Julio S G Montaner

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. ncbi request reprint Management of HIV-infected Patients with Multidrug-resistant Virus
    Julio S G Montaner
    University of British Columbia St Paul s Hospital, 667 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Curr Infect Dis Rep 4:259-265. 2002
  2. ncbi request reprint Randomized, controlled study of the effects of a short course of prednisone on the incidence of rash associated with nevirapine in patients infected with HIV-1
    Julio S G Montaner
    St Paul s Hospital University of British Columbia, Vancouver, British Columbia, Canada
    J Acquir Immune Defic Syndr 33:41-6. 2003
  3. ncbi request reprint Nucleoside-related mitochondrial toxicity among HIV-infected patients receiving antiretroviral therapy: insights from the evaluation of venous lactic acid and peripheral blood mitochondrial DNA
    Julio S G Montaner
    BC Centre for Excellence in HIV AIDS and the Canadian HIV Trials Network, St Paul s Hospital, Providence Health Care, University of British Columbia, Vancouver, Canada
    Clin Infect Dis 38:S73-9. 2004
  4. ncbi request reprint Mitochondrial toxicity in the era of HAART: evaluating venous lactate and peripheral blood mitochondrial DNA in HIV-infected patients taking antiretroviral therapy
    Julio S G Montaner
    British Columbia Centrefor Excellence in HIV AIDS and the Canadian HIV Trials Network, St Paul s Hospital, Providence Health Care, University of British Columbia, Vancouver, Canada
    J Acquir Immune Defic Syndr 34:S85-90. 2003
  5. pmc Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART
    Robert S Hogg
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    PLoS Med 3:e356. 2006
  6. ncbi request reprint Total lymphocyte count as a possible surrogate of CD4 cell count to prioritize eligibility for antiretroviral therapy among HIV-infected individuals in resource-limited settings
    Richard Bedell
    Centre for Excellence in HIV AIDS, University of British Columbia, Vancouver, British Columbia, Canada
    Antivir Ther 8:379-84. 2003
  7. ncbi request reprint Prevalence and clinical implications of insertions in the HIV-1 p6Gag N-terminal region in drug-naive individuals initiating antiretroviral therapy
    Zabrina L Brumme
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    Antivir Ther 8:91-6. 2003
  8. ncbi request reprint Antiretroviral resistance among HIV-infected persons who have died in British Columbia, in the era of modern antiretroviral therapy
    Magdalena A Recsky
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Infect Dis 190:285-92. 2004
  9. ncbi request reprint Antiretroviral adherence and HIV treatment outcomes among HIV/HCV co-infected injection drug users: the role of methadone maintenance therapy
    Anita Palepu
    Centre for Health Evaluation and Outcome Sciences, St Paul s Hospital, University of British Columbia, BC, Canada
    Drug Alcohol Depend 84:188-94. 2006
  10. ncbi request reprint Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy
    P Richard Harrigan
    British Columbia Centre for Excellence in HIV AIDS, and Department of Medicine, University of British Columbia, Vancouver, Canada
    J Infect Dis 191:339-47. 2005

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Management of HIV-infected Patients with Multidrug-resistant Virus
    Julio S G Montaner
    University of British Columbia St Paul s Hospital, 667 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Curr Infect Dis Rep 4:259-265. 2002
    ..The potential roles of newer agents, adjuvants, treatment interruptions, and immune-based therapies remain under investigation...
  2. ncbi request reprint Randomized, controlled study of the effects of a short course of prednisone on the incidence of rash associated with nevirapine in patients infected with HIV-1
    Julio S G Montaner
    St Paul s Hospital University of British Columbia, Vancouver, British Columbia, Canada
    J Acquir Immune Defic Syndr 33:41-6. 2003
    ..To examine the effect of 2 weeks of treatment with prednisone on the incidence of nevirapine-associated rash in HIV-1-infected patients receiving combination antiretroviral therapy...
  3. ncbi request reprint Nucleoside-related mitochondrial toxicity among HIV-infected patients receiving antiretroviral therapy: insights from the evaluation of venous lactic acid and peripheral blood mitochondrial DNA
    Julio S G Montaner
    BC Centre for Excellence in HIV AIDS and the Canadian HIV Trials Network, St Paul s Hospital, Providence Health Care, University of British Columbia, Vancouver, Canada
    Clin Infect Dis 38:S73-9. 2004
    ..A statistically significant increase in the mtDNA : nDNA ratio was observed after the discontinuation of antiretroviral therapy. Full validation of monitoring the mtDNA : nDNA ratio is currently under way...
  4. ncbi request reprint Mitochondrial toxicity in the era of HAART: evaluating venous lactate and peripheral blood mitochondrial DNA in HIV-infected patients taking antiretroviral therapy
    Julio S G Montaner
    British Columbia Centrefor Excellence in HIV AIDS and the Canadian HIV Trials Network, St Paul s Hospital, Providence Health Care, University of British Columbia, Vancouver, Canada
    J Acquir Immune Defic Syndr 34:S85-90. 2003
    ..These results suggest that measurement of this parameter should be investigated as a potential clinical management tool...
  5. pmc Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART
    Robert S Hogg
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    PLoS Med 3:e356. 2006
    ..The objective of this study was to determine the impact of the emergence of drug-resistance mutations on survival among persons initiating HAART...
  6. ncbi request reprint Total lymphocyte count as a possible surrogate of CD4 cell count to prioritize eligibility for antiretroviral therapy among HIV-infected individuals in resource-limited settings
    Richard Bedell
    Centre for Excellence in HIV AIDS, University of British Columbia, Vancouver, British Columbia, Canada
    Antivir Ther 8:379-84. 2003
    ..To characterize the value of total lymphocyte counts in predicting risk of death among patients initiating triple combination antiretroviral therapy...
  7. ncbi request reprint Prevalence and clinical implications of insertions in the HIV-1 p6Gag N-terminal region in drug-naive individuals initiating antiretroviral therapy
    Zabrina L Brumme
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    Antivir Ther 8:91-6. 2003
    ..1). The data suggest that HIV p6Gag insertions are not exclusively related to drug resistance and may not influence response to antiretroviral therapy, but may be linked to sequence variations in the HIV envelope...
  8. ncbi request reprint Antiretroviral resistance among HIV-infected persons who have died in British Columbia, in the era of modern antiretroviral therapy
    Magdalena A Recsky
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Infect Dis 190:285-92. 2004
    ....
  9. ncbi request reprint Antiretroviral adherence and HIV treatment outcomes among HIV/HCV co-infected injection drug users: the role of methadone maintenance therapy
    Anita Palepu
    Centre for Health Evaluation and Outcome Sciences, St Paul s Hospital, University of British Columbia, BC, Canada
    Drug Alcohol Depend 84:188-94. 2006
    ..We examined the association of methadone maintenance therapy (MMT) with highly active antiretroviral therapy (HAART) adherence and HIV treatment outcomes among a cohort of HIV/HCV co-infected injection drug users (IDUs)...
  10. ncbi request reprint Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy
    P Richard Harrigan
    British Columbia Centre for Excellence in HIV AIDS, and Department of Medicine, University of British Columbia, Vancouver, Canada
    J Infect Dis 191:339-47. 2005
    ....
  11. ncbi request reprint Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy
    Viviane D Lima
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    AIDS 21:685-92. 2007
    ..To characterize the temporal changes in mortality and life expectancy among HIV-positive individuals initiating antiretroviral therapy in British Columbia, Canada, from 1993 to 2004...
  12. ncbi request reprint Effects of human leukocyte antigen class I genetic parameters on clinical outcomes and survival after initiation of highly active antiretroviral therapy
    Zabrina L Brumme
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
    J Infect Dis 195:1694-704. 2007
    ....
  13. doi request reprint Expanded access to highly active antiretroviral therapy: a potentially powerful strategy to curb the growth of the HIV epidemic
    Viviane D Lima
    British Columbia Centre for Excellence in HIV AIDS, British Columbia, Canada
    J Infect Dis 198:59-67. 2008
    ..These results provide powerful additional motivation to accelerate the roll out of HAART programs aggressively targeting those in medical need, both for their own benefit and as a means of decreasing new HIV infections...
  14. ncbi request reprint Characteristics of injection drug users who participate in drug dealing: implications for drug policy
    Thomas Kerr
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, Canada
    J Psychoactive Drugs 40:147-52. 2008
    ..These findings suggest that elements of "balanced" drug policies may undermine each other and indicate the need for alternative interventions...
  15. ncbi request reprint Clinical and immunological impact of HIV envelope V3 sequence variation after starting initial triple antiretroviral therapy
    Zabrina L Brumme
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, The Faculty of Medicine, University of British Columbia, 603 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    AIDS 18:F1-9. 2004
    ..We wished to determine the impact of specific V3 genotypes associated with viral phenotype and co-receptor usage on response to initial triple antiretroviral therapy...
  16. pmc Structural factors associated with an increased risk of HIV and sexually transmitted infection transmission among street-involved youth
    Brandon D L Marshall
    British Columbia Centre for Excellence in HIV AIDS, St, Paul s Hospital, 608 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    BMC Public Health 9:7. 2009
    ....
  17. pmc Improved virological outcomes in British Columbia concomitant with decreasing incidence of HIV type 1 drug resistance detection
    Vikram S Gill
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    Clin Infect Dis 50:98-105. 2010
    ....
  18. pmc Burden of HIV infection among aboriginal injection drug users in Vancouver, British Columbia
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, 608 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
    Am J Public Health 98:515-9. 2008
    ..We sought to examine whether there were differential rates of HIV incidence among Aboriginal and non-Aboriginal injection drug users in a Canadian setting...
  19. ncbi request reprint The impact of adherence on CD4 cell count responses among HIV-infected patients
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, BC, Canada
    J Acquir Immune Defic Syndr 35:261-8. 2004
    ....
  20. ncbi request reprint Higher baseline levels of plasma human immunodeficiency virus type 1 RNA are associated with increased mortality after initiation of triple-drug antiretroviral therapy
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, and Department of Health Care and Epidemiology, University of British Columbia, Vancouver, Canada
    J Infect Dis 188:1421-5. 2003
    ..71; 95% confidence interval, 1.08-2.70; P=.023). If appropriately confirmed, these findings have important implications for the development of therapeutic guidelines...
  21. doi request reprint Tenofovir-based rescue therapy for advanced liver disease in 6 patients coinfected with HIV and hepatitis B virus and receiving lamivudine
    Sonia Gutierrez
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Clin Infect Dis 46:e28-30. 2008
    ..We provide supporting evidence for the role of tenofovir in the management of advanced HBV infection in HIV-positive patients after the development of lamivudine resistance...
  22. doi request reprint CD4-dependent characteristics of coreceptor use and HIV type 1 V3 sequence in a large population of therapy-naive individuals
    Andrew J Low
    B C Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    AIDS Res Hum Retroviruses 24:219-28. 2008
    ..The ability to predict X4 virus using genotypic determinants at positions 25 and 6-8 of the V3 loop is CD4 dependent, while position 11 appears to be CD4 independent...
  23. pmc Alcohol use and incarceration adversely affect HIV-1 RNA suppression among injection drug users starting antiretroviral therapy
    Anita Palepu
    All the authors are with the University of British Columbia, British Columbia, Canada
    J Urban Health 80:667-75. 2003
    ..As well, increased outreach to HIV-infected drug users recently released from prison to ensure continuity of care needs to be further developed...
  24. ncbi request reprint Sociodemographic disparities in access to addiction treatment among a cohort of Vancouver injection drug users
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, 608 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Subst Use Misuse 40:1153-67. 2005
    ..These findings demonstrate low levels of addiction treatment among Vancouver IDUs and suggest that programs may need to be targeted towards specific populations with poor access...
  25. ncbi request reprint Prevalence and correlates of untreated human immunodeficiency virus type 1 infection among persons who have died in the era of modern antiretroviral therapy
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Infect Dis 188:1164-70. 2003
    ..5%) received antiretroviral medication >or=75% of the time during their first year receiving therapy. The data demonstrate the need for novel interventions to expand HIV care to specific populations...
  26. pmc Longitudinal community plasma HIV-1 RNA concentrations and incidence of HIV-1 among injecting drug users: prospective cohort study
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, Canada
    BMJ 338:b1649. 2009
    ..To examine the relation between plasma HIV-1 RNA concentrations in the community and HIV incidence among injecting drug users...
  27. pmc Incidence and determinants of initiation into cocaine injection and correlates of frequent cocaine injectors
    Elisa Lloyd-Smith
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital 608 1081, Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Drug Alcohol Depend 99:176-82. 2009
    ..To investigate the incidence and correlates of cocaine injection initiation and the impacts of daily cocaine injection among a cohort of injection drug users...
  28. ncbi request reprint Impact of baseline viral load and adherence on survival of HIV-infected adults with baseline CD4 cell counts > or = 200 cells/microl
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, 667 1081 Burrard Street, Vancouver, BC, Canada
    AIDS 20:1117-23. 2006
    ..There is uncertainty regarding the optimal strategy for patients with high plasma HIV RNA but CD4 cell count > or = 200 cells/microl...
  29. ncbi request reprint Gender differences in HIV-1 RNA rebound attributed to incomplete antiretroviral adherence among HIV-Infected patients in a population-based cohort
    Laura M Kuyper
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Acquir Immune Defic Syndr 37:1470-6. 2004
    ..We therefore examined the association between gender and time to HIV-1 RNA rebound in antiretroviral-naive HIV-infected patients initiating HAART in a population-based setting...
  30. ncbi request reprint "Discordant" increases in CD4 cell count relative to plasma viral load in a closely followed cohort of patients initiating antiretroviral therapy
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, Canada
    J Acquir Immune Defic Syndr 30:159-66. 2002
    ..We characterized plasma viral load (pVL) and CD4 cell count increases in closely followed patients to evaluate determinants and the prevalence of CD4 cell responses at a populational level...
  31. ncbi request reprint Rates of disease progression among human immunodeficiency virus-infected persons initiating multiple-drug rescue therapy
    Nelson Lee
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    J Infect Dis 188:137-41. 2003
    ..Over the short-term, patients receiving MDRT had relatively low mortality. After adjustment for baseline prognostic factors, rates of survival were comparable with those in patients initiating triple-drug ART...
  32. doi request reprint Social-structural factors associated with supportive service use among a cohort of HIV-positive individuals on antiretroviral therapy
    Nadia O'Brien
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, BC, Canada
    AIDS Care 25:937-47. 2013
    ..High service use by those demonstrating social and clinical vulnerabilities reaffirms the need for continued expansion of supportive services to facilitate a more equitable distribution of health among persons living with HIV. ..
  33. pmc Injection drug use among street-involved youth in a Canadian setting
    Thomas Kerr
    British Columbia Centre for Excellence in HIV AIDS, St, Paul s Hospital, British Columbia, Canada
    BMC Public Health 9:171. 2009
    ..We undertook this study to examine the prevalence of injection drug use and associated risks among street-involved youth in Vancouver, Canada...
  34. ncbi request reprint Factors associated with buying and selling syringes among injection drug users in a setting of one of North America's largest syringe exchange programs
    Laura M Kuyper
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, and Department of Health Care and Epidemiology, University of British Columbia, Vancouver, Canada
    Subst Use Misuse 41:883-99. 2006
    ..Syringe buyers were more likely to need help injecting, have difficulty finding new syringes, have binged on drugs, and have visited the SEP at least once weekly. Syringe buying most frequently occurred when the SEP was closed...
  35. ncbi request reprint Provider bias in the selection of non-nucleoside reverse transcriptase inhibitor and protease inhibitor-based highly active antiretroviral therapy and HIV treatment outcomes in observational studies
    Evan Wood
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, Canada
    AIDS 17:2629-34. 2003
    ....
  36. pmc Severe food insecurity is associated with elevated unprotected sex among HIV-seropositive injection drug users independent of HAART use
    Kate Shannon
    BC Centre for Excellence in HIV AIDS, Department of Medicine, University of British Columbia, Vancouver, Canada
    AIDS 25:2037-42. 2011
    ..To our knowledge, this study is the first to longitudinally evaluate the relationship between food insecurity and unprotected sex among HIV-seropositive people who inject drugs [injection drug users (IDUs)] both on and not on HAART...
  37. pmc Risk factors for developing a cutaneous injection-related infection among injection drug users: a cohort study
    Elisa Lloyd-Smith
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, BC, Canada
    BMC Public Health 8:405. 2008
    ..However, risk factors for CIRI have not been well described in the literature. We sought to characterize the risk factors for current CIRI among individuals who use North America's first supervised injection facility (SIF)...
  38. pmc HIV VprR77Q mutation does not influence clinical response of individuals initiating highly active antiretroviral therapy
    Celia Chui
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    AIDS Res Hum Retroviruses 22:615-8. 2006
    ..1). The high prevalence and the lack of association with pretherapy clinical parameters in this cohort argue against an association of R77Q with LTNP status. These results do not support an association between R77Q and HAART response...
  39. ncbi request reprint Hepatitis C coinfection is independently associated with decreased adherence to antiretroviral therapy in a population-based HIV cohort
    Paula Braitstein
    British Columbia Center for Excellence in HIV AIDS, University of British Columbia, Vancouver, Canada
    AIDS 20:323-31. 2006
    ..To characterize the impact of hepatitis C (HCV) serostatus on adherence to antiretroviral treatment (ART) among HIV-infected adults initiating ART...
  40. pmc Adherence and plasma HIV RNA responses to highly active antiretroviral therapy among HIV-1 infected injection drug users
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, BC
    CMAJ 169:656-61. 2003
    ..We evaluated virological responses to HAART among HIV-1 infected patients who were injection drug users (IDUs) in a population-based setting where HIV/AIDS care is delivered free of charge...
  41. pmc Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study
    Julio S G Montaner
    British Columbia Centre for Excellence in HIV AIDS, Providence Health Care, Vancouver, BC, Canada
    Lancet 376:532-9. 2010
    ..We aimed to estimate the association between plasma HIV-1 viral load, HAART coverage, and number of new cases of HIV in the population of a Canadian province...
  42. ncbi request reprint Molecular and clinical epidemiology of CXCR4-using HIV-1 in a large population of antiretroviral-naive individuals
    Zabrina L Brumme
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, and Faculty of Medicine, University of British Columbia, Canada
    J Infect Dis 192:466-74. 2005
    ..We wished to characterize the epidemiological and clinical correlates of CXCR4-using human immunodeficiency virus type 1 (HIV-1) ("X4 variants") in a cross-sectional analysis of a large population of antiretroviral-naive individuals...
  43. pmc The impact of unstable housing on emergency department use in a cohort of HIV-positive people in a Canadian setting
    Surita Parashar
    a BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, BC, Canada
    AIDS Care 26:53-64. 2014
    ..Supportive housing may contribute to decreased health-care costs and improved health outcomes amongst marginalized PHA. ..
  44. pmc Trends in plasma HIV-RNA suppression and antiretroviral resistance in British Columbia, 1997-2010
    Angela Cescon
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada University of British Columbia, Vancouver, British Columbia, Canada and Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
    J Acquir Immune Defic Syndr 65:107-14. 2014
    ....
  45. ncbi request reprint Antiretroviral concentrations in untimed plasma samples predict therapy outcome in a population with advanced disease
    Christopher S Alexander
    British Columbia Centre for Excellence in HIV AIDS, University of British Columbia, Vancouver, British Columbia, Canada
    J Infect Dis 188:541-8. 2003
    ..01). These results may reflect incomplete adherence, since a strong association (P<.001) was found between low drug levels and an imperfect prescription-refill record (<95%)...
  46. ncbi request reprint Performance of immunologic responses in predicting viral load suppression: implications for monitoring patients in resource-limited settings
    David M Moore
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    J Acquir Immune Defic Syndr 43:436-9. 2006
    ..The performance of immunologic monitoring for this purpose has not been evaluated, however...
  47. ncbi request reprint Short communication. Association of the CCR5delta32 mutation with clinical response and >5-year survival following initiation of first triple antiretroviral regimen
    Zabrina L Brumme
    B C Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    Antivir Ther 10:849-53. 2005
    ..Here we investigate associations between CCR5delta32 and HAART outcomes in a large, population-based cohort of >1000 antiretroviral-naive individuals initiating triple therapy over a median >5 year follow-up...
  48. ncbi request reprint The effect of adherence on the association between depressive symptoms and mortality among HIV-infected individuals first initiating HAART
    Viviane D Lima
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, 608 1081 Burrard Street, Vancouver, British Columbia, Canada
    AIDS 21:1175-83. 2007
    ..To determine the impact of depressive symptoms on mortality among HIV/AIDS patients first initiating HAART and the potential role of patient adherence as a confounder and effect modifier in this association...
  49. ncbi request reprint Determinants of nevirapine hypersensitivity and its effect on the association between hepatitis C status and mortality in antiretroviral drug-naive HIV-positive patients
    Elizabeth Phillips
    British Columbia Centre for Excellence in HIV AIDS, Providence Healthcare, St Paul s Hospital, 667 1081 Burrard Street, Vancouver, BC, Canada
    AIDS 21:1561-8. 2007
    ....
  50. ncbi request reprint Discordant immunologic and virologic responses to highly active antiretroviral therapy are associated with increased mortality and poor adherence to therapy
    David M Moore
    British Columbia Centre for Excellence in HIV AIDS, 608 1081 Burrard Street, Vancouver, British Columbia, Canada V6Z 1Y6
    J Acquir Immune Defic Syndr 40:288-93. 2005
    ..To examine the independent association of discordant virologic and immunologic responses to highly active antiretroviral therapy (HAART) with mortality...
  51. doi request reprint Prevalence and correlates of jugular injections among injection drug users
    Zia Hoda
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, BC, Canada
    Drug Alcohol Rev 27:442-6. 2008
    ..We evaluated factors associated with jugular injection among a cohort of injection drug users (IDU) in Vancouver, Canada...
  52. ncbi request reprint Slower uptake of HIV antiretroviral therapy among Aboriginal injection drug users
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, BC, Canada
    J Infect 52:233-6. 2006
    ..We examined the time to antiretroviral therapy (ART) use among antiretroviral naïve HIV infected injection drug users participating in a prospective cohort study in Vancouver, Canada...
  53. ncbi request reprint Rates of antiretroviral resistance among HIV-infected patients with and without a history of injection drug use
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, Canada
    AIDS 19:1189-95. 2005
    ....
  54. ncbi request reprint Disease progression in patients with virological suppression in response to HAART is associated with the degree of immunological response
    David M Moore
    BC Centre for Excellence in HIV AIDS, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    AIDS 20:371-7. 2006
    ..To determine if immunological response is associated with disease progression in patients with virological suppression after initiating HAART...
  55. ncbi request reprint Frequent needle exchange use and HIV incidence in Vancouver, Canada
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, BC, Canada
    Am J Med 120:172-9. 2007
    ..Opposition to needle exchange programs has been fueled by a Vancouver study showing an association between frequent program use and elevated rates of human immunodeficiency virus (HIV) infection among injection drug users...
  56. doi request reprint Lopinavir/ritonavir pharmacokinetics in a substitution of high-dose soft-gelatin capsule to tablet formulation
    Mark W Hull
    Canadian HIV Trials Network, Vancouver, Canada
    J Clin Pharmacol 49:155-61. 2009
    ....
  57. ncbi request reprint Modest decreases in NNRTI susceptibility do not influence virological outcome in patients receiving initial NNRTI-containing triple therapy
    P Richard Harrigan
    BC Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
    Antivir Ther 8:395-402. 2003
    ....
  58. pmc Application and validation of case-finding algorithms for identifying individuals with human immunodeficiency virus from administrative data in British Columbia, Canada
    Bohdan Nosyk
    BC Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    PLoS ONE 8:e54416. 2013
    ..To define a population-level cohort of individuals infected with the human immunodeficiency virus (HIV) in the province of British Columbia from available registries and administrative datasets using a validated case-finding algorithm...
  59. ncbi request reprint Immunologic response to antiretroviral therapy in hepatitis C virus-coinfected adults in a population-based HIV/AIDS treatment program
    Paula Braitstein
    British Columbia Centre for Excellence in HIV AIDS, University of British Columbia, Vancouver, Canada
    J Infect Dis 193:259-68. 2006
    ..We sought to characterize the impact that hepatitis C virus (HCV) infection has on CD4 cells during the first 48 weeks of antiretroviral therapy (ART) in previously ART-naive human immunodeficiency virus (HIV)-infected patients...
  60. pmc Elevated HIV risk behaviour among recently incarcerated injection drug users in a Canadian setting: a longitudinal analysis
    M J S Milloy
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, Canada
    BMC Public Health 9:156. 2009
    ..We sought to assess the impact of incarceration on risk factors for HIV infection after release from prison in a sample of active IDU in Vancouver, Canada...
  61. ncbi request reprint Is there a baseline CD4 cell count that precludes a survival response to modern antiretroviral therapy?
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, Canada
    AIDS 17:711-20. 2003
    ..We evaluated whether non-immune-based factors such as physician experience and adherence could affect survival among HIV-infected adults starting HAART...
  62. pmc Client demands for unsafe sex: the socioeconomic risk environment for HIV among street and off-street sex workers
    Kathleen N Deering
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Acquir Immune Defic Syndr 63:522-31. 2013
    ....
  63. pmc The effect of history of injection drug use and alcoholism on HIV disease progression
    Viviane Dias Lima
    a British Columbia Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
    AIDS Care 26:123-9. 2014
    ..Screening and detection of substance dependence will identify individuals at high-risk for nonadherence and ideally prevent their HIV disease from progressing to advanced stages where HIV disease can become difficult to manage...
  64. pmc The cascade of HIV care in British Columbia, Canada, 1996-2011: a population-based retrospective cohort study
    Bohdan Nosyk
    Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada BC Centre for Excellence in HIV AIDS, University of British Columbia, Vancouver, BC, Canada
    Lancet Infect Dis 14:40-9. 2014
    ..We aimed to characterise longitudinal changes in engagement with the cascade of HIV care in British Columbia, Canada, from 1996 to 2011...
  65. ncbi request reprint Mitochondrial:nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens
    Helene C F Cote
    B C Centre for Excellence in HIV AIDS, St Paul s Hospital, Department of Medicine, University of British Columbia, Vancouver, Canada
    J Infect Dis 187:1972-6. 2003
    ..24 months; P<.01). Because of survivor-bias effect, these results may represent a conservative estimate of these nucleosides' effect on mtDNA...
  66. doi request reprint Factors predictive of 30-day postoperative mortality in HIV/AIDS patients in the era of highly active antiretroviral therapy
    Sam M Wiseman
    Department of Surgery, St Paul s Hospital and Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Ann Surg 256:170-6. 2012
    ..Factors that predict HIV (human immunodeficiency virus)/AIDS patient postoperative mortality have remained poorly defined...
  67. doi request reprint Impact of neighborhood-level socioeconomic status on HIV disease progression in a universal health care setting
    Ruth Joy
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, BC, Canada
    J Acquir Immune Defic Syndr 47:500-5. 2008
    ....
  68. ncbi request reprint A simple screening approach to reduce B*5701-associated abacavir hypersensitivity on the basis of sequence variation in HIV reverse transcriptase
    Celia K S Chui
    British Columbia Centre for Excellence in HIV AIDS, University of British Columbia, Vancouver, Canada
    Clin Infect Dis 44:1503-8. 2007
    ....
  69. pmc Unstable housing and hepatitis C incidence among injection drug users in a Canadian setting
    Christina Kim
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, Canada
    BMC Public Health 9:270. 2009
    ....
  70. doi request reprint Increased resilience to the development of drug resistance with modern boosted protease inhibitor-based highly active antiretroviral therapy
    Viviane D Lima
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, British Columbia, Canada
    J Infect Dis 198:51-8. 2008
    ..We explore the temporal and regimen-specific changes of HIV-1 drug resistance in a large cohort of antiretroviral-naive individuals starting highly active antiretroviral therapy (HAART)...
  71. ncbi request reprint HIV-1 drug resistance: degree of underestimation by a cross-sectional versus a longitudinal testing approach
    P Richard Harrigan
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Infect Dis 191:1325-30. 2005
    ..Our results suggest that analysis of a combined historical genotype rather than of a cross-sectional genotype may lead to more accurate estimates of antiretroviral drug resistance in individual patients and in patient populations...
  72. ncbi request reprint Impact of HAART and injection drug use on life expectancy of two HIV-positive cohorts in British Columbia
    Elisa Lloyd-Smith
    Department of Health Care and Epidemiology, University of British Columbia, Vancouver, British Columbia, Canada
    AIDS 20:445-50. 2006
    ..However, there is evidence that not all populations have benefited equally from HAART and that mortality rates are higher in HIV-infected injection drug users than in non-users...
  73. ncbi request reprint The future face of coinfection: prevalence and incidence of HIV and hepatitis C virus coinfection among young injection drug users
    Cari L Miller
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, and Department of Health Care and Epidemiology, University of British Columbia, Vancouver, Canada
    J Acquir Immune Defic Syndr 36:743-9. 2004
    ..The median number of years injecting for youth seroconverting to a secondary infection was 3 years, suggesting that appropriate public health interventions should be implemented immediately...
  74. ncbi request reprint Initiating highly active antiretroviral therapy and continuity of HIV care: the impact of incarceration and prison release on adherence and HIV treatment outcomes
    Anita Palepu
    Centre for Health Evaluation and Outcome Sciences, St Paul s Hospital, University of British Columbia, BC, Canada
    Antivir Ther 9:713-9. 2004
    ..To examine the effect of incarceration within 12 months of initiating highly active antiretroviral therapy (HAART) on non-adherence and HIV-1 RNA suppression...
  75. ncbi request reprint Risks of non-accidental mortality by baseline CD4+ T-cell strata in hepatitis-C-positive and -negative individuals initiating highly active antiretroviral therapy
    David M Moore
    BC Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    Antivir Ther 11:125-9. 2006
    ..We designed a study to determine whether risks for later mortality are similar for HCV-positive and HCV-negative individuals when subjects are stratified on the basis of baseline CD4+ T-cell counts...
  76. ncbi request reprint Treatment interruption of highly active antiretroviral therapy in patients with nadir CD4 cell counts >200 cells/mm3
    Adrienne R Toulson
    BC Centre for Excellence in HIV AIDS, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    J Infect Dis 192:1787-93. 2005
    ..The goal of the present study was to characterize outcome and predictors of outcome of treatment interruption (TI) in highly active antiretroviral therapy (HAART)-treated patients...
  77. ncbi request reprint Intermittent use of triple-combination therapy is predictive of mortality at baseline and after 1 year of follow-up
    Robert S Hogg
    Division of Epidemiology and Population Health, BC Centre for Excellence in HIV AIDS, 608 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    AIDS 16:1051-8. 2002
    ..To characterize the impact of intermittent use of triple drug antiretroviral therapy on survival...
  78. ncbi request reprint Intentional nonadherence due to adverse symptoms associated with antiretroviral therapy
    Katherine V Heath
    Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    J Acquir Immune Defic Syndr 31:211-7. 2002
    ..To estimate the frequency and possible predictors of patient-mediated intentional alterations in antiretroviral medication regimens in direct response to symptoms associated with antiretroviral therapy use...
  79. ncbi request reprint Impaired virologic response to highly active antiretroviral therapy associated with ongoing injection drug use
    Anita Palepu
    Centre for Health Evaluation and Outcome Sciences, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Acquir Immune Defic Syndr 32:522-6. 2003
    ..07, 95% CI: 0.87-1.33). Current injection drug users were less likely to achieve HIV-1 RNA suppression compared with non-drug users. Adherence as measured by pharmacy refill compliance was not a reliable measure in this subpopulation...
  80. ncbi request reprint Complementary and alternative medicine use in British Columbia--a survey of HIV positive people on antiretroviral therapy
    Shayesta Dhalla
    Department of Health Care and Epidemiology, University of British Columbia, Vancouver, British Columbia, Canada
    Complement Ther Clin Pract 12:242-8. 2006
    ..45). CAM use is common. Both patients and health professionals should be aware of potential toxicities and drug interactions related to the use of CAM and HIV/AIDS treatment...
  81. doi request reprint Etravirine in combination with darunavir/ritonavir and optimized background regimen results in suppression of HIV replication in treatment-experienced patients. Evaluation of Katlama C, Haubrich R, Lalezari J, et al. Efficacy and safety of etravirine in t
    Mark W Hull
    Faculty of Medicine, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada
    Expert Opin Pharmacother 11:1433-7. 2010
    ....
  82. ncbi request reprint Management of HIV-infected patients with multidrug-resistant virus
    Marianne Harris
    British Columbia Centre for Excellence in HIV AIDS, Providence Health Care University of British Columbia, 667 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Curr HIV/AIDS Rep 1:116-21. 2004
    ..Some new drugs are available that may be helpful if used carefully with an active background regimen...
  83. ncbi request reprint When to initiate antiretroviral therapy in HIV-1-infected adults: a review for clinicians and patients
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, BC V6Z 1Y6, Canada
    Lancet Infect Dis 5:407-14. 2005
    ....
  84. ncbi request reprint Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients
    Helene C F Cote
    British Columbia Centre for Excellence in HIV AIDS, University of British Columbia, St Paul s Hospital, Providence Health Care, Vancouver, BC, Canada
    N Engl J Med 346:811-20. 2002
    ..We studied changes in mitochondrial DNA relative to nuclear DNA in the peripheral-blood cells of patients with symptomatic, nucleoside-induced hyperlactatemia...
  85. pmc Service uptake and characteristics of injection drug users utilizing North America's first medically supervised safer injecting facility
    Evan Wood
    Division of Epidemiology and Population Health, British Columbia Centre for Excellence in HIV AIDS, 608 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
    Am J Public Health 96:770-3. 2006
    ..Ongoing evaluation will be required to assess its impact on overdose rates and HIV infection levels, as well as its ability to improve IDU contact with medical care and addiction treatment...
  86. ncbi request reprint Prescribing practices in a population-based HIV postexposure prophylaxis program
    Paula Braitstein
    Division of Epidemiology and Population Health, BC Centre for Excellence in HIV AIDS, 608 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    AIDS 16:1067-70. 2002
    ..To characterize factors associated with being prescribed triple or double postexposure prophylaxis (PEP) against HIV in a population-based program...
  87. ncbi request reprint Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response
    Zabrina L Brumme
    B C Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, Canada
    AIDS 17:201-8. 2003
    ....
  88. doi request reprint Nonadherence increases the risk of hospitalization among HIV-infected antiretroviral naive patients started on HAART
    Sarah J Fielden
    B C Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada, Department of Interdisciplinary Studies, University of British Columbia, Vancouver, British Columbia, Canada
    J Int Assoc Physicians AIDS Care (Chic) 7:238-44. 2008
    ..The objective of this study was to assess the impact of adherence on hospitalization among antiretroviral-naïve HIV-infected persons initiating HAART...
  89. ncbi request reprint Why are baseline HIV RNA levels 100,000 copies/mL or greater associated with mortality after the initiation of antiretroviral therapy?
    Evan Wood
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Acquir Immune Defic Syndr 38:289-95. 2005
    ..We evaluated whether baseline CD4 cell count and plasma HIV RNA predicted virologic suppression (<500 copies/mL) and rebound (> or =500 copies/mL) among adherent HIV-infected patients...
  90. ncbi request reprint Incidence of morphological and lipid abnormalities: gender and treatment differentials after initiation of first antiretroviral therapy
    Katherine V Heath
    Centre for Excellence in HIV AIDS, Vancouver, Canada
    Int J Epidemiol 31:1016-20. 2002
    ..To provide population-based incidence estimates for constituent symptoms of human immundeficiency virus (HIV)-related lipodystrophy syndrome and to identify possible independent predictors of accrued cases...
  91. pmc Efficacy, safety and pharmacokinetics of once-daily saquinavir soft-gelatin capsule/ritonavir in antiretroviral-naive, HIV-infected patients
    Julio S G Montaner
    St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    MedGenMed 8:36. 2006
    ..Once-daily HIV treatment regimens are being used in clinical practice with the objective of improving patient acceptance and adherence...
  92. ncbi request reprint Transmission of drug-resistant HIV-1 from an infected individual to a caregiver
    Chanson J Brumme
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, BC, Canada
    Antivir Ther 12:1139-44. 2007
    ..To describe a suspected case of intrafamilial transmission of drug-resistant HIV-1 from an infected individual to his caregiver...
  93. pmc The combined effect of modern highly active antiretroviral therapy regimens and adherence on mortality over time
    Viviane D Lima
    British Columbia Centre for Excellence in HIV AIDS, St Paul s Hospital, 608 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    J Acquir Immune Defic Syndr 50:529-36. 2009
    ..To characterize the impact of longitudinal adherence on survival in drug-naive individuals starting currently recommended highly active antiretroviral therapy (HAART) regimens...
  94. ncbi request reprint CD4 cell count response to nonnucleoside reverse transcriptase inhibitor- or protease inhibitor-based highly active antiretroviral therapy in an observational cohort study
    Evan Wood
    J Acquir Immune Defic Syndr 34:347-8. 2003
  95. ncbi request reprint Expanding access to HIV antiretroviral therapy among marginalized populations in the developed world
    Evan Wood
    AIDS 17:2419-27. 2003
  96. ncbi request reprint Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America
    Jacob P Lalezari
    Quest Clinical Research, Mount Zion Hospital and the University of California, San Francisco, San Francisco 94115, USA
    N Engl J Med 348:2175-85. 2003
    ..The T-20 vs. Optimized Regimen Only Study 1 (TORO 1) was a randomized, open-label, phase 3 study of enfuvirtide (T-20), a human immunodeficiency virus type 1 (HIV-1) fusion inhibitor...
  97. ncbi request reprint Delavirdine increases drug exposure of ritonavir-boosted protease inhibitors
    Marianne Harris
    AIDS 16:798-9. 2002
  98. ncbi request reprint Antiretroviral treatment for adult HIV infection in 2002: updated recommendations of the International AIDS Society-USA Panel
    Patrick G Yeni
    Hopital Bichat Claude Bernard, Department of Infectious Diseases, 46 rue Henri Huchard, Paris, Cedex 18 France 75877
    JAMA 288:222-35. 2002
    ..These updated recommendations are intended to guide practicing physicians actively involved in human immunodeficiency virus (HIV)- and acquired immunodeficiency syndrome (AIDS)-related care...
  99. pmc Adverse effects of antiretroviral therapy for HIV infection
    Valentina Montessori
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, BC
    CMAJ 170:229-38. 2004
    ..A better understanding of the adverse effects of antiretroviral agents is of interest not only for HIV specialists as they try to optimize therapy, but also for other physicians who care for HIV-positive patients...
  100. ncbi request reprint A simple, dynamic measure of antiretroviral therapy adherence predicts failure to maintain HIV-1 suppression
    Robert Gross
    Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, Center for Education and Research in Therapeutics, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    J Infect Dis 194:1108-14. 2006
    ....
  101. ncbi request reprint Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society-USA panel
    Scott M Hammer
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    JAMA 296:827-43. 2006
    ..The International AIDS Society-USA panel has updated its recommendations as warranted by new developments in the field...