G Pierard

Summary

Country: Belgium

Publications

  1. ncbi [Mycosis fungoides and its new paradigm]
    P Quatresooz
    Service de Derma topathologie, CHU de Liege, Belgique
    Rev Med Liege 65:147-51. 2010
  2. ncbi Ageing across the life span: time to think again
    G E Pierard
    Department of Dermatopathology, University Medical Centre of Liège, Belgium
    J Cosmet Dermatol 3:50-3. 2004
  3. ncbi Commentary on cellulite: skin mechanobiology and the waist-to-hip ratio
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, Belgium
    J Cosmet Dermatol 4:151-2. 2005
  4. ncbi From skin microrelief to wrinkles. An area ripe for investigation
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, Belgium
    J Cosmet Dermatol 2:21-8. 2003
  5. pmc Ustekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis: a primer
    Pascale Quatresooz
    Department of Dermatopathology, University Hospital of Liege, 4000 Liege, Belgium
    J Biomed Biotechnol 2012:147413. 2012
  6. pmc Molecular dermatopathology in malignant melanoma
    Marie Annick Reginster
    Department of Dermatopathology, University Hospital Sart Tilman, 4000 Liege, Belgium
    Dermatol Res Pract 2012:684032. 2012
  7. pmc Chronicle of a pigmented superficial Basal cell carcinoma
    Marie Caucanas
    Department of Dermatology, Regional Hospital of Huy, Huy, Belgium
    Case Rep Dermatol Med 2012:693041. 2012
  8. pmc Intense pulsed-light therapy for proliferative haemangiomas of infancy
    Marie Caucanas
    Department of Dermatopathology, University Hospital of Liege, 4000 Liege, Belgium
    Case Rep Dermatol Med 2011:253607. 2011
  9. pmc The skin landscape in diabetes mellitus. Focus on dermocosmetic management
    Gerald E Pierard
    Laboratory of Skin Bioengineering and Imaging LABIC, University of Liege, Liege, Belgium
    Clin Cosmet Investig Dermatol 6:127-35. 2013
  10. pmc Ipilimumab, a promising immunotherapy with increased overall survival in metastatic melanoma?
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, 4000 Lieg, Belgium
    Dermatol Res Pract 2012:182157. 2012

Collaborators

Detail Information

Publications171 found, 100 shown here

  1. ncbi [Mycosis fungoides and its new paradigm]
    P Quatresooz
    Service de Derma topathologie, CHU de Liege, Belgique
    Rev Med Liege 65:147-51. 2010
    ..Such a situation implies that treatments at least in the initial stages of the disease, should primarily target the skin without searching for an impact on internal lymphoid tissues...
  2. ncbi Ageing across the life span: time to think again
    G E Pierard
    Department of Dermatopathology, University Medical Centre of Liège, Belgium
    J Cosmet Dermatol 3:50-3. 2004
    ..However, seven major types of skin ageing can be distinguished: genetic, chronological, solar, behavioural, endocrinological, catabolic and gravitational types. Preventative measures can target each of these...
  3. ncbi Commentary on cellulite: skin mechanobiology and the waist-to-hip ratio
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, Belgium
    J Cosmet Dermatol 4:151-2. 2005
    ..Some hypodermal fibrous strands become enlarged and others become loose and look similar to striae distensae. Cellulite is not a result of increased body mass, but its aspect may be influenced by the waist-to-hip ratio...
  4. ncbi From skin microrelief to wrinkles. An area ripe for investigation
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, Belgium
    J Cosmet Dermatol 2:21-8. 2003
    ..By contrast, only minimal dermal changes are found beneath permanent or reducible wrinkles compared with immediately adjacent skin. A series of objective and non-invasive methods is available to quantify the severity of wrinkling...
  5. pmc Ustekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis: a primer
    Pascale Quatresooz
    Department of Dermatopathology, University Hospital of Liege, 4000 Liege, Belgium
    J Biomed Biotechnol 2012:147413. 2012
    ..Ustekinumab is part of the recent biologic therapies active in psoriasis, autoimmune arthritides, and inflammatory bowel diseases...
  6. pmc Molecular dermatopathology in malignant melanoma
    Marie Annick Reginster
    Department of Dermatopathology, University Hospital Sart Tilman, 4000 Liege, Belgium
    Dermatol Res Pract 2012:684032. 2012
    ..The expected benefit should improve the patient management. This evolution points to a need for evolution in the training requirements and role of dermatopathologists...
  7. pmc Chronicle of a pigmented superficial Basal cell carcinoma
    Marie Caucanas
    Department of Dermatology, Regional Hospital of Huy, Huy, Belgium
    Case Rep Dermatol Med 2012:693041. 2012
    ....
  8. pmc Intense pulsed-light therapy for proliferative haemangiomas of infancy
    Marie Caucanas
    Department of Dermatopathology, University Hospital of Liege, 4000 Liege, Belgium
    Case Rep Dermatol Med 2011:253607. 2011
    ..The benefit-risk ratio favours the treatment of most types of haemangiomas which are out of the scope of betablocker administration...
  9. pmc The skin landscape in diabetes mellitus. Focus on dermocosmetic management
    Gerald E Pierard
    Laboratory of Skin Bioengineering and Imaging LABIC, University of Liege, Liege, Belgium
    Clin Cosmet Investig Dermatol 6:127-35. 2013
    ..Some relationships are established between diabetes mellitus (DM) and a series of cutaneous disorders. Specific dermatoses are markers for undiagnosed DM. Other disorders represent supervening complications in an already treated DM patient...
  10. pmc Ipilimumab, a promising immunotherapy with increased overall survival in metastatic melanoma?
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, 4000 Lieg, Belgium
    Dermatol Res Pract 2012:182157. 2012
    ..Under treatment, the overall survival of patients with MM metastases is moderately but significantly increased. The immuno-related adverse effects may be severe and life threatening...
  11. pmc Dermal ultrastructure in low Beighton score members of 17 families with hypermobile-type Ehlers-Danlos syndrome
    Trinh Hermanns-Le
    Department of Dermatopathology, University Hospital Sart Tilman, 4000 Liege, Belgium
    J Biomed Biotechnol 2012:878107. 2012
    ..Some EDSH family members fit with BJHS diagnosis. BJHS possibly represents a mild variant of EDSH...
  12. pmc Challenging regional psoriasis and ustekinumab biotherapy: impact of the patterns of disease
    Trinh Hermanns-Le
    Department of Dermatopathology, University Hospital of Liege, 4000 Liege, Belgium
    J Biomed Biotechnol 2012:413767. 2012
    ..Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations...
  13. pmc Cell proliferation in cutaneous malignant melanoma: relationship with neoplastic progression
    G E Pierard
    Department of Dermatopathology, University Hospital of Liege, 4000 Liege, Belgium
    ISRN Dermatol 2012:828146. 2012
    ..Key molecular components involved in the deregulation of the growth fraction, the cell cycle phases of proliferation, and apoptosis are presently described in CMM...
  14. pmc Malignant melanoma and its stromal nonimmune microecosystem
    Gerald E Pierard
    Department of Dermatopathology, Liege University Hospital, 4000 Liege, Belgium
    J Oncol 2012:584219. 2012
    ..Although much remains to be learned in this field, the active intervention of the peri-CMM stroma is likely involved in the inconspicuous early metastatic migration of CMM cells...
  15. pmc Autoimmunity-related granulomatous dermatitis in association with hepatitis
    Gregory Szepetiuk
    Department of Dermatology, Regional Hospital Citadelle, University Hospital of Liege, Liege, Belgium
    Case Rep Dermatol 4:80-4. 2012
    ..They probably represent different aspects of a disease spectrum encompassing the concept of autoimmunity-related granulomatous dermatitis (ARGD)...
  16. pmc Ustekinumab biotherapy and real-time psoriasis capacitance mapping: a pilot study
    Claudine Pierard-Franchimont
    Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital of Liege, 4000 Liege, Belgium
    J Biomed Biotechnol 2012:870194. 2012
    ..The present pilot study suggests that PCM could be used as a fast and convenient method for assessing the anti-inflammatory efficacy of ustekinumab and other biotherapies...
  17. pmc The skin ivory spot. A possible indicator for skinfield photo-carcinogenesis in recreational sunbed addicts
    Pascale Quatresooz
    Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital of Liege, Belgium
    Int J Environ Res Public Health 9:362-9. 2012
    ..Of note, rare spotty amelanotic macules presenting as skin ivory spots (SIS) was reported on any part of the body...
  18. pmc The weather-beaten dorsal hand clinical rating, shadow casting optical profilometry, and skin capacitance mapping
    Marie Delvenne
    Laboratory of Skin Bioengineering and Imaging LABIC, Department of Clinical Sciences, Liege University, 4000 Liege, Belgium
    Biomed Res Int 2013:913646. 2013
    ..This seemingly contradiction was in fact due to different levels of scale observation. The clinical centimetric scale and the instrumental inframillimetric scale possibly provide distinct aspects of a given biological impact. ..
  19. pmc Cyclic catamenial dermatoses
    Trinh Hermanns-Le
    Department of Dermatopathology, Unilab Lg, University Hospital of Liege, 4000 Liege, Belgium Department of Dermatology, Diagnostic Centre, 4800 Verviers, Belgium
    Biomed Res Int 2013:156459. 2013
    ..It is present under variable clinical aspects. A series of other recurrent skin conditions are not specifically induced but are merely exacerbated at the end of the ovarian cycle. ..
  20. pmc HOX Gene Aberrant Expression in Skin Melanoma: A Review
    Gerald E Pierard
    Department of Dermatopathology, Liege University Hospital, 4000 Liege, Belgium
    J Skin Cancer 2012:707260. 2012
    ..We present relevant peer-reviewed literature findings about the aberrant expression of HOX genes in CMM. The number of CMM cell nuclei exhibiting aberrant HOX protein expression appears correlated with tumour progression...
  21. pmc Immunohistochemical patterns in the interfollicular Caucasian scalps: influences of age, gender, and alopecia
    Claudine Pierard-Franchimont
    Department of Dermatopathology, University Hospital of Liege, 4000 Liege, Belgium Laboratory of Skin Bioengineering and Imaging, Department of Clinical Sciences, University of Liege, 4000 Liege, Belgium
    Biomed Res Int 2013:769489. 2013
    ..Immunohistochemistry revealed a prominent gender effect in young adults. Both Factor XIIIa+ dermal dendrocytes and the microvasculature size decreased with scalp ageing. Alopecia changes mimicked stress-induced premature senescence. ..
  22. pmc Alterations in hair follicle dynamics in women
    Claudine Pierard-Franchimont
    Department of Dermatopathology, Unilab Lg, University Hospital of Liege, CHU Sart Tilman, 4000 Liege, Belgium Department of Dermatology, Regional Hospital of Huy, 4500 Huy, Belgium
    Biomed Res Int 2013:957432. 2013
    ..Current hair treatment strategies are symptomatic and nonspecific so current researchers aim at developing new, targeted methods. ..
  23. pmc Revisiting the cutaneous impact of oral hormone replacement therapy
    Gerald E Pierard
    Laboratory of Skin Bioengineering and Imaging, Department of Clinical Sciences, B23, University of Liege, 4000 Liege, Belgium
    Biomed Res Int 2013:971760. 2013
    ..All the current reports indicate that chronologic aging, climacteric estrogen deficiency, and adequate hormone therapy exert profound effects on various parts of the skin. ..
  24. doi Scrutinizing skinfield melanin patterns in young Caucasian women
    Trinh Hermanns-Le
    Liege University, Liege University Hospital, Department of Dermatopathology, Department of Clinical Sciences, Laboratory of Skin Bioengineering and Imaging, Unilab Lg, Liege, Belgium
    Expert Opin Med Diagn 7:455-62. 2013
    ..When using adequate wavelength illumination and high resolution recordings, Caucasian skin color appears uneven. The patterns of faint mosaic melanoderma (FMM) are diverse and possibly related to the risk of skin cancer development...
  25. doi Characterization of spontaneous collagen fibrillogenesis in a cell-free and tension-free environment
    G E Pierard
    Department of Clinical Science, University of Liege, Liege, Belgium
    Clin Exp Dermatol 38:417-20. 2013
    ..The possible interventions of stromal cells and of other macromoleules of the extracellular matrix were not considered in this study...
  26. doi Critical assessment of diabetic xerosis
    Gerald E Pierard
    University Hospital of Liege, Department of Dermatopathology, Laboratory of Skin Bioengineering and Imaging LABIC, Liege, Belgium
    Expert Opin Med Diagn 7:201-7. 2013
    ..Diabetes mellitus is commonly responsible for skin changes including discrete to mild xerosis...
  27. doi Field melanin mapping of the hairless scalp
    Gerald E Pierard
    Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Skin Res Technol 18:431-5. 2012
    ..Mottled subclinical melanoderma (MSM) is frequently seen on facial skin using the ultraviolet light enhanced visualization (ULEV) method. The corresponding aspect on the hairless scalp remains unknown...
  28. doi Scleroderma: skin stiffness assessment using the stress-strain relationship under progressive suction
    Gerald E Pierard
    University of Liege, Laboratory of Skin Bioengineering and Imaging LABIC, Liege, Belgium
    Expert Opin Med Diagn 7:119-25. 2013
    ..A few non-invasive biometrological methods are available for monitoring skin stiffening in systemic scleroderma. Among them, the Cutometer® is used for years by several clinical teams...
  29. ncbi Toxic epidermal necrolysis and antifolate drugs in cancer chemotherapy
    Claudine Pierard-Franchimont
    Department of Dermatopathology, University Hospital of Liege, Belgium
    Curr Drug Saf 7:357-60. 2012
    ..Whether or not the TEN/SJS presentation of ACSR is a regular condition similar to that induced by other drugs or a variant condition supported by a unique pathomechanism is unsettled...
  30. ncbi Deciphering supportive treatment strategies for toxic epidermal necrolysis
    Serge Jennes
    Burn Unit, Queen Astrid Military Hospital, Brussels, Belgium
    Curr Drug Saf 7:361-6. 2012
    ....
  31. doi Miconazole, a pharmacological barrier to skin fungal infections
    Gerald E Pierard
    University Hospital of Liege, Department of Dermatopathology, CHU Sart Tilman, B 4000 Liege, Belgium
    Expert Opin Pharmacother 13:1187-94. 2012
    ..As a result, intracellular organelle destruction then leads to cell necrosis. Farnesol synthesis stimulated in Candida spp. prevents the yeast-to-mycelium formation. MCZ is further active against Gram-positive bacteria...
  32. doi Bioimpact of EGFR antagonists on the pilosebaceous follicles
    Gerald E Pierard
    Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital Sart Tilman, Liege, Belgium
    Eur J Dermatol 22:54-7. 2012
    ..The present findings suggest an EGFR inhibitor-induced kerosis (follicular hyperkeratosis) possibly responsible for acneiform reactions...
  33. doi Spotlight on adapalene
    Gerald E Pierard
    University Hospital of Liege, Department of Dermatopathology, CHU Sart Tilman, Liege, Belgium
    Expert Opin Drug Metab Toxicol 5:1565-75. 2009
    ..Adapalene is a naphthoic acid derivative showing some pharmacological activities similar to the regular retinoids. The drug is used singly or in combination for treating acne and a few other miscellaneous skin disorders...
  34. ncbi [How I treat....psoriasis comorbidities by adalimumab (Humira) anti-TNFalpha]
    C Pierard-Franchimont
    Service de Dermatopathologie, CHU de Liege
    Rev Med Liege 65:545-8. 2010
    ..We review the effects of biologicals, in particular adalimumab (Humira), on psoriatic comorbidities...
  35. ncbi [Basic initiatory glossary to clinical research]
    G E Pierard
    Service de Dermatopathologie, Universite de Liege
    Rev Med Liege 61:190-4. 2006
    ..We present a glossary of terms frequently used in medico-scientific studies...
  36. ncbi [Hydrocortisone 17-butyrate (Locoid), a thirty-year ongoing innovative drug]
    G E Pierard
    Service de Dermatopathologie, CHU Sart Tilman, Liege
    Rev Med Liege 61:128-30. 2006
    ..The original Locoid lipocream and Locoid Crelo presentations confer remarkable qualities to the product. We report a synopsis of clinical and translational studies devoted to this unique dermocorticoid...
  37. ncbi Spotlight on nail histomycology
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, CHU Sart Tilman, B 4000 Liege, Belgium
    Dermatol Clin 24:371-4. 2006
    ..The correct diagnosis provided by histomycology combined with culture not only allows for more efficient expenditure of funds and services but also is important for the timely alleviation of the disorder...
  38. ncbi Spores, sporodochia and fomites in onychomycosis
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, Belgium
    Dermatology 213:169-72. 2006
    ..In addition, the sporodochium, which is an exophytic fungal ball, may be attached underneath the distal free edge of some onychomycoses. It might represent an important source of fungal propagules in patients with poor nail trimming...
  39. doi Facing up to toxic epidermal necrolysis
    Gerald E Pierard
    University Hospital Sart Tilman, Department of Dermatopathology, Liege, Belgium
    Expert Opin Pharmacother 11:2443-6. 2010
    ..At present there is still a lack of validated mainstay treatment for TEN. However, a few treatment modalities have been reported to halt TEN progression in some patients...
  40. doi Updating corneofungimetry: a bioassay exploring dermatomycoses and antifungal susceptibility
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Mycopathologia 169:27-35. 2010
    ..Computerized morphometric assessments bring numerical values allowing statistical comparisons. Variants of corneofungimetry address more specific aspects related to fungal cell adhesion, fungitoxicity and lipid-dependent fungi...
  41. ncbi Fungal thigmotropism in onychomycosis and in a clear hydrogel pad model
    G E Pierard
    Department of Dermatopathology, University Hospital Sart Tilman, Liege, Belgium
    Dermatology 215:107-13. 2007
    ..This behavior has been shown experimentally with fungal hyphae of both dermatophytes and nondermatophyte molds, as well as with the mycelial phase of the dimorphic yeast Candida albicans...
  42. ncbi Emerging therapeutic agents for onychomycosis
    Gerald E Pierard
    CHU Sart Tilman, Department of Dermatopathology, B 4000 Liege, Belgium
    Expert Opin Emerg Drugs 12:345-53. 2007
    ..Thus, ongoing drug development activities have focused on novel delivery technologies to facilitate incorporation of existing antifungal drugs inside the nail plate and the discovery of new active antifungals...
  43. ncbi [Polishing up functional dermatopathology, dermometrology and mechanobiology]
    G E Pierard
    Service de Dermatopathologie, CHU du Sart Tilman, Liege, Belgique
    Rev Med Liege 62:73-8. 2007
    ....
  44. ncbi Novelties in the multifaceted miconazole effects on skin disorders
    Pascale Quatresooz
    University Hospital of Liege, Department of Dermatopathology, B 4000 Liege, Belgium
    Expert Opin Pharmacother 9:1927-34. 2008
    ..Miconazole nitrate is a time-honored antifungal of the imidazole class...
  45. pmc Skin protection creams in medical settings: successful or evil?
    Emmanuelle Xhauflaire-Uhoda
    Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, Liege, Belgium
    J Occup Med Toxicol 3:15. 2008
    ..In this study, two skin protection creams were assayed comparatively looking for a protective effect if any against a liquid soap and an alcohol-based gel designed for hand hygiene in medical settings...
  46. ncbi A pilot study on seborrheic dermatitis using pramiconazole as a potent oral anti-Malassezia agent
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Dermatology 214:162-9. 2007
    ..Little objective information is available so far from biometrological quantitative assessments of this skin condition. Pramiconazole is a novel triazole with potent in vitro antifungal activity, especially against Malassezia spp...
  47. ncbi [Malignant melanoma: conceptual and therapeutic innovations based on translational research]
    G E Pierard
    Service de Dermatopathologie, CHU du Sart Tilman, Liege, Belgique
    Rev Med Liege 63:579-84. 2008
    ..A new international multicentric approach using adjuvant therapy for stage III melanomas involves the clinical oncology department of the CHU of Liège. It concerns a targeted immunotherapy directed to the Mage A3 protein...
  48. ncbi Emerging therapies for ionizing radiation-associated skin field carcinogenesis
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Expert Opin Pharmacother 10:813-21. 2009
    ..Skin-field cancerization is another condition associated to or independent of clinically recognizable radiodermatitis. This condition leads to the risk of later occurrence of skin malignancies...
  49. ncbi [Can we sort out from the jumble about oral contraceptives and skin cancers?]
    G E Pierard
    CHU du Sart Tilman, Liege
    Rev Med Liege 62:463-6. 2007
    ..There is some evidence that steroid hormones present in oral contraceptives do not significantly increase the risk of developing skin cancer when estrogen exposure is not excessive...
  50. ncbi [3-D imaging of skin cancers and survival]
    G E Pierard
    Service de Dermatopathologie, CHU de Liege, Belgique
    Rev Med Liege 64:187-91. 2009
    ....
  51. ncbi [Cutaneous adverse reactions to chemotherapy and their management]
    G E Pierard
    Service de Dermatopathologie, CHU du Sart Tilman, Liege, Belgique
    Rev Med Liege 62:457-62. 2007
    ..It is wise to identify them with precision in order to chose the most adequate preventive and therapeutic measures. The dermatopathology assessment is helpful for the diagnostic...
  52. doi New approaches in light/laser therapies and photodynamic treatment of acne
    Claudine Pierard-Franchimont
    Department of Dermatopathology, University Hospital Sart Tilman, Liege, Belgium
    Expert Opin Pharmacother 12:493-501. 2011
    ..The relative effectiveness compared with other treatments is unconfirmed; from the published information, evidence-based efficacy assessment of light/laser therapies in acne remains almost impossible...
  53. ncbi EEMCO guidance for the assessment of hair shedding and alopecia
    G E Pierard
    Department of Dermatopathology, Unit of Dermocosmetology, University Hospital Sart Tilman, Liege, Belgium
    Skin Pharmacol Physiol 17:98-110. 2004
    ..Skin biopsy is indicated for diagnostic purposes, especially when the hair loss is accompanied by scarring...
  54. ncbi EEMCO guidance for the efficacy assessment of antiperspirants and deodorants
    G E Pierard
    Department of Dermatopathology, University Medical Center Sart Tilman, Liege, Belgium
    Skin Pharmacol Appl Skin Physiol 16:324-42. 2003
    ..Indirect support is provided by visualization of apocrine gland excretion and collection of sweat and volatile compounds. Microbiological assessments and chromatographic analysis also provide indirect information...
  55. ncbi Update on the histological presentation of facial wrinkles
    Gerald E Pierard
    Department of Dermatopathology CHU Sart Tilman, Liege, Belgium
    Eur J Dermatol 12:XIII-XIV. 2002
  56. ncbi Relationship between bone mass density and tensile strength of the skin in women
    G E Pierard
    Department of Dermatopathology, University of Liege, Liege, Belgium
    Eur J Clin Invest 31:731-5. 2001
    ..Skin and bone may be affected similarly during the climacteric and during long-term corticotherapy. Little is known about the correlation between the respective alterations in bone mass density (BMD) and tensile strength of the skin...
  57. ncbi Onychomycosis and other superficial fungal infections of the foot in the elderly: a pan-European survey
    G Pierard
    Department of Dermatopathology, University of Liege, Belgium
    Dermatology 202:220-4. 2001
    ..With the increasing life expectancy, the prevalence of onychomycosis and other superficial fungal infections is likely to increase further without adequate prevention and treatment...
  58. ncbi Itraconazole
    G E Pierard
    Department of Dermatopathology, Institute of Pathology, University Medical Center of Liege, Belgium
    Expert Opin Pharmacother 1:287-304. 2000
    ..However, a potential for drug interactions exists, mediated through the cytochrome P450 enzyme 3A4 system, which should be considered when itraconazole is used as part of a multi-drug regimen...
  59. ncbi The boosted antifungal topical treatment (BATT) for onychomycosis
    G E Pierard
    Department of Dermatopathology, University Medical Center of Liege, Belgium
    Med Mycol 38:391-2. 2000
    ..It consists of the combination of an antifungal with a device boosting germination of fungal propagules in order to render these cells more responsive to treatment. Preliminary results of a pilot study support such a concept...
  60. ncbi Tensile properties of relaxed excised skin exhibiting striae distensae
    G E Pierard
    Belgian SSTC Research Center, Department of Dermatopathology, University Medical Center Sart Tilman, Liege, Belgium
    J Med Eng Technol 23:69-72. 1999
    ..The ex vivo and in vivo evaluations of the tensile properties and functions of skin are complementary particularly when the connective tissue is abnormal...
  61. ncbi Would cyclosporin A be beneficial to mitigate drug-induced toxic epidermal necrolysis?
    P Paquet
    Department of Dermatopathology, University of Liege, Belgium
    Dermatology 198:198-202. 1999
    ..CsA has already been used successfully on a limited series of TEN patients. We have reviewed the potential theoretical useful effects of CsA in TEN. We conclude that CsA could be a good candidate to reverse TEN progression...
  62. ncbi [Dioxin, poisoning information or brainwashing? On Seveso's and Yushchenko's acne]
    G E Pierard
    CHU du Sart Tilman, Service de Dermatopathologie, Liege
    Rev Med Liege 60:18-22. 2005
    ..They may be responsible for some birth defects...
  63. ncbi [Skin photophysics and colors]
    G E Pierard
    CHU du Sart Tilman, Service de Dermatopathologie, Liege
    Rev Med Liege 60:48-52. 2005
    ..Spectrophotometry, tristimulus colorimetry and computerized image analysis are well codified methods. Epidermal melanisation is detected with great sensitivity under ultraviolet light illumination...
  64. ncbi Itraconazole corneofungimetry bioassay on Malassezia species
    G E Pierard
    Department of Dermatopathology, University Medical Center of Liege, Liege, Belgium
    Mycoses 47:418-21. 2004
    ..pachydermatis. Their growth was abated to almost the same level after itraconazole treatment. It is concluded that in vivo treatment with itraconazole is highly active against all Malassezia spp. colonizing the human stratum corneum...
  65. doi Analytic assessment under ultraviolet light of actinic lentigines under bleaching treatment
    Gerald E Pierard
    Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, CHU Sart Tilman, University Hospital of Liege, Liege, Belgium
    J Cosmet Dermatol 10:104-9. 2011
    ..Bleaching (whitening) agents are commonly offered to fade their darker aspect. In general, regular colorimetric methods show poor sensitivity to disclose any bleaching effect...
  66. ncbi [Spotlight on sensory irritation and its treatment]
    C Pierard-Franchimont
    CHU du Sart Tilman, Service de Dermatopathologie
    Rev Med Liege 60:796-8. 2005
    ..The responsible ingredients are often agents affecting functions of stratum corneum without being obvious chemical irritants...
  67. ncbi The key role of corneocytes in pityrosporoses
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Dermatology 212:23-6. 2006
    ..We frame as a hypothesis that the primary defect in some Malassezia-driven disorders resides in the corneocytes and their precursor keratinocytes...
  68. doi Focus on skin cancer association and progression under TNF antagonist therapy
    Claudine Pierard-Franchimont
    University Hospital Sart Tilman, Department of Dermatopathology, CHU Sart Tilman, B 4000 Liege, Belgium
    Expert Opin Biol Ther 11:1215-22. 2011
    ..Their prevalence is higher in immunocompromized patients. Results of some animal experiments have indicated that TNF acts both as a tumour promotor and an inductor of apoptosis...
  69. ncbi [How I prevent ... minor acne]
    G E Pierard
    CHU de Sart Tilman et Sauvenière, Service de Dermatopathologie
    Rev Med Liege 60:741-3. 2005
    ..The therapeutic strategy depends on these progression characteristics and must fit to each individual patient. This review focuses on the minor but the most frequent types of acne that may benefit from dermocosmetic treatments...
  70. ncbi [Skin reactions to tattoo ink]
    C Pierard-Franchimont
    Service de Dermatopathologie, CHU de Liege, Belgique
    Rev Med Liege 66:430-3. 2011
    ..These procedures are not indicated in inflamed tattoos. Indeed, the pigment dispersed during photolysis may perpetuate the reaction. Pseudotattoos due to the stratum corneum staining are frequently responsible for photoeczema...
  71. ncbi The nail under fungal siege in patients with type II diabetes mellitus
    Gerald E Pierard
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Mycoses 48:339-42. 2005
    ..Diabetic patients, particularly men, are at increased risk of developing onychomycosis. The morbidity linked to this disorder, and its impact on the foot status in diabetic subjects merit to be better appreciated by clinicians...
  72. ncbi [Some trouble in the field of onychomycosis]
    G E Pierard
    CHU du Sart Tilman, Service de Dermatopathologie, Liege
    Rev Med Liege 60:242-6. 2005
    ..This review is an attempt to shed some light on this topic using objective and qualified medical information...
  73. doi The therapeutic potential of TNF-alpha antagonists for skin psoriasis comorbidities
    Gerald E Pierard
    University Hospital Sart Tilman, Department of Dermatopathology, Liege, Belgium
    Expert Opin Biol Ther 10:1197-208. 2010
    ..TNF-alpha antagonists are used to treat psoriasis. Adalimumab is one of the recognized active agents for this indication...
  74. ncbi Corneofungimetry bioassay on Malassezia spp. under ketoconazole and desonide influences
    C Pierard-Franchimont
    Department of Dermatopathology, University Hospital Sart Tilman, BE 4000 Liege, Belgium
    Skin Pharmacol Physiol 18:98-102. 2005
    ..Glucocorticoids can boost some Malassezia-driven dermatoses. However, both antifungals and topical corticosteroids improve lesions of seborrheic dermatitis...
  75. ncbi Factor XIIIa-related antigen immunoreactivity of fungal cell wall: a biologically relevant feature?
    J E Arrese
    Department of Dermatopathology, University of Liege, Belgium
    Dermatology 190:119-23. 1995
    ..A positive immunoreactivity of fungal walls for factor XIIIa has been recently described. Factor XIIIa is a transglutaminase involved in the formation of covalent peptide bounds between some specific proteins...
  76. ncbi Dandruff-associated smouldering alopecia: a chronobiological assessment over 5 years
    C Pierard-Franchimont
    Department of Dermatopathology, University Hospital Sart Tilman, Liege, Belgium
    Clin Exp Dermatol 31:23-6. 2006
    ..In some individuals, dandruff may be recurrent and even chronic. This represents a difficult-to-treat condition. Excessive hair shedding and diffuse alopecia may develop...
  77. ncbi [Impact of the HIV infection on skin cancers]
    P Quatresooz
    Chef de Laboratoire, Service de Dermatopathologie, CHU de Liege
    Rev Med Liege 64:37-40. 2009
    ..The leading neoplasms correspond to basal and squamous cell carcinomas, some primary cutaneous lymphomas and malignant melanomas. In these patients, early diagnosis and radical treatment on sight should be considered...
  78. ncbi Comparative effect of hormone replacement therapy on bone mass density and skin tensile properties
    G E Pierard
    Department of Dermatopathology, Belgian SSTC Research Center 5596, University Medical Centre Sart Tilman, B 4000 Liege, Belgium
    Maturitas 40:221-7. 2001
    ..Hormone replacement therapy (HRT) can help mitigate their atrophy. The aim of this study was to compare the HRT effect on the skin tensile properties and bone mass density...
  79. ncbi [Corneofungimetry: A bioassay for dermato-mycology.]
    J E Arrese Estrada
    Servicio de Dermatopatología, Universidad de Liège, Belgica
    Rev Iberoam Micol 15:253-5. 1998
    ..Similarly, the potency of oral antifungals can be evaluated at the level of the stratum corneum...
  80. ncbi Perineal herpes simplex infection in bedridden geriatric patients
    Arjen F Nikkels
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Am J Clin Dermatol 8:79-83. 2007
    ..Herpes simplex virus (HSV) lesions are prone to reactivation and recurrence in response to various local or systemic triggering factors...
  81. ncbi Drug-induced toxic epidermal necrolysis and pancytopenia: a puzzling association
    Philippe Paquet
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Int J Mol Med 16:29-33. 2005
    ..This finding entails that TEN treatments should target the keratinocyte metabolism rather than the circulating inflammatory cells which presumably play a limited role, if any, in the epidermal destructive process...
  82. doi Topical treatment options for drug-induced toxic epidermal necrolysis (TEN)
    Philippe Paquet
    University Hospital Sart Tilman, Department of Dermatopathology, Liege, Belgium
    Expert Opin Pharmacother 11:2447-58. 2010
    ..The mortality rate of 25 - 30% is mainly due to both metabolic failures and septicemia following loss of epidermal integrity. Topical treatments are important options in these patients...
  83. ncbi Toxic epidermal necrolysis: revisiting the tentative link between early apoptosis and late necrosis (review)
    Philippe Paquet
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Int J Mol Med 19:3-10. 2007
    ..The necrotic events follow apoptosis when both phenomena are present...
  84. doi Occult varicella
    Arjen F Nikkels
    Department of Dermatology, CHU du Sart Tilman, Liege, Belgium
    Pediatr Infect Dis J 28:1073-5. 2009
    ..Localized varicella has been associated with UV-exposure and skin trauma. Varicella restricted to a pre-existent dermatitis is exceptional...
  85. doi New insights in toxic epidermal necrolysis (Lyell's syndrome): clinical considerations, pathobiology and targeted treatments revisited
    Philippe Paquet
    Department of Dermatopathology, University Hospital of Liege, CHU Sart Tilman, Liege, Belgium
    Drug Saf 33:189-212. 2010
    ..g. anti-TNF-alpha antibodies plus N-acetylcysteine) targeting different levels of the keratinocyte failure machinery...
  86. doi Immunohistochemical clues at aging of the skin microvascular unit
    Pascale Quatresooz
    Department of Dermatopathology, University Hospital Sart Tilman, Liege, Belgium
    J Cutan Pathol 36:39-43. 2009
    ..We also explored the effect of substance P released by capsaicin because this neuropeptide is known to affect the microvasculature environment...
  87. ncbi Cryoscopy: a novel enhancing method of in vivo skin imaging
    Arjen F Nikkels
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Skin Res Technol 13:377-84. 2007
    ..In this respect, cryoscopy refers to the direct observation by dermoscopy, with or without digital recording, of the visual alterations of the frozen tissues...
  88. ncbi Photodynamic therapy for cutaneous verrucous carcinoma
    Arjen F Nikkels
    Department of Dermatopathology, University Hospital of Liege, Belgium
    J Am Acad Dermatol 57:516-9. 2007
    ..The use of methyl-aminolevulinate-photodynamic therapy for treating cutaneous verrucous carcinoma had not been reported so far. It may represent a convenient therapeutic alternative in this setting...
  89. ncbi Occult herpes simplex virus colonization of bullous dermatitides
    Arjen F Nikkels
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Am J Clin Dermatol 9:163-8. 2008
    ..A possible occult viral colonization has never been documented in these disorders. The manner in which the primary bullous disorders are contaminated by herpesviridae remains unclear...
  90. ncbi Lipodystrophy reactions to insulin: effects of continuous insulin infusion and new insulin analogs
    Regis P Radermecker
    Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, University Hospital Sart Tilman, University of Liege, Liege, Belgium
    Am J Clin Dermatol 8:21-8. 2007
    ..Conversely, exceptional cases of lipoatrophy have occurred in patients receiving lispro insulin analog via CSII. Lipodystrophy reactions remain a potential problem when managing diabetic patients with new insulin therapy technologies...
  91. doi Simultaneous determination of five beta-lactam antibiotics (cefepim, ceftazidim, cefuroxim, meropenem and piperacillin) in human plasma by high-performance liquid chromatography with ultraviolet detection
    Raphael Denooz
    Laboratoire de Toxicologie Clinique et de Toxicologie Médico Légale, Centre Hospitalier Universitaire Sart Tilman B 35, B 4000 Liege, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 864:161-7. 2008
    ..9 and 12.2%. The method has been applied to plasma samples obtained from patients treated with beta-lactam antibiotics and is appropriated for easy determination of plasma concentrations for therapeutic monitoring applications...
  92. ncbi [Squamous cell carcinoma of the leg in an octogenarian woman]
    P Quatresooz
    CHU du Sart Tilman, Service de Dermatopathologie
    Rev Med Liege 60:680-2. 2005
    ..The dermal dendrocytes were abundant in the peritumoral stroma. This situation was previously interpreted as a favourable prognostic factor...
  93. ncbi Activity of the triazole antifungal r126638 as assessed by corneofungimetry
    C Pierard-Franchimont
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Skin Pharmacol Physiol 19:50-6. 2006
    ..R126638 is a novel triazole exhibiting potent in vitro and in vivo antifungal activity against fungal pathogens including dermatophytes and yeasts...
  94. ncbi [Hic et Nunc. Naevus or melanoma?]
    C Pierard-Franchimont
    CHU du Sart Tilman, Service de Dermatopathologie, Liege, Belgique
    Rev Med Liege 61:43-7. 2006
    ..In this field, Belgium is not destituted. We report a brief review of the contribution of the Mosan Study Group of Pigmentary Tumors (GMETP) at the University Hospital of Liège...
  95. ncbi [Cutaneous side effects of interferons]
    P Paquet
    , Service de Dermatopathologie
    Rev Med Liege 56:699-702. 2001
    ..The main clinical presentations include vesiculo-bullous sometimes infiltrated dermatitis, vasculitis, necrosis, ulceration and alopecia. Exacerbation of dermatoses such as psoriasis is also possible...
  96. ncbi Simultaneous reactivation of herpes simplex virus and varicella-zoster virus in a patient with idiopathic thrombocytopenic purpura
    A F Nikkels
    Department of Dermatopathology, University Medical Center of Liege, Belgium
    Dermatology 199:361-4. 1999
    ..Intravenous aciclovir was initiated. The present case of simultaneous clinical infections by HSV-I and VZV underlines the importance of complementary viral identification testing in the event of unusual clinical presentations...