Kenneth B Storey

Summary

Affiliation: Carleton University
Country: Canada

Publications

  1. ncbi request reprint Purification and characterization of fructose bisphosphate aldolase from the ground squirrel, Spermophilus lateralis: enzyme role in mammalian hibernation
    Justin A MacDonald
    Institute of Biochemistry and Department of Biology, College of Natural Sciences, Carleton University, Ottawa, Ont, Canada
    Arch Biochem Biophys 408:279-85. 2002
  2. ncbi request reprint Insect freeze tolerance: Roles of protein phosphatases and protein kinase A
    Thomas D Pfister
    Institute of Biochemistry and Department of Chemistry, Carleton University, Ottawa, Canada K1S 5B6
    Insect Biochem Mol Biol 36:18-24. 2006
  3. ncbi request reprint Responses of protein phosphatases and cAMP-dependent protein kinase in a freeze-avoiding insect, Epiblema scudderiana
    Thomas D Pfister
    Institute of Biochemistry and Department of Chemistry, Carleton University, Ottawa, Canada
    Arch Insect Biochem Physiol 62:43-54. 2006
  4. doi request reprint Comparative enzymology-new insights from studies of an "old" enzyme, lactate dehydrogenase
    Kenneth B Storey
    Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada Electronic address
    Comp Biochem Physiol B Biochem Mol Biol 199:13-20. 2016
  5. doi request reprint Regulation of hypometabolism: insights into epigenetic controls
    Kenneth B Storey
    Institute of Biochemistry and Departments of Biology and Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada
    J Exp Biol 218:150-9. 2015
  6. pmc Living without Oxygen: Anoxia-Responsive Gene Expression and Regulation
    Kevin Larade
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, K1S 5B6, Canada
    Curr Genomics 10:76-85. 2009
  7. pmc An overview of stress response and hypometabolic strategies in Caenorhabditis elegans: conserved and contrasting signals with the mammalian system
    Benjamin Lant
    Institute of Biochemistry, Carleton University, Ottawa, Ont, Canada
    Int J Biol Sci 6:9-50. 2010
  8. pmc Forever young: mechanisms of natural anoxia tolerance and potential links to longevity
    Anastasia Krivoruchko
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON, CA
    Oxid Med Cell Longev 3:186-98. 2010
  9. pmc Glucose-6-Phosphate Dehydrogenase Regulation in Anoxia Tolerance of the Freshwater Crayfish Orconectes virilis
    Benjamin Lant
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6
    Enzyme Res 2011:524906. 2011
  10. pmc Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance
    C W Wu
    Department of Biology, Institute of Biochemistry, Carleton University, Ottawa, ON, Canada
    Braz J Med Biol Res 46:1-13. 2013

Collaborators

Detail Information

Publications114 found, 100 shown here

  1. ncbi request reprint Purification and characterization of fructose bisphosphate aldolase from the ground squirrel, Spermophilus lateralis: enzyme role in mammalian hibernation
    Justin A MacDonald
    Institute of Biochemistry and Department of Biology, College of Natural Sciences, Carleton University, Ottawa, Ont, Canada
    Arch Biochem Biophys 408:279-85. 2002
    ..Thus, mammalian hibernators may exploit low-temperature characteristics of aldolase to benefit the metabolic needs of the hibernating state...
  2. ncbi request reprint Insect freeze tolerance: Roles of protein phosphatases and protein kinase A
    Thomas D Pfister
    Institute of Biochemistry and Department of Chemistry, Carleton University, Ottawa, Canada K1S 5B6
    Insect Biochem Mol Biol 36:18-24. 2006
    ..PTP activities were also strongly increased under these conditions and may act to antagonize tyrosine kinase mediated cell growth and proliferation responses and, thereby, contribute to hypometabolism and diapause over the winter...
  3. ncbi request reprint Responses of protein phosphatases and cAMP-dependent protein kinase in a freeze-avoiding insect, Epiblema scudderiana
    Thomas D Pfister
    Institute of Biochemistry and Department of Chemistry, Carleton University, Ottawa, Canada
    Arch Insect Biochem Physiol 62:43-54. 2006
    ..The strong responses by PTPs suggest that these may be involved in cell cycle and growth arrest during winter diapause...
  4. doi request reprint Comparative enzymology-new insights from studies of an "old" enzyme, lactate dehydrogenase
    Kenneth B Storey
    Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada Electronic address
    Comp Biochem Physiol B Biochem Mol Biol 199:13-20. 2016
    ....
  5. doi request reprint Regulation of hypometabolism: insights into epigenetic controls
    Kenneth B Storey
    Institute of Biochemistry and Departments of Biology and Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada
    J Exp Biol 218:150-9. 2015
    ..g. protein acetylation) are now proving to apply to many central metabolic enzymes (e.g. lactate dehydrogenase), suggesting a new layer of regulatory control that can contribute to coordinating the depression of metabolic rate. ..
  6. pmc Living without Oxygen: Anoxia-Responsive Gene Expression and Regulation
    Kevin Larade
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, K1S 5B6, Canada
    Curr Genomics 10:76-85. 2009
    ..Analysis of data generated from non-mainstream model systems allows for insight into the response by cells to anoxia stress...
  7. pmc An overview of stress response and hypometabolic strategies in Caenorhabditis elegans: conserved and contrasting signals with the mammalian system
    Benjamin Lant
    Institute of Biochemistry, Carleton University, Ottawa, Ont, Canada
    Int J Biol Sci 6:9-50. 2010
    ..Hence, the C. elegans model outlines a framework of critical molecular mechanisms that may be employed in the future as therapeutic targets for addressing disease states...
  8. pmc Forever young: mechanisms of natural anoxia tolerance and potential links to longevity
    Anastasia Krivoruchko
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON, CA
    Oxid Med Cell Longev 3:186-98. 2010
    ..In the present review we discuss the recent advances made in understanding the molecular nature of anoxia tolerance in turtles and the potential links between this tolerance and longevity...
  9. pmc Glucose-6-Phosphate Dehydrogenase Regulation in Anoxia Tolerance of the Freshwater Crayfish Orconectes virilis
    Benjamin Lant
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6
    Enzyme Res 2011:524906. 2011
    ..Anoxia-induced phosphorylation of G6PDH could contribute to modifying carbon flow through the PPP under anoxic conditions, potentially maintaining NADPH supply for antioxidant defense during prolonged anoxia-induced hypometabolism...
  10. pmc Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance
    C W Wu
    Department of Biology, Institute of Biochemistry, Carleton University, Ottawa, ON, Canada
    Braz J Med Biol Res 46:1-13. 2013
    ..Hence, the molecular networks that may regulate reversible insulin resistance in hibernating mammals represent a novel approach by providing insight into medical treatment of insulin resistance in humans...
  11. pmc Purification and Properties of White Muscle Lactate Dehydrogenase from the Anoxia-Tolerant Turtle, the Red-Eared Slider, Trachemys scripta elegans
    Neal J Dawson
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6
    Enzyme Res 2013:784973. 2013
    ....
  12. doi request reprint Molecular biology of freezing tolerance
    Kenneth B Storey
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, Ontario, Canada
    Compr Physiol 3:1283-308. 2013
    ..These help to remodel metabolism to preserve core functions while suppressing energy expensive metabolic activities such as the cell cycle. All of these advances are providing a much more complete picture of life in the frozen state...
  13. pmc Anti-apoptotic signaling as a cytoprotective mechanism in mammalian hibernation
    Andrew N Rouble
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, Ontario, Canada K1S 5B6
    Peerj 1:e29. 2013
    ..The data show that anti-apoptotic pathways have organ-specific responses in hibernators with a prominent potential role in heart and brain where coordinated enhancement of anti-apoptotic proteins occurred in response to torpor...
  14. pmc Novel control of lactate dehydrogenase from the freeze tolerant wood frog: role of posttranslational modifications
    Jean Abboud
    Institute of Biochemistry, Department of Biology and Department of Chemistry, Carleton University, Canada
    Peerj 1:e12. 2013
    ..LDH from muscle of dehydrated wood frogs showed significantly lower levels of acetylation, providing one of the first demonstrations of a potential role for protein acetylation in the stress-responsive control of a metabolic enzyme...
  15. pmc Glucose-6-phosphate dehydrogenase regulation in the hepatopancreas of the anoxia-tolerant marine mollusc, Littorina littorea
    Judeh L Lama
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, Ontario, Canada K1S 5B6
    Peerj 1:e21. 2013
    ....
  16. doi request reprint Expression of freeze-responsive proteins, Fr10 and Li16, from freeze-tolerant frogs enhances freezing survival of BmN insect cells
    Kyle K Biggar
    Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada
    FASEB J 27:3376-83. 2013
    ..Results from this study will provide new insights into adapting intolerant cells for medical organ cryoprotection using a natural vertebrate model of tolerance...
  17. doi request reprint Stress response and adaptation: a new molecular toolkit for the 21st century
    Kenneth B Storey
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Comp Biochem Physiol A Mol Integr Physiol 165:417-28. 2013
    ..Commercial tools such as Luminex allow researchers to simultaneously quantify up to 100 different analytes in a single sample, thereby creating broad functional analyses of metabolism and cell signaling pathways...
  18. doi request reprint Metabolic mechanisms for anoxia tolerance and freezing survival in the intertidal gastropod, Littorina littorea
    Kenneth B Storey
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, K1S 5B6, Canada
    Comp Biochem Physiol A Mol Integr Physiol 165:448-59. 2013
    ....
  19. doi request reprint Aestivation: signaling and hypometabolism
    Kenneth B Storey
    Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada, K1S 5B6
    J Exp Biol 215:1425-33. 2012
    ..This commentary examines the current knowledge about cell signaling pathways that participate in regulating aestivation, including signaling cascades mediated by the AMP-activated kinase, Akt, ERK, and FoxO1...
  20. pmc Regulation of 5'-adenosine monophosphate deaminase in the freeze tolerant wood frog, Rana sylvatica
    Christopher A Dieni
    Institute of Biochemistry and Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, K1S 5B6, Canada
    BMC Biochem 9:12. 2008
    ..The present study investigated AMPD control in wood frog muscle...
  21. ncbi request reprint De novo protein biosynthesis responses to water stresses in wood frogs: freeze-thaw and dehydration-rehydration
    K B Storey
    Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada
    Cryobiology 34:200-13. 1997
    ..These proteins may represent stress-related (or shock) proteins or may have specific roles in metabolic adaptation in each state such as in water and ionic balance or cell volume regulation...
  22. ncbi request reprint Gene expression during estivation in spadefoot toads, Scaphiopus couchii: upregulation of riboflavin binding protein in liver
    K B Storey
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, Ontario, Canada K1S 5B6
    J Exp Zool 284:325-33. 1999
    ....
  23. ncbi request reprint Life in the slow lane: molecular mechanisms of estivation
    Kenneth B Storey
    Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Comp Biochem Physiol A Mol Integr Physiol 133:733-54. 2002
    ..The mechanisms of metabolic depression in estivators are similar to those seen in hibernation and anaerobiosis, and contribute to the development of a unified set of biochemical principles for the control of metabolic arrest in nature...
  24. ncbi request reprint Metabolic rate depression in animals: transcriptional and translational controls
    Kenneth B Storey
    College of Natural Sciences, Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Biol Rev Camb Philos Soc 79:207-33. 2004
    ..The analysis draws primarily from current research on two animal models, hibernating mammals and anoxia-tolerant molluscs, with selected examples from multiple other sources...
  25. ncbi request reprint Strategies for exploration of freeze responsive gene expression: advances in vertebrate freeze tolerance
    Kenneth B Storey
    Institute of Biochemistry, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ont, Canada K1S 5B6
    Cryobiology 48:134-45. 2004
    ....
  26. ncbi request reprint Adventures in oxygen metabolism
    Kenneth B Storey
    Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6
    Comp Biochem Physiol B Biochem Mol Biol 139:359-69. 2004
    ....
  27. doi request reprint Cold ischemic organ preservation: lessons from natural systems
    Kenneth B Storey
    Institute of Biochemistry, College of Natural Sciences, Carleton University, Ottawa, ON, Canada
    J Investig Med 52:315-22. 2004
    ..These offer new targets for innovative applied treatments that could enhance cytoprotection and cold ischemia survival of organ explants...
  28. ncbi request reprint Reptile freeze tolerance: metabolism and gene expression
    Kenneth B Storey
    Institute of Biochemistry, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ont, Canada K1S 5B6
    Cryobiology 52:1-16. 2006
    ....
  29. ncbi request reprint Genomic and proteomic approaches in comparative biochemistry and physiology
    Kenneth B Storey
    Institute of Biochemistry, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada
    Physiol Biochem Zool 79:324-32. 2006
    ....
  30. ncbi request reprint Anoxia tolerance in turtles: metabolic regulation and gene expression
    Kenneth B Storey
    Institute of Biochemistry, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Comp Biochem Physiol A Mol Integr Physiol 147:263-76. 2007
    ....
  31. ncbi request reprint Tribute to P. L. Lutz: putting life on 'pause'--molecular regulation of hypometabolism
    Kenneth B Storey
    Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, K1S 5B6, Canada
    J Exp Biol 210:1700-14. 2007
    ..g. antioxidants, chaperone proteins, protease inhibitors) that stabilize macromolecules and promote long-term viability in the hypometabolic state...
  32. ncbi request reprint Freezing and anoxia tolerance of slugs: a metabolic perspective
    Kenneth B Storey
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON, Canada, K1S 5B6
    J Comp Physiol B 177:833-40. 2007
    ..laeve also showed this pattern during freezing, suggesting a natural switch to anaerobiosis to support freezing survival...
  33. doi request reprint Phosphoglycerate kinase 1 expression responds to freezing, anoxia, and dehydration stresses in the freeze tolerant wood frog, Rana sylvatica
    Shaobo Wu
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, Ont, Canada
    J Exp Zool A Ecol Genet Physiol 311:57-67. 2009
    ....
  34. doi request reprint Out cold: biochemical regulation of mammalian hibernation - a mini-review
    Kenneth B Storey
    Institute of Biochemistry, Carleton University, Ottawa, Ont, Canada
    Gerontology 56:220-30. 2010
    ....
  35. doi request reprint Metabolic regulation and gene expression during aestivation
    Kenneth B Storey
    Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada, K1S 5B6
    Prog Mol Subcell Biol 49:25-45. 2010
    ..Recent advances in understanding the regulation of aestivation are discussed with a particular emphasis on land snail and anuran models...
  36. ncbi request reprint Metabolic rate depression: the biochemistry of mammalian hibernation
    Kenneth B Storey
    Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada
    Adv Clin Chem 52:77-108. 2010
    ....
  37. ncbi request reprint Up-regulation of acidic ribosomal phosphoprotein P0 in response to freezing or anoxia in the freeze tolerant wood frog, Rana sylvatica
    Shaobo Wu
    Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ont, Canada K1S 5B6
    Cryobiology 50:71-82. 2005
    ..This suggests that P0 expression responds to anoxia stress during freezing. Changes in P0 content in ribosomes may contribute to altered patterns of protein synthesis under anoxia or ischemia...
  38. ncbi request reprint Freeze-induced expression of a novel gene, fr47, in the liver of the freeze-tolerant wood frog, Rana sylvatica
    J Dayre McNally
    Department of Biology, Institute of Biochemistry, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Biochim Biophys Acta 1625:183-91. 2003
    ..Finally, assessment of putative signal transduction pathways regulating fr47 gene expression, via in vitro incubations of liver slices, indicated the involvement of a protein kinase C-mediated pathway...
  39. doi request reprint Regulation of the heat shock response under anoxia in the turtle, Trachemys scripta elegans
    Anastasia Krivoruchko
    Department of Biology, Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada
    J Comp Physiol B 180:403-14. 2010
    ..s. elegans and suggest that the heat shock response is an important aspect of cytoprotection during facultative anaerobiosis, particularly with regard to underwater hibernation of turtles in cold water...
  40. ncbi request reprint Identification and characterization of a novel freezing inducible gene, li16, in the wood frog Rana sylvatica
    J Dayre McNally
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, Ontario, Canada K1S 5B6
    FASEB J 16:902-4. 2002
    ..The strong response of li16 to both freezing and anoxia, and the rapid down-regulation of the gene when oxygen was reintroduced, suggest that the Li16 protein may play a role in ischemia resistance during freezing...
  41. ncbi request reprint Mammalian hibernation. Transcriptional and translational controls
    Kenneth B Storey
    Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada
    Adv Exp Med Biol 543:21-38. 2003
    ..Studies of gene expression, protein synthesis regulation, controls on fuel metabolism, and signal transduction pathways are combining to produce an integrated model of the biochemical regulation of hibernation...
  42. ncbi request reprint Up-regulation of fatty acid-binding proteins during hibernation in the little brown bat, Myotis lucifugus
    Sean F Eddy
    Department of Chemistry and Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6
    Biochim Biophys Acta 1676:63-70. 2004
    ..These likely contribute to optimizing the function of FABPs at the low body temperatures (near 0 degrees C) experienced in the hibernating state...
  43. ncbi request reprint Upregulation of the mitochondrial phosphate carrier during freezing in the wood frog Rana sylvatica: potential roles of transporters in freeze tolerance
    J N Amritha De Croos
    Institute of Biochemistry, College of Natural Sciences, Carleton University, Ottawa, Ontario, Canada
    J Bioenerg Biomembr 36:229-39. 2004
    ..This modulation of PiC protein levels may play a role in mitochondrial ionic and/or osmotic balance during freeze-induced cell volume reduction...
  44. ncbi request reprint Vertebrate freezing survival: Regulation of the multicatalytic proteinase complex and controls on protein degradation
    Ashley K Woods
    Institute of Biochemistry and Department of Biology, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Biochim Biophys Acta 1760:395-403. 2006
    ..4-fold increase in protein carbonyl content in muscle and liver during freezing. Ubiquitin and ubiquitin conjugate levels were unchanged in muscle but changed markedly in liver during freeze-thaw...
  45. doi request reprint Cold acclimation-induced up-regulation of the ribosomal protein L7 gene in the freeze tolerant wood frog, Rana sylvatica
    Shaobo Wu
    Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Gene 424:48-55. 2008
    ..Cold- and freezing-responsive up-regulation of the rpl7 gene and RPL7 protein in selected organs suggests that targeted changes in selected ribosomal proteins may be an integral part of natural freeze tolerance...
  46. pmc Characterization of fructose-1,6-bisphosphate aldolase during anoxia in the tolerant turtle, Trachemys scripta elegans: an assessment of enzyme activity, expression and structure
    Neal J Dawson
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, Ontario, Canada
    PLoS ONE 8:e68830. 2013
    ..It is likely that the turtle is unique in its ability to regulate a heterotetramer of aldolase A and B, with a higher overall enzymatic activity, to achieve greater rates of glycolytic output and support anoxia survival. ..
  47. doi request reprint Differential expression of microRNA species in organs of hibernating ground squirrels: a role in translational suppression during torpor
    Pier Morin
    Institute of Biochemistry and Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada
    Biochim Biophys Acta 1779:628-33. 2008
    ....
  48. doi request reprint Myocyte enhancer factor-2 and cardiac muscle gene expression during hibernation in thirteen-lined ground squirrels
    Shannon N Tessier
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Gene 501:8-16. 2012
    ..These data provide insights into the changes in gene/protein in expression that help to prepare cardiac muscle for hibernation...
  49. doi request reprint Regulation of p53 by reversible post-transcriptional and post-translational mechanisms in liver and skeletal muscle of an anoxia tolerant turtle, Trachemys scripta elegans
    Jing Zhang
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6
    Gene 513:147-55. 2013
    ..These findings show an activation of p53 in response to anoxia exposure and suggest an important role for the p53 stress response pathway in regulating natural anoxia tolerance and hypometabolism in a vertebrate facultative anaerobe...
  50. doi request reprint Evidence for cell cycle suppression and microRNA regulation of cyclin D1 during anoxia exposure in turtles
    Kyle K Biggar
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON, Canada
    Cell Cycle 11:1705-13. 2012
    ....
  51. doi request reprint Environmental stress responsive expression of the gene li16 in Rana sylvatica, the freeze tolerant wood frog
    Katrina J Sullivan
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Cryobiology 64:192-200. 2012
    ....
  52. ncbi request reprint HIF-1alpha involvement in low temperature and anoxia survival by a freeze tolerant insect
    Pier Morin
    Institute of Biochemistry and Department of Chemistry, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada
    Mol Cell Biochem 280:99-106. 2005
    ..The data provide the first documentation of a potential role for HIF-1 in regulating the expression of genes that can aid freezing survival in a cold-hardy animal...
  53. doi request reprint Regulation of hexokinase by reversible phosphorylation in skeletal muscle of a freeze-tolerant frog
    Christopher A Dieni
    Institute of Biochemistry and Department of Chemistry, Carleton University, Ottawa, Ontario, Canada
    Comp Biochem Physiol B Biochem Mol Biol 159:236-43. 2011
    ..Finally, the activity and structure of HK from frozen frogs is more sensitive to non-compatible osmolytes than the enzyme in control frogs...
  54. ncbi request reprint Differential expression of mitochondria-encoded genes in a hibernating mammal
    Dustin S Hittel
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, Ontario, Canada K1S 5B6
    J Exp Biol 205:1625-31. 2002
    ....
  55. ncbi request reprint Accumulation and translation of ferritin heavy chain transcripts following anoxia exposure in a marine invertebrate
    Kevin Larade
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada, K1S 5B6
    J Exp Biol 207:1353-60. 2004
    ..Taken together, these results suggest that ferritin heavy chain is actively regulated during anoxia exposure in the marine snail, L. littorea...
  56. ncbi request reprint Regulation of skeletal muscle creatine kinase from a hibernating mammal
    Khalil Abnous
    Institute of Biochemistry and Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ont, Canada K1S 5B6
    Arch Biochem Biophys 467:10-9. 2007
    ..About 20-25% of CK was bound to the insoluble fraction of muscle and bound CK showed different kinetic responses to kinase and phosphatase treatments...
  57. ncbi request reprint Characterization of a novel gene up-regulated during anoxia exposure in the marine snail, Littorina littorea
    Kevin Larade
    Institute of Biochemistry, Department of Biology, Carleton University, 1125 Colonel By Drive, Ontario, K1S 5B6, Ottawa, Canada
    Gene 283:145-54. 2002
    ..The data suggest that the kvn transcript is both transcribed and translated during anoxia, indicating a possible significant role for the KVN protein in the survival of anoxia by L. littorea...
  58. doi request reprint Anoxia-responsive regulation of the FoxO transcription factors in freshwater turtles, Trachemys scripta elegans
    Anastasia Krivoruchko
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada Electronic address
    Biochim Biophys Acta 1830:4990-8. 2013
    ..We hypothesized that activation of these transcription factors could play crucial roles in low oxygen survival in the anoxia-tolerant turtle, Trachemys scripta elegans...
  59. doi request reprint Dehydration mediated microRNA response in the African clawed frog Xenopus laevis
    Cheng Wei Wu
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada
    Gene 529:269-75. 2013
    ..This study is the first report that shows a tissue specific mode of microRNA expression during amphibian dehydration, providing evidence for microRNAs as crucial regulators of metabolic depression. ..
  60. ncbi request reprint Up-regulation of the endoplasmic reticulum molecular chaperone GRP78 during hibernation in thirteen-lined ground squirrels
    Hapsatou Mamady
    Institute of Biochemistry and Department of Biology, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Mol Cell Biochem 292:89-98. 2006
    ..Changes in grp78 gene and protein expression appear to aid stress tolerance in two highly oxygen-dependent organs that are critical to whole animal survival during hibernation...
  61. pmc MicroRNA regulation in extreme environments: differential expression of microRNAs in the intertidal snail Littorina littorea during extended periods of freezing and anoxia
    Kyle K Biggar
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada
    Genomics Proteomics Bioinformatics 10:302-9. 2012
    ..Alterations in expression of these miRNAs in L. littorea tissues may contribute to organismal survival under freezing and anoxia...
  62. doi request reprint Activation of the unfolded protein response during anoxia exposure in the turtle Trachemys scripta elegans
    Anastasia Krivoruchko
    Department of Biology, Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada
    Mol Cell Biochem 374:91-103. 2013
    ..The data demonstrate that the UPR is activated in turtle heart, kidney, and liver in response to anoxia, suggesting that this pathway mediates an integrated stress response to protect tissues during oxygen deprivation...
  63. doi request reprint Pattern of cellular quiescence over the hibernation cycle in liver of thirteen-lined ground squirrels
    Cheng Wei Wu
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON, Canada
    Cell Cycle 11:1714-26. 2012
    ..Elevated expression of cyclin A and B protein expression during arousal stages of torpor suggests cell cycle progression is reversibly arrested during torpor and is reinitiated upon return to euthermia...
  64. ncbi request reprint Cloning and expression of hypoxia-inducible factor 1alpha from the hibernating ground squirrel, Spermophilus tridecemlineatus
    Pier Morin
    Institute of Biochemistry and Department of Chemistry, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Biochim Biophys Acta 1729:32-40. 2005
    ....
  65. ncbi request reprint Analysis of signal transduction pathways during anoxia exposure in a marine snail: a role for p38 MAP kinase and downstream signaling cascades
    Kevin Larade
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Comp Biochem Physiol B Biochem Mol Biol 143:85-91. 2006
    ..The present analysis of a variety of signaling pathways has implicated the p38 MAPK pathway as a key anoxia-responsive signal transduction pathway in L. littorea...
  66. ncbi request reprint Suppression of Na+/K+-ATPase activity during estivation in the land snail Otala lactea
    Christopher J Ramnanan
    Institute of Biochemistry, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    J Exp Biol 209:677-88. 2006
    ..Reversible phosphorylation control of Na+/K+-ATPase can provide the means of coordinating ATP use by this ion pump with the rates of ATP generation by catabolic pathways in estivating snails...
  67. ncbi request reprint Differential expression of selected mitochondrial genes in hibernating little brown bats, Myotis lucifugus
    Sean F Eddy
    Institute of Biochemistry and Department of Chemistry Carleton University, Ottawa, Ont, Canada K1S 5B6
    J Exp Zool A Comp Exp Biol 305:620-30. 2006
    ..This study provides further evidence for a key role of mitochondria in hibernation...
  68. ncbi request reprint Purification and properties of glutathione reductase from liver of the anoxia-tolerant turtle, Trachemys scripta elegans
    William G Willmore
    Institute of Biochemistry, Carleton University, Ottawa, ON, Canada, K1S 5B6
    Mol Cell Biochem 297:139-49. 2007
    ..The high affinity of turtle GR suggests that turtles have high redox buffering capacity of tissues to protect against oxidative stress encountered during anoxia/reoxygenation...
  69. ncbi request reprint Gene hunting in hypoxia and exercise
    Kenneth B Storey
    Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada
    Adv Exp Med Biol 588:293-309. 2006
    ....
  70. ncbi request reprint Arrest of transcription following anoxic exposure in a marine mollusc
    Kevin Larade
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON, Canada
    Mol Cell Biochem 303:243-9. 2007
    ..Since gene transcription is an ATP expensive process in cells, suppression of transcription to minimum levels provides substantial energy savings for the hepatopancreas, and the organism as a whole, under anoxic conditions...
  71. doi request reprint Mitochondria of cold hardy insects: responses to cold and hypoxia assessed at enzymatic, mRNA and DNA levels
    David C McMullen
    Department of Chemistry, Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ont, Canada
    Insect Biochem Mol Biol 38:367-73. 2008
    ..However, both COX transcript and 12S rRNA levels decreased in response to hypoxia exposure in both species, whereas COX DNA did not, which indicates that transcription of the mitochondrial genome is sensitive to oxygen levels...
  72. doi request reprint Expression of Nrf2 and its downstream gene targets in hibernating 13-lined ground squirrels, Spermophilus tridecemlineatus
    Pier Morin
    Institute of Biochemistry and Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6
    Mol Cell Biochem 312:121-9. 2008
    ..g., proline residues at positions 111 and 230) that might be important for conformational stability of the protein at near 0 degrees C body temperatures in the torpid state...
  73. doi request reprint Activation of antioxidant defenses in response to freezing in freeze-tolerant painted turtle hatchlings
    Anastasia Krivoruchko
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, Ontario, Canada K1S 5B6
    Biochim Biophys Acta 1800:662-8. 2010
    ..A number of antioxidant enzymes are under the control of the NF-E2 related factor 2 (Nrf2) transcription factor including members of the glutathione S-transferase (GST) and aldo-keto reductase (AKR) families...
  74. ncbi request reprint Anoxia-induced transcriptional upregulation of sarp-19: cloning and characterization of a novel EF-hand containing gene expressed in hepatopancreas of Littorina littorea
    Kevin Larade
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON, Canada
    Biochem Cell Biol 82:285-93. 2004
    ..The SARP-19 protein may play a role in calcium-activated signaling during anoxia exposure in L. littorea...
  75. ncbi request reprint Cloning and expression of PPAR-gamma and PGC-1alpha from the hibernating ground squirrel, Spermophilus tridecemlineatus
    Sean F Eddy
    Institute of Biochemistry and Department of Chemistry, Carleton University, Ottawa, Canada
    Mol Cell Biochem 269:175-82. 2005
    ..5-fold) and skeletal muscle (1.8-fold). Our current findings indicate a role for increased expression of PPARy and PGC-1alpha in hibernating animals...
  76. ncbi request reprint p38 MAPK regulation of transcription factor targets in muscle and heart of the hibernating bat, Myotis lucifugus
    Sean F Eddy
    Institute of Biochemistry and Department of Chemistry, Carleton University, Ottawa, Ont, Canada K1S 5B6
    Cell Biochem Funct 25:759-65. 2007
    ..These data implicate p38 MAPK and its transcription factor targets, CREB, ATF-2 and Elk-1 in skeletal muscle maintenance during hibernation...
  77. doi request reprint Coping with the stress: expression of ATF4, ATF6, and downstream targets in organs of hibernating ground squirrels
    Hapsatou Mamady
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ont, Canada K1S 5B6
    Arch Biochem Biophys 477:77-85. 2008
    ..The data suggest that ATF4 up-regulation may play an important role in coordinating gene expression responses that support the hibernating phenotype...
  78. doi request reprint Epigenetics in anoxia tolerance: a role for histone deacetylases
    Anastasia Krivoruchko
    Institute of Biochemistry, Carleton University, Ottawa, ON, Canada
    Mol Cell Biochem 342:151-61. 2010
    ..s. elegans, suggesting that these enzymes play a key role in anoxia tolerance, probably by contributing to the transcriptional silencing necessary in this hypometabolic state...
  79. doi request reprint Reversible phosphorylation regulation of NADPH-linked polyol dehydrogenase in the freeze-avoiding gall moth, Epiblema scudderiana: role in glycerol metabolism
    Helen A Holden
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, Ontario, Canada
    Arch Insect Biochem Physiol 77:32-44. 2011
    ..scudderiana and suggest that this regulatory mechanism makes a significant contribution to controlling the synthesis, maintenance, and degradation of glycerol pools over the winter months...
  80. doi request reprint Transcriptional regulation of antioxidant enzymes by FoxO1 under dehydration stress
    Amal Idris Malik
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada
    Gene 485:114-9. 2011
    ..laevis liver, by enhanced production of antioxidant enzymes under FoxO1 regulation...
  81. pmc Differential expression of mature microRNAs involved in muscle maintenance of hibernating little brown bats, Myotis lucifugus: a model of muscle atrophy resistance
    Samantha F Kornfeld
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada
    Genomics Proteomics Bioinformatics 10:295-301. 2012
    ....
  82. doi request reprint Cell cycle regulation in the freeze tolerant wood frog, Rana sylvatica
    Jing Zhang
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON, Canada
    Cell Cycle 11:1727-42. 2012
    ..g., an alternative action of cyclin D1 as a transcription factor may contribute to the upregulation of glucose-6-phosphatase, a key enzyme needed for the export of glucose cryoprotectant...
  83. ncbi request reprint The translation state of differentially expressed mRNAs in the hibernating 13-lined ground squirrel (Spermophilus tridecemlineatus)
    Dustin Hittel
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Arch Biochem Biophys 401:244-54. 2002
    ..This may indicate the existence of a tissue-specific mechanism for the translational control of a subset of genes that are physiologically relevant to the survival of hibernation...
  84. ncbi request reprint Differential expression of Akt, PPARgamma, and PGC-1 during hibernation in bats
    Sean F Eddy
    Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada
    Biochem Cell Biol 81:269-74. 2003
    ....
  85. ncbi request reprint Reversible suppression of protein synthesis in concert with polysome disaggregation during anoxia exposure in Littorina littorea
    Kevin Larade
    Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada
    Mol Cell Biochem 232:121-7. 2002
    ..These results suggest that metabolic suppression during anoxia exposure in L. littorea involves a decrease in protein translation...
  86. ncbi request reprint Purification and properties of the glutathione S-transferases from the anoxia-tolerant turtle, Trachemys scripta elegans
    William G Willmore
    Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada
    FEBS J 272:3602-14. 2005
    ....
  87. ncbi request reprint Antioxidant defense in hibernation: cloning and expression of peroxiredoxins from hibernating ground squirrels, Spermophilus tridecemlineatus
    Pier Morin
    Institute of Biochemistry and Department of Chemistry, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Arch Biochem Biophys 461:59-65. 2007
    ..Some unique amino acid substitutions were identified that might contribute to stabilizing Prdx2 conformation at the near 0 degrees C body temperatures during torpor...
  88. ncbi request reprint Cytosolic phospholipase A2 regulation in the hibernating thirteen-lined ground squirrel
    Ashley K Woods
    Institute of Biochemistry, Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada
    Cell Mol Biol Lett 12:621-32. 2007
    ....
  89. doi request reprint Skeletal muscle hexokinase: regulation in mammalian hibernation
    Khalil Abnous
    Institute of Biochemistry and Department of Chemistry, Carleton University, Ottawa, ON, Canada
    Mol Cell Biochem 319:41-50. 2008
    ..We conclude that differential control of muscle HK in euthermic versus hibernating states is derived from two main regulatory influences, reversible protein phosphorylation and temperature effects on kinetic properties...
  90. doi request reprint In cold-hardy insects, seasonal, temperature, and reversible phosphorylation controls regulate sarco/endoplasmic reticulum Ca2+-ATPase (SERCA)
    David C McMullen
    Institute of Biochemistry and Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada
    Physiol Biochem Zool 83:677-86. 2010
    ....
  91. doi request reprint Expression of myocyte enhancer factor-2 and downstream genes in ground squirrel skeletal muscle during hibernation
    Shannon N Tessier
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON, Canada
    Mol Cell Biochem 344:151-62. 2010
    ..The data suggest a significant role for MEF2-mediated gene transcription in the selective adjustment of muscle protein complement over the course of torpor-arousal cycles...
  92. doi request reprint Regulation of liver glutamate dehydrogenase by reversible phosphorylation in a hibernating mammal
    Ryan A V Bell
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Comp Biochem Physiol B Biochem Mol Biol 157:310-6. 2010
    ..This is the first study to show that mammalian liver GDH can be regulated by reversible phosphorylation, providing an important new regulatory mechanism for GDH control...
  93. doi request reprint Chaperone proteins and winter survival by a freeze tolerant insect
    Guijun Zhang
    Institute of Biochemistry and Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    J Insect Physiol 57:1115-22. 2011
    ..9-fold under anoxia. Overall, the data provide strong evidence for the importance of protein chaperones as a mechanism of cell preservation in freeze tolerant insects...
  94. doi request reprint Activation of antioxidant defense during dehydration stress in the African clawed frog
    Amal Idris Malik
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, Ontario, Canada
    Gene 442:99-107. 2009
    ..5-2-fold. The results show that metabolic responses to dehydration include activation of the Nrf2 transcription factor and selective up-regulation of genes under Nrf2 control...
  95. ncbi request reprint Protein phosphatase type-1 from skeletal muscle of the freeze-tolerant wood frog
    Justin A MacDonald
    Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada
    Comp Biochem Physiol B Biochem Mol Biol 131:27-36. 2002
    ..Overall, the results suggest an important role for PP-1 in signal transduction in the skeletal muscle of freeze-tolerant amphibians...
  96. ncbi request reprint Freezing and anoxia stresses induce expression of metallothionein in the foot muscle and hepatopancreas of the marine gastropod Littorina littorea
    Tamara E English
    Institute of Biochemistry and Department of Biology, College of Natural Sciences, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    J Exp Biol 206:2517-24. 2003
    ..Upregulation of MT during environmental stress could serve one or more possible roles, including a function in antioxidant defense...
  97. ncbi request reprint Evidence for a reduced transcriptional state during hibernation in ground squirrels
    Pier Morin
    Institute of Biochemistry and Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ont, Canada K1S 5B6
    Cryobiology 53:310-8. 2006
    ..These data support an overall decrease in transcriptional activity in skeletal muscle of hibernating animals that is accomplished by multiple molecular mechanisms...
  98. ncbi request reprint Regulation of Akt during hibernation in Richardson's ground squirrels
    Khalil Abnous
    Institute of Biochemistry and Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Biochim Biophys Acta 1780:185-93. 2008
    ..Altered enzyme properties and suppression of Akt activity would contribute to the coordinated suppression of energy-expensive anabolic and growth processes that is needed to maintain viability during over weeks of winter torpor...
  99. doi request reprint Suppression of Na+K+ -ATPase activity by reversible phosphorylation over the winter in a freeze-tolerant insect
    David C McMullen
    Department of Chemistry, Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ont, Canada K1S 5B6
    J Insect Physiol 54:1023-7. 2008
    ..Rather, it appears that winter suppression of ion motive ATPase activity may be part of a program of winter metabolic suppression...
  100. ncbi request reprint Urea and KCl have differential effects on enzyme activities in liver and muscle of estivating versus nonestivating species
    Kyra J Cowan
    Institute of Biochemistry and Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada
    Biochem Cell Biol 80:745-55. 2002
    ....
  101. ncbi request reprint Purification and characterization of protein phosphatase-1 from two cold-hardy goldenrod gall insects
    Thomas D Pfister
    Institute of Biochemistry and Department of Chemistry, Carleton University, Ottawa, Ontario, Canada
    Arch Insect Biochem Physiol 49:56-64. 2002
    ..The data identify multiple ways by which PP-1 can be inhibited at low temperature and this inhibition appears to be key to sustaining high glycogen phosphorylase activity in support of polyol synthesis at low temperatures...