Arun Dharmarajan

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. pmc The expression of tumor necrosis factor-alpha, its receptors and steroidogenic acute regulatory protein during corpus luteum regression
    Michael Abdo
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Reprod Biol Endocrinol 6:50. 2008
  2. pmc Function of caspase-14 in trophoblast differentiation
    Lloyd J White
    School of Anatomy and Human Biology, Faculty of Life and Physical Sciences, The University of Western Australia, Perth, Western Australia, Australia
    Reprod Biol Endocrinol 7:98. 2009
  3. ncbi request reprint Antioxidants mimic the ability of chorionic gonadotropin to suppress apoptosis in the rabbit corpus luteum in vitro: a novel role for superoxide dismutase in regulating bax expression
    A M Dharmarajan
    Department of Anatomy and Human Biology, University of Western Australia, Nedlands, Perth, Australia
    Endocrinology 140:2555-61. 1999
  4. pmc SFRP-4 abrogates Wnt-3a-induced beta-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation
    Thecla Constantinou
    School of Anatomy and Human Biology, University of Western Australia, 35 Stirling Highway, Crawley, Perth, 6009 Western Australia
    J Mol Signal 3:10. 2008
  5. ncbi request reprint Role of apoptosis in functional luteolysis in the pregnant rabbit corpus luteum: evidence of a role for placental-derived factors in promoting luteal cell survival
    A M Dharmarajan
    Department of Gynecology and Obstetrics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Apoptosis 9:807-14. 2004
  6. ncbi request reprint Superoxide dismutase activity, lipid peroxide production and corpus luteum steroidogenesis during natural luteolysis and regression induced by oestradiol deprivation of the ovary in pseudopregnant rabbits
    J S Hesla
    Department of Gynecology and Obstetrics, John Hopkins University School of Medicine, Baltimore, MD 21205
    J Reprod Fertil 95:915-24. 1992
  7. ncbi request reprint Inhibitors of caspase homologues suppress an apoptotic phenotype in cultured rabbit corpora lutea
    M A Abdo
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands
    Reprod Fertil Dev 13:395-403. 2001
  8. ncbi request reprint Apoptosis in rat placenta is zone-dependent and stimulated by glucocorticoids
    B J Waddell
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Western Australia
    Biol Reprod 63:1913-7. 2000
  9. ncbi request reprint Patterns of apoptosis in the corpora lutea of the rat during the oestrous cycle, pregnancy and in vitro culture
    N W Bruce
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Australia
    Reprod Fertil Dev 13:105-9. 2001
  10. ncbi request reprint Inhibition of nitric oxide synthesis potentiates apoptosis in the rabbit corpus luteum
    S Preutthipan
    Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Reprod Biomed Online 9:264-70. 2004

Collaborators

  • J L Tilly
  • Brendan J Waddell
  • B Singh
  • Dongmin Liu
  • Frank Arfuso
  • Ajit Muley
  • Lloyd J White
  • S Hisheh
  • Thecla Constantinou
  • Michael Abdo
  • A K Charles
  • S Preutthipan
  • S Saurer
  • R Friis
  • R R Lareu
  • M D Lacher
  • J M Drake
  • V Wolf
  • N W Bruce
  • M A Abdo
  • Helena Viola
  • Syamantak Majumder
  • Steve Parkinson
  • Suvro Chatterjee
  • Gopi Krishna Kolluru
  • Ruth Ganss
  • Livia Hool
  • Wim Declercq
  • Adrian K Charles
  • Robert Friis
  • Susan Hisheh
  • Fabrizio Baumann
  • Markus D Lacher
  • Susanne Saurer
  • K Guo
  • R M Rao
  • A J Rao
  • W Bielke
  • J E Dickinson
  • S H Chen
  • K Kugu
  • Xi Yan
  • R R Friis
  • R Jager
  • S Hett
  • L Xuan
  • A Siegenthaler
  • N Atiya
  • A Richards
  • S Parkinson
  • Z Feng
  • G Ke
  • L Artuso
  • J S Hesla
  • L M Dasko
  • E E Wallach
  • T Miyazaki

Detail Information

Publications16

  1. pmc The expression of tumor necrosis factor-alpha, its receptors and steroidogenic acute regulatory protein during corpus luteum regression
    Michael Abdo
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Reprod Biol Endocrinol 6:50. 2008
    ..Previous studies suggest this process occurs by the production of luteolytic factors, such as tumour necrosis factor-alpha (TNF-alpha)...
  2. pmc Function of caspase-14 in trophoblast differentiation
    Lloyd J White
    School of Anatomy and Human Biology, Faculty of Life and Physical Sciences, The University of Western Australia, Perth, Western Australia, Australia
    Reprod Biol Endocrinol 7:98. 2009
    ..It promotes keratinocyte differentiation by cleaving profilaggrin to stabilise keratin intermediate filaments, and indirectly providing hydration and UV protection. However its role in the trophoblast remains unexplored...
  3. ncbi request reprint Antioxidants mimic the ability of chorionic gonadotropin to suppress apoptosis in the rabbit corpus luteum in vitro: a novel role for superoxide dismutase in regulating bax expression
    A M Dharmarajan
    Department of Anatomy and Human Biology, University of Western Australia, Nedlands, Perth, Australia
    Endocrinology 140:2555-61. 1999
    ....
  4. pmc SFRP-4 abrogates Wnt-3a-induced beta-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation
    Thecla Constantinou
    School of Anatomy and Human Biology, University of Western Australia, 35 Stirling Highway, Crawley, Perth, 6009 Western Australia
    J Mol Signal 3:10. 2008
    ..We previously isolated the SFRP-4 gene from an involuting rat mammary gland and later showed that transgenic mice inappropriately expressing SFRP-4 during lactation exhibited a high level of apoptosis with reduced survival of progeny...
  5. ncbi request reprint Role of apoptosis in functional luteolysis in the pregnant rabbit corpus luteum: evidence of a role for placental-derived factors in promoting luteal cell survival
    A M Dharmarajan
    Department of Gynecology and Obstetrics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Apoptosis 9:807-14. 2004
    ..The data suggest that a factor(s) derived from the placenta may be responsible for the prolongation of CL life span during pregnancy by its ability to alter the bax:bcl -x rheostat and suppress apoptosis...
  6. ncbi request reprint Superoxide dismutase activity, lipid peroxide production and corpus luteum steroidogenesis during natural luteolysis and regression induced by oestradiol deprivation of the ovary in pseudopregnant rabbits
    J S Hesla
    Department of Gynecology and Obstetrics, John Hopkins University School of Medicine, Baltimore, MD 21205
    J Reprod Fertil 95:915-24. 1992
    ..These data suggest that Mn SOD may be involved in regulating function of the corpus luteum during pseudopregnancy in rabbits and that oxygen free radicals may play a role in regression of corpus luteum in this species...
  7. ncbi request reprint Inhibitors of caspase homologues suppress an apoptotic phenotype in cultured rabbit corpora lutea
    M A Abdo
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands
    Reprod Fertil Dev 13:395-403. 2001
    ..The results of the present study clearly demonstrate a time-dependent link between the caspases, specifically caspase-3 and spontaneous apoptosis in the rabbit CL...
  8. ncbi request reprint Apoptosis in rat placenta is zone-dependent and stimulated by glucocorticoids
    B J Waddell
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Western Australia
    Biol Reprod 63:1913-7. 2000
    ..These data support the hypothesis that placental apoptosis is an important player in the regulation of feto-placental growth, and establish the rat as a useful model to study the endocrine control of placental apoptosis...
  9. ncbi request reprint Patterns of apoptosis in the corpora lutea of the rat during the oestrous cycle, pregnancy and in vitro culture
    N W Bruce
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands, Australia
    Reprod Fertil Dev 13:105-9. 2001
    ..However, rat CL clearly retain the potential for high rates of apoptosis and so present a useful model for examining molecular mechanisms of apoptotic cell death...
  10. ncbi request reprint Inhibition of nitric oxide synthesis potentiates apoptosis in the rabbit corpus luteum
    S Preutthipan
    Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Reprod Biomed Online 9:264-70. 2004
    ..While NO does not appear to directly affect progesterone secretion, there does appear to be a role for NO in CL maintenance, or a role for inhibition of NO production in CL regression...
  11. ncbi request reprint The role of sFRP4, a secreted frizzled-related protein, in ovulation
    J M Drake
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, WA, Australia
    Apoptosis 8:389-97. 2003
    ..This study demonstrates an association between sFRP4 and apoptosis in rat ovulation...
  12. ncbi request reprint The expression of apoptosis related genes in the first trimester human placenta using a short term in vitro model
    A K Charles
    Department of Pathology King Edward Memorial Hospital, University of Western Australia, Perth, Western Australia
    Apoptosis 10:135-40. 2005
    ..Cleavage of Caspase-3 rather than transcriptional regulation appears to be the main determinant of Caspase-3 activity in first trimester placental villi...
  13. pmc Secreted frizzled-related protein 4: an angiogenesis inhibitor
    Ajit Muley
    AU KBC Research Center, Anna University, Chennai, India
    Am J Pathol 176:1505-16. 2010
    ..The data demonstrate sFRP4 to be a potent angiogenesis inhibitor that warrants further investigation as a therapeutic agent in the control of angiogenesis-associated pathology...
  14. ncbi request reprint Role of DDC-4/sFRP-4, a secreted frizzled-related protein, at the onset of apoptosis in mammary involution
    M D Lacher
    Department of Clinical Research, University of Berne, Tiefenaustrasse 120, CH 3004 Bern, Switzerland
    Cell Death Differ 10:528-38. 2003
    ..Taken together, our results show a role for DDC-4/sFRP-4 in abrogating an epithelial cell survival pathway at the onset of mammary gland involution...
  15. ncbi request reprint Apoptosis-associated gene expression in the corpus luteum of the rat
    K Guo
    Department of Clinical Research, University of Berne, Switzerland
    Biol Reprod 58:739-46. 1998
    ....
  16. ncbi request reprint DDC-4, an apoptosis-associated gene, is a secreted frizzled relative
    V Wolf
    Department of Clinical Research, University of Berne, Switzerland
    FEBS Lett 417:385-9. 1997
    ..e. the ligand-binding domain, of the fizzled gene family originally defined as tissue polarity genes in Drosophila. The homology of Y81 clone 40 is most extensive with the newly described secreted frizzled relatives, the frzb subfamily...