Duncan B Sparrow

Summary

Affiliation: Victor Chang Cardiac Research Institute
Country: Australia

Publications

  1. ncbi Old wares and new: five decades of investigation of somitogenesis in Xenopus laevis
    Duncan B Sparrow
    Developmental Biology Program, Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Adv Exp Med Biol 638:73-94. 2008
  2. doi A mechanism for gene-environment interaction in the etiology of congenital scoliosis
    Duncan B Sparrow
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia
    Cell 149:295-306. 2012
  3. doi Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis
    Kylie Lopes Floro
    Developmental Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Hum Mol Genet 20:1097-110. 2011
  4. doi Gene-environment interaction demonstrates the vulnerability of the embryonic heart
    Victoria C O'Reilly
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW 2010, Australia Electronic address
    Dev Biol 391:99-110. 2014
  5. doi Cited2 is required in trophoblasts for correct placental capillary patterning
    Julie L M Moreau
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia Electronic address
    Dev Biol 392:62-79. 2014
  6. ncbi Disruption of the somitic molecular clock causes abnormal vertebral segmentation
    Duncan B Sparrow
    Developmental Biology Program, Victor Chang Cardiac Research Institute, Sydney, Australia
    Birth Defects Res C Embryo Today 81:93-110. 2007
  7. doi Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis
    Gavin Chapman
    Developmental Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Hum Mol Genet 20:905-16. 2011
  8. pmc Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis
    Duncan B Sparrow
    Developmental Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Eur J Hum Genet 18:674-9. 2010
  9. pmc BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4
    Milena B Furtado
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    Genes Dev 22:3037-49. 2008
  10. pmc Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5
    Mauro W Costa
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    PLoS ONE 6:e24812. 2011

Collaborators

Detail Information

Publications18

  1. ncbi Old wares and new: five decades of investigation of somitogenesis in Xenopus laevis
    Duncan B Sparrow
    Developmental Biology Program, Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Adv Exp Med Biol 638:73-94. 2008
    ....
  2. doi A mechanism for gene-environment interaction in the etiology of congenital scoliosis
    Duncan B Sparrow
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia
    Cell 149:295-306. 2012
    ..Our results potentially provide a mechanism for the genesis of a host of common sporadic congenital abnormalities through gene-environment interaction...
  3. doi Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis
    Kylie Lopes Floro
    Developmental Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Hum Mol Genet 20:1097-110. 2011
    ..The clinical relevance of these findings lies in the fact that heterozygous mutation of human CITED2 is associated with congenital heart disease and laterality defects...
  4. doi Gene-environment interaction demonstrates the vulnerability of the embryonic heart
    Victoria C O'Reilly
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW 2010, Australia Electronic address
    Dev Biol 391:99-110. 2014
    ..Importantly, these findings extend our understanding of the roles of Hif1α in cardiovascular development...
  5. doi Cited2 is required in trophoblasts for correct placental capillary patterning
    Julie L M Moreau
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia Electronic address
    Dev Biol 392:62-79. 2014
    ....
  6. ncbi Disruption of the somitic molecular clock causes abnormal vertebral segmentation
    Duncan B Sparrow
    Developmental Biology Program, Victor Chang Cardiac Research Institute, Sydney, Australia
    Birth Defects Res C Embryo Today 81:93-110. 2007
    ..This review describes our current understanding of the somitic molecular clock and highlights how key findings in developmental biology can impact on clinical practice...
  7. doi Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis
    Gavin Chapman
    Developmental Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Hum Mol Genet 20:905-16. 2011
    ....
  8. pmc Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis
    Duncan B Sparrow
    Developmental Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Eur J Hum Genet 18:674-9. 2010
    ..In vitro functional analysis revealed that one of the mutant HES7 proteins was unable to repress gene expression by DNA binding or protein heterodimerization...
  9. pmc BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4
    Milena B Furtado
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    Genes Dev 22:3037-49. 2008
    ..We conclude that BMP/SMAD1 signaling sets a bilateral, repressive threshold for NODAL-dependent Nodal activation in LPM, limiting availability of SMAD4. This repressive threshold is essential for bistable output of the LR system...
  10. pmc Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5
    Mauro W Costa
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    PLoS ONE 6:e24812. 2011
    ..We also observe SUMOylation of Nkx2-5 cofactors, which may be critical to Nkx2-5 regulation. Our data reveal highly complex regulatory mechanisms driven by SUMOylation to modulate Nkx2-5 activity...
  11. doi Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes spondylocostal dysostosis
    Duncan B Sparrow
    Developmental Biology Division, Victor ChangCardiac Research Institute, Darlinghurst, Sydney, NSW, Australia
    Hum Mol Genet 17:3761-6. 2008
    ..This is the first report of mutation in the human HES7 gene, and provides further evidence for the importance of the Notch signaling pathway in the correct patterning of the axial skeleton...
  12. doi Autosomal dominant spondylocostal dysostosis is caused by mutation in TBX6
    Duncan B Sparrow
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia
    Hum Mol Genet 22:1625-31. 2013
    ....
  13. doi Mutation of HES7 in a large extended family with spondylocostal dysostosis and dextrocardia with situs inversus
    Duncan B Sparrow
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Am J Med Genet A 161:2244-9. 2013
    ....
  14. pmc Placental insufficiency associated with loss of Cited1 causes renal medullary dysplasia
    Duncan B Sparrow
    Developmental Biology Division, Victor Chang Cardiac Research Institute, University of New South Wales, Sydney, Australia
    J Am Soc Nephrol 20:777-86. 2009
    ..Taken together, these findings suggest that renal medullary dysplasia in Cited1 mutant mice is a direct consequence of decreased tissue oxygenation resulting from placental insufficiency...
  15. ncbi Generation of conditional Cited2 null alleles
    Jost I Preis
    Developmental Biology Program, Victor Chang Cardiac Research Institute, Sydney, Australia
    Genesis 44:579-83. 2006
    ..These alleles are therefore useful genetic tools for dissecting the functions of Cited2 in the formation of different organs and patterning of the developing embryo. genesis..
  16. pmc Evolution of distinct EGF domains with specific functions
    Merridee A Wouters
    Computational Biology and Bioinformatics Program, Victor Chang Cardiac Research Institute, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia
    Protein Sci 14:1091-103. 2005
    ....
  17. doi The mouse notches up another success: understanding the causes of human vertebral malformation
    Duncan B Sparrow
    Developmental Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia
    Mamm Genome 22:362-76. 2011
    ..This review highlights the role that such mouse models have played in the identification of the genetic causes of the malsegmentation syndrome spondylocostal dysostosis...
  18. ncbi Diverse requirements for Notch signalling in mammals
    Duncan B Sparrow
    Developmental Biology Unit, Victor Chang Cardiac Research Institute, Sydney, Australia
    Int J Dev Biol 46:365-74. 2002
    ..Finally, since not all cases of SCD are due to mutation of DLL3, we are investigating various genes to find other candidates involved in this genetic disease...