Andre La Gerche

Summary

Affiliation: St Vincent's Hospital
Country: Australia

Publications

  1. ncbi Effect of heart rate on tissue Doppler measures of diastolic function
    Andrew T Burns
    Cardiac Investigation Unit, St Vincent s Hospital, Melbourne, Victoria, Australia
    Echocardiography 24:697-701. 2007
  2. doi Can intensive exercise harm the heart? You can get too much of a good thing.
    Andr La Gerche
    From St Vincent s Hospital Department of Medicine, University of Melbourne, Fitzroy, Australia A L G and Heart Center, Jessa Hospital, Hasselt, Belgium H H
    Circulation 130:992-1002. 2014
  3. doi Cardiac imaging and stress testing asymptomatic athletes to identify those at risk of sudden cardiac death
    Andre La Gerche
    St Vincent s Department of Medicine, University of Melbourne, Melbourne, Australia Department of Cardiovascular Medicine, University Hospital Leuven, Leuven, Belgium Electronic address
    JACC Cardiovasc Imaging 6:993-1007. 2013
  4. doi Transit of micro-bubbles through the pulmonary circulation of Thoroughbred horses during exercise
    A La Gerche
    St Vincent s Department of Medicine, University of Melbourne, Fitzroy, Australia
    Res Vet Sci 95:644-7. 2013
  5. doi Can intense endurance exercise cause myocardial damage and fibrosis?
    Andre La Gerche
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Fitzroy, Australia
    Curr Sports Med Rep 12:63-9. 2013
  6. doi Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes
    Andre La Gerche
    Department of Medicine, University of Melbourne, St Vincent s Hospital, 29 Regent Street, Fitzroy, VIC 3065, Australia
    Eur Heart J 33:998-1006. 2012
  7. doi Maximal oxygen consumption is best predicted by measures of cardiac size rather than function in healthy adults
    Andre La Gerche
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Fitzroy, Australia
    Eur J Appl Physiol 112:2139-47. 2012
  8. ncbi Exercise--is it possible to have too much of a good thing?
    Andre La Gerche
    St Vincent s Hospital, Cardiac Investigation Unit, Victoria Parade, Fitzroy, Melbourne, VIC 3065, Australia
    Heart Lung Circ 16:S102-4. 2007
  9. doi Disproportionate exercise load and remodeling of the athlete's right ventricle
    Andre La Gerche
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Melbourne, Australia
    Med Sci Sports Exerc 43:974-81. 2011
  10. doi Pulmonary transit of agitated contrast is associated with enhanced pulmonary vascular reserve and right ventricular function during exercise
    Andre La Gerche
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Melbourne, Australia
    J Appl Physiol (1985) 109:1307-17. 2010

Collaborators

Detail Information

Publications34

  1. ncbi Effect of heart rate on tissue Doppler measures of diastolic function
    Andrew T Burns
    Cardiac Investigation Unit, St Vincent s Hospital, Melbourne, Victoria, Australia
    Echocardiography 24:697-701. 2007
    ..Our aim was to study the independent effect of heart rate (HR) on parameters of diastolic function, particularly mitral annular velocities measured by tissue Doppler imaging (TDI), an effect which is not well understood...
  2. doi Can intensive exercise harm the heart? You can get too much of a good thing.
    Andr La Gerche
    From St Vincent s Hospital Department of Medicine, University of Melbourne, Fitzroy, Australia A L G and Heart Center, Jessa Hospital, Hasselt, Belgium H H
    Circulation 130:992-1002. 2014
  3. doi Cardiac imaging and stress testing asymptomatic athletes to identify those at risk of sudden cardiac death
    Andre La Gerche
    St Vincent s Department of Medicine, University of Melbourne, Melbourne, Australia Department of Cardiovascular Medicine, University Hospital Leuven, Leuven, Belgium Electronic address
    JACC Cardiovasc Imaging 6:993-1007. 2013
    ....
  4. doi Transit of micro-bubbles through the pulmonary circulation of Thoroughbred horses during exercise
    A La Gerche
    St Vincent s Department of Medicine, University of Melbourne, Fitzroy, Australia
    Res Vet Sci 95:644-7. 2013
    ..Further investigation is warranted to investigate whether this phenomenon may be associated with superior physiology and performance measures as has been implicated in other species. ..
  5. doi Can intense endurance exercise cause myocardial damage and fibrosis?
    Andre La Gerche
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Fitzroy, Australia
    Curr Sports Med Rep 12:63-9. 2013
    ..Moreover, some arrhythmias appear to be more prevalent amongst endurance athletes. Only large prospective trials will enable us to really assess the health benefits and risks of regular intense endurance sports...
  6. doi Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes
    Andre La Gerche
    Department of Medicine, University of Melbourne, St Vincent s Hospital, 29 Regent Street, Fitzroy, VIC 3065, Australia
    Eur Heart J 33:998-1006. 2012
    ....
  7. doi Maximal oxygen consumption is best predicted by measures of cardiac size rather than function in healthy adults
    Andre La Gerche
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Fitzroy, Australia
    Eur J Appl Physiol 112:2139-47. 2012
    ..A combination of ventricular volume, mass and heart rate reserve explains much of the variance in VO(2max), whilst measures of myocardial function do not further strengthen predictive models...
  8. ncbi Exercise--is it possible to have too much of a good thing?
    Andre La Gerche
    St Vincent s Hospital, Cardiac Investigation Unit, Victoria Parade, Fitzroy, Melbourne, VIC 3065, Australia
    Heart Lung Circ 16:S102-4. 2007
    ..Given the increasing popularity of endurance sporting pursuits, there is a need for further research into the cardiac adaptations and consequences of extreme habitual exercise...
  9. doi Disproportionate exercise load and remodeling of the athlete's right ventricle
    Andre La Gerche
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Melbourne, Australia
    Med Sci Sports Exerc 43:974-81. 2011
    ..Using a novel method of estimating end-systolic wall stress (ES-σ), we compared the RV and LV during exercise and assessed whether this influenced chronic ventricular remodeling in athletes...
  10. doi Pulmonary transit of agitated contrast is associated with enhanced pulmonary vascular reserve and right ventricular function during exercise
    Andre La Gerche
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Melbourne, Australia
    J Appl Physiol (1985) 109:1307-17. 2010
    ..0 ± 0.4 vs. 96.7 ± 1.4%, P < 0.0001) was not influenced by PTAC status (P = 0.96). Increased PTAC during exercise is a marker of pulmonary vascular reserve reflected by greater flow, reduced PVR, and enhanced RV function...
  11. ncbi Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise
    A La Gerche
    Cardiac Investigation Unit, St Vincent s Hospital, PO Box 2900, Fitzroy 3065, Victoria, Australia
    Heart 94:860-6. 2008
    ..The extent and duration of these changes remains unresolved. Recent reports have speculated that structural adaptations to exercise, particularly of the right ventricle, may predispose to tachyarrhythmias and sudden cardiac death...
  12. doi Exercise strain rate imaging demonstrates normal right ventricular contractile reserve and clarifies ambiguous resting measures in endurance athletes
    Andre La Gerche
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Melbourne, Australia
    J Am Soc Echocardiogr 25:253-262.e1. 2012
    ..The aim of this study was to test the hypothesis that RV functional reserve would be normal in EAs despite reduced deformation measures at rest...
  13. doi Left ventricular strain and strain rate: characterization of the effect of load in human subjects
    Andrew T Burns
    Cardiac Investigation Unit, St Vincent s Hospital Melbourne, PO Box 2900, Fitzroy, Victoria, Australia
    Eur J Echocardiogr 11:283-9. 2010
    ..Left ventricular (LV) strain and strain rate have been proposed as novel indices of systolic function; however, there are limited data about the effect of acute changes on these parameters...
  14. doi Accuracy of Echocardiography to Evaluate Pulmonary Vascular and RV Function During Exercise
    Guido Claessen
    Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium University Hospitals Leuven, Leuven, Belgium Electronic address
    JACC Cardiovasc Imaging 9:532-43. 2016
    ..The authors have compared exercise echocardiography and exercise cardiac magnetic resonance imaging with simultaneous invasive pressure registration (ExCMRip) for the assessment of pulmonary vascular and right ventricular (RV) function...
  15. doi Right ventricular and pulmonary vascular reserve in asymptomatic BMPR2 mutation carriers
    Guido Claessen
    Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium University Hospitals Leuven, Leuven, Belgium Electronic address
    J Heart Lung Transplant . 2016
    ..Non-invasive estimates have suggested that asymptomatic BMPR2 mutation carriers may have an abnormal pulmonary vascular response to exercise and hypoxia. However, this has not been assessed with "gold standard" invasive measures...
  16. doi Exercise-induced right ventricular dysfunction is associated with ventricular arrhythmias in endurance athletes
    Andre La Gerche
    Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium Sports Cardiology, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia St Vincent s Hospital Melbourne, Fitzroy, Australia
    Eur Heart J 36:1998-2010. 2015
    ..Intense exercise places disproportionate strain on the right ventricle (RV) which may promote pro-arrhythmic remodelling in some athletes. RV exercise imaging may enable early identification of athletes at risk of arrhythmias...
  17. doi Athlete's heart: the potential for multimodality imaging to address the critical remaining questions
    Andre La Gerche
    St Vincent s Hospital and University of Melbourne, Melbourne, Australia
    JACC Cardiovasc Imaging 2:350-63. 2009
    ..Tissue characterization and imaging studies during exercise are emphasized as important future directions of inquiry with the potential to address remaining controversies...
  18. doi Ventricular arrhythmias associated with long-term endurance sports: what is the evidence?
    Hein Heidbuchel
    Department of Cardiovascular Sciences, University Hospital Leuven, Leuven, Belgium
    Br J Sports Med 46:i44-50. 2012
    ..Sports cardiologists, like orthopaedic specialists, should be prepared to realise that excessive sports activity can lead to cardiac sports injuries in some, which will help to council on safe participation in all...
  19. doi Modest agreement in ECG interpretation limits the application of ECG screening in young athletes
    Maria Brosnan
    Department of Cardiology, St Vincent s Hospital, Fitzroy, Australia St Vincent s Department of Medicine, University of Melbourne, Fitzroy, Australia Electronic address
    Heart Rhythm 12:130-6. 2015
    ..An important component that has not been assessed is the reproducibility of ECG interpretation...
  20. doi The Seattle Criteria increase the specificity of preparticipation ECG screening among elite athletes
    Maria Brosnan
    Department of Cardiology, St Vincent s Hospital, Melbourne, Australia Department of Medicine St Vincent s, University of Melbourne, Melbourne, Australia
    Br J Sports Med 48:1144-50. 2014
    ..Recently, the 'Seattle Criteria', a series of revisions to these recommendations, was published, with the aim of improving the specificity of ECG screening in athletes...
  21. ncbi Augmentation of left ventricular torsion with exercise is attenuated with age
    Andrew T Burns
    Cardiac Investigation Unit, St Vincent s Hospital Melbourne, Melbourne, Australia
    J Am Soc Echocardiogr 21:315-20. 2008
    ..The effect of exercise on torsion in the general population and the influence of aging on changes in torsion with exercise are not known...
  22. doi Left ventricular untwisting is an important determinant of early diastolic function
    Andrew T Burns
    Cardiac Investigation Unit, St Vincent s Hospital Melbourne, Victoria, Australia
    JACC Cardiovasc Imaging 2:709-16. 2009
    ..We sought to establish the relationship between invasive measures of diastolic function and untwisting parameters measured with speckle tracking imaging...
  23. doi Left ventricular torsion parameters are affected by acute changes in load
    Andrew T Burns
    Cardiac Investigation Unit, St Vincent s Hospital Melbourne, Victoria, Australia 3065
    Echocardiography 27:407-14. 2010
    ..Quantification of left ventricular torsion may provide new indices of systolic and diastolic function. We sought to characterize the effect of acute manipulation of load on cardiac torsion, plecotropy in human subjects...
  24. doi The athlete's heart.
    David L Prior
    Department of Cardiology, St Vincent s Hospital, Melbourne, PO Box 2900, Fitzroy, VIC 3065, Australia
    Heart 98:947-55. 2012
  25. doi Exercise pathophysiology and sildenafil effects in chronic thromboembolic pulmonary hypertension
    Guido Claessen
    Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium University Hospitals Leuven, Leuven, Belgium
    Heart 101:637-44. 2015
    ..We hypothesised that exercise imaging of RV function would better explain exercise limitation and the acute effects of pulmonary vasodilator administration than resting measurements...
  26. pmc Relationship between Inflammatory Cytokines and Indices of Cardiac Dysfunction following Intense Endurance Exercise
    Andre La Gerche
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia St Vincent s Hospital Melbourne, Fitzroy, Australia University Hospitals Leuven, KU Leuven, Belgium
    PLoS ONE 10:e0130031. 2015
    ..We sought to evaluate whether exercise-induced cardiac dysfunction was associated with increases in cytokines, particularly the pro-inflammatory cytokines IL-1β, IL-12p70 and TNFα, which have been most implicated in cardiac pathology...
  27. doi Signs of RV overload on the athlete's ECG
    Guido Claessen
    Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium Electronic address
    J Electrocardiol 48:399-406. 2015
    ..This article describes ECG findings observed in healthy endurance athletes versus athletes with underlying RV pathology and illustrates their differentiation using 4 case presentations. ..
  28. doi Comparison of frequency of significant electrocardiographic abnormalities in endurance versus nonendurance athletes
    Maria Brosnan
    Department of Cardiology, St Vincent s Hospital, Melbourne, Victoria, Australia St Vincent s Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia Electronic address
    Am J Cardiol 113:1567-73. 2014
    ..The predictive value of ECG screening and criteria for abnormal findings in elite EAs requires specific appraisal. ..
  29. doi Should pre-participation cardiovascular screening for competitive athletes be introduced in Australia? A timely debate in a sport-loving nation
    Andre La Gerche
    Department of Medicine, University of Melbourne, Australia
    Heart Lung Circ 20:629-33. 2011
    ..We review the evidence for and against screening and propose that systematic collection of Australian data is required before routine pre-participation screening can be introduced in Australia...
  30. doi Exercise and the right ventricle: a potential Achilles' heel
    Andre La Gerche
    Sports Cardiology and Cardiac Magnetic Resonance Imaging Lab, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Victoria 3004, Australia
    Cardiovasc Res 113:1499-1508. 2017
    ..Finally, we will discuss recent evidence defining the role of exercise restriction as a therapeutic intervention in individuals predisposed to arrhythmogenic cardiomyopathy...
  31. doi Cardiovascular Effects of Performance-Enhancing Drugs
    Andre La Gerche
    From Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia A L G, M J B St Vincent s Hospital, Fitzroy, Victoria, Australia A L G, M J B and Department of Cardiovascular Medicine, University of Leuven, Belgium A L G
    Circulation 135:89-99. 2017
    ..This provides a window of opportunity for athletes to exploit with relative immunity. It could be argued that all off-label use of any agent should be deemed illegal...
  32. doi Is exercise good for the right ventricle? Concepts for health and disease
    Andre La Gerche
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia Department of Cardiovascular Medicine, University of Leuven, Leuven, Belgium Electronic address
    Can J Cardiol 31:502-8. 2015
    ....
  33. doi Right ventricular fatigue developing during endurance exercise: an exercise cardiac magnetic resonance study
    Guido Claessen
    1Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, BELGIUM 2Department of Cardiovascular Imaging and Dynamics, University of Leuven, Leuven, BELGIUM 3Department of Radiology, University Hospitals Leuven, Leuven, BELGIUM 4Department of Laboratory Medicine, University Hospitals Leuven, Leuven, BELGIUM and 5St Vincent s Hospital Department of Medicine, University of Melbourne, Fitzroy, Australia
    Med Sci Sports Exerc 46:1717-26. 2014
    ..The effect of prolonged exercise on the heart has not been adequately measured during exercise itself...
  34. doi Reduced and delayed untwisting of the left ventricle in patients with hypertension and left ventricular hypertrophy: a study using two-dimensional speckle tracking imaging
    Andrew T Burns
    Eur Heart J 29:825; author reply 825-6. 2008