Natasja Bruin

Summary

Affiliation: Fraunhofer IME-TMP
Location: Frankfurt am Main, Duitsland
URL: http://www.linkedin.com/in/natasjadebruin/

Publications

  1. doi request reprint SLV330, a cannabinoid CB(1) receptor antagonist, attenuates ethanol and nicotine seeking and improves inhibitory response control in rats
    N M W J De Bruin
    Abbott Healthcare Products BV, C J van Houtenlaan 36, 1381 CP Weesp, The Netherlands
    Behav Brain Res 217:408-15. 2011
  2. ncbi request reprint Beneficial effects of galantamine on performance in the object recognition task in Swiss mice: deficits induced by scopolamine and by prolonging the retention interval
    Natasja de Bruin
    Johnson and Johnson Pharmaceutical Research and Development J and J PRD CNS Discovery Research Turnhoutseweg 30, B 2340 Beerse, Belgium
    Pharmacol Biochem Behav 85:253-60. 2006
  3. doi request reprint Effects of risperidone, clozapine and the 5-HT6 antagonist GSK-742457 on PCP-induced deficits in reversal learning in the two-lever operant task in male Sprague Dawley rats
    N M W J De Bruin
    Abbott Healthcare Products BV Formerly Solvay Pharmaceuticals BV, C J van Houtenlaan 36, 1381 CP Weesp, The Netherlands
    Behav Brain Res 244:15-28. 2013
  4. doi request reprint The 5-HT₆ serotonin receptor antagonist SB-271046 attenuates the development and expression of nicotine-induced locomotor sensitisation in Wistar rats
    N M W J De Bruin
    Abbott Healthcare Products BV, C J van Houtenlaan 36, 1381 CP Weesp, The Netherlands
    Neuropharmacology 61:451-7. 2011
  5. ncbi request reprint Dopamine characteristics in different rat genotypes: the relation to absence epilepsy
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Neurosci Res 38:165-73. 2000
  6. ncbi request reprint Hippocampal and cortical sensory gating in rats: effects of quinpirole microinjections in nucleus accumbens core and shell
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Neuroscience 105:169-80. 2001
  7. ncbi request reprint Dopamine characteristics in rat genotypes with distinct susceptibility to epileptic activity: apomorphine-induced stereotyped gnawing and novelty/amphetamine-induced locomotor stimulation
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands
    Behav Pharmacol 12:517-25. 2001
  8. ncbi request reprint The effects of early maternal deprivation on auditory information processing in adult Wistar rats
    Bart A Ellenbroek
    Department of Psychoneuropharmacology, Nijmegen Institute for Cognition and Information, Nijmegen, The Netherlands
    Biol Psychiatry 55:701-7. 2004
  9. doi request reprint Effects of amisulpride and aripiprazole on progressive-ratio schedule performance: comparison with clozapine and haloperidol
    F S den Boon
    Psychopharmacology Section, Division of Psychiatry, University of Nottingham, Nottingham, UK
    J Psychopharmacol 26:1231-43. 2012
  10. doi request reprint Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors
    Jos H M Lange
    Abbott Healthcare Products B V, Chemical Design and Synthesis Unit, C J van Houtenlaan 36, 1381 CP Weesp, The Netherlands
    Eur J Med Chem 46:4808-19. 2011

Detail Information

Publications24

  1. doi request reprint SLV330, a cannabinoid CB(1) receptor antagonist, attenuates ethanol and nicotine seeking and improves inhibitory response control in rats
    N M W J De Bruin
    Abbott Healthcare Products BV, C J van Houtenlaan 36, 1381 CP Weesp, The Netherlands
    Behav Brain Res 217:408-15. 2011
    ..The combined action of reducing the reinforcing and motivational properties of nicotine and alcohol and the improvement of impulse control supports the idea that the cannabinoid system is a promising target for anti-relapse medication...
  2. ncbi request reprint Beneficial effects of galantamine on performance in the object recognition task in Swiss mice: deficits induced by scopolamine and by prolonging the retention interval
    Natasja de Bruin
    Johnson and Johnson Pharmaceutical Research and Development J and J PRD CNS Discovery Research Turnhoutseweg 30, B 2340 Beerse, Belgium
    Pharmacol Biochem Behav 85:253-60. 2006
    ..In conclusion, galantamine was shown to possess memory-enhancing effects in two conditions that reduced object discrimination: scopolamine-induced deficits and when a longer retention interval was used...
  3. doi request reprint Effects of risperidone, clozapine and the 5-HT6 antagonist GSK-742457 on PCP-induced deficits in reversal learning in the two-lever operant task in male Sprague Dawley rats
    N M W J De Bruin
    Abbott Healthcare Products BV Formerly Solvay Pharmaceuticals BV, C J van Houtenlaan 36, 1381 CP Weesp, The Netherlands
    Behav Brain Res 244:15-28. 2013
    ..The lowest dose of GSK-742457 (0.63 mg/kg) fully reversed the PCP-induced deficits while the higher dose (5.0 mg/kg) had an intermediate effect...
  4. doi request reprint The 5-HT₆ serotonin receptor antagonist SB-271046 attenuates the development and expression of nicotine-induced locomotor sensitisation in Wistar rats
    N M W J De Bruin
    Abbott Healthcare Products BV, C J van Houtenlaan 36, 1381 CP Weesp, The Netherlands
    Neuropharmacology 61:451-7. 2011
    ..Further studies are warranted to substantiate this conclusion and further understand the role of 5-HT(6) receptors in addiction...
  5. ncbi request reprint Dopamine characteristics in different rat genotypes: the relation to absence epilepsy
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Neurosci Res 38:165-73. 2000
    ..Finally, further research is required to provide evidence in favor of the hypothesis that the relative dominance of the dopaminergic mesolimbic system is smaller in WAG/Rij than in APO-SUS...
  6. ncbi request reprint Hippocampal and cortical sensory gating in rats: effects of quinpirole microinjections in nucleus accumbens core and shell
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Neuroscience 105:169-80. 2001
    ..This casts doubt on whether dopamine receptor activation affects the putative inhibitory process between the first and the second stimulus...
  7. ncbi request reprint Dopamine characteristics in rat genotypes with distinct susceptibility to epileptic activity: apomorphine-induced stereotyped gnawing and novelty/amphetamine-induced locomotor stimulation
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands
    Behav Pharmacol 12:517-25. 2001
    ..It is suggested that the functional dopaminergic mesolimbic dominance is an important factor in the susceptibility to show spontaneously occurring spike-wave discharges...
  8. ncbi request reprint The effects of early maternal deprivation on auditory information processing in adult Wistar rats
    Bart A Ellenbroek
    Department of Psychoneuropharmacology, Nijmegen Institute for Cognition and Information, Nijmegen, The Netherlands
    Biol Psychiatry 55:701-7. 2004
    ..The present set of experiments was designed to further characterize the information processing deficits of maternally deprived Wistar rats...
  9. doi request reprint Effects of amisulpride and aripiprazole on progressive-ratio schedule performance: comparison with clozapine and haloperidol
    F S den Boon
    Psychopharmacology Section, Division of Psychiatry, University of Nottingham, Nottingham, UK
    J Psychopharmacol 26:1231-43. 2012
    ..Amisulpride produced a short-lived enhancement, followed by a long-lasting reduction, of reinforcer value. Both drugs impaired motor performance...
  10. doi request reprint Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors
    Jos H M Lange
    Abbott Healthcare Products B V, Chemical Design and Synthesis Unit, C J van Houtenlaan 36, 1381 CP Weesp, The Netherlands
    Eur J Med Chem 46:4808-19. 2011
    ..The presented holistic approach is anticipated to facilitate the identification of compounds with best-in-class properties at an early research stage...
  11. doi request reprint N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT₆R) antagonists with unique structural features
    Arnold van Loevezijn
    Abbott Healthcare Products B V formerly Solvay Pharmaceuticals B V, C J van Houtenlaan 36, 1381 CP Weesp, The Netherlands
    J Med Chem 54:7030-54. 2011
    ..The optimized structure 42 is an extremely selective, hERG-free, high-affinity 5-HT(6)R antagonist showing good human in vitro metabolic stability. Rat pharmacokinetic data were sufficiently good to enable further in vivo profiling...
  12. ncbi request reprint Neural correlates of sensory gating in the rat: decreased Fos induction in the lateral septum
    G van Luijtelaar
    NICI, Department of Psychology, University of Nijmegen, Nijmegen, The Netherlands
    Brain Res Bull 54:145-51. 2001
    ..The results might be relevant for theories on sensory gating deficits in schizophrenia...
  13. ncbi request reprint Performance of F2 B6x129 hybrid mice in the Morris water maze, latent inhibition and prepulse inhibition paradigms: Comparison with C57Bl/6J and 129sv inbred mice
    Natasja de Bruin
    Johnson and Johnson, Pharmaceutical Research and Development J and J PRD, CNS Discovery Research, Beerse, Belgium
    Behav Brain Res 172:122-34. 2006
    ..Following the setup of these procedures in mice, we are now able to compare the effects of gene knockout/mutations used for target validation with results in the present study as a frame of reference...
  14. ncbi request reprint Combined uridine and choline administration improves cognitive deficits in spontaneously hypertensive rats
    N M W J De Bruin
    Numico Research B V, Department of Condition and Disease Specific Research Neuroendocrinology section, Bosrandweg 20, 6704 PH Wageningen, PO Box 7005, 6700 CA Wageningen, The Netherlands
    Neurobiol Learn Mem 80:63-79. 2003
    ..A combination of uridine and choline administration improved selective attention and spatial learning in SHR...
  15. doi request reprint A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats
    N M W J De Bruin
    Abbott Healthcare Products BV, Formerly Solvay Pharmaceuticals BV, CJ van Houtenlaan 36, 1381 CP Weesp, The Netherlands
    Behav Brain Res 236:157-65. 2013
    ..Specifically, we demonstrated for the first time effects on nicotine self-administration and on nicotine and ethanol reinstatement. Further, these effects are probably not mediated by effects on impulse control...
  16. doi request reprint Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats
    N M W J De Bruin
    Abbott Healthcare Products BV, C J van Houtenlaan 36, 1381 CP Weesp, The Netherlands
    Neurobiol Learn Mem 96:392-402. 2011
    ..This suggests that these compounds could have potential as monotherapy, but also as adjunctive therapy in patients with AD treated with common treatments such as donepezil...
  17. ncbi request reprint Sensory gating of auditory evoked potentials in rats: effects of repetitive stimulation and the interstimulus interval
    N M de Bruin
    NICI Department of Psychoneuropharmacology, University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Biol Psychol 55:195-213. 2001
    ..The ISI effects on gating are due to an increase of the amplitude to S2. The results have implications for the discussion about the rat homologue of the human P50...
  18. ncbi request reprint Attentional performance of (C57BL/6Jx129Sv)F2 mice in the five-choice serial reaction time task
    N M W J De Bruin
    Johnson and Johnson Pharmaceutical Research and Development J and J PRD, CNS Discovery Research, Belgium
    Physiol Behav 89:692-703. 2006
    ..This offers the opportunity to test transgenic and knockout mice with similar background as the B6129F2 as animal models of psychiatric and neurological diseases...
  19. ncbi request reprint Auditory information processing in rat genotypes with different dopaminergic properties
    N M de Bruin
    Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands
    Psychopharmacology (Berl) 156:352-9. 2001
    ..These effects have been linked to DA hyperactivity in the mesolimbic system. A non-invasive approach in studying the role of the DA system in PPI and AEP gating is to compare rat genotypes that are marked by distinct DA systems...
  20. ncbi request reprint Differential effects of ketamine on gating of auditory evoked potentials and prepulse inhibition in rats
    N M de Bruin
    NICI Department of Comparative and Physiological Psychology, University of Nijmegen, The Netherlands
    Psychopharmacology (Berl) 142:9-17. 1999
    ..Secondly, PPI and the C-T paradigm reflect distinct inhibitory sensory processes, since both paradigms are differentially influenced by ketamine...
  21. doi request reprint The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment
    N M W J De Bruin
    Abbott Healthcare Products BV formerly Solvay Pharmaceuticals, C J van Houtenlaan 36, 1381 CP Weesp, The Netherlands Electronic address
    Neurobiol Learn Mem 133:100-17. 2016
    ..In conclusion, SLV was investigated in several rodent animal models and found to be effective at a least effective dose (LED) of 20mg/kg and 10mg/kg (p.o.) in the rat and the mouse, respectively. ..
  22. doi request reprint Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis
    N M W J De Bruin
    Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Theodor Stern Kai 7, 60596 Frankfurt am Main, Germany Electronic address
    Behav Brain Res 300:160-74. 2016
    ..These data indicate that improvements in behavioral deficits can occur in absence of clinical scores, which indicate subtle drug effects and may have translational value for human MS...