Duncan John Campbell

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint The kallikrein-kinin system in humans
    D J Campbell
    St Vincent s Institute of Medical Research and The University of Melbourne Department of Medicine, Fitzroy, Victoria, Australia
    Clin Exp Pharmacol Physiol 28:1060-5. 2001
  2. ncbi request reprint Type 2 bradykinin-receptor antagonism does not modify kinin or angiotensin peptide levels
    D J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    Hypertension 33:1233-6. 1999
  3. ncbi request reprint Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice
    Duncan J Campbell
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Hypertension 43:854-9. 2004
  4. ncbi request reprint Heart failure: how can we prevent the epidemic?
    Duncan J Campbell
    St Vincent s Institute of Medical Research, and Department of Medicine, University of Melbourne, Fitzroy, VIC 3065
    Med J Aust 179:422-5. 2003
  5. ncbi request reprint Vasopeptidase inhibition: a double-edged sword?
    Duncan John Campbell
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Hypertension 41:383-9. 2003
  6. ncbi request reprint Renin-angiotensin system inhibition: how much is too much of a good thing?
    D J Campbell
    St Vincent s Institute of Medical Research, Department of Medicine, University of Melbourne, Melbourne, Victoria 3065, Australia
    Intern Med J 32:616-20. 2002
  7. ncbi request reprint Activation of the kallikrein-kinin system by cardiopulmonary bypass in humans
    D J Campbell
    St Vincent s Institute of Medical Research, St Vincent s Hospital, Fitzroy, Victoria 3065, Australia
    Am J Physiol Regul Integr Comp Physiol 281:R1059-70. 2001
  8. ncbi request reprint Plasma amino-terminal pro-brain natriuretic peptide levels in subjects presenting to the Emergency Department with suspected acute coronary syndrome: possible role in selecting patients for follow up?
    D J Campbell
    St Vincent s Institute of Medical Research, St Vincent s Hospital, Melbourne, Australia
    Intern Med J 31:211-9. 2001
  9. ncbi request reprint Urinary levels of substance P and its metabolites are not increased in interstitial cystitis
    D J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    BJU Int 87:35-8. 2001
  10. ncbi request reprint Towards understanding the kallikrein-kinin system: insights from measurement of kinin peptides
    D J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    Braz J Med Biol Res 33:665-77. 2000

Research Grants

Detail Information

Publications14

  1. ncbi request reprint The kallikrein-kinin system in humans
    D J Campbell
    St Vincent s Institute of Medical Research and The University of Melbourne Department of Medicine, Fitzroy, Victoria, Australia
    Clin Exp Pharmacol Physiol 28:1060-5. 2001
    ..8. Measurement of individual bradykinin and kallidin peptides and their metabolites gives important information about the operation of the plasma and tissue KKS and their role in physiology and disease states...
  2. ncbi request reprint Type 2 bradykinin-receptor antagonism does not modify kinin or angiotensin peptide levels
    D J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    Hypertension 33:1233-6. 1999
    ..This study demonstrated that kinin levels are not subject to short-loop-feedback regulation mediated through B2 receptors and that endogenous kinin levels acting through the B2 receptor do not modulate the renin-angiotensin system...
  3. ncbi request reprint Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice
    Duncan J Campbell
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Hypertension 43:854-9. 2004
    ..These studies demonstrate that ACE is the predominant pathway of angiotensin II formation in blood and tissues of mice and plays a major role in bradykinin (1-9) metabolism in blood and, to a lesser extent, in kidney and heart...
  4. ncbi request reprint Heart failure: how can we prevent the epidemic?
    Duncan J Campbell
    St Vincent s Institute of Medical Research, and Department of Medicine, University of Melbourne, Fitzroy, VIC 3065
    Med J Aust 179:422-5. 2003
    ....
  5. ncbi request reprint Vasopeptidase inhibition: a double-edged sword?
    Duncan John Campbell
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Hypertension 41:383-9. 2003
    ..Vasopeptidase inhibitors will therefore require careful evaluation before they are introduced to patient care...
  6. ncbi request reprint Renin-angiotensin system inhibition: how much is too much of a good thing?
    D J Campbell
    St Vincent s Institute of Medical Research, Department of Medicine, University of Melbourne, Melbourne, Victoria 3065, Australia
    Intern Med J 32:616-20. 2002
    ..There is therefore a need for caution in the combination of ACE inhibition and AR antagonism, particularly in patients receiving beta-blockers, until the impact of this strategy is evaluated...
  7. ncbi request reprint Activation of the kallikrein-kinin system by cardiopulmonary bypass in humans
    D J Campbell
    St Vincent s Institute of Medical Research, St Vincent s Hospital, Fitzroy, Victoria 3065, Australia
    Am J Physiol Regul Integr Comp Physiol 281:R1059-70. 2001
    ..Aprotinin administration prevented activation of the KKS. The changes in circulating kinin and kallikrein levels indicate activation of both the plasma and tissue KKS during activation of the contact system by CPB...
  8. ncbi request reprint Plasma amino-terminal pro-brain natriuretic peptide levels in subjects presenting to the Emergency Department with suspected acute coronary syndrome: possible role in selecting patients for follow up?
    D J Campbell
    St Vincent s Institute of Medical Research, St Vincent s Hospital, Melbourne, Australia
    Intern Med J 31:211-9. 2001
    ..Plasma amino-terminal pro-brain natriuretic peptide (NT-proBNP) level is a sensitive and specific indicator of cardiac dysfunction...
  9. ncbi request reprint Urinary levels of substance P and its metabolites are not increased in interstitial cystitis
    D J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    BJU Int 87:35-8. 2001
    ....
  10. ncbi request reprint Towards understanding the kallikrein-kinin system: insights from measurement of kinin peptides
    D J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    Braz J Med Biol Res 33:665-77. 2000
    ..Measurement of the levels of individual kinin peptides has given important information about the operation of the kallikrein-kinin system and its role in physiology and disease states...
  11. ncbi request reprint Angiotensin-converting enzyme inhibition modifies angiotensin but not kinin peptide levels in human atrial tissue
    D J Campbell
    St Vincent s Institute of Medical Research, Victoria, Australia
    Hypertension 34:171-5. 1999
    ..These data support a role for reduced Ang II levels but do not support a role for increased kinin peptide levels in mediating the direct cardiac effects of ACE inhibition...
  12. ncbi request reprint Increased bradykinin and "normal" angiotensin peptide levels in diabetic Sprague-Dawley and transgenic (mRen-2)27 rats
    D J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    Kidney Int 56:211-21. 1999
    ..Bradykinin (BK) and Ang II are potent vasoactive peptides that may participate in the vascular and metabolic abnormalities of diabetes...
  13. doi request reprint Aliskiren reduces myocardial ischemia-reperfusion injury by a bradykinin B2 receptor- and angiotensin AT2 receptor-mediated mechanism
    Suang Suang Koid
    St Vincent s Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Hypertension 63:768-73. 2014
    ..In addition, aliskiren attenuates valsartan-induced increases in angiotensin II levels, thus preventing AT2 receptor-mediated cardioprotection by valsartan. ..
  14. ncbi request reprint Valsartan in chronic heart failure
    Duncan John Campbell
    N Engl J Med 346:1173-4. 2002

Research Grants1

  1. PREDICTORS OF RECURRENT STROKE IN THE PROGRESS STUDY
    Duncan Campbell; Fiscal Year: 2003
    ..In addition, plasma markers that predict risk of recurrent stroke may indicate novel therapies to prevent this condition. ..