourne, 3004 Victoria, Australia
    Best Pract Res Clin Endocrinol Metab 22:1-16. 2008
  4. pmc Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
    Assam El-Osta
    Diabetes and Metabolism Division, Baker Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    J Exp Med 205:2409-17. 2008
  5. ncbi request reprint Mechanisms of abnormal gene expression in tumor cells
    Assam El-Osta
    The Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Second Floor Commercial Road, Prahran, Victoria 3181, Australia
    EXS . 2006
  6. pmc Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain
    Joanne H Gibson
    Western Sydney Genetics Program, The Children s Hospital at Westmead, Sydney, Australia
    BMC Neurosci 11:53. 2010
  7. ncbi request reprint Coordination of epigenetic events
    A El-Osta
    Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, The Alfred Medical Research and Education Precinct AMREP, Prahran, Victoria, Australia
    Cell Mol Life Sci 61:2135-6. 2004
  8. ncbi request reprint Understanding the consequences of epigenetic mechanisms and its effects on transcription in health and disease
    Assam El-Osta
    Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Prahran, Victoria, Australia
    Cancer Biol Ther 3:816-8. 2004
  9. ncbi request reprint The rise and fall of genomic methylation in cancer
    Assam El-Osta
    The Alfred Medical Research and Education Precinct AMREP, Epigenetics in Human Health and Disease Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia
    Leukemia 18:233-7. 2004
  10. ncbi request reprint DNMT cooperativity--the developing links between methylation, chromatin structure and cancer
    Assam El-Osta
    The Alfred Medical Research and Education Precinct AMREP, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Second Floor, Commercial Road, Prahran, Victoria 3181, Australia
    Bioessays 25:1071-84. 2003

Collaborators

Detail Information

Publications76

  1. ncbi request reprint DNA damage detection and repair, and the involvement of epigenetic states
    Sahar Bassal
    Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Prahran, Australia
    Hum Mutat 25:101-9. 2005
    ..The implications of pathway cross-over and communication form a seamless continuation of genomic integrity and stability...
  2. ncbi request reprint Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy
    Josephine M Forbes
    Address correspondence to Dr Josephine Forbes, Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute, P O Box 6492, St Kilda Road, Melbourne, Victoria, 8008, Australia
    J Am Soc Nephrol 16:2363-72. 2005
    ..It is postulated that ACE inhibition reduces the accumulation of AGE in diabetes partly by increasing the production and secretion of sRAGE into plasma...
  3. doi request reprint Epigenetic regulation and fetal programming
    Christine Gicquel
    Epigenetics in Human Health and Disease, Baker Medical Research Institute, 75 Commercial Road, Melbourne, 3004 Victoria, Australia
    Best Pract Res Clin Endocrinol Metab 22:1-16. 2008
    ..Such improvements should also lead to the development of preventive and therapeutic strategies...
  4. pmc Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
    Assam El-Osta
    Diabetes and Metabolism Division, Baker Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    J Exp Med 205:2409-17. 2008
    ....
  5. ncbi request reprint Mechanisms of abnormal gene expression in tumor cells
    Assam El-Osta
    The Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Second Floor Commercial Road, Prahran, Victoria 3181, Australia
    EXS . 2006
    ..This review examines the latest experimental evidence that questions the mechanisms underlying the consequence of epigenetic changes in gene regulation and cancer development...
  6. pmc Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain
    Joanne H Gibson
    Western Sydney Genetics Program, The Children s Hospital at Westmead, Sydney, Australia
    BMC Neurosci 11:53. 2010
    ..The Rett Syndrome (RTT) brain displays regional histopathology and volumetric reduction, with frontal cortex showing such abnormalities, whereas the occipital cortex is relatively less affected...
  7. ncbi request reprint Coordination of epigenetic events
    A El-Osta
    Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, The Alfred Medical Research and Education Precinct AMREP, Prahran, Victoria, Australia
    Cell Mol Life Sci 61:2135-6. 2004
    ..The scene is set for a new view of damage detection and repair by the coordination of epigenetic states...
  8. ncbi request reprint Understanding the consequences of epigenetic mechanisms and its effects on transcription in health and disease
    Assam El-Osta
    Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Prahran, Victoria, Australia
    Cancer Biol Ther 3:816-8. 2004
    ..In this vein, we discuss the consequences of deregulating epigenetic mechanisms with a viewpoint on transcriptional control, chromatin function and human disease...
  9. ncbi request reprint The rise and fall of genomic methylation in cancer
    Assam El-Osta
    The Alfred Medical Research and Education Precinct AMREP, Epigenetics in Human Health and Disease Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia
    Leukemia 18:233-7. 2004
    ..This review article discusses these recent findings and reflects on the antithetical association between DNA methylation and carcinogenesis and the re-examination of studies performed almost two decades ago...
  10. ncbi request reprint DNMT cooperativity--the developing links between methylation, chromatin structure and cancer
    Assam El-Osta
    The Alfred Medical Research and Education Precinct AMREP, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Second Floor, Commercial Road, Prahran, Victoria 3181, Australia
    Bioessays 25:1071-84. 2003
    ..This review discusses the current understanding of cancer-epigenetic information and highlights recent studies that connect the methylation machinery and chromatin remodelling with cancer susceptibility...
  11. ncbi request reprint Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs
    Emma K Baker
    Epigenetics in Human Health and Disease Laboratory, The Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Commercial Road, Prahran, Victoria 3181, Australia
    Oncogene 24:8061-75. 2005
    ..Our results demonstrate that chemotherapeutic drugs can actively induce epigenetic changes within the MDR1 promoter, and enhance the MDR phenotype...
  12. doi request reprint Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells
    Jun Okabe
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    Circ Res 110:1067-76. 2012
    ..The precise mechanism whereby chromatin structure and subsequent gene expression are regulated by glucose in vascular endothelial cells remain to be fully defined...
  13. pmc Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells
    Luciano Pirola
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    Genome Res 21:1601-15. 2011
    ..We uncover that hyperglycemia-mediated induction of genes and pathways associated with endothelial dysfunction occur through modulation of acetylated H3K9/K14 inversely correlated with methyl-CpG content...
  14. ncbi request reprint Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing
    K N Harikrishnan
    The Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Second Floor, Commercial Road, Prahran, Victoria 3181, Australia
    Nat Genet 37:254-64. 2005
    ..We show that Brm and MeCP2 assembly on chromatin occurs on methylated genes in cancer and the gene FMR1 in fragile X syndrome. These experimental findings identify a new role for SWI/SNF in gene repression by MeCP2...
  15. pmc The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart
    Prabhu Mathiyalagan
    Epigenetics in Human Health and Disease Laboratory, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia, Experimental Cardiology, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia and Central Clinical School, Faculty of Medicine, Monash University, Victoria, Australia
    Nucleic Acids Res 42:790-803. 2014
    ..These studies provide a framework for MHC expression and regulation of genes implicated in pathological remodeling of ventricular hypertrophy. ..
  16. doi request reprint Alleviating transcriptional inhibition of the norepinephrine slc6a2 transporter gene in depolarized neurons
    K N Harikrishnan
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
    J Neurosci 30:1494-501. 2010
    ..These results now begin to offer a new perspective on the mechanism of Slc6a2 gene regulation...
  17. doi request reprint gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci
    Raja S Vasireddy
    Epigenetics in Human Health and Disease, BakerIDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Vic, Australia
    Cell Mol Life Sci 67:291-4. 2010
    ..Here, we have extended those studies and provide evidence that gammaH2AX foci form preferentially in actively transcribing euchromatin following gamma-irradiation...
  18. ncbi request reprint Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments
    K N Harikrishnan
    Epigenetics in Human Health and Disease, Baker Medical Research Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    Cell Cycle 7:468-76. 2008
    ..Overall, our findings are consistent with the emerging interest in the use histone deacetylase inhibitors in combination with radiotherapy for the treatment of cancer...
  19. pmc Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes
    Tom C Karagiannis
    Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    Aging (Albany NY) 2:659-68. 2010
    ..More generally, our findings highlight the importance of investigating potential side effects that may be associated with emerging combination therapies for cancer...
  20. doi request reprint Chromatin modifications associated with diabetes
    Samuel T Keating
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Vic, Australia
    J Cardiovasc Transl Res 5:399-412. 2012
    ..The best-characterised enzyme is the lysine specific Set7 methyltransferase. The contribution of Set7 to the aetiology of diabetic complications may extend to other transcriptional events through methylation of non-histone substrates...
  21. ncbi request reprint The epigenetic modifier, valproic acid, enhances radiation sensitivity
    Tom C Karagiannis
    Molecular Radiation Biology, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Epigenetics 1:131-7. 2006
    ....
  22. ncbi request reprint MDR1, chemotherapy and chromatin remodeling
    Emma K Baker
    Epigenetics in Human Health and Disease Laboratory, Baker Heart Research Institute, Alfred Medical Research and Education Precinct AMREP, Prahran, Victoria, Australia
    Cancer Biol Ther 3:819-24. 2004
    ..This review examines some of these studies, and discusses how new developments from the greatly expanding epigenetics field may extend to MDR1 transcriptional research...
  23. doi request reprint Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes
    Katherine Ververis
    Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 75 Commercial Road, Melbourne, Vic, Australia
    Cell Mol Life Sci 68:4101-14. 2011
    ..These observations highlight the importance of investigating potential side-effects, in relevant model systems, which may be associated with emerging combination therapies for cancer...
  24. doi request reprint Double-strand breaks and the concept of short- and long-term epigenetic memory
    Christian Orlowski
    Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 75 Commercial Road, Melbourne, Victoria, Australia
    Chromosoma 120:129-49. 2011
    ....
  25. doi request reprint Epigenetic regulation of multidrug resistance 1 gene expression: profiling CpG methylation status using bisulphite sequencing
    Emma K Baker
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Methods Mol Biol 596:183-98. 2010
    ..The bisulphite sequencing and cloning method allows a precise interpretation of the methylation status of each individual CpG dinucleotide in the MDR1 region...
  26. ncbi request reprint Expression analysis of the epigenetic methyltransferases and methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL)
    Harikrishnan Kn
    The Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Prahran, Victoria, Australia
    Cancer Biol Ther 3:989-94. 2004
    ..We envisage changes in the epigenetic program are multifactorial in nature and postulate that the prevalent genomic methylases just one component of a larger epigenetic repertoire...
  27. doi request reprint Dynamic changes in the cardiac methylome during postnatal development
    Choon Boon Sim
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia and Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    FASEB J 29:1329-43. 2015
    ..This study provides novel evidence for widespread alterations in DNA methylation during postnatal heart maturation and suggests that cardiomyocyte cell cycle arrest during the neonatal period is subject to regulation by DNA methylation...
  28. pmc Non-referenced genome assembly from epigenomic short-read data
    Antony Kaspi
    a Epigenetics in Human Health and Disease Laboratory Baker IDI Heart and Diabetes Institute The Alfred Medical Research and Education Precinct Melbourne, Victoria, Australia
    Epigenetics 9:1329-38. 2014
    ..The pipeline described uses open source software for fast annotation and visualization of unreferenced genomic regions from short-read data...
  29. doi request reprint Epigenetic mechanisms in the pathogenesis of diabetic foot ulcers
    Haloom Rafehi
    Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    J Diabetes Complications 26:554-61. 2012
    ..An overview of epigenetic mechanisms is provided and the focus is on the emerging evidence for aberrant epigenetic mechanisms in diabetic foot ulcers...
  30. doi request reprint Glycemic memory associated epigenetic changes
    Andrew L Siebel
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Biochem Pharmacol 80:1853-9. 2010
    ..Further characterisation of these glucose-induced epigenetic events and the identification of key enzymes involved will improve our understanding of the pathways implicated in diabetic vascular injury...
  31. ncbi request reprint Clinical potential of histone deacetylase inhibitors as stand alone therapeutics and in combination with other chemotherapeutics or radiotherapy for cancer
    Tom C Karagiannis
    Molecular Radiation Biology, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Epigenetics 1:121-6. 2006
    ..In this article the molecular basis for the clinical potential of HDAC inhibitors, either as stand alone cancer therapeutics or in combination with other chemotherapy agents or ionizing radiation will be overviewed...
  32. doi request reprint RNA sequencing supports distinct reactive oxygen species-mediated pathways of apoptosis by high and low size mass fractions of Bay leaf (Lauris nobilis) in HT-29 cells
    Annabelle L Rodd
    Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    Food Funct 6:2507-24. 2015
    ..The results support ferrous iron in cell culture systems and potentially in vivo, can invoke different extra-cellular versus intra-cellular ROS-mediated chemistries, that may be regulated by exogenous, including dietary species. ..
  33. pmc Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis
    Haloom Rafehi
    Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 75 Commercial Road, Melbourne, Vic, Australia
    Genes Nutr 7:343-55. 2012
    ..Overall, our findings provide insights into the mechanisms of action of hydroxytyrosol, and more generally, we identify potential gene candidates for further exploration...
  34. doi request reprint Endothelial transcriptome in response to pharmacological methyltransferase inhibition
    Jun Okabe
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004 Australia Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria 3800 Australia
    ChemMedChem 9:1755-62. 2014
    ..These results imply that inhibition of protein methylation by AMI-1 and AMI-5 can differentially regulate specific pathways with potential to interrupt pathological signaling in the vascular endothelium. ..
  35. doi request reprint Deep sequencing reveals novel Set7 networks
    Samuel T Keating
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Vic, 3004, Australia
    Cell Mol Life Sci 71:4471-86. 2014
    ..From initial characterization of Set7 as specific for methyl-lysine 4 of H3 histones (H3K4m1), biochemical activity toward non-histone substrates has revealed additional mechanisms of gene regulation...
  36. doi request reprint A pipeline for the identification and characterization of chromatin modifications derived from ChIP-Seq datasets
    Antony Kaspi
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    Biochimie 94:2353-9. 2012
    ..We provide an overview of best-practise approaches with background information and considerations of integrative analysis from ChIP-Seq experiments...
  37. doi request reprint Epigenetic phenomena linked to diabetic complications
    Luciano Pirola
    Epigenetics in Human Health and Disease Laboratory, The Alfred Medical Research and Education Precinct, Baker IDI Heart and Diabetes Institute, 5th Floor, 75 Commercial Road, Melbourne, VIC 3004, Australia
    Nat Rev Endocrinol 6:665-75. 2010
    ..Interestingly, transient exposure to hyperglycemia results in long-lasting epigenetic modifications that lead to changes in chromatin structure and gene expression, which mediate these persistent metabolic characteristics...
  38. ncbi request reprint The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation
    Tom C Karagiannis
    Molecular Radiation Biology, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cell Cycle 5:288-95. 2006
    ..This review focuses on the different mechanisms by which histone deacetylase inhibitors modify cellular responses to ionizing radiation...
  39. doi request reprint The emerging role of epigenetic modifications and chromatin remodeling in spinal muscular atrophy
    Sebastian Lunke
    Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    J Neurochem 109:1557-69. 2009
    ....
  40. ncbi request reprint Cardiac genes show contextual SWI/SNF interactions with distinguishable gene activities
    Lisa Chang
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    Epigenetics 6:760-8. 2011
    ..We hypothesize that cardiac hypertrophy and the fetal gene expression program are associated with distinguishable binding of Brm and Brg1 on genes present in distinct complexes, suggesting possible independent-regulatory roles...
  41. pmc Set7 mediated interactions regulate transcriptional networks in embryonic stem cells
    Natasha K Tuano
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    Nucleic Acids Res 44:9206-9217. 2016
    ..We conclude the broad substrate specificity of Set7 serves to control key transcriptional networks in embryonic stem cells...
  42. pmc HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes
    Jenny Y Y Ooi
    a Epigenetics in Human Health and Disease Laboratory Baker IDI Heart and Diabetes Institute Melbourne, Victoria, Australia
    Epigenetics 10:418-30. 2015
    ..The results of this study provides a framework for HDAC inhibitor function in the heart and argues the long held views of acetylation is subject to more flexibility than previously thought. ..
  43. doi request reprint Glycemic memories and the epigenetic component of diabetic nephropathy
    Samuel T Keating
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, 3004, Australia
    Curr Diab Rep 13:574-81. 2013
    ..Exploration of epigenetic mechanisms underlying the hyperglycemic cue mediating persistent transcriptional changes in renal cells holds novel therapeutic potential for diabetic nephropathy. ..
  44. doi request reprint Influence of natural and synthetic histone deacetylase inhibitors on chromatin
    Paul V Licciardi
    Allergy and Immune Disorders, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    Antioxid Redox Signal 17:340-54. 2012
    ..At least 15 HDACIs are currently undergoing clinical trials either alone or in combination with other therapeutic modalities for the treatment of numerous hematological and solid malignancies...
  45. doi request reprint Glycemic memory
    Assam El-Osta
    Epigenetics in Human Health and Disease Laboratory, The University of Melbourne, Parkville, Melbourne, Victoria, Australia
    Curr Opin Lipidol 23:24-9. 2012
    ..1. 7-8) is a tale that looks beyond the present by linking the past with the future. The present article examines the resurgence in the field to understand gene-regulating epigenetic changes conferring glycemic memory...
  46. ncbi request reprint FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle
    Robert J Southgate
    Cellular and Molecular Metabolism Laboratory, The Baker Heart Research Institute, Commercial Road, Melbourne 3004, Victoria, Australia
    J Biol Chem 282:21176-86. 2007
    ..These data suggest that FOXO1 may be an important therapeutic target for human diseases where anabolism is impaired...
  47. ncbi request reprint Cardiac ventricular chambers are epigenetically distinguishable
    Prabhu Mathiyalagan
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Vic, Australia
    Cell Cycle 9:612-7. 2010
    ..We present evidence for the first time that the pattern of gene expression is closely linked with histone modifications and propose the left and right chambers of the heart are epigenetically distinguishable...
  48. doi request reprint Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    Ann N Y Acad Sci 1148:338-48. 2008
    ....
  49. pmc Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks
    Li Jeen Mah
    Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    Genome Integr 2:3. 2011
    ..This review will explore the emerging applicability of γH2AX as a marker for monitoring the effectiveness of radiation-modifying compounds...
  50. doi request reprint Chromatin modifications remodel cardiac gene expression
    Prabhu Mathiyalagan
    Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    Cardiovasc Res 103:7-16. 2014
    ..In this review, we discuss the role of HDACs and HMTs with a focus on chromatin modification and gene function as well as the clinical treatment of heart failure. ..
  51. pmc Motif analysis in DNAse hypersensitivity regions uncovers distal cis elements associated with gene expression
    Mark Ziemann
    Epigenetics in Human Health and Disease Laboratory Epigenomics Profiling Facility, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    Bioinformation 9:212-5. 2013
    ..AVAILABILITY: The DHC-MEGE shell script can be obtained from Sourceforge https://sourceforge.net/projects/dhcmege/ and the generated GMT file is attached as supplementary data...
  52. doi request reprint Epigenetic modification of the norepinephrine transporter gene in postural tachycardia syndrome
    Richard Bayles
    Baker IDI Heart and Diabetes Institute, The University of Melbourne, Melbourne, Victoria 3004, Australia
    Arterioscler Thromb Vasc Biol 32:1910-6. 2012
    ..A coding mutation in the norepinephrine transporter gene (SLC6A2) sequence has been reported in 1 family kindred only. The goal of the present study was to further characterize the role and regulation of the SLC6A2 gene in POTS...
  53. pmc Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail
    Daniella Brasacchio
    Epigenetics in Human Health and Disease Laboratory, The Alfred Medical Research and Education Precinct, Baker IDI Heart and Diabetes Institute, Victoria, Australia
    Diabetes 58:1229-36. 2009
    ..We have hypothesized that transient hyperglycemia mediates persistent gene-activating events attributed to changes in epigenetic information...
  54. doi request reprint Epigenetics: mechanisms and implications for diabetic complications
    Mark E Cooper
    Baker IDI Heart and Diabetes Institute, Monash University, Victoria, Australia
    Circ Res 107:1403-13. 2010
    ....
  55. doi request reprint Genetic and epigenetic events in diabetic wound healing
    Haloom Rafehi
    Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Int Wound J 8:12-21. 2011
    ..Indeed, epigenetic changes have already been identified as key factors in diabetes and related complications and these are overviewed in this review...
  56. doi request reprint Epigenetic-mediated reprogramming of pancreatic endocrine cells
    Prabhu Mathiyalagan
    1 Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Australia
    Antioxid Redox Signal 22:1483-95. 2015
    ..In the context of T1D, the scarcity of organ donors has driven research to alternate sources of functionally competent, insulin-secreting β-cells as substitute for donor islets to meet the clinical need for transplantation therapy...
  57. pmc Evaluation of microRNA alignment techniques
    Mark Ziemann
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, AustraliaEpigenomics Profiling Facility, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    RNA 22:1120-38. 2016
    ..These results will inform on best practice for smRNA mapping and enable more accurate smRNA detection and quantification of expression and RNA editing. ..
  58. doi request reprint Improving understanding of chromatin regulatory proteins and potential implications for drug discovery
    Haloom Rafehi
    a Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Expert Rev Proteomics 13:435-45. 2016
    ..Reviewed here is how high-throughput sequencing improves our understanding of chromatin regulator proteins and the potential implications for the study of human disease and drug development and discovery. ..
  59. pmc Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy
    Jay C Jha
    Diabetic Complications Division, Juvenile Diabetes Research Foundation Danielle Alberti Memorial Centre for Diabetic Complications, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia Department of Medicine, Monash University, Melbourne, Victoria, Australia
    J Am Soc Nephrol 25:1237-54. 2014
    ..Collectively, these results identify Nox4 as a key source of ROS responsible for kidney injury in diabetes and provide proof of principle for an innovative small molecule approach to treat and/or prevent chronic kidney failure...
  60. pmc Applicability of histone deacetylase inhibition for the treatment of spinal muscular atrophy
    Sebastian Lunke
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Vic, 3004, Australia
    Neurotherapeutics 10:677-87. 2013
    ..Here, we review the history and current state of use of histone deacetylase inhibitors in SMA, as well as the success of clinical trials investigating the clinical applicability of these epigenetic modifiers in SMA treatment. ..
  61. ncbi request reprint The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X
    Tom C Karagiannis
    Molecular Radiation Biology, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, Victoria, Australia
    Cancer Biol Ther 4:787-93. 2005
    ..More generally, our findings are consistent with those from recent studies and support the development of histone deacetylase inhibitors for use as radiation sensitizers, particularly for targeting radioresistant cancers...
  62. ncbi request reprint The rise of DNA methylation and the importance of chromatin on multidrug resistance in cancer
    Emma K Baker
    The Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Second Floor, Commercial Road, Prahran, Victoria 3181, Australia
    Exp Cell Res 290:177-94. 2003
    ..Finally, we explore transcriptional regulation and highlight recent progress with engineered ZFP's (zinc finger proteins)...
  63. ncbi request reprint Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophages
    Genevieve Escher
    Baker Heart Research Institute, Melbourne, Victoria, 8008, Australia
    J Lipid Res 46:356-65. 2005
    ..However, transfection with CYP27A1 led to a 2- to 4-fold increase of cholesterol efflux. We conclude that treatment with 5-azacytidine can be used for high-efficiency transient transfection of macrophages...
  64. doi request reprint Epigenetic Changes in Diabetes and Cardiovascular Risk
    Samuel T Keating
    From the Epigenetics in Human Health and Disease Laboratory S T K, A E O and Epigenomics Profiling Facility A E O, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA J P Department of Pathology, The University of Melbourne, Victoria, Australia A E O and Central Clinical School, Department of Medicine, Monash University, Victoria, Australia A E O
    Circ Res 118:1706-22. 2016
    ....
  65. pmc Gene name errors are widespread in the scientific literature
    Mark Ziemann
    Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, 3004, Australia
    Genome Biol 17:177. 2016
    ..A programmatic scan of leading genomics journals reveals that approximately one-fifth of papers with supplementary Excel gene lists contain erroneous gene name conversions. ..
  66. doi request reprint Epigenomic changes associated with impaired norepinephrine transporter function in postural tachycardia syndrome
    Abdul Waheed Khan
    Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia Electronic address
    Neurosci Biobehav Rev . 2016
    ..In this article, we discuss the epigenetic mechanisms involved in SLC6A2 repression and highlight the potential therapeutic application of targeting these mechanisms in POTS...
  67. doi request reprint Metabolism and chromatin dynamics in health and disease
    Hanah Rodriguez
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia
    Mol Aspects Med . 2016
    ..Moreover, damaging gene expression patterns observed in metabolic diseases such as diabetes are driven by persistent changes in chromatin structure, raising the possibility of targeting epigenetic pathways for the treatment of disease...
  68. doi request reprint Epigenetics and metabolism
    Samuel T Keating
    From the Epigenetics in Human Health and Disease Laboratory S T K, A E O and Epigenomics Profiling Facility S T K, A E O, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia Department of Pathology, The University of Melbourne, Victoria, Australia A E O and Central Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia A E O
    Circ Res 116:715-36. 2015
    ..These emerging concepts open new perspectives to combat the rising global epidemic of metabolic disorders. ..
  69. pmc Rapid development of non-alcoholic steatohepatitis in Psammomys obesus (Israeli sand rat)
    Briana Spolding
    Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia
    PLoS ONE 9:e92656. 2014
    ....
  70. ncbi request reprint FMR1 silencing and the signals to chromatin: a unified model of transcriptional regulation
    Assam El-Osta
    Sir Donald and Lady Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, VIC 3002, Australia
    Biochem Biophys Res Commun 295:575-81. 2002
    ..Examining general transcription systems controlled by DNA methylation, proteins that recognize the methyl-CpG moiety and the enzyme that maintains methylation, a unified model of FMR1 gene silencing are discussed...
  71. pmc Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation
    Assam El-Osta
    Sir Donald and Lady Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Mol Cell Biol 22:1844-57. 2002
    ..Inhibition of histone deacetylase is not an overriding mechanism in the reactivation of methylated MDR1. Our results provide us with a clearer understanding of the molecular mechanism necessary for repression of MDR1...
  72. ncbi request reprint Epigenetic changes activate widespread signals in response to double-strand breaks
    Tom C Karagiannis
    Molecular Radiation Biology, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, Australia
    Cancer Biol Ther 3:617-23. 2004
    ..In particular, findings from recent studies suggest mechanisms by which highly localized double-strand breaks may activate widespread signals throughout the cell by inducing alterations in chromatin structure...
  73. ncbi request reprint RNA interference and potential therapeutic applications of short interfering RNAs
    Tom C Karagiannis
    Molecular Radiation Biology, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, Melbourne, Australia
    Cancer Gene Ther 12:787-95. 2005
    ..The article will focus on recent developments related to the use of RNA interference technologies in mammalian systems and on potential clinical applications of short interfering RNA-mediated RNA interference...
  74. ncbi request reprint The neuronal noradrenaline transporter, anxiety and cardiovascular disease
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    J Psychopharmacol 20:60-6. 2006
    ....
  75. ncbi request reprint On the use of DNA methylation inhibitors and the reversal of transcriptional silencing
    Assam El-Osta
    Blood 101:1656; author reply 1657-8. 2003
  76. ncbi request reprint siRNAs: mechanism of RNA interference, in vivo and potential clinical applications
    Tom C Karagiannis
    Molecular Radiation Biology, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, Melbourne, Australia
    Cancer Biol Ther 3:1069-74. 2004
    ..The article will outline in vivo and potential clinical applications of small interfering RNA molecules...