Yanning Cai

Summary

Publications

  1. pmc Calpastatin gene (CAST) is not associated with late onset sporadic Parkinson's disease in the Han Chinese population
    Lan Zhang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing, P R China
    PLoS ONE 8:e70935. 2013
  2. doi request reprint PITX3 polymorphism is not associated with Parkinson's disease in a Chinese population
    Yanning Cai
    Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, PR China
    Neurosci Lett 505:260-2. 2011
  3. doi request reprint Allele-specific extension allows base-pair neutral homozygotes to be discriminated by high-resolution melting of small amplicons
    Yanning Cai
    Department of Neurology and Neurobiology, Ministry of Education, Xuan Wu Hospital, Capital Medical University, Beijing, People s Republic of China
    Anal Biochem 406:29-33. 2010
  4. doi request reprint Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population
    Yanning Cai
    Department of Neurology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, PR China
    Neurosci Lett 498:124-6. 2011
  5. doi request reprint Oscillation development for neurotransmitter-related genes in the mouse striatum
    Yanning Cai
    Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, PR China
    Neuroreport 21:79-83. 2010
  6. doi request reprint Suprachiasmatic nucleus slices induce molecular oscillations in fibroblasts
    Ning Li
    Cell Therapy Center, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, 45 Changchun Street, Beijing, PR China
    Biochem Biophys Res Commun 377:1179-84. 2008
  7. doi request reprint Postnatal ontogenesis of molecular clock in mouse striatum
    Yanning Cai
    Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, 45 Changchun Street, Beijing 100053, PR China
    Brain Res 1264:33-8. 2009
  8. doi request reprint Clinical profiles of Parkinson's disease associated with common leucine-rich repeat kinase 2 and glucocerebrosidase genetic variants in Chinese individuals
    Chaodong Wang
    Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China Key Laboratory on Neurodegenerative Disease of Ministry of Education and Key Laboratory on Parkinson s Disease of Beijing, Beijing, China Department of Neurology, The Affiliated Sanming First Hospital of Fujian Medical University, Sanming, Fujian, China
    Neurobiol Aging 35:725.e1-6. 2014
  9. doi request reprint Decreased expression of Bmal2 in patients with Parkinson's disease
    Hui Ding
    Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China
    Neurosci Lett 499:186-8. 2011
  10. doi request reprint Promoter methylation analysis of seven clock genes in Parkinson's disease
    Qingling Lin
    Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, PR China
    Neurosci Lett 507:147-50. 2012

Collaborators

Detail Information

Publications16

  1. pmc Calpastatin gene (CAST) is not associated with late onset sporadic Parkinson's disease in the Han Chinese population
    Lan Zhang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing, P R China
    PLoS ONE 8:e70935. 2013
    ..Similarly, none of the common haplotypes was associated with a risk for PD. Our data do not support a significant association between the CAST gene polymorphisms and late onset sporadic PD in the Han Chinese population. ..
  2. doi request reprint PITX3 polymorphism is not associated with Parkinson's disease in a Chinese population
    Yanning Cai
    Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, PR China
    Neurosci Lett 505:260-2. 2011
    ..Our results suggest that these PITX3 SNPs do not contribute to the risk of developing PD in EOPD or LOPD in Chinese...
  3. doi request reprint Allele-specific extension allows base-pair neutral homozygotes to be discriminated by high-resolution melting of small amplicons
    Yanning Cai
    Department of Neurology and Neurobiology, Ministry of Education, Xuan Wu Hospital, Capital Medical University, Beijing, People s Republic of China
    Anal Biochem 406:29-33. 2010
    ..In conclusion, ASE-HRM is a simple, inexpensive, closed-tube genotyping method that can be used to examine all types of SNP...
  4. doi request reprint Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population
    Yanning Cai
    Department of Neurology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, PR China
    Neurosci Lett 498:124-6. 2011
    ....
  5. doi request reprint Oscillation development for neurotransmitter-related genes in the mouse striatum
    Yanning Cai
    Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, PR China
    Neuroreport 21:79-83. 2010
    ..In conclusion, circadian expression of these neurotransmitter-related genes develops in the mouse striatum after birth gradually...
  6. doi request reprint Suprachiasmatic nucleus slices induce molecular oscillations in fibroblasts
    Ning Li
    Cell Therapy Center, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, 45 Changchun Street, Beijing, PR China
    Biochem Biophys Res Commun 377:1179-84. 2008
    ..Results demonstrated that diffusible signals released from SCN slices could regulate molecular rhythms in cultured fibroblasts. Moreover, Rev-Erb alpha oscillation was more robust and appeared earlier than Per1...
  7. doi request reprint Postnatal ontogenesis of molecular clock in mouse striatum
    Yanning Cai
    Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, 45 Changchun Street, Beijing 100053, PR China
    Brain Res 1264:33-8. 2009
    ..For Cry1, however, the abundance at P3 and P60 were similar while that at P14 was much lower. In conclusion, the striatal molecular clock machinery, although works efficiently in adult, develops gradually after birth in mice...
  8. doi request reprint Clinical profiles of Parkinson's disease associated with common leucine-rich repeat kinase 2 and glucocerebrosidase genetic variants in Chinese individuals
    Chaodong Wang
    Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China Key Laboratory on Neurodegenerative Disease of Ministry of Education and Key Laboratory on Parkinson s Disease of Beijing, Beijing, China Department of Neurology, The Affiliated Sanming First Hospital of Fujian Medical University, Sanming, Fujian, China
    Neurobiol Aging 35:725.e1-6. 2014
    ..These findings strengthen our understanding of the clinical heterogeneity of PD, and may have implications for molecular classification of the disease...
  9. doi request reprint Decreased expression of Bmal2 in patients with Parkinson's disease
    Hui Ding
    Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China
    Neurosci Lett 499:186-8. 2011
    ..The expression of Bmal2 is significantly lower in PD at 21:00 h (p=0.005) and 00:00 h (p=0.025). These results together with our previous findings suggest that the molecular clock in total leukocytes is disturbed in PD patients...
  10. doi request reprint Promoter methylation analysis of seven clock genes in Parkinson's disease
    Qingling Lin
    Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, PR China
    Neurosci Lett 507:147-50. 2012
    ..Interestingly, the methylation frequency of the NPAS2 promoter was significantly decreased in PD patients. These results suggest that altered promoter methylation may contribute to the abnormal expression of clock genes in PD...
  11. ncbi request reprint Penetrance of LRRK2 G2385R and R1628P is modified by common PD-associated genetic variants
    Chaodong Wang
    Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45Changchun Street, Beijing, China
    Parkinsonism Relat Disord 18:958-63. 2012
    ..However, testing interactions among multiple genes by genetic association studies is still challenging. Future studies with much larger sample sizes are needed to confirm our findings...
  12. doi request reprint Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients
    Yang Song
    Department of Neurology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China
    Neurosci Lett 569:85-8. 2014
    ..We compared DNA methylation levels at these sites in leukocytes from 50 PD patients and 50 healthy controls. Our results indicated that there were no significant differences in DNA methylation between PD patients and controls. ..
  13. doi request reprint 2,2,2-Trichloroethanol lengthens the circadian period of Bmal1-driven circadian bioluminescence rhythms in U2OS cells
    Jie Gao
    Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Parkinson s Disease Center of Beijing Institute for Brain Disorders, Beijing 100053, PR China
    Biochem Biophys Res Commun 462:239-44. 2015
    ..In summary, our study reveals a direct regulation of TCOH on molecular clock. ..
  14. doi request reprint Ischemia, immunosuppression, and SSEA-1-negative cells all contribute to tumors resulting from mouse embryonic stem cell-derived neural progenitor transplantation
    Yunqian Guan
    Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, People s Republic of China Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, People s Republic of China
    J Neurosci Res 92:74-85. 2014
    ..Second, transplanted NPCs that led to 100% tumors in nude mice contained approximately 1.5 × 10(3) Oct-4-positive cells; however, even 5 × 10(5) undifferentiated ES cells formed neoplasm only in 40% nude mice...
  15. pmc Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation
    Ruiping Zhang
    Beijing Institute of Geriatrics and Department of Neurobiology and Neurology, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, China
    Evid Based Complement Alternat Med 2011:156810. 2011
    ..In conclusion, our results support that GL may be a promising agent for the treatment of PD through anti-inflammation...
  16. ncbi request reprint Chronobiological analysis of circadian patterns in transcription of seven key clock genes in six peripheral tissues in mice
    Shu Liu
    Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, P R China
    Chronobiol Int 24:793-820. 2007
    ..e., testis and thymus), as denoted by the presence of ultradian patterns resulting in two or more peaks within 24 h...