Hong Zhou

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. doi request reprint Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice
    Hong Zhou
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney, NSW 2139, Australia
    Development 136:427-36. 2009
  2. ncbi request reprint Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through Wnt signaling
    Hong Zhou
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney 2139, NSW, Australia
    J Biol Chem 283:1936-45. 2008
  3. doi request reprint Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis
    Li Laine Ooi
    Bone Research Program, ANZAC Research Institute, University of Sydney, Australia
    Bone 47:795-803. 2010
  4. doi request reprint Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism
    Holger Henneicke
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney, Australia
    Bone 49:733-42. 2011
  5. doi request reprint Endogenous glucocorticoid signalling in osteoblasts is necessary to maintain normal bone structure in mice
    Robert Kalak
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
    Bone 45:61-7. 2009
  6. doi request reprint Vitamin D deficiency promotes prostate cancer growth in bone
    Yu Zheng
    Bone Research Program, ANZAC Research Institute, University of Sydney, Concord, Sydney, NSW, Australia
    Prostate 71:1012-21. 2011
  7. doi request reprint Bone resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis
    Yu Zheng
    Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, Australia
    Clin Exp Metastasis 25:559-67. 2008
  8. doi request reprint Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis
    Li Laine Ooi
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Cancer Res 70:1835-44. 2010
  9. doi request reprint Osteoblast-targeted disruption of glucocorticoid signalling does not delay intramembranous bone healing
    Agnes J Weber
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Hospital Road, Concord NSW 2139, Sydney, Australia
    Steroids 75:282-6. 2010
  10. ncbi request reprint Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone
    Yu Zheng
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Cancer Res 67:9542-8. 2007

Collaborators

Detail Information

Publications48

  1. doi request reprint Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice
    Hong Zhou
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney, NSW 2139, Australia
    Development 136:427-36. 2009
    ....
  2. ncbi request reprint Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through Wnt signaling
    Hong Zhou
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney 2139, NSW, Australia
    J Biol Chem 283:1936-45. 2008
    ..This glucocorticoid-dependent forward control function indicates a central role for osteoblasts in the regulation of early osteoblastogenesis...
  3. doi request reprint Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis
    Li Laine Ooi
    Bone Research Program, ANZAC Research Institute, University of Sydney, Australia
    Bone 47:795-803. 2010
    ..In this study, we examined the effects of vitamin D deficiency on tumor growth in an osteosclerotic model of intra-skeletal breast cancer in mice...
  4. doi request reprint Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism
    Holger Henneicke
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney, Australia
    Bone 49:733-42. 2011
    ..3-11βHSD2 transgenic mouse model of osteoblast-targeted disruption of glucocorticoid signalling...
  5. doi request reprint Endogenous glucocorticoid signalling in osteoblasts is necessary to maintain normal bone structure in mice
    Robert Kalak
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
    Bone 45:61-7. 2009
    ..Taken together, our results demonstrate that endogenous glucocorticoids may be required for normal bone growth but that their effect on bone structure and strength varies according to the skeletal site and sexual maturity of the animals...
  6. doi request reprint Vitamin D deficiency promotes prostate cancer growth in bone
    Yu Zheng
    Bone Research Program, ANZAC Research Institute, University of Sydney, Concord, Sydney, NSW, Australia
    Prostate 71:1012-21. 2011
    ..Vitamin D is considered as an important determinant of bone turnover as well as cancer growth. Using a murine model of bone metastasis, we investigated the effect of vitamin D deficiency on prostate cancer cell growth in bone...
  7. doi request reprint Bone resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis
    Yu Zheng
    Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, Australia
    Clin Exp Metastasis 25:559-67. 2008
    ..Treatment of breast cancer patients through correction of calcium deficiency and/or with anti-resorptive agents such as OPG, may improve patient outcomes in the adjuvant as well as palliative settings...
  8. doi request reprint Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis
    Li Laine Ooi
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Cancer Res 70:1835-44. 2010
    ..These effects are partly mediated through secondary changes in the bone microenvironment, along with direct effects of vitamin D on tumor growth...
  9. doi request reprint Osteoblast-targeted disruption of glucocorticoid signalling does not delay intramembranous bone healing
    Agnes J Weber
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Hospital Road, Concord NSW 2139, Sydney, Australia
    Steroids 75:282-6. 2010
    ..The role of endogenous glucocorticoids in fracture healing is not well understood. We examined whether endogenous glucocorticoids affect bone healing in an in vivo model of cortical defect repair...
  10. ncbi request reprint Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone
    Yu Zheng
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Cancer Res 67:9542-8. 2007
    ..Treatment to correct calcium insufficiency and/or treatment with antiresorptive agents, such as osteoprotegerin, may be of benefit in the adjuvant as well as palliative setting...
  11. doi request reprint Targeting IL-6 and RANKL signaling inhibits prostate cancer growth in bone
    Yu Zheng
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, 2139, Australia
    Clin Exp Metastasis 31:921-33. 2014
    ..Both pathways may be targeted for effective therapeutic intervention. ..
  12. doi request reprint The challenge of continuous exogenous glucocorticoid administration in mice
    Markus Herrmann
    ANZAC Research Institute, The University of Sydney, and Department of Endocrinology and Metabolism, Concord Hospital, Hospital Road, Gate 3, Concord, NSW 2139, Australia
    Steroids 74:245-9. 2009
    ..Chronic administration of exogenous glucocorticoids is often required in experimental research. We compared the efficacy and reliability of three different methods of continuous glucocorticoid administration in mice...
  13. doi request reprint Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo
    Frank Buttgereit
    ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Arthritis Rheum 60:1998-2007. 2009
    ..The aim of this study was to investigate the impact of osteoblast-targeted disruption of GC signaling on joint inflammation, cartilage damage, and bone metabolism in the K/BxN mouse serum transfer model of autoimmune arthritis...
  14. doi request reprint Transgenic Disruption of Glucocorticoid Signaling in Osteoblasts Attenuates Joint Inflammation in Collagen Antibody-Induced Arthritis
    Jinwen Tu
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
    Am J Pathol 186:1293-301. 2016
    ..These data corroborate the concept that osteoblasts modulate the inflammatory response in immune-mediated arthritis via a GC-dependent pathway. ..
  15. pmc Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism
    Tara C Brennan-Speranza
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, Australia
    J Clin Invest 122:4172-89. 2012
    ..These data suggest that the effects of exogenous high-dose glucocorticoids on insulin target tissues and systemic energy metabolism are mediated, at least in part, through the skeleton...
  16. doi request reprint Long-term corticosterone treatment induced lobe-specific pathology in mouse prostate
    Ulla Simanainen
    Department of Andrology, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
    Prostate 71:289-97. 2011
    ..Glucocorticoids influence prostate development and pathology, yet the underlying mechanisms including possible direct glucocorticoid effect on the prostate are not well characterized...
  17. pmc Disruption of glucocorticoid signaling in chondrocytes delays metaphyseal fracture healing but does not affect normal cartilage and bone development
    Jinwen Tu
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, Australia
    Bone 69:12-22. 2014
    ..We conclude that endogenous GC signaling in chondrocytes plays an important role during metaphyseal fracture healing but is not essential for normal long bone growth...
  18. doi request reprint Biphasic glucocorticoid-dependent regulation of Wnt expression and its inhibitors in mature osteoblastic cells
    Wendy Mak
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Hospital Road, Concord, 2139, Sydney, NSW, Australia
    Calcif Tissue Int 85:538-45. 2009
    ..05). We conclude that the contrasting anabolic and catabolic effects of glucocorticoids on bone are, at least in part, mediated through the regulation of Wnt expression and its inhibitors in mature osteoblasts...
  19. ncbi request reprint Inhibition of bone resorption, rather than direct cytotoxicity, mediates the anti-tumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis
    Yu Zheng
    Bone Research Program, ANZAC Research Institute, Hospital Road, Concord NSW 2139, Australia
    Bone 40:471-8. 2007
    ....
  20. pmc Follicle-stimulating hormone increases bone mass in female mice
    Charles M Allan
    ANZAC Research Institute, University of Sydney, Concord Hospital, NSW 2139, Australia
    Proc Natl Acad Sci U S A 107:22629-34. 2010
    ....
  21. doi request reprint Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate
    Bin Zhao
    Andrology, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
    Prostate 74:1068-78. 2014
    ..Glucocorticoids are used as a last resort treatment for prostate cancer but the cell-specific glucocorticoid receptor (GR) mediated actions and the role of endogenous glucocorticoids in prostate are not understood...
  22. doi request reprint Continuous corticosterone delivery via the drinking water or pellet implantation: A comparative study in mice
    Sylvia J Gasparini
    Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney, Australia Electronic address
    Steroids 116:76-82. 2016
    ..A dose of 50μg CS/mL drinking water is appropriate for the investigation of chronic glucocorticoid excess in mice...
  23. doi request reprint Androgen receptor inactivation resulted in acceleration in pubertal mammary gland growth, upregulation of ERα expression, and Wnt/β-catenin signaling in female mice
    Yan Ru Ellen Gao
    Andrology Laboratory Y R G, K A W, R D, D J H, U S and Bone research Program H Z, ANZAC Research Institute, University of Sydney, Sydney New South Wales 2139, Australia
    Endocrinology 155:4951-63. 2014
    ..In summary, our findings reveal an inhibitory role of AR-mediated androgen actions in pubertal mammary gland development by reducing epithelial cell proliferation and could be mediated by regulation of Wnt/β-catenin signaling. ..
  24. doi request reprint Glucocorticoids and bone: local effects and systemic implications
    Holger Henneicke
    Bone Research Program, The Australian and New Zealand Army Corps ANZAC Research Institute, The University of Sydney, Sydney, Australia
    Trends Endocrinol Metab 25:197-211. 2014
    ..In this article we review the physiology and pathophysiology of GC action on bone cells, and discuss current and emerging concepts regarding the molecular mechanisms underlying adverse effects of GCs such as osteoporosis and diabetes. ..
  25. pmc Genetic and hormonal control of bone volume, architecture, and remodeling in XXY mice
    Peter Y Liu
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute LA BioMed at Harbor UCLA Medical Center, Torrance, CA, USA
    J Bone Miner Res 25:2148-54. 2010
    ..Testosterone deficiency does not explain the bone phenotype because testosterone-replaced XXY mice show reduced bone volume despite similar blood testosterone levels...
  26. doi request reprint Direct crosstalk between cancer and osteoblast lineage cells fuels metastatic growth in bone via auto-amplification of IL-6 and RANKL signaling pathways
    Yu Zheng
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, Australia The Kinghorn Cancer Centre and Cancer Research Program, Garvan Institute of Medical Research, Sydney, Australia
    J Bone Miner Res 29:1938-49. 2014
    ..RANKL and IL-6 mediate direct paracrine-autocrine signaling between cells of the osteoblast lineage and cancer cells, significantly enhancing the growth of metastatic breast cancers within bone...
  27. doi request reprint Biological response of human bone cells to zinc-modified Ca-Si-based ceramics
    Yogambha Ramaswamy
    Biomaterials and Tissue Engineering Research Unit, Biomedical Engineering, School of AMME, The University of Sydney, Sydney, NSW, Australia
    Acta Biomater 4:1487-97. 2008
    ....
  28. doi request reprint Animal models for breast cancer metastasis to bone: opportunities and limitations
    Konstantin Horas
    a Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
    Cancer Invest 33:459-68. 2015
    ..This review provides an overview of the currently available animal models for breast cancer metastasis to bone with an emphasis on innovative xenograft models and imaging technologies. ..
  29. doi request reprint Glucocorticoids, bone and energy metabolism
    Mark S Cooper
    Adrenal Steroid Group, ANZAC Research Institute, Concord Repatriation General Hospital, Hospital Road, Concord Hospital, NSW 2139, Australia Electronic address
    Bone 82:64-8. 2016
    ..This article is part of a Special Issue entitled Bone and diabetes. ..
  30. doi request reprint Glucocorticoid-induced osteoporosis: mechanisms, management, and future perspectives
    Markus J Seibel
    Bone Research Program, Concord Hospital, Concord, Sydney, NSW, Australia ANZAC Research Institute, Concord Hospital, Concord, Sydney, NSW, Australia Department of Endocrinology and Metabolism, Concord Hospital, Concord, Sydney, NSW, Australia Concord Clinical School, Concord Hospital, Concord, Sydney, NSW, Australia Electronic address
    Lancet Diabetes Endocrinol 1:59-70. 2013
    ....
  31. ncbi request reprint Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis
    Julie M Blair
    ANZAC Research Institute, University of Sydney, NSW, Australia
    Nat Clin Pract Oncol 3:41-9. 2006
    ..This review summarizes the current evidence of osteoprotegerin, RANK ligand and RANK involvement in the pathophysiology of skeletal metastasis, and of therapeutic targeting of this process...
  32. pmc Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation
    Rowan S Hardy
    Bone Research Program, ANZAC Research Institute, University of Sydney, Hospital Road, Concord, Sydney, 2139, Australia
    Arthritis Res Ther 15:R24. 2013
    ..Additionally, this study provides guidelines for the effective characterisation, duration and treatment of murine FLS culture...
  33. ncbi request reprint Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts
    Yun Shan Hu
    Bone, Joint, and Cancer Unit, St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    J Bone Miner Res 19:89-99. 2004
    ..OCIL shows promise as a new antiresorptive...
  34. ncbi request reprint Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep
    Hong Zhou
    Division of Rheumatology and Immunology, CB 7280, Rm 3330 Thurston Bldg, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7280, USA
    Blood 104:2353-8. 2004
    ..Pharmacologic agents that block monocyte TF activity may be a novel therapeutic approach in APS...
  35. ncbi request reprint Characterization of sugar binding by osteoclast inhibitory lectin
    Christine T Gange
    St Vincent s Institute of Medical Research, St Vincent s Hospital, Fitzroy, Victoria, Australia
    J Biol Chem 279:29043-9. 2004
    ....
  36. doi request reprint Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2
    Julie Audoy-Rémus
    Department of Oncology and Molecular Endocrinology, Laval University Hospital Research Center, Quebec City, Quebec, Canada
    J Neurosci 28:10187-99. 2008
    ..This study extends our understanding of the behavior of monocytes at the blood-brain interface and provides a way to block their infiltration into the nervous tissue under inflammatory conditions...
  37. ncbi request reprint Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro
    Wenrong Xu
    School of Life Science, Nanjing Normal University, Nanjing, Jiangsu, 210097, China
    Exp Biol Med (Maywood) 229:623-31. 2004
    ..Cardiomyocytes cultured from bone marrow sources are potentially valuable for repairing injured myocardium...
  38. ncbi request reprint Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis
    Lynn B Eckert
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Cancer Res 64:4585-92. 2004
    ....
  39. ncbi request reprint Localization of pigment epithelium-derived factor in growing mouse bone
    Gerald M Y Quan
    Department of Orthopaedics, University of Melbourne, St Vincent s Hospital Melbourne, Fitzroy 3065, Australia
    Calcif Tissue Int 76:146-53. 2005
    ....
  40. ncbi request reprint Koboquinone A and B, new metabolites of kobophenol a in rats
    Gaolin Liang
    The School of Pharmacy, Fudan University, Shanghai, China
    Chem Pharm Bull (Tokyo) 52:1489-91. 2004
    ..Their structures were determined by spectroscopic methods. 2 also showed activity of stimulating the proliferation of cultured osteoblasts...
  41. ncbi request reprint Resistance of epiphyseal cartilage to invasion by osteosarcoma is likely to be due to expression of antiangiogenic factors
    Gerald M Y Quan
    Department of Orthopaedics, University of Melbourne, St Vincent s Hospital Melbourne, Melbourne, Vic, Australia
    Pathobiology 70:361-7. 2002
    ..The aim of this study was to examine the chronological and spatial patterns of osteosarcoma growth and invasion of local tissue structures including epiphyseal cartilage...
  42. ncbi request reprint Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro
    Akira Nakamura
    St Vincent s Institute, 9, Princes Street, Fitzroy, Victoria, Australia
    Bone 40:305-15. 2007
    ..In addition, the reduction of adipocyte formation in KUSA O cells by OCIL indicates that OCIL may have wider effects on the mesenchymal lineage that may be important for both bone metabolism and other connective tissue functions...
  43. ncbi request reprint Keratinocytes induce local tolerance to skin graft by activating interleukin-10-secreting T cells in the context of costimulation molecule B7-H1
    Yingping Cao
    Unit of Immunoregulation, Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai, China
    Transplantation 75:1390-6. 2003
    ..In this study we examine the down-regulatory mechanisms underlying the effect of the autologous skin islets...
  44. ncbi request reprint Effect of isoverbascoside, a phenylpropanoid glycoside antioxidant, on proliferation and differentiation of human gastric cancer cell
    Rui Chuan Chen
    Cancer Research Center, School of Life Sciences, Xiamen University, Xiamen 361005, China
    Acta Pharmacol Sin 23:997-1001. 2002
    ..To investigate the effects of phenylpropanoid glycoside antioxidant isoverbascoside on cell proliferation and differentiation of human gastric cancer cell line MGC 803...
  45. ncbi request reprint [Effects of human mesenchymal stem cells and fibroblastoid cell line as feeder layers on expansion of umbilical cord blood CD34(+) cells in vitro]
    Li Jun Ma
    Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:949-54. 2006
    ..MSC with addition of a certain proportion of HFCL can significantly enhance the efficiency of CD34(+) cell expansion...
  46. doi request reprint Antimalarial artesunate protects sepsis model mice against heat-killed Escherichia coli challenge by decreasing TLR4, TLR9 mRNA expressions and transcription factor NF-kappa B activation
    Bin Li
    Department of Pharmacology, College of Pharmaceutical, Third Military Medical University, Chongqing 400038, China
    Int Immunopharmacol 8:379-89. 2008
    ..coli challenge was associated with a reduction in proinflammatory cytokine release and endotoxin levels via a mechanism involving a decrease in TLR4, TLR9 mRNA expression and NF-kappaB activation...
  47. ncbi request reprint Osteoclast inhibitory lectin, a family of new osteoclast inhibitors
    Hong Zhou
    St Vincent s Institute of Medical Research, The University of Melbourne, St Vincent s Hospital, Fitzroy, 3065, Australia
    J Biol Chem 277:48808-15. 2002
    ..The identification of three distinct genes that were functionally related implies redundancy for OCIL, and their concordant expression with that of RANKL suggests that the RANKL:OPG axis may be further influenced by OCIL family members...
  48. ncbi request reprint Activation of NF-kappaB and apoptosis of intestinal epithelial cells induced by hydrogen peroxide
    Jianming Li
    Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Chin J Traumatol 5:209-13. 2002
    ..In vitro model of hydrogen peroxide induced apoptosis of SW-480 cells was used to investigate the role of NF-kappaB in the pathogenesis of reactive oxygen species induced apoptosis of intestinal epithelial cells...