L P Bignold

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi request reprint Hypothesis for the influence of fixatives on the chromatin patterns of interphase nuclei, based on shrinkage and retraction of nuclear and perinuclear structures
    L P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Br J Biomed Sci 59:105-13. 2002
  2. ncbi request reprint Mutation, replicative infidelity of DNA and aneuploidy sequentially in the formation of malignant pleomorphic tumors
    L P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Histol Histopathol 22:321-6. 2007
  3. ncbi request reprint Variation, "evolution", immortality and genetic instabilities in tumour cells
    L P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, P O Box 14, Rundle Mall, Adelaide, SA 5068, Australia
    Cancer Lett 253:155-69. 2007
  4. ncbi request reprint Cancer morphology, carcinogenesis and genetic instability: a background
    Leon P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, SA, Australia
    EXS . 2006
  5. doi request reprint Mechanisms of clastogen-induced chromosomal aberrations: a critical review and description of a model based on failures of tethering of DNA strand ends to strand-breaking enzymes
    L P Bignold
    Division of Surgical Pathology, Institute of Medical and Veterinary Science, P O Box 14, Rundle Mall, Adelaide, SA 5001, Australia
    Mutat Res 681:271-98. 2009
  6. ncbi request reprint Hansemann, Boveri, chromosomes and the gametogenesis-related theories of tumours
    Leon P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, Australia
    Cell Biol Int 30:640-4. 2006
  7. ncbi request reprint Alkylating agents and DNA polymerases
    Leon P Bignold
    Institute of Medical and Veterinary Science, Adelaide, SA 5001, Australia
    Anticancer Res 26:1327-36. 2006
  8. pmc Embryonic reversions and lineage infidelities in tumour cells: genome-based models and role of genetic instability
    Leon P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, PO Box 14, Rundle Mall, Adelaide, SA 5068, Australia
    Int J Exp Pathol 86:67-79. 2005
  9. ncbi request reprint The cell-type-specificity of inherited predispositions to tumours: review and hypothesis
    Leon P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, PO Box 14, Rundle Mall, Adelaide, SA 5001, Australia
    Cancer Lett 216:127-46. 2004
  10. ncbi request reprint Chaotic genomes make chaotic cells: the mutator phenotype theory of carcinogenesis applied to clinicopathological relationships of solid tumors
    L P Bignold
    Department of Pathology, University of Adelaide, Adelaide, South Australia, Australia
    Cancer Invest 22:338-43. 2004

Detail Information

Publications18

  1. ncbi request reprint Hypothesis for the influence of fixatives on the chromatin patterns of interphase nuclei, based on shrinkage and retraction of nuclear and perinuclear structures
    L P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Br J Biomed Sci 59:105-13. 2002
    ....
  2. ncbi request reprint Mutation, replicative infidelity of DNA and aneuploidy sequentially in the formation of malignant pleomorphic tumors
    L P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Histol Histopathol 22:321-6. 2007
    ..These resulting cells would regain fidelity of replication of DNA, and hence could give rise to populations which are relatively genomically stable, hyperploid and immortal...
  3. ncbi request reprint Variation, "evolution", immortality and genetic instabilities in tumour cells
    L P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, P O Box 14, Rundle Mall, Adelaide, SA 5068, Australia
    Cancer Lett 253:155-69. 2007
    ..Thus extensively mutant and variable, hyperploid, and occasionally immortal cells might arise...
  4. ncbi request reprint Cancer morphology, carcinogenesis and genetic instability: a background
    Leon P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, SA, Australia
    EXS . 2006
    ....
  5. doi request reprint Mechanisms of clastogen-induced chromosomal aberrations: a critical review and description of a model based on failures of tethering of DNA strand ends to strand-breaking enzymes
    L P Bignold
    Division of Surgical Pathology, Institute of Medical and Veterinary Science, P O Box 14, Rundle Mall, Adelaide, SA 5001, Australia
    Mutat Res 681:271-98. 2009
    ..Predictions are made concerning likely results in various suggested studies including those involving sensitive assays for DNA-end-to-enzyme tethering functions in vitro...
  6. ncbi request reprint Hansemann, Boveri, chromosomes and the gametogenesis-related theories of tumours
    Leon P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, Australia
    Cell Biol Int 30:640-4. 2006
    ..Hansemann's contribution is seen as both the original, and the more significant of the chromosomal theories of cancer...
  7. ncbi request reprint Alkylating agents and DNA polymerases
    Leon P Bignold
    Institute of Medical and Veterinary Science, Adelaide, SA 5001, Australia
    Anticancer Res 26:1327-36. 2006
    ....
  8. pmc Embryonic reversions and lineage infidelities in tumour cells: genome-based models and role of genetic instability
    Leon P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, PO Box 14, Rundle Mall, Adelaide, SA 5068, Australia
    Int J Exp Pathol 86:67-79. 2005
    ..Genomic models are described which might account for the origin of these phenomena in each of these circumstances...
  9. ncbi request reprint The cell-type-specificity of inherited predispositions to tumours: review and hypothesis
    Leon P Bignold
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, PO Box 14, Rundle Mall, Adelaide, SA 5001, Australia
    Cancer Lett 216:127-46. 2004
    ..Additional investigations may involve fluorescent in situ hybridisations on interphase tumour nuclei...
  10. ncbi request reprint Chaotic genomes make chaotic cells: the mutator phenotype theory of carcinogenesis applied to clinicopathological relationships of solid tumors
    L P Bignold
    Department of Pathology, University of Adelaide, Adelaide, South Australia, Australia
    Cancer Invest 22:338-43. 2004
    ..Possible implications of this concept for staging, grading, multifocality, and therapy of cancers are discussed...
  11. ncbi request reprint Carcinogen-induced impairment of enzymes for replicative fidelity of DNA and the initiation of tumours
    Leon P Bignold
    Institute of Medical and Veterinary Science, Adelaide, South Australia and Department of Pathology, University of Adelaide, SA 5005, Australia
    Carcinogenesis 25:299-307. 2004
    ....
  12. ncbi request reprint Initiation of genetic instability and tumour formation: a review and hypothesis of a nongenotoxic mechanism
    L P Bignold
    Department of Pathology, University of Adelaide, SA 5005, Australia
    Cell Mol Life Sci 60:1107-17. 2003
    ..However, the acquired genetic instability in this cell line causes secondary mutations which lead to uncontrolled growth, and the heterogeneous morphologic and behavioural features of a tumour resembling the parent cell type...
  13. ncbi request reprint The mutator phenotype theory of carcinogenesis and the complex histopathology of tumours: support for the theory from the independent occurrence of nuclear abnormality, loss of specialisation and invasiveness among occasional neoplastic lesions
    L P Bignold
    Department of Pathology, University of Adelaide, SA 5005, Australia
    Cell Mol Life Sci 60:883-91. 2003
    ..paragraph sign These examples are considered to provide further support for the importance of the mutator phenotype to the pathogenesis of neoplasia...
  14. ncbi request reprint Pathogenetic mechanisms of nuclear pleomorphism of tumour cells based on the mutator phenotype theory of carcinogenesis
    L P Bignold
    Department of Pathology, University of Adelaide, South Australia, Australia
    Histol Histopathol 18:657-64. 2003
    ....
  15. ncbi request reprint The mutator phenotype theory can explain the complex morphology and behaviour of cancers
    L P Bignold
    Department of Pathology, University of Adelaide, South Australia, Australia
    Cell Mol Life Sci 59:950-8. 2002
    ..Further, because virtually all solid tumours are histologically abnormal, genetic instability is likely to be essential for the malignant process. The concepts of mutator phenotype and clonal selection are therefore supported...
  16. ncbi request reprint Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production in vitro by a new C5a receptor antagonist
    D R Haynes
    Department of Pathology, University of Adelaide, 5005, Adelaide, South Australia, Australia
    Biochem Pharmacol 60:729-33. 2000
    ..These results show that F-[OPdChaWR] inhibits several important inflammatory activities of C5a and suggest that C5a receptor antagonists may be effective in the treatment of inflammatory diseases mediated by C5a...
  17. pmc Interleukin-5 transgenic mice show enhanced resistance to primary infections with Nippostrongylus brasiliensis but not primary infections with Toxocara canis
    L A Dent
    Departments of Microbiology and Immunology, University of Adelaide, Adelaide, South Australia
    Infect Immun 67:989-93. 1999
    ..These results and other data suggest that eosinophils can contribute to host resistance to some parasite species. Parasite transit time through the host may correlate with relative sensitivity to eosinophils...
  18. pmc The "aneuploidy-modified mutator-phenotype" theory of malignant tumors
    Leon P Bignold
    Cell Oncol 30:459. 2008