Arend Bonen

Summary

Affiliation: University of Guelph
Country: Canada

Publications

  1. doi request reprint PGC-1alpha-induced improvements in skeletal muscle metabolism and insulin sensitivity
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 34:307-14. 2009
  2. ncbi request reprint A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism
    Arend Bonen
    Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Endocrinol Metab 292:E1740-9. 2007
  3. ncbi request reprint Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Tokyo, Japan
    Appl Physiol Nutr Metab 31:31-9. 2006
  4. ncbi request reprint Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: molecular, biochemical, and physiological evidence
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Physiology (Bethesda) 22:15-29. 2007
  5. ncbi request reprint Lipid metabolism, exercise and insulin action
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Essays Biochem 42:47-59. 2006
  6. pmc Rosiglitazone increases fatty acid oxidation and fatty acid translocase (FAT/CD36) but not carnitine palmitoyltransferase I in rat muscle mitochondria
    Carley R Benton
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 586:1755-66. 2008
  7. ncbi request reprint Regulation of fatty acid transport by fatty acid translocase/CD36
    Arend Bonen
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Proc Nutr Soc 63:245-9. 2004
  8. pmc FAT/CD36 expression is not ablated in spontaneously hypertensive rats
    Arend Bonen
    Department of Human Health and Nutritional Sciences University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    J Lipid Res 50:740-8. 2009
  9. doi request reprint Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R1202-12. 2009
  10. ncbi request reprint Tissue-specific and fatty acid transporter-specific changes in heart and soleus muscle over a 1-yr period
    Arend Bonen
    Department of Human Health and Nutritional Sciences University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Mol Cell Biochem 291:145-54. 2006

Detail Information

Publications99

  1. doi request reprint PGC-1alpha-induced improvements in skeletal muscle metabolism and insulin sensitivity
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 34:307-14. 2009
    ....
  2. ncbi request reprint A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism
    Arend Bonen
    Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Endocrinol Metab 292:E1740-9. 2007
    ..7-fold greater in WT compared with KO mice. In conclusion, the present studies demonstrate that FAT/CD36 has a critical role in regulating fatty acid esterification and oxidation, particularly during stimulation with insulin or AICAR...
  3. ncbi request reprint Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Tokyo, Japan
    Appl Physiol Nutr Metab 31:31-9. 2006
    ....
  4. ncbi request reprint Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: molecular, biochemical, and physiological evidence
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Physiology (Bethesda) 22:15-29. 2007
  5. ncbi request reprint Lipid metabolism, exercise and insulin action
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Essays Biochem 42:47-59. 2006
    ..Accumulation of excess intramyocellular lipid can be avoided by exercise, which improves the capacity for fatty acid oxidation...
  6. pmc Rosiglitazone increases fatty acid oxidation and fatty acid translocase (FAT/CD36) but not carnitine palmitoyltransferase I in rat muscle mitochondria
    Carley R Benton
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 586:1755-66. 2008
    ..Moreover, these studies identify for the first time a mechanism by which rosiglitazone stimulates fatty acid oxidation in skeletal muscle, namely the chronic, subcellular relocation of FAT/CD36 to mitochondria...
  7. ncbi request reprint Regulation of fatty acid transport by fatty acid translocase/CD36
    Arend Bonen
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Proc Nutr Soc 63:245-9. 2004
    ..Clearly, FAT/CD36 has an important role in FA homeostasis in skeletal muscle and the heart...
  8. pmc FAT/CD36 expression is not ablated in spontaneously hypertensive rats
    Arend Bonen
    Department of Human Health and Nutritional Sciences University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    J Lipid Res 50:740-8. 2009
    ..In conclusion, SHRs (North American strain) are not a natural FAT/CD36 null model, the North American strain of SHR express FAT/CD36, albeit at reduced levels...
  9. doi request reprint Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R1202-12. 2009
    ..Upregulation of fatty acid transport increased red muscle, but not cardiac, triacylglycerol accumulation. White muscle lipid metabolism dysregulation was not observed...
  10. ncbi request reprint Tissue-specific and fatty acid transporter-specific changes in heart and soleus muscle over a 1-yr period
    Arend Bonen
    Department of Human Health and Nutritional Sciences University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Mol Cell Biochem 291:145-54. 2006
    ..We speculate that the rapid upregulation of fatty acid transport rates in heart and muscle are needed to support the increased rates of fatty oxidation that have been previously observed in these tissues...
  11. doi request reprint FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle
    Graham P Holloway
    1Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R960-7. 2009
    ..Nevertheless, the KO animals reveal that FAT/CD36 contributes to the regulation of mitochondrial fatty acid oxidation, which is especially important for meeting the increased metabolic demands during muscle contraction...
  12. pmc Compensatory increases in nuclear PGC1alpha protein are primarily associated with subsarcolemmal mitochondrial adaptations in ZDF rats
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Diabetes 59:819-28. 2010
    ....
  13. pmc Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada
    J Physiol 571:201-10. 2006
    ..We further suggest that decreased CPTI M-CoA sensitivity and increased mitochondrial FAT/CD36 protein are both important for increasing whole body fatty acid oxidation during prolonged exercise...
  14. doi request reprint In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 296:E738-47. 2009
    ..The additional fatty acid taken up is channeled primarily to esterification, suggesting that upregulation in fatty acid transport as opposed to altered fatty acid oxidation is the major determinant of intramuscular lipid accumulation...
  15. pmc The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis
    Brendon J Gurd
    Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    J Physiol 587:1817-28. 2009
    ..Taken altogether these experiments are not consistent with the notion that SIRT1 protein plays an obligatory regulatory role in the process of PGC-1alpha-mediated mitochondrial biogenesis in mammalian muscle...
  16. ncbi request reprint Insulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm
    Adrian Chabowski
    Department of Human Biology and Nutritional Sciences, University of Guelph, ON N1G 2W1, Canada
    Am J Physiol Endocrinol Metab 287:E781-9. 2004
    ..The present studies have shown that insulin regulates protein expression of FAT/CD36, but not FABPpm, via the PI 3-kinase/Akt insulin-signaling pathway...
  17. pmc Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada, N1G 2W1
    J Physiol 582:393-405. 2007
    ....
  18. ncbi request reprint Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of ZDF rats
    Adrian Chabowski
    Dept of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Am J Physiol Endocrinol Metab 291:E675-82. 2006
    ....
  19. ncbi request reprint Inverse relationship between PGC-1alpha protein expression and triacylglycerol accumulation in rodent skeletal muscle
    Carley R Benton
    Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada
    J Appl Physiol (1985) 100:377-83. 2006
    ..Therefore, we speculate that the intramuscular lipid sensing may be involved in regulating the protein expression of PGC-1alpha in skeletal muscle...
  20. doi request reprint PGC-1alpha increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4
    Carley R Benton
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Physiol Genomics 35:45-54. 2008
    ..Thus, MCT1 and CD147 belong to the family of metabolic genes whose expression is regulated by PGC-1alpha in skeletal muscle...
  21. doi request reprint Restoring AS160 phosphorylation rescues skeletal muscle insulin resistance and fatty acid oxidation while not reducing intramuscular lipids
    Hakam Alkhateeb
    Dept of Human Health and Nutritional Sciences, Univ of Guelph, Guelph, ON, N1G 2W1, Canada
    Am J Physiol Endocrinol Metab 297:E1056-66. 2009
    ....
  22. ncbi request reprint Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    Arend Bonen
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    FASEB J 18:1144-6. 2004
    ....
  23. pmc Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle
    Swati S Jain
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    FEBS Lett 586:2428-35. 2012
    ..Hence, Munc18c provides stimulus-specific regulation of GLUT4 trafficking, but not FA transporter trafficking...
  24. ncbi request reprint Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd, Guelph, Ontario, Canada N1G2W1
    Am J Physiol Endocrinol Metab 292:E1782-9. 2007
    ..In addition, it appears that mitochondrial FAT/CD36 may be involved in regulating fatty acid oxidation in human skeletal muscle...
  25. ncbi request reprint Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts
    Adrian Chabowski
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Mol Cell Biochem 288:201-12. 2006
    ..Thus, activation of AMPK is a key mechanism regulating the expression as well as the plasmalemmal localization of fatty acid transporters...
  26. ncbi request reprint Metabolic challenges reveal impaired fatty acid metabolism and translocation of FAT/CD36 but not FABPpm in obese Zucker rat muscle
    Xiao Xia Han
    Dept of Human Health and Nutritional Sciences, Univ of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Endocrinol Metab 293:E566-75. 2007
    ..Finally, 4) there is no evidence that plasmalemmal fatty acid transporters contribute to the channeling of fatty acids to specific metabolic destinations within the muscle...
  27. ncbi request reprint The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR
    Adrian Chabowski
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ont, Canada
    FEBS Lett 579:2428-32. 2005
    ....
  28. pmc Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal muscle
    James G Nickerson
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 284:16522-30. 2009
    ..In vivo, FAT/CD36 and FATP4 are the most effective fatty acid transporters, whereas FABPpm and FAT/CD36 are key for stimulating fatty acid oxidation...
  29. doi request reprint Exercise training increases sarcolemmal and mitochondrial fatty acid transport proteins in human skeletal muscle
    Jason L Talanian
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 299:E180-8. 2010
    ..These results suggest that increases in skeletal muscle fatty acid oxidation following training are related in part to changes in fatty acid transport protein content and localization...
  30. ncbi request reprint A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria
    Shannon E Campbell
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 279:36235-41. 2004
    ....
  31. doi request reprint PGC-1alpha's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1alpha and PGC-1beta protein
    Graham P Holloway
    Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 294:E1060-9. 2008
    ..Also, it does not appear that alterations in the proteins associated with mitochondrial network formation and degradation can account for the observed decrease in mitochondrial content...
  32. doi request reprint Decreasing intramuscular phosphagen content simultaneously increases plasma membrane FAT/CD36 and GLUT4 transporter abundance
    Kristin E Pandke
    Dept of Human Health and Nutritional Sciences, Univ of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 295:R806-13. 2008
    ..Thus the content of sarcolemmal transporters for both of the major energy substrates for muscle increased in response to a reduced energy charge. Increased phosphorylation of AMPK may be one of the triggers for this response...
  33. doi request reprint Oral administration of a PPAR-delta agonist to rodents worsens, not improves, maximal insulin-stimulated glucose transport in skeletal muscle of different fibers
    Justin Cresser
    Dept of Human Health and Nutritional Sciences, Univ of Guelph, Ontario, Canada, N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 299:R470-9. 2010
    ..However, an accumulation of diacylglycerol and ceramide, while associated with diet-induced insulin resistance, does not appear to be responsible for the agonist-induced reduction in insulin-stimulated glucose transport...
  34. ncbi request reprint Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation
    Veronic Bezaire
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 290:E509-15. 2006
    ....
  35. pmc In vivo, fatty acid translocase (CD36) critically regulates skeletal muscle fuel selection, exercise performance, and training-induced adaptation of fatty acid oxidation
    Jay T McFarlan
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 287:23502-16. 2012
    ..Thus, sarcolemmal CD36 has a key role in muscle fuel selection, exercise performance, and training-induced muscle FAO adaptation, challenging long held views of mechanisms involved in acute and adaptive regulation of muscle FAO...
  36. pmc Testosterone increases lactate transport, monocarboxylate transporter (MCT) 1 and MCT4 in rat skeletal muscle
    Taisuke Enoki
    Department of Life Sciences, College of Arts and Sciences, University of Tokyo, Komaba 3 8 1, Meguro ku, Tokyo 153, Japan
    J Physiol 577:433-43. 2006
    ....
  37. pmc In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidation
    Graham P Holloway
    Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada
    J Physiol 589:169-80. 2011
    ..Rather, increased sarcolemmal LCFA transport proteins and rates of LCFA transport result in a greater number of lipid droplets within cardiac muscle...
  38. ncbi request reprint Regulation of fatty acid transport and membrane transporters in health and disease
    Arend Bonen
    Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada
    Mol Cell Biochem 239:181-92. 2002
    ....
  39. ncbi request reprint Protein-mediated fatty acid uptake: regulation by contraction, AMP-activated protein kinase, and endocrine signals
    James G Nickerson
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 32:865-73. 2007
    ..Finally, studies in FAT/CD36 null mice indicate that this transporter has a key role in regulating fatty acid metabolism in muscle...
  40. pmc Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle
    Yuko Yoshida
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 582:1317-35. 2007
    ..e. an intracellular lactate shuttle) does not occur within the matrix in either IMF or SS mitochondria obtained from red or white rat skeletal muscle, because of the very limited quantity of LDH within mitochondria...
  41. doi request reprint Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats
    Kerry L Mullen
    Department of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada, N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 296:R243-51. 2009
    ....
  42. doi request reprint Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Clin Nutr 89:455S-62S. 2009
    ..These findings imply that obese individuals would benefit from interventions that increase the skeletal muscle mitochondrial content and the potential for oxidizing FAs...
  43. doi request reprint Rapid exercise-induced changes in PGC-1alpha mRNA and protein in human skeletal muscle
    Anila S Mathai
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Appl Physiol (1985) 105:1098-105. 2008
    ..The beta-isoform declined rather than increasing, and this was greater when glycogen was not resynthesized to rest levels...
  44. doi request reprint High-intensity aerobic interval training increases fat and carbohydrate metabolic capacities in human skeletal muscle
    Christopher G R Perry
    Department of Human Health and Nutritional Sciences, University of Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 33:1112-23. 2008
    ..week-1) is a powerful method to increase whole-body and skeletal muscle capacities to oxidize fat and carbohydrate in previously untrained individuals...
  45. ncbi request reprint Chronic leptin administration decreases fatty acid uptake and fatty acid transporters in rat skeletal muscle
    Gregory R Steinberg
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 277:8854-60. 2002
    ..88, p < 0.01) and plasma membrane FABPpm protein (r = 0.94, p < 0.01). These studies provide the first evidence that protein-mediated long chain fatty acid transport is subject to long term regulation by leptin...
  46. ncbi request reprint Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats
    Gregory R Steinberg
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1
    Am J Physiol Endocrinol Metab 282:E593-600. 2002
    ..e., carnitine palmitoyltransferase I regulation) or electron transport uncoupling (i.e., uncoupling protein-3 expression)...
  47. doi request reprint Additive effects of insulin and muscle contraction on fatty acid transport and fatty acid transporters, FAT/CD36, FABPpm, FATP1, 4 and 6
    Swati S Jain
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    FEBS Lett 583:2294-300. 2009
    ..Insulin and muscle contraction increased plasmalemmal FAT/CD36, FABPpm, FATP1, and FATP4, but not FATP6. Only FAT/CD36 and FATP1 were stimulated in an additive manner by insulin and by muscle contraction...
  48. ncbi request reprint T3 increases lactate transport and the expression of MCT4, but not MCT1, in rat skeletal muscle
    Yuxiang Wang
    Department of Kinesiology, University of Waterloo, Ontario, Canada
    Am J Physiol Endocrinol Metab 285:E622-8. 2003
    ..This latter effect is difficult to explain by the modest changes in plasmalemmal MCT4. We speculate that either the activity of sarcolemmal MCTs has been altered or else other MCTs in muscle may have been upregulated...
  49. ncbi request reprint Relationship between skeletal muscle MCT1 and accumulated exercise during voluntary wheel running
    Yuko Yoshida
    Department of Sports Sciences, University of Tokyo, Komaba 3 8 1, Meguro ku, Tokyo 153 8902, Japan
    J Appl Physiol (1985) 97:527-34. 2004
    ..These studies have shown that mild exercise training fails to increase MCT4 and that changes in MCT1 are complex, depending not only the accumulated exercise but also on the stage of training...
  50. ncbi request reprint Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia
    Angela C Smith
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Endocrinol Metab 293:E172-81. 2007
    ..Thus reduction of skeletal muscle FAT/CD36 and content of ceramide and DAG may be important mechanisms by which exercise training blunts the progression of diet-induced insulin resistance in skeletal muscle...
  51. doi request reprint Fatty acid transport proteins chronically relocate to the transverse-tubules in muscle from obese Zucker rats but are resistant to further insulin-induced translocation
    Leslie E Stefanyk
    Department of Human Health and Nutritional Science, University of Guelph, Guelph, ON, Canada, N1G 2W1
    Metabolism 62:1296-304. 2013
    ..Furthermore, it is not known whether the insulin-stimulated translocation of the various FA transport proteins to the t-tubules is impaired in insulin resistance...
  52. pmc Exercise- and training-induced upregulation of skeletal muscle fatty acid oxidation are not solely dependent on mitochondrial machinery and biogenesis
    Yuko Yoshida
    A Bonen University of Guelph, Human Health and Nutritional Sciences, Gordon St Bldg 70, Guelph, ON, Canada, N1G 2W1
    J Physiol 591:4415-26. 2013
    ..This CD36 molecular mechanism challenges the view that skeletal muscle FAO is solely regulated by muscle mitochondrial content and machinery...
  53. doi request reprint Recovered insulin response by 2 weeks of leptin administration in high-fat fed rats is associated with restored AS160 activation and decreased reactive lipid accumulation
    Leslie E Stefanyk
    Dept of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada, N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 301:R159-71. 2011
    ....
  54. ncbi request reprint Activation of the A1 adenosine receptor increases insulin-stimulated glucose transport in isolated rat soleus muscle
    Farah S L Thong
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Appl Physiol Nutr Metab 32:701-10. 2007
    ..This effect is limited to increasing insulin sensitivity, but not to either basal or maximal insulin-stimulated glucose uptake in rat soleus muscle...
  55. doi request reprint Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoids
    Anna M D'souza
    Muscle Health Research Center and Physical Activity and Chronic Disease Unit, School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 302:G850-63. 2012
    ..Thus a HFD dramatically exacerbates the development of NAFLD and characteristics of the metabolic syndrome in conditions of chronically elevated Cort...
  56. doi request reprint Acute endurance exercise increases plasma membrane fatty acid transport proteins in rat and human skeletal muscle
    Nicolette S Bradley
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 302:E183-9. 2012
    ..This study is also the first to demonstrate that endurance cycling induces an increase in plasma membrane FAT/CD36 and FABPpm content in human skeletal muscle, which is predicted to increase fatty acid transport...
  57. doi request reprint Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada, N1G 2W1
    Diabetologia 58:2381-91. 2015
    ....
  58. doi request reprint Fatty acid transport and transporters in muscle are critically regulated by Akt2
    Swati S Jain
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    FEBS Lett 589:2769-75. 2015
    ..Instead, Akt2 mediates intracellular retention of both latter transporters. Collectively, our observations reveal novel complexities in signaling mechanisms regulating the translocation of fatty acid transporters in muscle. ..
  59. ncbi request reprint A dual mechanism of action for skeletal muscle FAT/CD36 during exercise
    Brennan K Smith
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Exerc Sport Sci Rev 40:211-7. 2012
    ..Specifically, fatty acid translocase/CD36 seems to have a novel dual mechanism of action with regard to fatty acid oxidation during exercise, influencing transport of lipids across the sarcolemmal membrane and into the mitochondria...
  60. doi request reprint Insulin and contraction-induced movement of fatty acid transport proteins to skeletal muscle transverse-tubules is distinctly different than to the sarcolemma
    Leslie E Stefanyk
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
    Metabolism 61:1518-22. 2012
    ..FATP1, a variable and unresponsive protein on the sarcolemma, appears to reside primarily in the t-tubules where it is responsive to stimuli...
  61. ncbi request reprint Viability of the isolated soleus muscle during long-term incubation
    Hakam Alkhateeb
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 31:467-76. 2006
    ..This provides for opportunities to examine muscle metabolic function under very highly controlled conditions...
  62. ncbi request reprint Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women
    Jason L Talanian
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Appl Physiol (1985) 102:1439-47. 2007
    ..In summary, seven sessions of HIIT over 2 wk induced marked increases in whole body and skeletal muscle capacity for fatty acid oxidation during exercise in moderately active women...
  63. ncbi request reprint Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining
    Kirsten A Burgomaster
    Exercise Metabolism Research Group, Dept of Kinesiology, McMaster Univ, Hamilton, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 292:R1970-6. 2007
    ..05). We conclude that short-term SIT induces rapid increases in skeletal muscle oxidative capacity but has divergent effects on proteins associated with glucose, lactate, and fatty acid transport...
  64. ncbi request reprint Exercise training alleviates MCT1 and MCT4 reductions in heart and skeletal muscles of STZ-induced diabetic rats
    Taisuke Enoki
    Department of Sports Sciences, College of Arts and Sciences, University of Tokyo, Tokyo 153 8902, Japan
    J Appl Physiol (1985) 94:2433-8. 2003
    ..05)]. These studies have shown that 1) with STZ-induced diabetes, MCT1 and MCT4 are reduced in skeletal muscle and/or the heart and 2) exercise training alleviated these diabetes-induced reductions...
  65. ncbi request reprint Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity
    Hakam Alkhateeb
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
    Am J Physiol Endocrinol Metab 293:E783-93. 2007
    ....
  66. pmc The development of a metabolic disease phenotype in CTP:phosphoethanolamine cytidylyltransferase-deficient mice
    Morgan D Fullerton
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 284:25704-13. 2009
    ....
  67. doi request reprint A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle
    Jonathan D Schertzer
    Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Endocrinology 150:1935-40. 2009
    ....
  68. doi request reprint FAT/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation
    Brennan K Smith
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
    Biochem J 437:125-34. 2011
    ..We further support this model by providing evidence that FAT/CD36 is not located in mitochondrial contact sites, and therefore does not directly interact with carnitine palmitoyltransferase-I as original proposed...
  69. doi request reprint Seasonal upregulation of fatty acid transporters in flight muscles of migratory white-throated sparrows (Zonotrichia albicollis)
    Jay T McFarlan
    Department of Biology, University of Western Ontario, London, ON, Canada
    J Exp Biol 212:2934-40. 2009
    ..These results support the hypothesis that enhanced protein-mediated transport of fatty acids from the circulation into muscle is a key component of the changes in muscle biochemistry required for migration in birds...
  70. ncbi request reprint Sarcolemmal FAT/CD36 in human skeletal muscle colocalizes with caveolin-3 and is more abundant in type 1 than in type 2 fibers
    Bodil Vistisen
    Copenhagen Muscle Research Centre, Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 45:603-9. 2004
    ..Furthermore, we provide evidence that FAT/CD36 expression is significantly higher in type 1 compared with type 2 fibers, whereas caveolin-3 expression is significantly higher in type 2 fibers than in type 1 fibers...
  71. ncbi request reprint Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36
    Joost J F P Luiken
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Diabetes 51:3113-9. 2002
    ..In conclusion, we have demonstrated a novel role of insulin in cardiac FA utilization. Malfunctioning of insulin-induced FAT/CD36 translocation may be involved in the development of type 2 diabetic cardiomyopathies...
  72. ncbi request reprint Changes in fatty acid transport and transporters are related to the severity of insulin deficiency
    Joost J F P Luiken
    Department of Kinesiology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Am J Physiol Endocrinol Metab 283:E612-21. 2002
    ....
  73. pmc Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice
    Tahar Hajri
    Department of Physiology and Biophysics, State University of New York at Stony Brook, New York 11794 8661, USA
    J Clin Invest 109:1381-9. 2002
    ..In humans, CD36 deficiency may be an important factor in the metabolic adaptation to diet and in susceptibility to some forms of diet-induced pathology...
  74. ncbi request reprint Exercise and insulin increase muscle fatty acid uptake by recruiting putative fatty acid transporters to the sarcolemma
    Jan F C Glatz
    Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 5:365-70. 2002
    ..The focus of this review is to describe newly obtained insights on the recruitment of fatty acid transporters and their malfunctioning in diabetes...
  75. ncbi request reprint Insulin induces the translocation of the fatty acid transporter FAT/CD36 to the plasma membrane
    Joost J F P Luiken
    Department of Physiology, Maastricht University, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 282:E491-5. 2002
    ..This reveals a previously unknown level of regulation of fatty acid transport by insulin and may well have important consequences in furthering our understanding of the relation between fatty acid metabolism and insulin resistance...
  76. ncbi request reprint Muscle contraction increases lactate transport while reducing sarcolemmal MCT4, but not MCT1
    Mio Tonouchi
    Department of Kinesiology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Am J Physiol Endocrinol Metab 282:E1062-9. 2002
    ....
  77. ncbi request reprint Exercise training increases lipid metabolism gene expression in human skeletal muscle
    Rebecca J Tunstall
    School of Health Sciences, Deakin University, Burwood, Victoria 3125, Australia
    Am J Physiol Endocrinol Metab 283:E66-72. 2002
    ..We conclude that enhanced fat oxidation after exercise training is most closely associated with the genes involved in regulating FA uptake across the plasma membrane (FAT/CD36) and across the mitochondrial membrane (CPT I)...
  78. pmc Differential effects of contraction and PPAR agonists on the expression of fatty acid transporters in rat skeletal muscle
    Carley R Benton
    Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada N2L 2W1
    J Physiol 573:199-210. 2006
    ....
  79. ncbi request reprint Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake
    Susan L M Coort
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 239:213-9. 2002
    ....
  80. ncbi request reprint Enhanced sarcolemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats
    Susan L M Coort
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, NL 6200 Maastricht, Netherlands
    Diabetes 53:1655-63. 2004
    ....
  81. ncbi request reprint Monocarboxylate transporters in subsarcolemmal and intermyofibrillar mitochondria
    Carley R Benton
    Department of Kinesiology, University of Waterloo, Waterloo, Ont, Canada N2L 3G1
    Biochem Biophys Res Commun 323:249-53. 2004
    ..Thus, the controversy as to whether mitochondria can take up and oxidize lactate will need to take account of the different distribution of MCTs between SS and IMF mitochondria...
  82. ncbi request reprint Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats
    Peipei Wang
    Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Am J Physiol Heart Circ Physiol 288:H2102-10. 2005
    ....
  83. ncbi request reprint Leptin, skeletal muscle lipids, and lipid-induced insulin resistance
    John J Dube
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Physiol Regul Integr Comp Physiol 293:R642-50. 2007
    ..Furthermore, insulin resistance induced by an acute lipid infusion is prevented by HL...
  84. ncbi request reprint Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
    Debby P Y Koonen
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, NL 6200 MD Maastricht, The Netherlands
    Biochim Biophys Acta 1736:163-80. 2005
    ..Hence, FAT/CD36 might provide a useful therapeutic target for the prevention or treatment of insulin resistance...
  85. ncbi request reprint Hypoxia-induced fatty acid transporter translocation increases fatty acid transport and contributes to lipid accumulation in the heart
    Adrian Chabowski
    Department of Physiology, Medical University of Bialystok, ul Mickiewicza 2c, 15 089 Bialystok, Poland
    FEBS Lett 580:3617-23. 2006
    ....
  86. ncbi request reprint AMPK-mediated increase in myocardial long-chain fatty acid uptake critically depends on sarcolemmal CD36
    Daphna D J Habets
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochem Biophys Res Commun 355:204-10. 2007
    ..CD36 is almost entirely responsible for AMPK-mediated stimulation of LCFA uptake in cardiomyocytes, indicating a pivotal role for CD36 in mediating changes in cardiac LCFA fluxes...
  87. pmc Cardiac substrate uptake and metabolism in obesity and type-2 diabetes: role of sarcolemmal substrate transporters
    Susan L M Coort
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 299:5-18. 2007
    ..These novel insights may result in new strategies for the prevention of development of cardiac dysfunction and insulin resistance in obesity and T2DM...
  88. ncbi request reprint Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria
    Carley R Benton
    Departments of Kinesiology and Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    J Biol Chem 283:4228-40. 2008
    ....
  89. doi request reprint Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4
    Masja M van Oort
    Division of Endocrinology and Metabolism, Department of Biology and Institute of Biomembranes, Utrecht University, NL 3584 CH Utrecht, The Netherlands
    Biochim Biophys Acta 1781:61-71. 2008
    ..Taken together, this study is the first to present morphological evidence for CD36 translocation, and shows this process to resemble GLUT4 translocation...
  90. ncbi request reprint Different mechanisms can alter fatty acid transport when muscle contractile activity is chronically altered
    Debby P Y Koonen
    Department of Molecular Genetics, Cardiovascular Reseasrch Institute Maastricht, Maastricht University, The Netherlands
    Am J Physiol Endocrinol Metab 286:E1042-9. 2004
    ....
  91. ncbi request reprint A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle
    David Cameron-Smith
    School of Health Sciences, Deakin University, Burwood, Victoria, Australia
    Am J Clin Nutr 77:313-8. 2003
    ..Dietary fatty acids may be important in regulating gene expression. However, little is known about the effect of changes in dietary fatty acids on gene regulation in human skeletal muscle...
  92. ncbi request reprint Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling
    Joost J F P Luiken
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Diabetes 52:1627-34. 2003
    ..We conclude that AMP kinase regulates cardiac FA use through mobilization of FAT/CD36 from a contraction-inducible intracellular storage compartment...
  93. ncbi request reprint Aerobic conditioning effects on substrate responses during graded cycling in pregnancy
    Larry A Wolfe
    School of Physical and Health Education, Department of Physiology, Queen s University, Kingston, ON K7L 3N6, Canada
    Can J Physiol Pharmacol 81:696-703. 2003
    ..These findings support our original experimental hypothesis that aerobic conditioning prevents exercise-induced hypoglycemia and preserves the ability to utilize carbohydrate and produce lactate during heavy exercise in late gestation...
  94. ncbi request reprint A null mutation in H-FABP only partially inhibits skeletal muscle fatty acid metabolism
    Bert Binas
    Deptartment of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843, USA
    Am J Physiol Endocrinol Metab 285:E481-9. 2003
    ..The substantial increase in FA metabolism in contracting H-FABP-null muscle may indicate that other FABPs are also present, a possibility that we were not able to completely eliminate...
  95. ncbi request reprint Palmitate movement across red and white muscle membranes of rainbow trout
    Jeff G Richards
    Department of Zoology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Am J Physiol Regul Integr Comp Physiol 286:R46-53. 2004
    ..Five days of aerobic swimming at approximately 2 body lengths/s and 9 days of chronic cortisol elevation in vivo, both of which stimulate lipid metabolism, had no effect on the rate of palmitate movement in red or white muscle vesicles...
  96. ncbi request reprint Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status
    Clinton R Bruce
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    J Clin Endocrinol Metab 88:5444-51. 2003
    ..Furthermore, skeletal muscle oxidative capacity was a better predictor of insulin sensitivity than either TG(m) concentration or long-chain fatty acyl CoA content...
  97. ncbi request reprint Overexpression of membrane-associated fatty acid binding protein (FABPpm) in vivo increases fatty acid sarcolemmal transport and metabolism
    David C Clarke
    Department of Kinesiology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Physiol Genomics 17:31-7. 2004
    ..This suggests that other mechanisms are required to realize the full potential offered by FABPpm overexpression...
  98. ncbi request reprint Sarcolemmal fatty acid transport in normal and diseased hearts
    Jan F C Glatz
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Curr Hypertens Rep 9:450-4. 2007
    ..As a result, membrane fatty acid transporters are now regarded as a promising therapeutic target to rectify abnormalities in cardiac fatty acid use in chronic cardiac disease...
  99. ncbi request reprint Regulation of sarcolemmal transport of substrates in the healthy and diseased heart
    Jan F C Glatz
    Dept of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Cardiovasc Drugs Ther 20:471-6. 2006
    ..g., diabetic cardiomyopathy). Cardiac substrate preference is regulated not only at the level of mitochondrial oxidation (Randle cycle) but also at the level of sarcolemmal uptake of substrates...