D A Saint

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi request reprint Propofol block of cardiac sodium currents in rat isolated myocardial cells is increased at depolarized resting potentials
    D A Saint
    Department of Physiology, University of Adelaide, South Australia, Australia
    Clin Exp Pharmacol Physiol 25:336-40. 1998
  2. ncbi request reprint Pacemaking in the heart: the interplay of ionic currents
    D A Saint
    Department of Physiology, University of Adelaide, South Australia, Australia
    Clin Exp Pharmacol Physiol 25:841-6. 1998
  3. ncbi request reprint Variability of channel subconductance states of the cardiac sodium channel induced by protease
    D A Saint
    Department of Physiology, University of Adelaide, Australia
    Receptors Channels 6:283-94. 1999
  4. ncbi request reprint Gene expression of stretch-activated channels and mechanoelectric feedback in the heart
    D Kelly
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia
    Clin Exp Pharmacol Physiol 33:642-8. 2006
  5. ncbi request reprint Subconductance states of the cardiac K(ATP) channel revealed by partial block with glybenclamide
    Y K Ju
    Department of Physiology, University of Sydney, NSW, Australia
    Pflugers Arch 442:867-73. 2001
  6. ncbi request reprint Heterogeneous expression of tandem-pore K+ channel genes in adult and embryonic rat heart quantified by real-time polymerase chain reaction
    W Liu
    School of Molecular and Biomedical Sciences, University of Adelaide, Adelaide, South Australia, Australia
    Clin Exp Pharmacol Physiol 31:174-8. 2004
  7. ncbi request reprint Suppression of calcium sparks in rat ventricular myocytes and direct inhibition of sheep cardiac RyR channels by EPA, DHA and oleic acid
    B N Honen
    Department of Physiology, University of Adelaide, Adelaide, SA 5005, Australia
    J Membr Biol 196:95-103. 2003
  8. ncbi request reprint Trek-like potassium channels in rat cardiac ventricular myocytes are activated by intracellular ATP
    J H C Tan
    Cellular Biophysics Laboratory, The Department of Physiology, University of Adelaide, Adelaide SA 5005, Australia
    J Membr Biol 185:201-7. 2002
  9. pmc The cardiac persistent sodium current: an appealing therapeutic target?
    D A Saint
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA, Australia
    Br J Pharmacol 153:1133-42. 2008

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Propofol block of cardiac sodium currents in rat isolated myocardial cells is increased at depolarized resting potentials
    D A Saint
    Department of Physiology, University of Adelaide, South Australia, Australia
    Clin Exp Pharmacol Physiol 25:336-40. 1998
    ..7. It is concluded that propofol produces a block of sodium currents in cardiac myocytes at concentrations that are comparable to those that may be attained during anaesthesia...
  2. ncbi request reprint Pacemaking in the heart: the interplay of ionic currents
    D A Saint
    Department of Physiology, University of Adelaide, South Australia, Australia
    Clin Exp Pharmacol Physiol 25:841-6. 1998
    ..The limitations of single cell models in reproducing many of the complex responses to nerve stimulation of multicellular tissue, such as postinhibitory rebound, are discussed and possible improvements to models are suggested...
  3. ncbi request reprint Variability of channel subconductance states of the cardiac sodium channel induced by protease
    D A Saint
    Department of Physiology, University of Adelaide, Australia
    Receptors Channels 6:283-94. 1999
    ....
  4. ncbi request reprint Gene expression of stretch-activated channels and mechanoelectric feedback in the heart
    D Kelly
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia
    Clin Exp Pharmacol Physiol 33:642-8. 2006
    ..5. The importance of MEF and the non-homogeneous gene expression and strain distribution for arrhythmias is discussed...
  5. ncbi request reprint Subconductance states of the cardiac K(ATP) channel revealed by partial block with glybenclamide
    Y K Ju
    Department of Physiology, University of Sydney, NSW, Australia
    Pflugers Arch 442:867-73. 2001
    ..The observation that subconductance states can be induced by low concentrations of glybenclamide may have implications for models of how the binding of glybenclamide is translated into closure of the Kir6.2 pore...
  6. ncbi request reprint Heterogeneous expression of tandem-pore K+ channel genes in adult and embryonic rat heart quantified by real-time polymerase chain reaction
    W Liu
    School of Molecular and Biomedical Sciences, University of Adelaide, Adelaide, South Australia, Australia
    Clin Exp Pharmacol Physiol 31:174-8. 2004
    ..5. The physiological implications of the differential gene expression of the tandem-pore K+ channels is discussed...
  7. ncbi request reprint Suppression of calcium sparks in rat ventricular myocytes and direct inhibition of sheep cardiac RyR channels by EPA, DHA and oleic acid
    B N Honen
    Department of Physiology, University of Adelaide, Adelaide, SA 5005, Australia
    J Membr Biol 196:95-103. 2003
    ..8. Inhibition was independent of the n-alkane solvent and whether RyRs were activated by ATP or Ca(2+). DHA and oleic acid also inhibited RyRs, suggesting that free fatty acids generally inhibit RyRs at micromolar concentrations...
  8. ncbi request reprint Trek-like potassium channels in rat cardiac ventricular myocytes are activated by intracellular ATP
    J H C Tan
    Cellular Biophysics Laboratory, The Department of Physiology, University of Adelaide, Adelaide SA 5005, Australia
    J Membr Biol 185:201-7. 2002
    ..We conclude that intracellular ATP directly activates TREK-like channels, a property not previously described...
  9. pmc The cardiac persistent sodium current: an appealing therapeutic target?
    D A Saint
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA, Australia
    Br J Pharmacol 153:1133-42. 2008
    ....