Nathalie Grandvaux

Summary

Country: Canada

Publications

  1. ncbi Innate host defense: Nox and Duox on phox's tail
    Nathalie Grandvaux
    Department of Biochemistry, Faculty of Medicine and Unite INSERM U743, Centre de recherche du CHUM Hôpital St Luc, University of Montreal, 264 Rene Levesque Est, PEA 311, Montreal, Quebec, Canada H2X 1P1
    Biochimie 89:1113-22. 2007
  2. doi Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis
    Virginie Williams
    CRCHUM Centre de Recherche du Centre Hospitalier de l Université de Montréal, 900 rue Saint Denis, Montreal, QC H2X 0A9, Canada
    BMC Cancer 17:356. 2017
  3. doi [The IKKε kinase in breast cancer: from oncogenesis to treatment resistance]
    Nathalie Grandvaux
    Chaire de recherche du Canada en signalisation et infections virales, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Hopital Saint Luc, 264, boulevard René Lévesque Est, PEA 311 Montréal Québec, H2X 1P1, Canada
    Med Sci (Paris) 27:619-25. 2011
  4. pmc Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity
    Benjamin R tenOever
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    J Virol 78:10636-49. 2004
  5. pmc Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association
    Jean François Clément
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada
    J Virol 82:3984-96. 2008
  6. pmc Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression
    Anton Soucy-Faulkner
    CRCHUM Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    PLoS Pathog 6:e1000930. 2010
  7. ncbi Dual role of NOX2 in respiratory syncytial virus- and sendai virus-induced activation of NF-kappaB in airway epithelial cells
    Karin Fink
    Centre Hospitalier de l Université de Montréal Research Center St Luc Hospital and Institut National de la Santé et de la Recherche Médicale Unité 743, Montreal, Quebec, Canada
    J Immunol 180:6911-22. 2008
  8. ncbi Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA
    Marc J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and the Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 278:9441-7. 2003
  9. ncbi Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon
    Jennifer Harris
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 3755 chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada
    J Immunol 177:2527-35. 2006
  10. ncbi Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages
    Mayra Solis
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, QE, Canada
    Eur J Immunol 37:528-39. 2007

Collaborators

Detail Information

Publications42

  1. ncbi Innate host defense: Nox and Duox on phox's tail
    Nathalie Grandvaux
    Department of Biochemistry, Faculty of Medicine and Unite INSERM U743, Centre de recherche du CHUM Hôpital St Luc, University of Montreal, 264 Rene Levesque Est, PEA 311, Montreal, Quebec, Canada H2X 1P1
    Biochimie 89:1113-22. 2007
    ..Moreover, the potential role of Nox/Duox enzymes in the innate response to virus infections will be discussed...
  2. doi Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis
    Virginie Williams
    CRCHUM Centre de Recherche du Centre Hospitalier de l Université de Montréal, 900 rue Saint Denis, Montreal, QC H2X 0A9, Canada
    BMC Cancer 17:356. 2017
    ..Molecular studies have provided the rational for a key implication of IKKε in breast cancer cells proliferation and invasiveness through the phosphorylation of several substrates...
  3. doi [The IKKε kinase in breast cancer: from oncogenesis to treatment resistance]
    Nathalie Grandvaux
    Chaire de recherche du Canada en signalisation et infections virales, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Hopital Saint Luc, 264, boulevard René Lévesque Est, PEA 311 Montréal Québec, H2X 1P1, Canada
    Med Sci (Paris) 27:619-25. 2011
    ..Interestingly, IKKε is involved in the development of resistance to Tamoxifène. Thus, IKKε is a promising therapeutic target for newly developed breast cancer treatment...
  4. pmc Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity
    Benjamin R tenOever
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    J Virol 78:10636-49. 2004
    ..Induction of IKKepsilon potentially functions as a component of the amplification mechanism involved in the establishment of the antiviral state...
  5. pmc Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association
    Jean François Clément
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada
    J Virol 82:3984-96. 2008
    ..Importantly, our study establishes a molecular link between the role of serine 339 in IRF-3 homodimerization, CBP association, and its destabilization...
  6. pmc Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression
    Anton Soucy-Faulkner
    CRCHUM Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    PLoS Pathog 6:e1000930. 2010
    ..Taken together these data reveal a new facet to the regulation of the innate host defense against viruses through the identification of an unrecognized role of NOX2 and ROS...
  7. ncbi Dual role of NOX2 in respiratory syncytial virus- and sendai virus-induced activation of NF-kappaB in airway epithelial cells
    Karin Fink
    Centre Hospitalier de l Université de Montréal Research Center St Luc Hospital and Institut National de la Santé et de la Recherche Médicale Unité 743, Montreal, Quebec, Canada
    J Immunol 180:6911-22. 2008
    ..These results illustrate a previously unrecognized dual role of NOX2 in the regulation of NF-kappaB in response to RSV and Sendai virus in human AEC...
  8. ncbi Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA
    Marc J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and the Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 278:9441-7. 2003
    ..The inability of the phosphospecific antibody to detect Ser(396) phosphorylation in lipopolysaccharide-treated cells suggests that other major pathways may be involved in IRF-3 activation following Toll-like receptor 4 stimulation...
  9. ncbi Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon
    Jennifer Harris
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 3755 chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada
    J Immunol 177:2527-35. 2006
    ..These results illustrate a previously unrecognized aspect of cRel regulation, controlled by direct IKKepsilon/TBK1 phosphorylation...
  10. ncbi Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages
    Mayra Solis
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, QE, Canada
    Eur J Immunol 37:528-39. 2007
    ..These data support a differential role of TBK1 and IKKepsilon in the downstream response mediated by IRF-3 and IRF-7 to LPS in primary human macrophages...
  11. pmc Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta
    Fabrice Yoboua
    Centre de recherche du CHUM Hôpital St Luc, 264 Rene Levesque Est, PEA 311, Montreal, Quebec H2X 1P1, Canada
    J Virol 84:7267-77. 2010
    ....
  12. ncbi Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response
    Nathalie Grandvaux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Canada
    FEBS J 272:3120-31. 2005
    ..These results show for the first time that the ArgII gene is an early IRF-3-regulated gene, which participates in the IFN-independent antiviral response through polyamine production and induction of apoptosis...
  13. pmc IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH oxidase-mediated airway antiviral response
    Karin Fink
    Centre de Recherche du CHUM CRCHUM, Montreal, Quebec, Canada
    Cell Res 23:673-90. 2013
    ..In this regard, the importance of the novel DUOX2-dependent antiviral pathway is further underlined by the observation that the human respiratory syncytial virus is able to subvert DUOX2 induction...
  14. pmc Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression
    Sylvain Lefort
    Rheumatology and Immunology Research Center, Room T1 49, 2705 Laurier Blvd, Quebec, Quebec G1V 4G2, Canada
    J Virol 81:10950-60. 2007
    ..A new role for K-bZIP as a protein involved in immune evasion is therefore uncovered...
  15. ncbi Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes
    Sylvie Bannwarth
    Molecular Oncology Group Lady Davis Institute for Medical Research, Montreal, QC, Canada, H3T 1E2
    J Mol Biol 355:898-910. 2006
    ..These studies suggest that the cell specifity of HIV-1 expression and replication may be regulated, in part, through the control of TRBP1 expression...
  16. ncbi Triggering the interferon antiviral response through an IKK-related pathway
    Sonia Sharma
    Lady Davis Institute for Medical Research Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    Science 300:1148-51. 2003
    ..These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection...
  17. pmc Individual interferon regulatory factor-3 thiol residues are not critical for its activation following virus infection
    Nicolas Zucchini
    CRCHUM Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    J Interferon Cytokine Res 32:393-400. 2012
    ....
  18. pmc Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5
    Nathalie Grandvaux
    CRCHUM Centre Hospitalier de l Université de Montréal, Montreal, Que, Canada
    J Innate Immun 6:650-62. 2014
    ..MDA5 plays a similar role during Sendai virus infection suggesting that this model is not restricted to RSV amongst paramyxoviruses...
  19. pmc Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses
    Martin Baril
    Institut de recherche en immunologie et en cancérologie IRIC, Universite de Montreal, Montreal, Quebec, Canada
    PLoS Pathog 9:e1003416. 2013
    ..The study identifies novel avenues for broad-spectrum antiviral targets and preventing immune-mediated diseases upon viral infection...
  20. ncbi Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation
    Annie Bibeau-Poirier
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    J Immunol 177:5059-67. 2006
    ....
  21. ncbi Synergistic activation of interferon-beta gene transcription by the viral FLICE inhibitory protein of Kaposi's sarcoma-associated herpesvirus and type I IFN activators
    Nathalie Cloutier
    Laboratory of Virology, Rheumatology and Immunology Research Center, CHUL Research Center and Faculty of Medicine, Laval University, Quebec, Canada
    Eur J Immunol 37:2772-8. 2007
    ..Our work therefore contributes to increase our knowledge on v-FLIP, highlighting the complex immunomodulatory properties of this anti-apoptotic viral protein...
  22. doi Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients
    Loubna Jouan
    Institut de recherche en immunologie et en cancérologie IRIC, Universite de Montreal, Quebec, Canada H3T 1J4
    J Hepatol 56:70-7. 2012
    ..However, whether HCV mediates evasion of innate immunity in patients with chronic infection remains unclear...
  23. pmc Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes
    Nathalie Grandvaux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Virol 76:5532-9. 2002
    ....
  24. pmc Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins
    Yan Desfosses
    McGill AIDS Center, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T1E2
    J Virol 79:9180-91. 2005
    ..Swapping the activation domains of Tat B, C, and E identified the cyclin T1 association domain as a critical determinant of the transactivation efficiency and of Tat-defective HIV-1 provirus rescue...
  25. pmc Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines
    Espérance Mukawera
    CRCHUM Centre Hospitalier de l Université de Montréal, 900 rue Saint Denis, Montreal, QC, Canada H2X 0A9 Electronic address
    Redox Biol 6:9-18. 2015
    ..Taken together, our results suggest that redox-modulating compounds targeting NOX2 could present a particular therapeutic interest in combination therapy against breast carcinomas exhibiting IKKε amplification. ..
  26. pmc Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein
    Joanna Jaworska
    Rheumatology and Immunology Research Center, Room T1 49, 2705 Laurier Blvd, Quebec, Quebec, Canada G1V 4G2
    J Virol 81:5737-48. 2007
    ....
  27. ncbi Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells
    Sonia Sharma
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada
    J Immunol 169:3120-30. 2002
    ..These experiments constitute the first detailed analysis of human IRF-4 transcriptional regulation within the context of HTLV-I infection and transformation of CD4(+) T lymphocytes...
  28. doi HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms
    Delphine Planas
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    JCI Insight 2:. 2017
    ..Together, our results identify mTOR as a druggable key regulator of HIV permissiveness in gut-homing CCR6+ T cells...
  29. ncbi The interferon antiviral response: from viral invasion to evasion
    Nathalie Grandvaux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Curr Opin Infect Dis 15:259-67. 2002
    ....
  30. doi Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease
    Loubna Jouan
    laboratoire d immunologie virale, Centre de Recherche du CHUM CRCHUM, Hopital Saint Luc, 264 Rene Levesque Est, PEA 312, Quebec, Canada
    J Hepatol 52:167-75. 2010
    ..Hepatitis C Virus (HCV) can interfere with the innate host response and the NS3/4A protease was reported to specifically block antiviral signaling pathways, a finding that had yet to be studied in human primary hepatocytes...
  31. doi Regulation of normal and cystic fibrosis airway epithelial repair processes by TNF-α after injury
    Emilie Maillé
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 301:L945-55. 2011
    ..Finally, the stimulatory effect of TNF-α on airway wound repair was confirmed on primary airway epithelial cells, from non-CF and CF patients...
  32. pmc The ribonucleotide reductase R1 subunits of herpes simplex virus 1 and 2 protect cells against poly(I · C)-induced apoptosis
    Florent Dufour
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, QC, Canada
    J Virol 85:8689-701. 2011
    ..Thus, by interacting with caspase 8 and RIP1, HSV R1s impair the apoptotic host defense mechanism prompted by dsRNA...
  33. pmc Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology
    Sandra L Cervantes-Ortiz
    CRCHUM Centre Hospitalier de l Université de Montréal, Montreal, QC H2X 0A9, Canada
    Viruses 8:. 2016
    ..We summarize the evidence linking these stress responses with the regulation of RSV replication and the associated pathogenesis. ..
  34. doi Lung epithelial NOX/DUOX and respiratory virus infections
    Nathalie Grandvaux
    CRCHUM Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada, H2X 0A9
    Clin Sci (Lond) 128:337-47. 2015
    ....
  35. doi Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7
    Patricia Monteiro
    Department of Microbiology and Immunology, University of Montreal, Montreal, H3C 3J7 Quebec, Canada
    J Immunol 186:4618-30. 2011
    ....
  36. pmc Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation
    Benjamin R tenOever
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2
    J Virol 76:3659-69. 2002
    ..Altogether, this study suggests that IRF-3 recognizes nucleocapsid structures during the course of an MeV infection and triggers the induction of interferon production...
  37. ncbi IRF-4 activities in HTLV-I-induced T cell leukemogenesis
    Yael Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology and Immunology, McGill University, Montreal, Canada
    J Interferon Cytokine Res 22:135-43. 2002
    ..Further investigation of these novel IRF-4-regulated genes will permit a mechanistic understanding of IRF-4 function in HTLV-I-induced leukemogenesis...
  38. ncbi Cryptic O2- -generating NADPH oxidase in dendritic cells
    Sylvie Elsen
    Laboratoire de Biochimie et Biophysique des Systèmes Intégrés UMR 5092 CNRS CEA UJF, Departement Reponse et Dynamique Cellulaires, CEA Grenoble, Grenoble Cedex, France
    J Cell Sci 117:2215-26. 2004
    ....
  39. pmc Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon
    Adrien Breiman
    Unité Hépacivirus, Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 79:3969-78. 2005
    ..The partial restoration of the capacity of the host cell to transcribe IFN-beta indicates that IKKepsilon expression is able to bypass the HCV-mediated inhibition and restore the innate antiviral response...
  40. ncbi Multiple signaling pathways leading to the activation of interferon regulatory factor 3
    Marc J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute Jewish General Hospital, McGill University, 3755 Cote Ste, Catherine Montreal, Que, Canada
    Biochem Pharmacol 64:985-92. 2002
    ..This review summarizes recent observations in the identification of novel signaling pathways leading to IRF-3 activation...
  41. ncbi Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis
    John Hiscott
    Lady Davis Institute for Medical Research, Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Canada H3T 1E2
    Ann N Y Acad Sci 1010:237-48. 2003
    ..We report that the IKK-related kinases-IKKepsilon/TBK-1-are components of VAK that mediate IRF-3 and IRF-7 phosphorylation and thus functionally link the NF-kappaB and IRF pathways in the development of the antiviral response...
  42. ncbi Repression of IRF-4 target genes in human T cell leukemia virus-1 infection
    Yael Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology and Immunology, McGill University, Montreal, Canada H3T 1E2
    Oncogene 21:6751-65. 2002
    ..Several of the identified genes are dysregulated in ATL and may provide important mechanistic information concerning pathways critical to the emergence of ATL...