Marc J Servant

Summary

Country: Canada

Publications

  1. ncbi Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA
    Marc J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and the Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 278:9441-7. 2003
  2. pmc Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association
    Jean François Clément
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada
    J Virol 82:3984-96. 2008
  3. ncbi Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation
    Annie Bibeau-Poirier
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    J Immunol 177:5059-67. 2006
  4. ncbi Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions
    Simon Pierre Gravel
    Faculty of Pharmacy, University of Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 280:7477-86. 2005
  5. pmc Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter
    Suzanne Paz
    Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Mol Cell Biol 29:3401-12. 2009
  6. doi Pyroglutamylated RF-amide peptide (QRFP) gene is regulated by metabolic endotoxemia
    Christian Jossart
    Faculty of Pharmacy C J, M M, S M, M J S, H O, Universite de Montreal C P 6128, Succursale Centre Ville, Quebec, Canada, H3C 3J7 and Laboratory of Molecular and Cellular Endocrinology R G, D G, E G, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
    Mol Endocrinol 28:65-79. 2014
  7. pmc Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity
    Wendy J van Zuylen
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec Canada
    PLoS Pathog 8:e1002747. 2012
  8. doi Role of IκB kinase-β in the growth-promoting effects of angiotensin II in vitro and in vivo
    Priscilla Doyon
    From the Faculty of Pharmacy, Universite de Montreal, Montreal, Canada
    Arterioscler Thromb Vasc Biol 33:2850-7. 2013
  9. pmc Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes
    Nathalie Grandvaux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Virol 76:5532-9. 2002
  10. ncbi The proinflammatory actions of angiotensin II are dependent on p65 phosphorylation by the IkappaB kinase complex
    Annie Douillette
    Faculty of Pharmacy, University of Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 281:13275-84. 2006

Collaborators

  • Rongtuan Lin
  • Tiejun Zhao
  • Richard Larivière
  • Eliane F Meurs
  • R Granata
  • P Moreau
  • Nathalie Grandvaux
  • Ganes Sen
  • Sylvain Meloche
  • Huy Ong
  • Anne Claude Gingras
  • J Hiscott
  • Jean François Clément
  • Annie Bibeau-Poirier
  • Priscilla Doyon
  • Simon Pierre Gravel
  • Kashif Aziz Khan
  • Christian Jossart
  • Wendy J van Zuylen
  • Mukandila Mulumba
  • Florence Dô
  • Sylvie Marleau
  • Davide Gallo
  • Ezio Ghigo
  • Suzanne Paz
  • Huy Hao Dao
  • Annie Douillette
  • Philippe Lépicier
  • James R Woodgett
  • Bradley W Doble
  • Alexandre Marineau
  • Benjamin R tenOever
  • Tasheen Wissanji
  • Myriam St-Amant-Verret
  • Lisa M D'Ambrosio
  • Gregory Emery
  • Emanuel Escher
  • Meztli Arguello
  • Myriam Vilasco
  • Thi Lien Anh Nguyen
  • Scott Zaari
  • Elena A Shestakova
  • Judith Lacoste
  • Qiang Sun
  • Pierre Thibault
  • Eric Bonneil
  • Sébastien Rolland
  • Geneviève Rodier
  • Simon Moreau
  • Caroline Lagneux
  • Celine Bouvet
  • Philippe Coulombe
  • Daniel Lamontagne
  • Jacques de Champlain
  • Pierre Beaucage
  • Valérie Chénard

Detail Information

Publications23

  1. ncbi Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA
    Marc J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and the Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 278:9441-7. 2003
    ..The inability of the phosphospecific antibody to detect Ser(396) phosphorylation in lipopolysaccharide-treated cells suggests that other major pathways may be involved in IRF-3 activation following Toll-like receptor 4 stimulation...
  2. pmc Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association
    Jean François Clément
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada
    J Virol 82:3984-96. 2008
    ..Importantly, our study establishes a molecular link between the role of serine 339 in IRF-3 homodimerization, CBP association, and its destabilization...
  3. ncbi Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation
    Annie Bibeau-Poirier
    Faculty of Pharmacy, University of Montreal, Montreal, Canada
    J Immunol 177:5059-67. 2006
    ....
  4. ncbi Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions
    Simon Pierre Gravel
    Faculty of Pharmacy, University of Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 280:7477-86. 2005
    ..Our results thus add additional molecular clues to a possible role of HCMV as a modulator of atherogenesis through the induction of a proinflammatory response that is, in part, dependent of an IKK-related kinase pathway...
  5. pmc Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter
    Suzanne Paz
    Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Mol Cell Biol 29:3401-12. 2009
    ..These results provide further support for the differential role of IKKepsilon and TBK-1 in the RIG-I/Mda5 pathway...
  6. doi Pyroglutamylated RF-amide peptide (QRFP) gene is regulated by metabolic endotoxemia
    Christian Jossart
    Faculty of Pharmacy C J, M M, S M, M J S, H O, Universite de Montreal C P 6128, Succursale Centre Ville, Quebec, Canada, H3C 3J7 and Laboratory of Molecular and Cellular Endocrinology R G, D G, E G, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
    Mol Endocrinol 28:65-79. 2014
    ..In conclusion, LPS induces IFN-β release from macrophages, which reduces QRFP expression in both macrophages and adipocytes in an autocrine/paracrine-dependent manner, suggesting QRFP as a potential biomarker in ME...
  7. pmc Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity
    Wendy J van Zuylen
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec Canada
    PLoS Pathog 8:e1002747. 2012
    ....
  8. doi Role of IκB kinase-β in the growth-promoting effects of angiotensin II in vitro and in vivo
    Priscilla Doyon
    From the Faculty of Pharmacy, Universite de Montreal, Montreal, Canada
    Arterioscler Thromb Vasc Biol 33:2850-7. 2013
    ....
  9. pmc Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes
    Nathalie Grandvaux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Virol 76:5532-9. 2002
    ....
  10. ncbi The proinflammatory actions of angiotensin II are dependent on p65 phosphorylation by the IkappaB kinase complex
    Annie Douillette
    Faculty of Pharmacy, University of Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 281:13275-84. 2006
    ....
  11. pmc Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation
    Benjamin R tenOever
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2
    J Virol 76:3659-69. 2002
    ..Altogether, this study suggests that IRF-3 recognizes nucleocapsid structures during the course of an MeV infection and triggers the induction of interferon production...
  12. ncbi Endothelin is a dose-dependent trophic factor and a mitogen in small arteries in vivo
    Huy Hao Dao
    Faculty of Pharmacy, Universite de Montreal, 2900 Edouard Montpetit, Pavillon Jean Coutu, room 3197, P O Box 6128, Station Centre ville Montreal, Quebec, Canada H3C 3J7
    Cardiovasc Res 71:61-8. 2006
    ..Moreover, the signaling of ET in vivo to produce these effects is largely unknown...
  13. pmc Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway
    Kashif Aziz Khan
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 35:3029-43. 2015
    ..This study identifies the role of a GSK-3/β-catenin axis in antiviral innate immunity. ..
  14. pmc Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells
    Priscilla Doyon
    Faculty of Pharmacy and Groupe de Recherche Universitaire sur le Médicament, Universite de Montreal, Montreal H3C 3J7, Canada
    J Biol Chem 285:30708-18. 2010
    ....
  15. doi The IKK-related kinases: from innate immunity to oncogenesis
    Jean François Clément
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Cell Res 18:889-99. 2008
    ..This review will therefore summarize and discuss the role of TBK1 and IKKi in cellular transformation and oncogenesis by focusing on their regulation and substrate specificity...
  16. ncbi The interferon antiviral response: from viral invasion to evasion
    Nathalie Grandvaux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Curr Opin Infect Dis 15:259-67. 2002
    ....
  17. pmc Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5
    Nathalie Grandvaux
    CRCHUM Centre Hospitalier de l Université de Montréal, Montreal, Que, Canada
    J Innate Immun 6:650-62. 2014
    ..MDA5 plays a similar role during Sendai virus infection suggesting that this model is not restricted to RSV amongst paramyxoviruses...
  18. doi Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling
    Annie Bibeau-Poirier
    Faculte de Pharmacie, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, Quebec, Canada
    Cytokine 43:359-67. 2008
    ..More precisely, this review will discuss the most recent advances that address the role of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling...
  19. ncbi Signaling pathways involved in the cardioprotective effects of cannabinoids
    Philippe Lépicier
    Faculty of Pharmacy, Universite de Montreal, Canada
    J Pharmacol Sci 102:155-66. 2006
    ....
  20. doi GPR103b functions in the peripheral regulation of adipogenesis
    Mukandila Mulumba
    Faculty of Pharmacy, Université de Montréal Case Postale 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Mol Endocrinol 24:1615-25. 2010
    ..Furthermore, QRFP was bioactive in omental adipocytes from obese individuals, inhibiting ISO-induced lipolysis in these cells. Our results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis...
  21. ncbi Overlapping and distinct mechanisms regulating IRF-3 and IRF-7 function
    Marc J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Departments of Medicine, McGill University, Montreal, Canada
    J Interferon Cytokine Res 22:49-58. 2002
    ....
  22. ncbi Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis
    John Hiscott
    Lady Davis Institute for Medical Research, Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Canada H3T 1E2
    Ann N Y Acad Sci 1010:237-48. 2003
    ..We report that the IKK-related kinases-IKKepsilon/TBK-1-are components of VAK that mediate IRF-3 and IRF-7 phosphorylation and thus functionally link the NF-kappaB and IRF pathways in the development of the antiviral response...
  23. ncbi Multiple signaling pathways leading to the activation of interferon regulatory factor 3
    Marc J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute Jewish General Hospital, McGill University, 3755 Cote Ste, Catherine Montreal, Que, Canada
    Biochem Pharmacol 64:985-92. 2002
    ..This review summarizes recent observations in the identification of novel signaling pathways leading to IRF-3 activation...