Etienne Pays

Summary

Country: Belgium

Publications

  1. ncbi request reprint Regulation of antigen gene expression in Trypanosoma brucei
    Etienne Pays
    Laboratory of Molecular Parasitology, Institut de Biologie Moléculaire et Médicale, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, B6041 Gosselies, Belgium
    Trends Parasitol 21:517-20. 2005
  2. ncbi request reprint The variant surface glycoprotein as a tool for adaptation in African trypanosomes
    Etienne Pays
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Microbes Infect 8:930-7. 2006
  3. doi request reprint Mutual self-defence: the trypanolytic factor story
    Etienne Pays
    Laboratory of Molecular Parasitology, Universite Libre de Bruxelles, Gosselies, Belgium
    Microbes Infect 10:985-9. 2008
  4. ncbi request reprint The trypanolytic factor of human serum
    Etienne Pays
    Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine IBMM, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Nat Rev Microbiol 4:477-86. 2006
  5. ncbi request reprint Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries
    Etienne Pays
    Laboratory of Molecular Parasitology, IBMM, Free University of Brussels, 12, rue des Professeurs Jeener et Brachet, B6041 Gosselies, Belgium
    Curr Opin Microbiol 7:369-74. 2004
  6. ncbi request reprint Characterization of a TFIIH homologue from Trypanosoma brucei
    Laurence Lecordier
    Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine, Universite Libre de Bruxelles, 12, rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Mol Microbiol 64:1164-81. 2007
  7. pmc C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
    Laurence Lecordier
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    PLoS Pathog 5:e1000685. 2009
  8. ncbi request reprint Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes
    David Perez-Morga
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Science 309:469-72. 2005
  9. ncbi request reprint Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream
    Amelia Amiguet-Vercher
    Laboratory of Molecular Parasitology, IBMM, Free University of Brussels, 12, rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Mol Microbiol 51:1577-88. 2004
  10. pmc Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Proc Natl Acad Sci U S A 104:4118-23. 2007

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Regulation of antigen gene expression in Trypanosoma brucei
    Etienne Pays
    Laboratory of Molecular Parasitology, Institut de Biologie Moléculaire et Médicale, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, B6041 Gosselies, Belgium
    Trends Parasitol 21:517-20. 2005
    ..The high recombination frequency prevailing in the telomere that harbours the active VSG expression site has been exploited by the parasite to both drive antigenic variation and generate VSG-based adaptive proteins...
  2. ncbi request reprint The variant surface glycoprotein as a tool for adaptation in African trypanosomes
    Etienne Pays
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Microbes Infect 8:930-7. 2006
    ..The high recombination potential of the telomeric VSG expression sites, coupled to their dynamic mono-allelic expression control, provides trypanosomes with a powerful capacity for adaptation to their hosts...
  3. doi request reprint Mutual self-defence: the trypanolytic factor story
    Etienne Pays
    Laboratory of Molecular Parasitology, Universite Libre de Bruxelles, Gosselies, Belgium
    Microbes Infect 10:985-9. 2008
    ..In this location SRA is thought to neutralize apoL1 through coiled-coil interactions between alpha-helices. We discuss the potential of these discoveries in terms of fight against the disease...
  4. ncbi request reprint The trypanolytic factor of human serum
    Etienne Pays
    Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine IBMM, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Nat Rev Microbiol 4:477-86. 2006
    ..In this Opinion article, we argue that apolipoprotein L1 is the factor that is responsible for the trypanolytic activity of human serum...
  5. ncbi request reprint Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries
    Etienne Pays
    Laboratory of Molecular Parasitology, IBMM, Free University of Brussels, 12, rue des Professeurs Jeener et Brachet, B6041 Gosselies, Belgium
    Curr Opin Microbiol 7:369-74. 2004
    ..So far, the identification of mechanisms and factors involved still resists technological developments and genome sequencing...
  6. ncbi request reprint Characterization of a TFIIH homologue from Trypanosoma brucei
    Laurence Lecordier
    Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine, Universite Libre de Bruxelles, 12, rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Mol Microbiol 64:1164-81. 2007
    ....
  7. pmc C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
    Laurence Lecordier
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    PLoS Pathog 5:e1000685. 2009
    ..In addition, they provide a possible explanation for the ability of Papio serum to kill T. b. rhodesiense, and offer a perspective to generate transgenic cattle resistant to both T. b. brucei and T. b. rhodesiense...
  8. ncbi request reprint Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes
    David Perez-Morga
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Science 309:469-72. 2005
    ..In Trypanosoma brucei, apolipoprotein L-I was targeted to the lysosomal membrane and triggered depolarization of this membrane, continuous influx of chloride, and subsequent osmotic swelling of the lysosome until the trypanosome lysed...
  9. ncbi request reprint Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream
    Amelia Amiguet-Vercher
    Laboratory of Molecular Parasitology, IBMM, Free University of Brussels, 12, rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Mol Microbiol 51:1577-88. 2004
    ..This inactivation is accompanied by a strong overall reduction of nuclear DNA transcription. Although cAMP is involved in the LS to SS transformation, no direct effect of cAMP was observed on the VSG ES control...
  10. pmc Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Proc Natl Acad Sci U S A 104:4118-23. 2007
    ..Thus, apoL-I is responsible for the trypanolytic activity of normal human serum, whereas Hpr allows fast uptake of the carrier HDL particles, presumably through their binding to an Hp/Hpr surface receptor of the parasite...
  11. ncbi request reprint Characterization of RNA polymerase II subunits of Trypanosoma brucei
    Sara Devaux
    Laboratory of Molecular Parasitology, Institute for Molecular Biology and Medicine IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    Mol Biochem Parasitol 148:60-8. 2006
    ..As in the case of TbRPB5, two genes coding for different isoforms of TbRPB6 were identified, suggesting the existence of polymerase-specific isoforms for both TbRPB5 and TbRPB6...
  12. pmc Identification and characterization of two trypanosome TFIIS proteins exhibiting particular domain architectures and differential nuclear localizations
    Pierrick Uzureau
    Laboratoire de Parasitologie Moleculaire, ULB IBMM, rue des Pr Jeneer et Brachet 12, B 6041 Gosselies, Belgium
    Mol Microbiol 69:1121-36. 2008
    ..Repetitive failure to generate a double knockout of TbTFIIS1 and TbTFIIS2-1 strongly suggests synthetical lethality and thus an essential function shared by the two proteins in trypanosome growth...
  13. ncbi request reprint The Trypanosoma brucei reference strain TREU927/4 contains T. brucei rhodesiense-specific SRA sequences, but displays a distinct phenotype of relative resistance to human serum
    Luc Vanhamme
    Laboratory of Molecular Parasitology, Department of Molecular Biology, IBMM, Free University of Brussels, 12, rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Mol Biochem Parasitol 135:39-47. 2004
    ....
  14. doi request reprint A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Science 320:677-81. 2008
    ..Thus, in humans the presence of haptoglobin-related protein has diverted the function of the trypanosome haptoglobin-hemoglobin receptor to elicit innate host immunity against the parasite...
  15. ncbi request reprint The trypanosome lytic factor of human serum and the molecular basis of sleeping sickness
    Luc Vanhamme
    Department of Molecular Biology, Laboratory of Molecular Parasitology, IBMM, University of Brussels, 12, rue des Professeurs Jeener et Brachet, B6041 Gosselies, Belgium
    Int J Parasitol 34:887-98. 2004
    ..This research also allowed the identification of a specific diagnostic DNA probe for T. b. rhodesiense, and may lead to the development of novel anti-trypanosome strategies for use in the field...
  16. pmc Cellular and molecular remodeling of the endocytic pathway during differentiation of Trypanosoma brucei bloodstream forms
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Eukaryot Cell 9:1272-82. 2010
    ..In addition, we observed that in ST forms the lysosome relocates anterior to the nucleus. Altogether, we identified novel morphological and molecular features that characterize SL-to-ST differentiation...
  17. doi request reprint Mechanism of Trypanosoma brucei gambiense resistance to human serum
    Pierrick Uzureau
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12 rue des Prof Jeener et Brachet, B 6041 Gosselies, Belgium
    Nature 501:430-4. 2013
    ..b. gambiense infection and malaria, the main cause of haemolysis-induced hypohaptoglobinaemia in western and central Africa. ..
  18. ncbi request reprint Human serum lyses Trypanosoma brucei by triggering uncontrolled swelling of the parasite lysosome
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, IBMM, Universite Libre De Bruxelles U L B, 12, rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    J Eukaryot Microbiol 54:448-51. 2007
    ..Thus, irrespective of experimental conditions NHS reproducibly induced the swelling of the parasite lysosome...
  19. pmc A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei
    Jose A Garcia-Salcedo
    Institute of Molecular Biology and Medicine, Free University of Brussels, 12 rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    EMBO J 22:5851-62. 2003
    ..Both of these responses correlated with the level of TbSIR2RP1 expression. We propose that histone modification by TbSIR2RP1 is involved in DNA repair...
  20. ncbi request reprint Trypanosoma brucei RNA interference in the mammalian host
    Laurence Lecordier
    Laboratory of Molecular Parasitology, Institute for Molecular Biology and Medicine IBMM, Free University of Brussels, 12 rue des Professeurs Jeener et Brachet, 6041 Gosselies, Belgium
    Mol Biochem Parasitol 140:127-31. 2005
  21. pmc Diversification of function by different isoforms of conventionally shared RNA polymerase subunits
    Sara Devaux
    Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, 6041 Gosselies, Belgium
    Mol Biol Cell 18:1293-301. 2007
    ....
  22. ncbi request reprint Characterization of subunits of the RNA polymerase I complex in Trypanosoma brucei
    David Walgraffe
    Laboratory of Molecular Parasitology, Department of Molecular Biology, IBMM, Free University of Brussels, 12, rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Mol Biochem Parasitol 139:249-60. 2005
    ..Whereas these studies demonstrated that TbRPA1 was phosphorylated, no evidence for phosphorylation of TbRPA2 was found...
  23. ncbi request reprint Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    N Engl J Med 355:2752-6. 2006
    ..Trypanolytic activity was restored by the addition of recombinant APOL1. The lack of APOL1 explained the patient's infection with T. evansi...
  24. ncbi request reprint Apolipoprotein L-I is the trypanosome lytic factor of human serum
    Luc Vanhamme
    Laboratory of Molecular Parasitology, IBMM, University of Brussels, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Nature 422:83-7. 2003
    ..We propose that apoL-I is the trypanosome lytic factor of NHS, and that SRA confers resistance to lysis by interaction with apoL-I in the lysosome...
  25. pmc Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms
    Anaïs Brasseur
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    Eukaryot Cell 12:168-81. 2013
    ..We propose that TbFKBP12 differentially affects stage-specific processes through association with the cytoskeleton...
  26. doi request reprint Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host
    Didier Salmon
    Laboratory of Molecular Parasitology, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, 12, rue des Professeurs Jeener et Brachet, B6041 Gosselies, Belgium
    Science 337:463-6. 2012
    ..Thus, adenylate cyclase activity of lyzed trypanosomes favors early host colonization by live parasites. The role of adenylate cyclases at the host-parasite interface could explain the expansion and polymorphism of this gene family...
  27. doi request reprint Human innate immunity against African trypanosomes
    Etienne Pays
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Curr Opin Immunol 21:493-8. 2009
    ..Hpr or apoL1 deficiency respectively leads to the reduction or abolishment of human protection against T. brucei...
  28. doi request reprint The trypanolytic factor of human serum: many ways to enter the parasite, a single way to kill
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Mol Microbiol 76:806-14. 2010
    ..While Hpr is involved as TLF ligand, the lytic activity is due to apoL1, a Bcl-2-like pore-forming protein. We discuss the in vivo relevance of this uptake pathway in the context of other potentially redundant delivery routes...
  29. ncbi request reprint Diagnostic potential of a conserved genomic rearrangement in the Trypanosoma brucei gambiense-specific TGSGP locus
    Cecile Felu
    Laboratory of Molecular Parasitology, Institut de Biologie et Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    Am J Trop Med Hyg 76:922-9. 2007
    ..b. gambiense isolates...
  30. pmc A differential role for actin during the life cycle of Trypanosoma brucei
    Jose A Garcia-Salcedo
    Laboratory of Molecular Parasitology, ULB Institute of Molecular Biology and Medicine, Gosselies, Belgium
    EMBO J 23:780-9. 2004
    ..However, the flagellar pocket was not affected. These findings suggest that trypanosomes have different functional requirements for actin during the bloodstream and procyclic phases of the life cycle...
  31. doi request reprint Cytokinesis of Trypanosoma brucei bloodstream forms depends on expression of adenylyl cyclases of the ESAG4 or ESAG4-like subfamily
    Didier Salmon
    Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine, Universite Libre de Bruxelles, 12, rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Mol Microbiol 84:225-42. 2012
    ..How deregulated adenylyl cyclases or cAMP might impair cytokinesis is discussed...
  32. ncbi request reprint Distribution of apolipoprotein L-I and trypanosome lytic activity among primate sera
    Philippe Poelvoorde
    Laboratory of Molecular Parasitology, IBMM, Free University of Brussels, 12 rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Mol Biochem Parasitol 134:155-7. 2004
  33. ncbi request reprint Characterization of two protein disulfide isomerases from the endocytic pathway of bloodstream forms of Trypanosoma brucei
    Joyce Rubotham
    Laboratory of Molecular Parasitology, Free University of Brussels Institute of Molecular Biology and Medicine, 12 rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    J Biol Chem 280:10410-8. 2005
    ..Although generally PDIs are considered essential, neither activity appeared to be essential for the growth of trypanosomes, at least in vitro...
  34. doi request reprint Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells
    Sophie Uzureau
    Laboratoire de Parasitologie Moleculaire, IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    Eur J Immunol 46:1854-66. 2016
    ..Finally, the BH3-like peptide of ApoLs appears to be involved in the DC death-promoting activity. We would like to propose that ApoLs are involved in cell death linked to activation of DCs by viral stimuli. ..
  35. pmc Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1
    Gilles Vanwalleghem
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles ULB, 12 rue des Prof Jeener et Brachet, B 6041 Gosselies, Belgium
    Nat Commun 6:8078. 2015
    ..Thus, trypanolysis by APOL1 is linked to apoptosis-like MMP occurring together with TbKIFC1-mediated transport of APOL1 from endolysosomal membranes to the mitochondrion. ..
  36. ncbi request reprint Searching for promoter activity in RIME/Ingi retrotransposons from Trypanosoma brucei: binding of a nuclear protein to their 5' extremity
    Jose A Garcia-Salcedo
    Laboratory of Molecular Parasitology, IBMM, University of Brussels, 12 rue des Professeurs Jeener et Brachet, Gosselies B 6041, Belgium
    Exp Parasitol 104:140-8. 2003
    ..brucei, suggesting that few Ingi copies, if any, are actually active...
  37. pmc Specific Endocytosis Blockade of Trypanosoma cruzi Exposed to a Poly-LAcNAc Binding Lectin Suggests that Lectin-Sugar Interactions Participate to Receptor-Mediated Endocytosis
    Sébastien Brosson
    Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    PLoS ONE 11:e0163302. 2016
    ..Taken together, our data suggest that N-glycan modification of endocytic components plays a crucial role in receptor-mediated endocytosis of T. cruzi...
  38. doi request reprint Adaptation of Trypanosoma rhodesiense to hypohaptoglobinaemic serum requires transcription of the APOL1 resistance gene in a RNA polymerase I locus
    Laurence Lecordier
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Profs Jeener et Brachet, B6041, Gosselies, Belgium
    Mol Microbiol 97:397-407. 2015
    ..gambiense provided with active receptor acquired resistance to HyHS only when TgsGP was moved to a pol-I locus. Thus, transcription by pol-I favours adaptive gene regulation, explaining the presence of SRA in a pol-I locus. ..
  39. doi request reprint Identification of Trypanosoma brucei components involved in trypanolysis by normal human serum
    Laurence Lecordier
    Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, B 6041, Gosselies, Belgium
    Mol Microbiol 94:625-36. 2014
    ..These data confirm that lowering the pH during endocytosis is required for APOL1 toxic activity. ..
  40. doi request reprint The molecular arms race between African trypanosomes and humans
    Etienne Pays
    Laboratory of Molecular Parasitology, Institut de Biologie et de Médecine Moléculaires IBMM, Universite Libre de Bruxelles ULB, 12 rue des Professeurs Jeener et Brachet, B6041 Gosselies, Belgium
    Nat Rev Microbiol 12:575-84. 2014
    ..b. rhodesiense, at the expense of the high probability of developing kidney sclerosis. These findings highlight the importance of resistance to trypanosomes in human evolution...
  41. pmc A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity
    Géraldine De Muylder
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles ULB, Gosselies, Belgium
    PLoS Pathog 9:e1003731. 2013
    ..In order to promote infection, the blood-borne parasite Trypanosoma brucei releases factors that upregulate arginase expression and activity in myeloid cells...
  42. ncbi request reprint Selective pressure can influence the resistance of Trypanosoma congolense to normal human serum
    Hoang Van Xong
    Department of Immunology, Parasitology and Ultrastructure, Flanders Interuniversity for Biotechnology, 65 Paardenstraat, B 1640, St Genesius Rode, Belgium
    Exp Parasitol 102:61-5. 2002
    ..congolense can be reversed like in T. b. rhodesiense. Our data suggest that T. congolense might be able to infect man in regions where animals may serve as reservoirs for the infection...
  43. ncbi request reprint Novel primer sequences for polymerase chain reaction-based detection of Trypanosoma brucei gambiense
    Magdalena Radwanska
    Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
    Am J Trop Med Hyg 67:289-95. 2002
    ..The TgsG-PCR was shown to be specific for T. b. gambiense and was suitable for detection of trypanosome DNA in blood samples of patients with confirmed sleeping sickness...
  44. ncbi request reprint G418, phleomycin and hygromycin selection of recombinant Trypanosoma brucei parasites refractory to long-term in vitro culture
    Pierrick Uzureau
    Laboratoire de Parasitologie Moleculaire, ULB IBMM, rue des Pr Jeneer et Brachet 12, B 6041 Gosselies, Belgium
    Mol Biochem Parasitol 154:90-4. 2007
  45. pmc Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells
    Maxime Dhainaut
    Department of Molecular Biology, Universite Libre de Bruxelles, Gosselies, Belgium
    EMBO J 34:1336-48. 2015
    ..These findings reveal a novel mechanism by which tTregs can maintain tolerance or prevent excessive, proinflammatory Th1 responses. ..
  46. ncbi request reprint A protein kinase specifically associated with proliferative forms of Trypanosoma brucei is functionally related to a yeast kinase involved in the co-ordination of cell shape and division
    Jose A Garcia-Salcedo
    Laboratory of Molecular Parasitology, ULB Institute of Molecular Biology and Medicine, 12 rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Mol Microbiol 45:307-19. 2002
    ..These results link the expression of TBPK50 and the growth status of trypanosomes and support the view that this protein kinase is likely to be involved in the control of life cycle progression and cell division of these parasites...
  47. pmc Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei
    Ali Kassem
    Laboratory of Molecular Parasitology, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, 6041 Gosselies, Belgium
    Proc Natl Acad Sci U S A 111:8943-8. 2014
    ....
  48. ncbi request reprint Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor
    Toya Nath Baral
    Department of Cellular and Molecular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Laboratorium voor Cellulaire en Moleculaire Immunologie, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
    Nat Med 12:580-4. 2006
    ..Treatment with this engineered conjugate resulted in clear curative and alleviating effects on acute and chronic infections of mice with both NHS-resistant and NHS-sensitive trypanosomes...
  49. ncbi request reprint The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense
    Magdalena Radwanska
    Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
    Am J Trop Med Hyg 67:684-90. 2002
    ..b. rhodesiense in 17 of 17 SRA gene-positive strains in which it was tested. These data strongly suggest that expression of the SRA gene is generally involved in resistance to lysis by NHS in T. b. rhodesiense strains...
  50. ncbi request reprint P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis
    Stefan Magez
    Laboratory of Cellular and Molecular Immunology, Department of Cellular and Molecular Recognition, Flanders Interuniversity Institute for Biotechnology, Free University of Brussels VUB, Brussels, Belgium
    J Infect Dis 189:527-39. 2004
    ....
  51. ncbi request reprint Trypanosoma brucei: growth differences in different mammalian sera are not due to the species-specificity of transferrin
    Didier Salmon
    Department of Medical Biochemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, 21941 590, Brazil
    Exp Parasitol 109:188-94. 2005
    ....
  52. ncbi request reprint [Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor]
    Toya Nath Baral
    Département des Interactions cellulaires et moléculaires, Vlaams Interuniversitair Instituut voor Biotechnologie, Laboratorium voor Cellulaire en Moleculaire Immunologie, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Bruxelles, Belgique
    Med Sci (Paris) 22:914-6. 2006