Richard J Lang

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi request reprint Pyeloureteral motility and ureteral peristalsis: essential role of sensory nerves and endogenous prostaglandins
    Richard J Lang
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Exp Physiol 87:129-46. 2002
  2. ncbi request reprint Characterization of the ion channel currents in single myocytes of the guinea pig prostate
    Richard J Lang
    Department of Physiology, Monash University, Clayton 3800, Victoria, Australia
    J Urol 172:1179-87. 2004
  3. ncbi request reprint Spontaneous electrical activity in the prostate gland
    Betty Exintaris
    Prostate Research Co operative, Victorian College of Pharmacy, Monash University, Parkville 3052, Melbourne, Australia
    Auton Neurosci 126:371-9. 2006
  4. doi request reprint alpha(1)-adrenoceptor modulation of spontaneous electrical waveforms in the guinea-pig prostate
    Dan Thanh T Nguyen
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia
    Eur J Pharmacol 608:62-70. 2009
  5. ncbi request reprint Electrical characterization of interstitial cells of Cajal-like cells and smooth muscle cells isolated from the mouse ureteropelvic junction
    Richard J Lang
    Department of Physiology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
    J Urol 177:1573-80. 2007
  6. ncbi request reprint Electrical and neurotransmitter activity of mature neurons derived from mouse embryonic stem cells by Sox-1 lineage selection and directed differentiation
    R J Lang
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Eur J Neurosci 20:3209-21. 2004
  7. ncbi request reprint Interstitial cell of Cajal-like cells in the upper urinary tract
    R J Lang
    Department of Physiology, Faculty of Medicine and Health Sciences, Monash University, Clayton, 3168, Victoria, Australia
    J Cell Mol Med 9:543-56. 2005
  8. ncbi request reprint Characterization of spontaneous depolarizations in smooth muscle cells of the Guinea pig prostate
    Richard J Lang
    Department of Physiology, Monash University, Clayton, Parkville, Victoria, Australia
    J Urol 175:370-80. 2006
  9. pmc Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers
    Richard J Lang
    Department of Physiology, Monash University, Clayton 3800, Australia
    J Physiol 576:695-705. 2006
  10. doi request reprint Role of hyperpolarization-activated cation channels in pyeloureteric peristalsis
    Richard J Lang
    Department of Physiology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Kidney Int 77:483-5. 2010

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Pyeloureteral motility and ureteral peristalsis: essential role of sensory nerves and endogenous prostaglandins
    Richard J Lang
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Exp Physiol 87:129-46. 2002
    ..However, the cellular mechanisms underlying the action of these endogenously-released agents remain to be elucidated...
  2. ncbi request reprint Characterization of the ion channel currents in single myocytes of the guinea pig prostate
    Richard J Lang
    Department of Physiology, Monash University, Clayton 3800, Victoria, Australia
    J Urol 172:1179-87. 2004
    ..We characterized membrane ionic currents underlying the action potential in single myocytes freshly isolated from the stroma of the guinea pig prostate...
  3. ncbi request reprint Spontaneous electrical activity in the prostate gland
    Betty Exintaris
    Prostate Research Co operative, Victorian College of Pharmacy, Monash University, Parkville 3052, Melbourne, Australia
    Auton Neurosci 126:371-9. 2006
    ..In contrast, nitric oxide donors reduce or abolish the spontaneous electrical events. However, the cellular mechanisms underlying the action of various endogenously released agents remain to be elucidated...
  4. doi request reprint alpha(1)-adrenoceptor modulation of spontaneous electrical waveforms in the guinea-pig prostate
    Dan Thanh T Nguyen
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia
    Eur J Pharmacol 608:62-70. 2009
    ..In the presence of nifedipine, the effects observed upon alpha(1)-adrenoceptor activation were dependent on Ca(2+) cycling by both the intracellular Ca(2+) stores and mitochondria...
  5. ncbi request reprint Electrical characterization of interstitial cells of Cajal-like cells and smooth muscle cells isolated from the mouse ureteropelvic junction
    Richard J Lang
    Department of Physiology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
    J Urol 177:1573-80. 2007
    ..We characterized membrane currents in smooth muscle cells and interstitial cells freshly isolated from the mouse ureteropelvic junction...
  6. ncbi request reprint Electrical and neurotransmitter activity of mature neurons derived from mouse embryonic stem cells by Sox-1 lineage selection and directed differentiation
    R J Lang
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Eur J Neurosci 20:3209-21. 2004
    ..It was concluded that ES-derived neurons fire action potentials, receive excitatory and inhibitory synaptic input and respond to various neurotransmitters in a manner akin to primary central neurons...
  7. ncbi request reprint Interstitial cell of Cajal-like cells in the upper urinary tract
    R J Lang
    Department of Physiology, Faculty of Medicine and Health Sciences, Monash University, Clayton, 3168, Victoria, Australia
    J Cell Mol Med 9:543-56. 2005
    ....
  8. ncbi request reprint Characterization of spontaneous depolarizations in smooth muscle cells of the Guinea pig prostate
    Richard J Lang
    Department of Physiology, Monash University, Clayton, Parkville, Victoria, Australia
    J Urol 175:370-80. 2006
    ..We characterized the electrical events recorded in small segments of the dorsal lobe of the prostate of immature male guinea pigs and examined some mechanisms underlying their generation...
  9. pmc Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers
    Richard J Lang
    Department of Physiology, Monash University, Clayton 3800, Australia
    J Physiol 576:695-705. 2006
    ....
  10. doi request reprint Role of hyperpolarization-activated cation channels in pyeloureteric peristalsis
    Richard J Lang
    Department of Physiology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Kidney Int 77:483-5. 2010
    ....
  11. doi request reprint Spontaneous electrical and Ca2+ signals in the mouse renal pelvis that drive pyeloureteric peristalsis
    Richard J Lang
    Department of Physiology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
    Clin Exp Pharmacol Physiol 37:509-15. 2010
    ..5. In summary, we have developed a model of pyeloureteric pacemaking in which atypical SMCs are indeed the primary pacemakers, but the function of ICC-like cells has yet to be determined...
  12. pmc Spontaneous electrical and Ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of Cajal-like cells of mouse renal pelvis
    Richard J Lang
    Department of Physiology, School of Biomedical Sciences, Faculty of Medicine and Health Sciences, Monash University, Clayton, Victoria 3800, Australia
    J Physiol 583:1049-68. 2007
    ..We speculate that ASMCs act as the primary pacemaker in the renal pelvis while ICC-LCs play a supportive role, but can take over pacemaking in the absence of the proximal pacemaker drive...
  13. pmc Role of Ca2+ entry and Ca2+ stores in atypical smooth muscle cell autorhythmicity in the mouse renal pelvis
    R J Lang
    Department of Physiology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
    Br J Pharmacol 152:1248-59. 2007
    ..We have investigated the role of Ca2+ entry and uptake into and release from internal stores in the generation of Ca2+ transients and spontaneous transient depolarizations (STDs) in ASMCs...
  14. pmc Sodium (2-sulfonatoethyl) methanethiosulfonate prevents S-nitroso-L-cysteine activation of Ca2+-activated K+ (BKCa) channels in myocytes of the guinea-pig taenia caeca
    Richard J Lang
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Br J Pharmacol 139:1153-63. 2003
    ..6. It was concluded that NOCys-evoked increases in BK(Ca) channel activity occur via the S-nitrosylation of cysteine residues within basic regions of the channel alpha subunit that have an accessible water interface...
  15. pmc Modulators of internal Ca2+ stores and the spontaneous electrical and contractile activity of the guinea-pig renal pelvis
    R J Lang
    Department of Physiology, Monash University, Clayton 3800, Victoria, Australia
    Br J Pharmacol 135:1363-74. 2002
    ..The inhibitory actions of modulators of internal Ca(2+) release were partially explained by a blockade of Ca(2+) entry...
  16. ncbi request reprint Electrical basis of peristalsis in the mammalian upper urinary tract
    R J Lang
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Clin Exp Pharmacol Physiol 25:310-21. 1998
    ....
  17. pmc Nitric oxide and thiol reagent modulation of Ca2+-activated K+ (BKCa) channels in myocytes of the guinea-pig taenia caeci
    R J Lang
    Department of Physiology, Monash University, Clayton 3800, Victoria, Australia
    J Physiol 525:363-76. 2000
    ..It was concluded that both redox modulation and nitrothiosylation of cysteine groups on the cytosolic surface of the alpha subunit of the BKCa channel protein can alter channel gating...
  18. pmc Inositol trisphosphate-dependent Ca stores and mitochondria modulate slow wave activity arising from the smooth muscle cells of the guinea pig prostate gland
    Betty Exintaris
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia
    Br J Pharmacol 156:1098-106. 2009
    ..Here, we have examined the role of internal Ca(2+) compartments in regulating slow wave activity in the guinea pig prostate...
  19. pmc Role of connexin 43 in the maintenance of spontaneous activity in the guinea pig prostate gland
    Anupa Dey
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia
    Br J Pharmacol 161:1692-707. 2010
    ..To investigate the role of connexin 43 in the maintenance of spontaneous activity in prostate tissue from young and old guinea pigs...
  20. pmc Effects of nitric oxide donors, S-nitroso-L-cysteine and sodium nitroprusside, on the whole-cell and single channel currents in single myocytes of the guinea-pig proximal colon
    R J Lang
    Department of Physiology, Monash University, Clayton Victoria, Australia
    Br J Pharmacol 123:505-17. 1998
    ....
  21. doi request reprint Nitric oxide signaling pathways involved in the inhibition of spontaneous activity in the guinea pig prostate
    Anupa Dey
    Medicinal Chemistry and Drug Action, Department of Pharmaceutical Biology and Pharmacology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia
    J Urol 187:2254-60. 2012
    ..We investigated nitric oxide mediated inhibition of spontaneous activity recorded in young and aging guinea pig prostates...
  22. doi request reprint Contractility and pacemaker cells in the prostate gland
    Dan Thanh T Nguyen
    Monash Institute of Pharmaceutical Sciences, Parkville and Department of Physiology, Monash University, Clayton, Victoria, Australia
    J Urol 185:347-51. 2011
    ..We focused on the current opinion on mechanisms generating stromal tone in the prostate gland...
  23. doi request reprint Spontaneous electrical waveforms in aging guinea pig prostates
    Anupa Dey
    Prostate Research Co operative, Victorian College of Pharmacy, Monash University, Parkville, Victoria, Australia
    J Urol 181:2797-805. 2009
    ..We characterized spontaneous electrical activity in the aging guinea pig prostate...
  24. ncbi request reprint Spontaneous slow wave and contractile activity of the guinea pig prostate
    Betty Exintaris
    Department of Pharmaceutical Biology and Pharmacology, Victorian College of Pharmacy and Monash University, Parkville, Australia
    J Urol 168:315-22. 2002
    ..We characterized the electrical events underlying spontaneous contractions of the stroma of the guinea pig prostate...
  25. pmc Potassium and ANO1/ TMEM16A chloride channel profiles distinguish atypical and typical smooth muscle cells from interstitial cells in the mouse renal pelvis
    Javed Iqbal
    Department of Physiology Anatomy and Development Biology, Monash University, Clayton, Victoria, Australia
    Br J Pharmacol 165:2389-408. 2012
    ..Although atypical smooth muscle cells (SMCs) in the proximal renal pelvis are thought to generate the pacemaker signals that drive pyeloureteric peristalsis, their location and electrical properties remain obscure...
  26. ncbi request reprint Pelviureteric peristaltic contractions in diabetic rats
    Margaret E Davidson
    Department of Physiology, School of Biomedical Sciences, Faculty of Medicine and Health Sciences, Monash University, Clayton, Vic, Australia
    J Smooth Muscle Res 43:145-55. 2007
    ..We speculate that the supersensitivity of the diabetic UUT to capsaicin, NKA and SP 8-10 weeks after STZ treatment could be arising from an earlier development of sensory neuropathy...
  27. doi request reprint Spontaneous Ca2+ signaling of interstitial cells in the guinea pig prostate
    Michelle Lam
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia
    J Urol 186:2478-86. 2011
    ..We investigated whether prostate interstitial cells generate spontaneous Ca(2+) oscillation, a proposed mechanism underlying pacemaker potentials to drive spontaneous activity in stromal smooth muscle cells...
  28. pmc Effects of intrinsic prostaglandins on the spontaneous contractile and electrical activity of the proximal renal pelvis of the guinea-pig
    Y Zhang
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Br J Pharmacol 113:431-8. 1994
    ..Keywords: Renal pelvis; action potentials; prostaglandins; indomethacin..
  29. ncbi request reprint Inhibition of voltage-activated K+ currents in smooth muscle cells of the guinea pig proximal colon by noradrenergic agonists
    F Vogalis
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Gen Pharmacol 31:239-45. 1998
    ..6. Our data suggest that stimulation of beta-adrenoceptors in the circular muscle layer of the guinea pig proximal colon inhibits voltage-activated Ca2+i-insensitive K+ currents...
  30. pmc Effects of okadaic acid and ATP gamma S on cell length and Ca(2+)-channel currents recorded in single smooth muscle cells of the guinea-pig taenia caeci
    R J Lang
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Br J Pharmacol 104:331-6. 1991
    ....
  31. pmc K+ channel modulation of slow wave activity in the guinea-pig prostate
    D T T Nguyen
    Department of Pharmaceutical Biology and Pharmacology, Prostate Research Co operative, Victorian College of Pharmacy, Monash University, Parkville Victoria, Australia
    Br J Pharmacol 151:828-36. 2007
    ..The aim of this study was to investigate the role of different K(+) channel populations and the inhibitory effect of various exogenously applied K(+) channel openers in the regulation of slow wave activity in the guinea-pig prostate...
  32. ncbi request reprint Thiol reagents and nitric oxide modulate the gating of BKCa channels from the guinea-pig taenia caeci
    R J Lang
    Department of Physiology, Monash University, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 29:944-9. 2002
    ..A consensus sequence of various mammalian alpha-subunits of the BKCa channel reveals two pairs of cysteine residues surrounded by basic amino acids that could be the site of action for NOCys and MTSES...
  33. ncbi request reprint Characterization of the spontaneous electrical and contractile activity of smooth muscle cells in the rat upper urinary tract
    R J Lang
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    J Urol 166:329-34. 2001
    ....
  34. ncbi request reprint Distribution of Ca2+-activated K+ channel (SK2 and SK3) immunoreactivity in intestinal smooth muscles of the guinea-pig
    Megan F Klemm
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Clin Exp Pharmacol Physiol 29:18-25. 2002
    ..6. We conclude that ICC-SK3 are a subpopulation of ICC that are directly innervated by enteric inhibitory motor nerves...
  35. doi request reprint Estradiol-17beta inhibits gonadotropin-releasing hormone-induced Ca2+ in gonadotropes to regulate negative feedback on luteinizing hormone release
    Javed Iqbal
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Endocrinology 150:4213-20. 2009
    ..Activation of the MAPK pathway by E(2) may be the mechanism for the time-delayed positive feedback effect on LH secretion at the level of the gonadotrope...
  36. doi request reprint Voltage-operated Ca(2) (+) currents and Ca(2) (+) -activated Cl(-) currents in single interstitial cells of the guinea-pig prostate
    Richard J Lang
    Department of Physiology, School of Biomedical Sciences, Faculty of Medicine Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia
    BJU Int 114:436-46. 2014
    ..To investigate the expression of 'T-type' and 'L-type' voltage-operated Ca(2) (+) channels in single interstitial cells of the guinea-pig prostate...
  37. doi request reprint Angiotensin receptor-1A knockout leads to hydronephrosis not associated with a loss of pyeloureteric peristalsis in the mouse renal pelvis
    Michael J Nguyen
    Department of Physiology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
    Clin Exp Pharmacol Physiol 43:535-42. 2016
    ..It was concluded that the hydronephrosis observed in ATr1A(-/-) mouse kidneys does not arise from a failure in the development of the essential pacemaker and contractile machinery driving pyeloureteric peristalsis...
  38. doi request reprint A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives
    Adam L Goulburn
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
    Stem Cells 29:462-73. 2011
    ..These studies highlight the diversity of cell types that can be generated from human NKX2.1(+) progenitors and demonstrate the utility of NKX2.1(GFP/w) hESCs for investigating human forebrain development and neuronal differentiation...
  39. doi request reprint CD133 expression by neural progenitors derived from human embryonic stem cells and its use for their prospective isolation
    Gary S L Peh
    Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Stem Cells Dev 18:269-82. 2009
    ..CD133(+)GCTM-2(-) cells formed neurospheres at the relative highest frequency. Thus, negative selection with GCTM-2 may be useful for the purification of specific cell types differentiated from hES cells...