Beverly Sara Mühlhäusler
Affiliation: University of South Australia
- Increased maternal nutrition increases leptin expression in perirenal and subcutaneous adipose tissue in the postnatal lambB S Muhlhausler
Early Origins of Adult Health Research Group, Sansom Research Institute, University of South Australia, Adelaide 5000, Australia
Endocrinology 148:6157-63. 2007..The results of this study provide evidence that the nutritional environment before and immediately after birth can influence the development of adipose tissue in early postnatal life...
- Rosiglitazone increases the expression of peroxisome proliferator-activated receptor-gamma target genes in adipose tissue, liver, and skeletal muscle in the sheep fetus in late gestationB S Muhlhausler
Sansom Research Institute, University of South Australia, Adelaide 5000, Australia
Endocrinology 150:4287-94. 2009....
- Nutritional models of type 2 diabetes mellitusBeverly Sara Mühlhäusler
Early Origins of Adult Health Research Group, Sansom Research Institute, University of South Australia, Adelaide, SA, 5000, Australia
Methods Mol Biol 560:19-36. 2009..The following chapter will discuss each of these nutritional models, their application and relationship to human aetiology, and will highlight the important insights these models have provided into the pathogenesis of T2DM...
- Early-life origins of metabolic dysfunction: role of the adipocyteBeverly Muhlhausler
Early Origins of Adult Health Research Group, Sansom Institute, University of South Australia, Adelaide, SA 5001, Australia
Trends Endocrinol Metab 20:51-7. 2009..Finally, we propose that interventions that inhibit this early increase in fat deposition have the potential to interrupt the pathway to obesity...
- Birth weight and gender determine expression of adipogenic, lipogenic and adipokine genes in perirenal adipose tissue in the young adult sheepB S Muhlhausler
Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5000, Australia
Domest Anim Endocrinol 35:46-57. 2008..In males, this is associated with an increased expression of lipogenic genes, and this may contribute to the increased propensity for visceral obesity in low birth weight males compared to females...
- Programming of the appetite-regulating neural network: a link between maternal overnutrition and the programming of obesity?B S Muhlhausler
Early Origins of Adult Health Research Group, Sansom Research Institute, School of Pharmacy and Medical Science, Division of Health Sciences, University of South Australia, City East Campus, Adelaide, SA 5000, Australia
J Neuroendocrinol 19:67-72. 2007..It is clear that this area of research has the potential to generate, within the next few years, interventions that could begin to alleviate the adverse long-term consequences of being exposed to an elevated nutrient supply before birth...
- Liver enzymes but not free fatty acid levels predict markers of insulin sensitivity in overweight and obese, nondiabetic adultsBelinda Gray
Children s Nutrition Research Centre, Queensland Children s Medical Research Institute, The University of Queensland, Royal Children s Hospital, Herston, Queensland, Australia Centre for Integrative Clinical and Molecular Medicine, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia School of Medicine, The University of Queensland, Adelaide, South Australia, Australia
Nutr Res 33:781-8. 2013..Despite previous data linking elevations in free fatty acid to the development of IR, we found no relationship between these variables in this study...
- Increased maternal nutrition stimulates peroxisome proliferator activated receptor-gamma, adiponectin, and leptin messenger ribonucleic acid expression in adipose tissue before birthB S Muhlhausler
Sansom Research Institute, University of South Australia, Adelaide 5000, South Australia, Australia
Endocrinology 148:878-85. 2007....
- Increased maternal nutrition alters development of the appetite-regulating network in the brainB S Muhlhausler
Research Centre for the Early Origins of Adult Health, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia
FASEB J 20:1257-9. 2006..05; agouti-related peptide, r2 = 0.39, P<0.01). These findings suggest that exposure to increased nutrition before birth alters the responses of the central appetite regulatory system to signals of increased adiposity after birth...
- Regulation of leptin synthesis and secretion before birth: implications for the early programming of adult obesityI C McMillen
Research Centre for the Early Origins of Adult Health, Discipline of Physiology, School of Molecular and Biomedical Sciences, University of Adelaide, South Australia 5000, Australia
Reproduction 131:415-27. 2006..This work is important in determining those initiating mechanisms within the 'fat-brain' axis in early life that precede the development of adult obesity...
- Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birthI C McMillen
Discipline of Physiology, School of Molecular and Biomedical Sciences, University of Adelaide, SA 5005, Australia
Proc Nutr Soc 63:405-12. 2004....
- Leptin alters the structural and functional characteristics of adipose tissue before birthB S J Yuen
Department of Physiology, Adelaide University, SA 5005, Australia
FASEB J 17:1102-4. 2003..This is the first demonstration that leptin can act to regulate the lipid storage characteristics, leptin synthetic capacity, and potential thermogenic functions of fat before birth...