Fadel Tissir

Summary

Country: Belgium

Publications

  1. doi Planar cell polarity signaling in neural development
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, avenue E Mounier, 73, Box 7382, B1200 Brussels, Belgium
    Curr Opin Neurobiol 20:572-7. 2010
  2. pmc Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
    Badri Vardarajan
    Department of Medicine Biomedical Genetics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Mol Neurodegener 8:10. 2013
  3. pmc DeltaNp73 regulates neuronal survival in vivo
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology Unit, Brussels, Belgium
    Proc Natl Acad Sci U S A 106:16871-6. 2009
  4. pmc Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice
    Yibo Qu
    Institute of Neuroscience, Developmental Neurobiology, Universite Catholique de Louvain, Brussels, Belgium
    J Neurosci 30:9392-401. 2010
  5. pmc Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice
    Libing Zhou
    Developmental Neurobiology, Universite Catholique de Louvain, 1200 Bruxelles, Belgique
    Science 320:946-9. 2008
  6. ncbi The atypical cadherin Celsr3 regulates the development of the axonal blueprint
    Libing Zhou
    University of Louvain, Developmental Neurobiology Unit, 73, Avenue Mourier, Bte DENE7382, B1200 Brussels, Belgium
    Novartis Found Symp 288:130-4; discussion 134-40, 276-81. 2007
  7. doi Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, Brussels, Belgium
    Nat Neurosci 13:700-7. 2010
  8. pmc A dual role for planar cell polarity genes in ciliated cells
    Camille Boutin
    Institute of Neuroscience, Developmental Neurobiology, Universite Catholique de Louvain, B1200 Brussels, Belgium
    Proc Natl Acad Sci U S A 111:E3129-38. 2014
  9. doi Celsr3 is required in motor neurons to steer their axons in the hindlimb
    Guoliang Chai
    Developmental Neurobiology, Institute of Neuroscience, Universite Catholique de Louvain, Brussels, Belgium
    Nat Neurosci 17:1171-9. 2014
  10. ncbi Expression of planar cell polarity genes during development of the mouse CNS
    Fadel Tissir
    Developmental Neurobiology Unit, University of Louvain Medical School, 73, Av E Mounier, Box DENE7382, B1200 Brussels, Belgium
    Eur J Neurosci 23:597-607. 2006

Collaborators

Detail Information

Publications27

  1. doi Planar cell polarity signaling in neural development
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, avenue E Mounier, 73, Box 7382, B1200 Brussels, Belgium
    Curr Opin Neurobiol 20:572-7. 2010
    ..Although several key players in PCP signaling have been identified, their mechanisms of action remain elusive, particularly in the nervous system...
  2. pmc Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
    Badri Vardarajan
    Department of Medicine Biomedical Genetics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Mol Neurodegener 8:10. 2013
    ..Here, we reevaluated tau pathologies in the same TgCRND8 mouse model as the previous studies...
  3. pmc DeltaNp73 regulates neuronal survival in vivo
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology Unit, Brussels, Belgium
    Proc Natl Acad Sci U S A 106:16871-6. 2009
    ....
  4. pmc Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice
    Yibo Qu
    Institute of Neuroscience, Developmental Neurobiology, Universite Catholique de Louvain, Brussels, Belgium
    J Neurosci 30:9392-401. 2010
    ..These data indicate that Celsr1-3 differentially regulate FBM neuron migration. Celsr1 helps to specify the direction of FBM neuron migration, whereas Celsr2 and 3 control its ability to migrate...
  5. pmc Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice
    Libing Zhou
    Developmental Neurobiology, Universite Catholique de Louvain, 1200 Bruxelles, Belgique
    Science 320:946-9. 2008
    ..These observations provide in vivo evidence that Celsr3-mediated interactions between axons and guidepost cells govern axonal tract formation in mammals...
  6. ncbi The atypical cadherin Celsr3 regulates the development of the axonal blueprint
    Libing Zhou
    University of Louvain, Developmental Neurobiology Unit, 73, Avenue Mourier, Bte DENE7382, B1200 Brussels, Belgium
    Novartis Found Symp 288:130-4; discussion 134-40, 276-81. 2007
    ....
  7. doi Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, Brussels, Belgium
    Nat Neurosci 13:700-7. 2010
    ..Our findings suggest that planar cell polarity signaling is involved in ependymal cilia development and in the pathophysiology of hydrocephalus, with possible implications in other ciliopathies...
  8. pmc A dual role for planar cell polarity genes in ciliated cells
    Camille Boutin
    Institute of Neuroscience, Developmental Neurobiology, Universite Catholique de Louvain, B1200 Brussels, Belgium
    Proc Natl Acad Sci U S A 111:E3129-38. 2014
    ..Loss of either of these signals is associated with specific defects in the cytoskeleton. Our data reveal unreported functions of PCP and provide an integrated view of planar polarization of the brain ciliated cells. ..
  9. doi Celsr3 is required in motor neurons to steer their axons in the hindlimb
    Guoliang Chai
    Developmental Neurobiology, Institute of Neuroscience, Universite Catholique de Louvain, Brussels, Belgium
    Nat Neurosci 17:1171-9. 2014
    ..The function of Celsr3 is Fzd3 dependent but Vangl2 independent. Our results provide evidence that the Celsr3-Fzd3 pathway interacts with EphA-ephrinA reverse signaling to guide motor axons in the hindlimb. ..
  10. ncbi Expression of planar cell polarity genes during development of the mouse CNS
    Fadel Tissir
    Developmental Neurobiology Unit, University of Louvain Medical School, 73, Av E Mounier, Box DENE7382, B1200 Brussels, Belgium
    Eur J Neurosci 23:597-607. 2006
    ..Like Celsr3, Dvl3 and Prickle2 were expressed more strongly in postmitotic neurons than in precursors. Thus, the analogy between the PCP and Celsr3-Fzd3 genetic networks is limited, but may include Dvl3 and/or Prickle2...
  11. pmc Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance
    Keisuke Onishi
    Neurobiology Section, Biological Sciences Division University of California, San Diego, La Jolla, California 92093 and Université Catholique de Louvain, Institute of Neuroscience, Brussels, B 1348 Belgium
    J Neurosci 33:19071-85. 2013
    ....
  12. ncbi Protocadherin Celsr3 is crucial in axonal tract development
    Fadel Tissir
    Developmental Neurobiology Unit, University of Louvain Medical School, 73, Avenue Mounier, Box DENE7382, B 1200 Brussels, Belgium
    Nat Neurosci 8:451-7. 2005
    ..Celsr3 and Fzd3 are expressed together during brain development and may act in synergy. Thus, a genetic pathway analogous to the one that controls PCP is key in the development of the axonal blueprint...
  13. doi Maturation of "neocortex isole" in vivo in mice
    Libing Zhou
    Institute of Neuroscience, University of Louvain Medical School, B1200 Brussels, Belgium
    J Neurosci 30:7928-39. 2010
    ....
  14. doi Role of the atypical cadherin Celsr3 during development of the internal capsule
    Libing Zhou
    University of Louvain, Brussels, Belgium
    Cereb Cortex 19:i114-9. 2009
    ..Mutant mice with defective corticospinal tracts survive normally and provide a model to evaluate in vivo the role of this tract in motor function in rodents...
  15. ncbi Reelin and brain development
    Fadel Tissir
    Developmental Genetics Unit, Universite Catholique de Louvain, UCL 7382, 73 Avenue E Mounier, B1200 Brussels, Belgium
    Nat Rev Neurosci 4:496-505. 2003
  16. doi Celsr1-3 cadherins in PCP and brain development
    Camille Boutin
    Institute of Neuroscience, Developmental Neurobiology, Universite Catholique de Louvain, Brussels, Belgium
    Curr Top Dev Biol 101:161-83. 2012
    ..Here, we review the literature on Celsr in PCP and neural development, point to several remaining questions, and consider future challenges and possible research trends...
  17. doi Shaping the nervous system: role of the core planar cell polarity genes
    Fadel Tissir
    University of Louvain, Institute of Neuroscience, Developmental Neurobiology Group, Avenue Mounier 73, Box B1 73 16, 1200 Brussels, Belgium
    Nat Rev Neurosci 14:525-35. 2013
    ..In particular, core PCP genes are crucial for the development and function of the nervous system. They are involved in neural tube closure, ependymal polarity, neuronal migration, dendritic growth and axon guidance. ..
  18. doi Cilia: conductors' batons of neuronal maturation
    Fadel Tissir
    Institute of Neuroscience, University of Louvain, Brussels, Belgium
    Nat Neurosci 15:344-5. 2012
    ..The primary cilium, a signal transduction organelle, is present on the cell bodies of adult-born dentate gyrus granule cells as they begin maturation. In its absence, their maturation and integration are impaired...
  19. ncbi The reelin signaling pathway: some recent developments
    Yves Jossin
    Developmental Genetics Unit, UCL GEDE 7382, 73 Avenue E Mounier, B1200 Brussels, Belgium
    Cereb Cortex 13:627-33. 2003
    ..Third, we present preliminary studies by in situ hybridization that demonstrate regulated expression of Reelin receptors and Dab1 by radial precursors in the ventricular zone...
  20. ncbi DeltaNp73 transcription factors modulate cell survival and tumor development
    Aurélia Ravni
    Institute of Neuroscience, University of Louvain, Brussels, Belgium
    Cell Cycle 9:1523-7. 2010
    ..Both effects on neuronal apoptosis and tumor development were milder than predicted from in vitro studies...
  21. pmc Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling
    Wei Wang
    Universite Catholique de Louvain, Institute of Neuroscience, 73 Avenue Mounier, Box B1 7316, 1200 Brussels, Belgium
    Nat Commun 7:10936. 2016
    ..Thus, Celsr3 and Fzd3 enable immature neurons to respond to Wnt7, upregulate Jag1 and thereby facilitate feedback signals that tune the timing of NPC fate decisions via Notch activation. ..
  22. doi Atypical cadherins Celsr1-3 and planar cell polarity in vertebrates
    Fadel Tissir
    Developmental Neurobiology, University of Louvain, Institute of Neuroscience, Box B1 73 16, Brussels, Belgium
    Prog Mol Biol Transl Sci 116:193-214. 2013
    ..Here, we review the literature on Celsr, focusing on PCP and particularly on brain development...
  23. ncbi Expression of the chemokine receptor Cxcr4 mRNA during mouse brain development
    Fadel Tissir
    Developmental Genetics Unit, University of Louvain Medical School, avenue E Mounier, 73 Box DENE 7382, B1200 Brussels, Belgium
    Brain Res Dev Brain Res 149:63-71. 2004
    ..This expression pattern suggests that Sdf1 and its receptor Cxcr4 may exert trophic influences on precursor cell proliferation and some neuronal targets that remain to be identified and studied further...
  24. ncbi Inhibition of SRC family kinases and non-classical protein kinases C induce a reeler-like malformation of cortical plate development
    Yves Jossin
    University of Louvain Medical School, Developmental Genetics Unit, GEDE 7382, B1200 Brussels, Belgium
    J Neurosci 23:9953-9. 2003
    ..Our observations demonstrate a key role for these enzymes in radial migration to the cortical plate, possibly via interference with Reelin signaling...
  25. doi Celsr3 and Fzd3 in axon guidance
    Guoliang Chai
    Institute of Neuroscience, Universite Catholique de Louvain, 73 Avenue Mounier, B1 73 16, Brussels 1200, Belgium
    Int J Biochem Cell Biol 64:11-4. 2015
    ..Here, we review some recent advances and discuss future trends in this emerging field. ..
  26. ncbi p73 and p63: Estranged relatives?
    Fadel Tissir
    University of Louvain, Brussels, Belgium
    Cell Cycle 10:1351. 2011
  27. doi A role for atypical cadherin Celsr3 in hippocampal maturation and connectivity
    Jia Feng
    Joint Laboratory for Brain Function and Health, Jinan University and the University of Hong Kong, Medical School of Jinan University, Guangzhou 510632, People s Republic of China
    J Neurosci 32:13729-43. 2012
    ..Postnatal neurogenesis was preserved and mutant interneurons were able to migrate to the hippocampus. Thus, like in neocortex, Celsr3 is required for hippocampal development, connectivity and function, and for pyramidal cell maturation...