Wendy Balemans

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. doi request reprint The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations
    Wendy Balemans
    Department of Medical Genetics, University and University Hospital of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Calcif Tissue Int 82:445-53. 2008
  2. ncbi request reprint Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling
    Wendy Balemans
    Department of Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium
    J Bone Miner Res 22:708-16. 2007
  3. doi request reprint Common genetic variation in the DKK1 gene is associated with hip axis length but not with bone mineral density and bone turnover markers in young adult men: results from the Odense Androgen Study
    Elke Piters
    Department of Medical Genetics, University of Antwerp and University Hospital, Antwerp, Belgium
    Calcif Tissue Int 86:271-81. 2010
  4. ncbi request reprint A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the SOST gene
    Wendy Balemans
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Bone 36:943-7. 2005
  5. ncbi request reprint The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes
    Wendy Balemans
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Endocrinology 148:2622-9. 2007
  6. ncbi request reprint Exclusion of OGDH and BMP4 as candidate genes in two siblings with autosomal recessive DOOR syndrome
    Yolande van Bever
    Department of Medical Genetics, University Hospital Antwerp, Edegem, Belgium
    Am J Med Genet A 143:763-7. 2007
  7. ncbi request reprint Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators
    Wendy Balemans
    Department of Medical Genetics, University of Antwerp and University Hospital, Antwerp 2610, Belgium
    Dev Biol 250:231-50. 2002
  8. ncbi request reprint Missense mutations in LRP5 are not a common cause of idiopathic osteoporosis in adult men
    Patricia Crabbe
    Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
    J Bone Miner Res 20:1951-9. 2005
  9. ncbi request reprint An autosomal dominant high bone mass phenotype in association with craniosynostosis in an extended family is caused by an LRP5 missense mutation
    Mei Lan Kwee
    Department of Clinical Genetics and Human Genetics, VU University Medical Center, Amsterdam, The Netherlands
    J Bone Miner Res 20:1254-60. 2005
  10. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008

Collaborators

Detail Information

Publications12

  1. doi request reprint The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations
    Wendy Balemans
    Department of Medical Genetics, University and University Hospital of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Calcif Tissue Int 82:445-53. 2008
    ..In conclusion, our results indicate that DKK1 and sclerostin are independent, and not synergistic, regulators of LRP5 signaling and that the function of each is impaired by HBM-LRP5 mutations...
  2. ncbi request reprint Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling
    Wendy Balemans
    Department of Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium
    J Bone Miner Res 22:708-16. 2007
    ..In vitro studies suggest that a reduced antagonistic effect of DKK1 on canonical Wnt signaling contributes to the molecular effect of this mutation and its pathogenic consequence...
  3. doi request reprint Common genetic variation in the DKK1 gene is associated with hip axis length but not with bone mineral density and bone turnover markers in young adult men: results from the Odense Androgen Study
    Elke Piters
    Department of Medical Genetics, University of Antwerp and University Hospital, Antwerp, Belgium
    Calcif Tissue Int 86:271-81. 2010
    ..This finding could be of interest but needs replication in independent populations...
  4. ncbi request reprint A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the SOST gene
    Wendy Balemans
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Bone 36:943-7. 2005
    ..This resulted in the identification of a novel putative disease-causing splice site mutation (IVS1 + 1 G-->C) homozygously present in both siblings...
  5. ncbi request reprint The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes
    Wendy Balemans
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Endocrinology 148:2622-9. 2007
    ..This review focuses on the genetics of LRP5 and summarizes the findings on monogenic bone conditions as well as the current knowledge of its involvement in the pathogenesis of osteoporosis...
  6. ncbi request reprint Exclusion of OGDH and BMP4 as candidate genes in two siblings with autosomal recessive DOOR syndrome
    Yolande van Bever
    Department of Medical Genetics, University Hospital Antwerp, Edegem, Belgium
    Am J Med Genet A 143:763-7. 2007
  7. ncbi request reprint Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators
    Wendy Balemans
    Department of Medical Genetics, University of Antwerp and University Hospital, Antwerp 2610, Belgium
    Dev Biol 250:231-50. 2002
    ..Here, we review the insights in the extracellular regulation of members of the BMP subfamily of secreted growth factors with a major emphasis on vertebrate BMP modulation...
  8. ncbi request reprint Missense mutations in LRP5 are not a common cause of idiopathic osteoporosis in adult men
    Patricia Crabbe
    Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
    J Bone Miner Res 20:1951-9. 2005
    ..We studied whether the LRP5 gene contributes to the clinical phenotype of IO in men. Mutation analysis in 66 IO men revealed a range of sequence variants, of which two missense variants were shown to be of functional relevance...
  9. ncbi request reprint An autosomal dominant high bone mass phenotype in association with craniosynostosis in an extended family is caused by an LRP5 missense mutation
    Mei Lan Kwee
    Department of Clinical Genetics and Human Genetics, VU University Medical Center, Amsterdam, The Netherlands
    J Bone Miner Res 20:1254-60. 2005
    ..These phenotypes can therefore be added to the clinical spectrum of LRP5-associated bone disorders...
  10. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    ..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population...
  11. ncbi request reprint Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal
    Jon E Wergedal
    Musculoskeletal Disease Center, J L Pettis Memorial Veterans Affairs Medical Center and Loma Linda University, Loma Linda, California 92357, USA
    J Clin Endocrinol Metab 88:5778-83. 2003
    ..None of these changes was found in Van Buchem carriers. These observations indicate that decreased expression of the SOST gene can lead to increased bone formation and to stronger bones...
  12. doi request reprint Genetic analysis and effect of triiodothyronine and prednisone trial on bone turnover in a patient with craniotubular hyperostosis
    José M López
    Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Bone 43:405-9. 2008
    ..This study provides additional data about the high bone turnover described in craniotubular hyperostosis, and also suggests an abnormal response to T3 excess in this condition...