J Hiscott

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi MasterCARD: a priceless link to innate immunity
    John Hiscott
    Lady Davis Institute for Medical Research Jewish General Hospital, Department of Microbiology and Immunology, McGill University, Montreal, QC, H3T 1E2, Canada
    Trends Mol Med 12:53-6. 2006
  2. pmc The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation
    Peyman Nakhaei
    The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000650. 2009
  3. pmc HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1)
    Stephanie Oliere
    Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    PLoS Pathog 6:e1001177. 2010
  4. pmc Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
    Pasi Kaukinen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Virol J 3:66. 2006
  5. ncbi Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis
    John Hiscott
    Lady Davis Institute for Medical Research, Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Canada H3T 1E2
    Ann N Y Acad Sci 1010:237-48. 2003
  6. ncbi Triggering the innate antiviral response through IRF-3 activation
    John Hiscott
    Lady Davis Institute for Medical Research Jewish General Hospital, Departments of Microbiology and Immunology, Medicine, and Oncology, McGill University, Montreal H3T 1E2, Canada
    J Biol Chem 282:15325-9. 2007
  7. ncbi Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease
    John Hiscott
    Lady Davis Institute for Medical Research Jewish General Hospital, Department of Microbiology and Immunology, McGill University, Montreal, Canada H3T 1E2
    Biochem Pharmacol 72:1477-84. 2006
  8. ncbi Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response
    John Hiscott
    Lady Davis Institute for Medical Research Jewish General Hospital, Departments of Microbiology and Immunology, Medicine and Oncology, McGill University, Montreal, Canada H3T 1E2
    Cytokine Growth Factor Rev 18:483-90. 2007
  9. ncbi Inhibition of the interferon antiviral response by hepatitis C virus
    John Hiscott
    McGill University, Lady Davis Institute for Medical Research Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, H3T 1E2, Canada
    Expert Rev Clin Immunol 2:49-58. 2006
  10. ncbi Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses
    J Hiscott
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada
    Oncogene 25:6844-67. 2006

Detail Information

Publications105 found, 100 shown here

  1. ncbi MasterCARD: a priceless link to innate immunity
    John Hiscott
    Lady Davis Institute for Medical Research Jewish General Hospital, Department of Microbiology and Immunology, McGill University, Montreal, QC, H3T 1E2, Canada
    Trends Mol Med 12:53-6. 2006
    ..These studies highlight a novel role for the mitochondria and for caspase activation and recruitment domain (CARD)-containing proteins in coordinating immune and apoptotic responses...
  2. pmc The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation
    Peyman Nakhaei
    The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000650. 2009
    ..Thus, Triad3A represents a versatile E3 ubiquitin ligase that negatively regulates RIG-like receptor signaling by targeting TRAF3 for degradation following RNA virus infection...
  3. pmc HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1)
    Stephanie Oliere
    Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    PLoS Pathog 6:e1001177. 2010
    ..These observations identify a novel SOCS1 driven mechanism of evasion of the type I IFN antiviral response against HTLV-1...
  4. pmc Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
    Pasi Kaukinen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Virol J 3:66. 2006
    ..Previously, the serine protease NS3/4A was shown to inhibit IFN-beta gene expression by blocking dsRNA-activated retinoic acid-inducible gene I (RIG-I) and Toll-like receptor 3 (TLR3)-mediated signaling pathways...
  5. ncbi Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis
    John Hiscott
    Lady Davis Institute for Medical Research, Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Canada H3T 1E2
    Ann N Y Acad Sci 1010:237-48. 2003
    ..We report that the IKK-related kinases-IKKepsilon/TBK-1-are components of VAK that mediate IRF-3 and IRF-7 phosphorylation and thus functionally link the NF-kappaB and IRF pathways in the development of the antiviral response...
  6. ncbi Triggering the innate antiviral response through IRF-3 activation
    John Hiscott
    Lady Davis Institute for Medical Research Jewish General Hospital, Departments of Microbiology and Immunology, Medicine, and Oncology, McGill University, Montreal H3T 1E2, Canada
    J Biol Chem 282:15325-9. 2007
    ..In murine knock-out models, the absence of IRF-3 and the closely related IRF-7 ablates IFN production and increases viral pathogenesis, thus supporting a pivotal role for IRF-3/IRF-7 in the development of the host antiviral response...
  7. ncbi Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease
    John Hiscott
    Lady Davis Institute for Medical Research Jewish General Hospital, Department of Microbiology and Immunology, McGill University, Montreal, Canada H3T 1E2
    Biochem Pharmacol 72:1477-84. 2006
    ..These observations provide an outline of the mechanism by which HCV evades the IFN antiviral response...
  8. ncbi Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response
    John Hiscott
    Lady Davis Institute for Medical Research Jewish General Hospital, Departments of Microbiology and Immunology, Medicine and Oncology, McGill University, Montreal, Canada H3T 1E2
    Cytokine Growth Factor Rev 18:483-90. 2007
    ..This review summarizes the unique features of the IKK-related kinases and offers a summary of recent advances in the regulation of the early host response to virus infection...
  9. ncbi Inhibition of the interferon antiviral response by hepatitis C virus
    John Hiscott
    McGill University, Lady Davis Institute for Medical Research Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, H3T 1E2, Canada
    Expert Rev Clin Immunol 2:49-58. 2006
    ....
  10. ncbi Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses
    J Hiscott
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada
    Oncogene 25:6844-67. 2006
    ....
  11. pmc Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2
    Mol Cell Biol 20:6342-53. 2000
    ....
  12. ncbi Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway
    S Paz
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Cell Mol Biol (Noisy-le-grand) 52:17-28. 2006
    ..These studies link RIG-I sensing of viral RNA to downstream kinase signaling and phosphorylation of IRF-3 and IRF-7 via the MAVS/IPS/VISA/Cardif adaptor...
  13. pmc Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada H3T 1E2
    Mol Cell Biol 19:2465-74. 1999
    ....
  14. ncbi Differential transcriptional activation in vitro by NF-kappa B/Rel proteins
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    J Biol Chem 270:3123-31. 1995
    ....
  15. pmc Chronic human immunodeficiency virus type 1 infection stimulates distinct NF-kappa B/rel DNA binding activities in myelomonoblastic cells
    A Roulston
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 67:5235-46. 1993
    ....
  16. pmc Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter
    M Algarte
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Departments of Microbiology and Immunology, Medicine, and Oncology, McGill University, Montreal, Canada H3T 1E2
    Mol Cell Biol 19:6140-53. 1999
    ..These observations provide the first in vivo characterization of a promoter proximal transcriptional switch involving NF-kappaB and Sp1 that is essential for autoregulation of the IkappaBalpha promoter...
  17. ncbi Triggering the interferon response: the role of IRF-3 transcription factor
    J Hiscott
    Lady Davis Institute for Medical Research, Department of Microbiology and Immunology, McGill University, Montreal, Canada
    J Interferon Cytokine Res 19:1-13. 1999
    ....
  18. ncbi Disruption of NF-kappaB signaling reveals a novel role for NF-kappaB in the regulation of TNF-related apoptosis-inducing ligand expression
    T M Baetu
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada
    J Immunol 167:3164-73. 2001
    ..The regulation of TRAIL expression by NF-kappaB may represent a general mechanism that contributes to the control of TRAIL-mediated apoptosis in T lymphocytes...
  19. pmc Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells
    A Roulston
    Lady Davis Institute for Medical Research, Quebec, Canada
    J Exp Med 175:751-63. 1992
    ....
  20. ncbi Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA
    Marc J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and the Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 278:9441-7. 2003
    ..The inability of the phosphospecific antibody to detect Ser(396) phosphorylation in lipopolysaccharide-treated cells suggests that other major pathways may be involved in IRF-3 activation following Toll-like receptor 4 stimulation...
  21. ncbi HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T IE2, Canada
    Oncogene 20:800-11. 2001
    ..These results illustrate that vIRF-1 is able to block the early stages of the IFN response to virus infection by interfering with the activation of IRF-3 responsive, immediate early IFN genes...
  22. ncbi Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3
    M J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, H3T 1E2 Canada
    J Biol Chem 276:355-63. 2001
    ..The failure of numerous well characterized pharmacological inhibitors to abrogate virus-induced IRF-3 phosphorylation suggests the involvement of a novel kinase activity in IRF-3 regulation by viruses...
  23. pmc Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication
    P Beauparlant
    Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    J Virol 70:5777-85. 1996
    ..These experiments suggest a strategy that may contribute to inhibition of HIV-1 gene expression by interfering with the NF-kappa B/Rel signaling pathway...
  24. ncbi Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state
    L Petropoulos
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Virology 252:189-99. 1998
    ..The association of Tax with hypophosphorylated I kappa B alpha may prevent I kappa B alpha from binding to NF-kappa B and also target I kappa B alpha to the proteasome for degradation via a phosphorylation-independent pathway...
  25. ncbi Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52
    Y Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and Department of Microbiology, McGill University, Montreal, Canada
    Immunity 12:129-40. 2000
    ..These results demonstrate a novel posttranslational mechanism of transcriptional control, mediated through the interaction of an immunophilin with a transcriptional regulator...
  26. ncbi Multiple regulatory domains control IRF-7 activity in response to virus infection
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal H3T 1E2, Canada
    J Biol Chem 275:34320-7. 2000
    ..These results demonstrate that IRF-3 and IRF-7 transcription factors possess distinct structural characteristics that impart complementary rather than redundant functional roles in cytokine gene activation...
  27. pmc Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity
    Benjamin R tenOever
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    J Virol 78:10636-49. 2004
    ..Induction of IKKepsilon potentially functions as a component of the amplification mechanism involved in the establishment of the antiviral state...
  28. ncbi Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR
    T Ishii
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    Oncogene 20:1900-12. 2001
    ..These data strongly support an indirect role of PKR in I kappa B alpha phosphorylation by modulating IKK activity through pathways that do not utilize the enzymatic and dsRNA-binding properties of PKR...
  29. ncbi Heterodimerization and transcriptional activation in vitro by NF-kappa B proteins
    L Cohen
    Lady Davis Institute for Medical Research of the Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec
    J Cell Physiol 152:10-8. 1992
    ..These experiments emphasize the role of NF-kappa B dimerization as a distinct level of transcriptional control that may permit functional diversification of a limited number of regulatory proteins...
  30. pmc IkappaB-mediated inhibition of virus-induced beta interferon transcription
    M Algarte
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2
    J Virol 73:2694-702. 1999
    ..These experiments demonstrate a major role for IkappaBalpha in the regulation of NF-kappaB-induced IFN-beta gene activation and a minor role for IkappaBbeta in the activation process...
  31. ncbi Interferon regulatory factors: the next generation
    Y Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada
    Gene 237:1-14. 1999
    ..The aim of this review is to provide an update on the novel discoveries in the area of IRF transcription factors and the important roles of the new generation of IRFs--particularly IRF-3, IRF-4 and IRF-7...
  32. ncbi Biological and biochemical inhibitors of the NF-kappa B/Rel proteins and cytokine synthesis
    P Beauparlant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Cytokine Growth Factor Rev 7:175-90. 1996
    ....
  33. pmc Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter
    Suzanne Paz
    Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Mol Cell Biol 29:3401-12. 2009
    ..These results provide further support for the differential role of IKKepsilon and TBK-1 in the RIG-I/Mda5 pathway...
  34. pmc Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 18:2986-96. 1998
    ....
  35. pmc I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain
    P Crepieux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Department of Medicine, McGill University, Montreal, Que, Canada
    Mol Cell Biol 17:7375-85. 1997
    ....
  36. ncbi A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity
    R Lin
    Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Mol Cell Biochem 191:169-80. 1999
    ..The present experiments, together with previously published studies with IkappaBalpha, c-Jun and other proteins, indicate a broad role for casein kinase II phosphorylation in the regulation of transcription factor activity...
  37. ncbi Activation of the wt1 Wilms' tumor suppressor gene by NF-kappaB
    M Dehbi
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Oncogene 16:2033-9. 1998
    ..Taken together, these results indicate that members of the NF-kappaB/Rel family are important for activating expression of wt1 and reside upstream of the regulatory cascade leading to wt1 activation...
  38. ncbi Multiple signaling pathways leading to the activation of interferon regulatory factor 3
    Marc J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute Jewish General Hospital, McGill University, 3755 Cote Ste, Catherine Montreal, Que, Canada
    Biochem Pharmacol 64:985-92. 2002
    ..This review summarizes recent observations in the identification of novel signaling pathways leading to IRF-3 activation...
  39. ncbi Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells
    Sonia Sharma
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada
    J Immunol 169:3120-30. 2002
    ..These experiments constitute the first detailed analysis of human IRF-4 transcriptional regulation within the context of HTLV-I infection and transformation of CD4(+) T lymphocytes...
  40. pmc Functional analysis of a dominant negative mutation of interferon regulatory factor 5
    Long Yang
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    PLoS ONE 4:e5500. 2009
    ..Activation of IRF-5 results in the production of pro-inflammatory cytokines such as TNFalpha, IL6 and IL12p40, as well as type I interferons...
  41. ncbi Disruption of NF-kappa B signaling and chemokine gene activation by retroviral mediated expression of IKK gamma/NEMO mutants
    C Le Page
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Canada
    Virology 286:422-33. 2001
    ..This study demonstrates the efficacy of Delta C-IKK gamma as a repressor of IKK signaling and NF-kappa B activation and suggests a potential gene therapy approach to limit chronic inflammation due to chemokine hyperactivation...
  42. pmc trans activation of type 1 interferon promoters by simian virus 40 T antigen
    J Hiscott
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Mol Cell Biol 8:3397-405. 1988
    ..Coexpression of T antigen and E1a proteins did not have a cooperative effect on type 1 IFN expression...
  43. ncbi Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon
    Jennifer Harris
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 3755 chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada
    J Immunol 177:2527-35. 2006
    ..These results illustrate a previously unrecognized aspect of cRel regulation, controlled by direct IKKepsilon/TBK1 phosphorylation...
  44. ncbi Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes
    Sylvie Bannwarth
    Molecular Oncology Group Lady Davis Institute for Medical Research, Montreal, QC, Canada, H3T 1E2
    J Mol Biol 355:898-910. 2006
    ..These studies suggest that the cell specifity of HIV-1 expression and replication may be regulated, in part, through the control of TRBP1 expression...
  45. ncbi The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways
    Tiejun Zhao
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Canada
    Nat Immunol 8:592-600. 2007
    ..IRF3 phosphorylation and interferon production were restored by ectopic expression of NEMO. Thus, NEMO, like MAVS, acts as an adaptor protein that allows RIG-I to activate both the NF-kappaB and IRF signaling pathways...
  46. pmc Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes
    Nathalie Grandvaux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Virol 76:5532-9. 2002
    ....
  47. ncbi Triggering the interferon antiviral response through an IKK-related pathway
    Sonia Sharma
    Lady Davis Institute for Medical Research Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    Science 300:1148-51. 2003
    ..These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection...
  48. ncbi Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20
    Rongtuan Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 281:2095-103. 2006
    ..These results suggest that the virus-inducible, NF-kappaB-dependent activation of A20 functions as a negative regulator of RIG-I-mediated induction of the antiviral state...
  49. pmc Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage
    Rongtuan Lin
    Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Quebec, Canada
    J Virol 80:6072-83. 2006
    ..These observations provide an outline of the mechanism by which hepatitis C virus evades the interferon antiviral response...
  50. ncbi Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response
    Nathalie Grandvaux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Canada
    FEBS J 272:3120-31. 2005
    ..These results show for the first time that the ArgII gene is an early IRF-3-regulated gene, which participates in the IFN-independent antiviral response through polyamine production and induction of apoptosis...
  51. ncbi A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization
    Rongtuan Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 280:3088-95. 2005
    ..Although IRF-5 is phosphorylated by IKKepsilon and TBK1 in co-transfected cells, the phosphorylation of IRF-5 did not lead to IRF-5 nuclear localization or activation...
  52. ncbi The interferon antiviral response: from viral invasion to evasion
    Nathalie Grandvaux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Curr Opin Infect Dis 15:259-67. 2002
    ....
  53. ncbi Repression of IRF-4 target genes in human T cell leukemia virus-1 infection
    Yael Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology and Immunology, McGill University, Montreal, Canada H3T 1E2
    Oncogene 21:6751-65. 2002
    ..Several of the identified genes are dysregulated in ATL and may provide important mechanistic information concerning pathways critical to the emergence of ATL...
  54. ncbi Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line
    S Bannwarth
    Molecular Oncology Group, McGill AIDS Centre, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 276:48803-13. 2001
    ..This minimal TRBP promoter activity may account for minimal HIV-1 replication in astrocytes...
  55. ncbi Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell lines
    Meztli Arguello
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    Oncogene 22:964-73. 2003
    ..These observations indicate that disruption of the B-cell-specific transcriptional program is likely to contribute to the incomplete B-cell phenotype characteristic of PEL cells...
  56. ncbi Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation
    Annie Bibeau-Poirier
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    J Immunol 177:5059-67. 2006
    ....
  57. pmc Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis
    Vanessa Fonseca Tumilasci
    Department of Microbiology and Immunology, Molecular Oncology Group, Lady Davis Institute Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Virol 82:8487-99. 2008
    ..Together, these data indicate that the use of BCL-2 inhibitors may improve VSV oncolysis in treatment-resistant hematological malignancies, such as CLL, with characterized defects in the apoptotic response...
  58. ncbi Regulatory studies of murine methylenetetrahydrofolate reductase reveal two major promoters and NF-kappaB sensitivity
    Laura Pickell
    Departments of Human Genetics, Pediatrics, Biology, McGill University, Montreal Children s Hospital, Montreal, Canada
    Biochim Biophys Acta 1731:104-14. 2005
    ....
  59. ncbi Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infection
    Ehssan Sharif-Askari
    Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Virology 365:20-33. 2007
    ..Therefore, virus-induced apoptosis through a Bax-dependent mitochondrial pathway appears to enhance the full development of the IRF-3 mediated IFN antiviral response...
  60. pmc Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation
    Benjamin R tenOever
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2
    J Virol 76:3659-69. 2002
    ..Altogether, this study suggests that IRF-3 recognizes nucleocapsid structures during the course of an MeV infection and triggers the induction of interferon production...
  61. ncbi Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway
    J Lanoix
    Terry Fox Molecular Oncology Group, Abe Stern Cancer Research Laboratory, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Oncogene 9:841-52. 1994
    ....
  62. pmc The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia
    F Hariri
    Department of Pathology and Cell Biology, Institute for Research in Immunology and Cancer IRIC, Universite de Montreal, Montreal, Quebec, Canada
    Leukemia 27:2047-55. 2013
    ..These findings provide novel insights into the transcriptional control of eIF4E and a novel molecular basis for its dysregulation in at least a subset of M4/M5 AML specimens. ..
  63. ncbi On the TRAIL to apoptosis
    Tudor M Baetu
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, Department of Microbiology and Immunology, McGill University, 3755 Cote St Catherine, Montreal, Que, Canada H3T 1E2
    Cytokine Growth Factor Rev 13:199-207. 2002
    ..Further knowledge of the regulation and physiological role of TRAIL and TRAIL receptors may aid in the rational design of regimens that utilize the TRAIL signaling pathway to eliminate tumor cells...
  64. ncbi Repression of DNA repair mechanisms in IRF-4-expressing and HTLV-I-infected T lymphocytes
    Yael Mamane
    Lady Davis Institute for Medical Research, McGill University, Montreal, Canada
    J Interferon Cytokine Res 25:43-51. 2005
    ..IRF-4 may thus represent a previously unidentified endogenous transcriptional repressor of DNA repair mechanisms...
  65. ncbi In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors
    Delphine Duguay
    Terry Fox Molecular Oncology Group, Lady Davis Institute Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Quebec H3T 1E2, Canada
    Cancer Res 62:5148-52. 2002
    ..These findings suggest a novel role for IRF-3 as a potential molecular target for gene therapy of cancer...
  66. ncbi Differential regulation of HIV-1 clade-specific B, C, and E long terminal repeats by NF-kappaB and the Tat transactivator
    Philippe Roof
    McGill AIDS Center, McGill University, Montreal, Quebec, Canada
    Virology 296:77-83. 2002
    ..Furthermore, preliminary evidence suggests that the acetylation of subtype-specific Tat proteins may correlate with their transactivation efficiency...
  67. ncbi Ub surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates
    Meztli D Arguello
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal H3T 1E2, Canada
    Cell Host Microbe 2:367-9. 2007
    ....
  68. doi Enhancing VSV oncolytic activity with an improved cytosine deaminase suicide gene strategy
    S Leveille
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    Cancer Gene Ther 18:435-43. 2011
    ..Altogether, this study emphasizes the potency of the VSV-CD::UPRT and 5FC combination, and demonstrates the necessity of optimizing each step of a multicomponent therapy to design efficient treatment...
  69. pmc Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors
    A Roulston
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Microbiol Rev 59:481-505. 1995
    ..Elevated levels of several inflammatory cytokines have been detected in the sera of HIV-1-infected individuals. Secretion of myeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders...
  70. ncbi Diminution of CD4 surface protein but not CD4 messenger RNA levels in monocytic cells infected by HIV-1
    R Geleziunas
    McGill AIDS Centre, McGill University, Montreal, Canada
    AIDS 5:29-33. 1991
    ..These data suggest that HIV-1-mediated depletion of cell-surface CD4 in monocytes does not involve transcript down-modulation as has been reported in T lymphocytes...
  71. pmc Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation
    Stephanie Oliere
    Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Canada H3T 1E2
    J Virol 82:5735-49. 2008
    ..These results demonstrate that VSV replication in primary T lymphocytes relies on cell cycle transition from the G(0) phase to the G(1) phase, which is characterized by a sharp increase in ribogenesis and protein synthesis...
  72. ncbi Gene expression profiling of the host response to HIV-1 B, C, or A/E infection in monocyte-derived dendritic cells
    Mayra Solis
    McGill AIDS Center, Lady Davis Institute for Medical Research, Jewish General Hospital, Department of Microbiology and Immunology, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T1E2
    Virology 352:86-99. 2006
    ..These analyses distinguish a temporally regulated host response to de novo HIV-1 infection in primary dendritic cells...
  73. pmc Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins
    Yan Desfosses
    McGill AIDS Center, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T1E2
    J Virol 79:9180-91. 2005
    ..Swapping the activation domains of Tat B, C, and E identified the cyclin T1 association domain as a critical determinant of the transactivation efficiency and of Tat-defective HIV-1 provirus rescue...
  74. ncbi IRF-4 activities in HTLV-I-induced T cell leukemogenesis
    Yael Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology and Immunology, McGill University, Montreal, Canada
    J Interferon Cytokine Res 22:135-43. 2002
    ..Further investigation of these novel IRF-4-regulated genes will permit a mechanistic understanding of IRF-4 function in HTLV-I-induced leukemogenesis...
  75. pmc Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7
    Delphine Goubau
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Que, Canada
    Eur J Immunol 39:527-40. 2009
    ..Altogether, these data further highlight the respective functions of IRF-3 and IRF-7 to program apoptotic, immune and anti-tumor responses...
  76. pmc Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis
    Thi Lien Anh Nguyen
    Molecular Oncology Group, Lady Davis Institute Jewish General Hospital, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 105:14981-6. 2008
    ..HDIs could have a profoundly positive impact on the clinical implementation of OV therapeutics...
  77. ncbi Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 production
    Meztli Arguello
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    J Immunol 176:7051-61. 2006
    ....
  78. pmc RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I
    Mayra Solis
    Terry Fox Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 85:1224-36. 2011
    ..This study reveals a novel PR-dependent mechanism employed by HIV-1 to counteract the early IFN response to viral RNA in infected cells...
  79. doi RIG-I-like receptors: sensing and responding to RNA virus infection
    Peyman Nakhaei
    The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Quebec, Canada
    Semin Immunol 21:215-22. 2009
    ..In this review, we will focus on RIG-I-like receptor (RLR) signal transduction and the regulatory mechanisms - ubiquitination, deubiquitination, ISGylation - underlying this important host response...
  80. doi The interface between the innate interferon response and expression of host retroviral restriction factors
    Renée N Douville
    Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, 3999 Cote Ste Catherine, Dept of Microbiology and Medicine, McGill University, Montreal, Quebec, Canada H3T 1E2
    Cytokine 52:108-15. 2010
    ....
  81. doi The emergence of combinatorial strategies in the development of RNA oncolytic virus therapies
    Thi Lien Anh Nguyen
    Terry Fox Molecular Oncology Group, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T1E2
    Cell Microbiol 11:889-97. 2009
    ..In this review, we summarize recent development of these concepts, the potential obstacles, and future prospects for the clinical utilization of RNA OVs in cancer therapy...
  82. ncbi Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages
    Mayra Solis
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, QE, Canada
    Eur J Immunol 37:528-39. 2007
    ..These data support a differential role of TBK1 and IKKepsilon in the downstream response mediated by IRF-3 and IRF-7 to LPS in primary human macrophages...
  83. ncbi Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophages
    Raphaelle Romieu-Mourez
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Cancer Res 66:10576-85. 2006
    ..In conclusion, transduction of active forms of IRF-3 or IRF-7 differentially modulate the apoptotic and antitumor properties of primary macrophages, with active IRF-7 leading to the acquisition of novel antitumor effector functions...
  84. ncbi A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virions
    Marco Sgarbanti
    Terry Fox Molecular Oncology Group, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada
    Oncogene 23:5770-80. 2004
    ....
  85. doi STING-ing the antiviral pathway
    Peyman Nakhaei
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, QC, Canada
    J Mol Cell Biol 2:110-2. 2010
    ..The cytosolic DNA sensing pathway has remained poorly defined thus far. A recent study by Ishikawa et al. demonstrates that STING is essential for DNA-mediated type I IFN production and host defence against DNA pathogens...
  86. pmc Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon
    Adrien Breiman
    Unité Hépacivirus, Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 79:3969-78. 2005
    ..The partial restoration of the capacity of the host cell to transcribe IFN-beta indicates that IKKepsilon expression is able to bypass the HCV-mediated inhibition and restore the innate antiviral response...
  87. ncbi TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB
    Harald Ehrhardt
    Dr von Haunersches Kinderspital, Department of Hematology Oncology, Lindwurmstr 4, Munich 80337, Germany
    Oncogene 22:3842-52. 2003
    ..Given the promising therapeutic potential of TRAIL as a novel anticancer drug, TRAIL-mediated survival or proliferation of target cells may restrict its use to apoptosis-sensitive tumors...
  88. ncbi VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents
    David F Stojdl
    Ottawa Regional Cancer Centre Research Laboratories, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6
    Cancer Cell 4:263-75. 2003
    ..While highly attenuated for growth in normal mice, both AV1 and AV2 effected complete and durable cures in the majority of treated animals when delivered systemically...
  89. ncbi Identification of mechanisms underlying transporter associated with antigen processing deficiency in metastatic murine carcinomas
    A Francesca Setiadi
    Biomedical Research Centre and Michael Smith Laboratories, Department of Zoology, University of British Columbia, Vancouver, British Columbia
    Cancer Res 65:7485-92. 2005
    ..These results have significant implications for understanding immune evasion mechanisms in tumors...
  90. ncbi Another detour on the Toll road to the interferon antiviral response
    John Hiscott
    Nat Struct Mol Biol 11:1028-30. 2004
  91. pmc Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells
    Pamela Osterlund
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Virol 79:9608-17. 2005
    ..Our results show that in human mDCs viruses can readily induce the expression of IL-28 and IL-29 genes whose gene products are likely to contribute to the host antiviral response...
  92. ncbi Effects of the hepatitis C virus core protein on innate cellular defense pathways
    Kristen Miller
    Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA 98104 2499, USA
    J Interferon Cytokine Res 24:391-402. 2004
    ..Core stimulated the human iNOS promoter and induced iNOS protein. The data indicate that HCV core can modulate IRF, Jak-Stat, and iNOS pathways and suggest mechanisms by which core could affect HCV persistence and pathogenesis...
  93. pmc A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
    Gregory Gautier
    Laboratory for Immunological Research, Schering Plough, 69571 Dardilly, France
    J Exp Med 201:1435-46. 2005
    ..Moreover, analysis of interferon regulatory factors (IRF) regulation in moDC suggests a role for IRF7/8 in mediating IRF3-independent type I IFN and possibly IL-12p35 synthesis in response to TLR7/8...
  94. ncbi Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon
    Ahmet Civas
    UPR 2228 CNRS, Laboratoire de Régulation Transcriptionnelle et Maladies Génétiques, UFR Biomédicale des Saints Pères, Universite Paris V, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    J Biol Chem 281:4856-66. 2006
    ....
  95. ncbi Super-activated interferon-regulatory factors can enhance plasmid immunization
    Jonathan L Bramson
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, 1200 Main Street West, Hamilton, Ont, Canada L8N 3Z5
    Vaccine 21:1363-70. 2003
    ..These results support further investigation of the potential of these agents as adjuvants for genetic immunization...
  96. ncbi Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3
    Geoffrey H Holm
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232 2581, USA
    J Biol Chem 282:21953-61. 2007
    ..Interferon-beta promoter stimulator-1 and IRF-3 are required for efficient apoptosis following reovirus infection, suggesting a common mechanism of antiviral cytokine induction and activation of the cell death response...
  97. ncbi A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells
    Patrizia Caposio
    Department of Public Health and Microbiology, University of Turin, Turin 10126, Italy
    J Biol Chem 282:33515-29. 2007
    ..Taken together, these data implicate IFI16 as a novel regulator of endothelial proinflammatory activity and provide new insights into the physiological functions of the IFN-inducible gene IFI16...
  98. ncbi Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription
    Pierre Morin
    UPR 2228 CNRS, Laboratoire de Régulation Transcriptionnelle et Maladies Génétiques, UFR Biomédicale des Saints Pères, Universite Paris V, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    J Mol Biol 316:1009-22. 2002
    ....
  99. ncbi Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells
    Taija E Pietila
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Immunol 178:253-61. 2007
    ..Our experiments reveal that expression of the CCL19 gene is regulated by a combined action of several members of the NF-kappaB, IRF, and STAT family transcription factors...
  100. ncbi IFN regulatory factor 4 participates in the human T cell lymphotropic virus type I-mediated activation of the IL-15 receptor alpha promoter
    Jennifer M Mariner
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:5667-74. 2002
    ..This loop of proliferation may facilitate viral propagation and play a role in HTLV-I-mediated disease progression...
  101. ncbi Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines
    Jukka Sirén
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Microbes Infect 8:2013-20. 2006
    ..In conclusion, our results show that in epithelial cells influenza A virus-induced antiviral cytokine gene expression is triggered by RIG-I and mda-5, whose expression is positively regulated by IFN-alpha...