Jack H Jhamandas

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi Galanin attenuates beta-amyloid (Abeta) toxicity in rat cholinergic basal forebrain neurons
    Xiling Ding
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Neurobiol Dis 21:413-20. 2006
  2. ncbi Role of amylin and its receptors in neurodegeneration
    Wen Fu
    Division of Neurology, Department of Medicine, Centre for Neuroscience, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Curr Protein Pept Sci 14:338-45. 2013
  3. pmc Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation
    Jack H Jhamandas
    Division of Neurology, Department of Medicine, Centre for Neuroscience, University of Alberta Edmonton, AB, Canada
    Front Endocrinol (Lausanne) 4:8. 2013
  4. ncbi Novel excitatory actions of galanin on rat cholinergic basal forebrain neurons: implications for its role in Alzheimer's disease
    Jack H Jhamandas
    Division of Neurology, Department of Medicine, University of Alberta, 530 Heritage Medical Research Centre, Edmonton, Alberta T6G 2S2, Canada
    J Neurophysiol 87:696-704. 2002
  5. ncbi Neuropeptide FF and neuropeptide VF inhibit GABAergic neurotransmission in parvocellular neurons of the rat hypothalamic paraventricular nucleus
    Jack H Jhamandas
    Heritage Medical Research Centre, Dept of Medicine Neurology, Univ of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Regul Integr Comp Physiol 292:R1872-80. 2007
  6. ncbi Fucoidan inhibits cellular and neurotoxic effects of beta-amyloid (A beta) in rat cholinergic basal forebrain neurons
    Jack H Jhamandas
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Eur J Neurosci 21:2649-59. 2005
  7. ncbi Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons
    Jack H Jhamandas
    Division of Neurology, Department of Medicine, Centre for Alzheimer and Neurodegenerative Research, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Neurosci 24:5579-84. 2004
  8. pmc Actions of β-amyloid protein on human neurons are expressed through the amylin receptor
    Jack H Jhamandas
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    Am J Pathol 178:140-9. 2011
  9. ncbi Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects
    Jack H Jhamandas
    Department of Medicine Neurology and Centre for Alzheimer and Neurodegenerative Research, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Neurophysiol 89:2923-30. 2003
  10. doi β-Amyloid protein (Aβ) and human amylin regulation of apoptotic genes occurs through the amylin receptor
    Jack H Jhamandas
    Division of Neurology, Department of Medicine, Centres for Neuroscience and for Prions and Protein Folding Diseases, University of Alberta, Heritage Medical Research Centre, Edmonton, AB, Canada
    Apoptosis 17:37-47. 2012

Collaborators

Detail Information

Publications44

  1. ncbi Galanin attenuates beta-amyloid (Abeta) toxicity in rat cholinergic basal forebrain neurons
    Xiling Ding
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Neurobiol Dis 21:413-20. 2006
    ..Galanin also attenuated cleavage of caspases-3 and -9 following exposure to Abeta. These findings support a neuroprotective role for galanin and may have implications for development of compounds based on this peptide to treat AD...
  2. ncbi Role of amylin and its receptors in neurodegeneration
    Wen Fu
    Division of Neurology, Department of Medicine, Centre for Neuroscience, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Curr Protein Pept Sci 14:338-45. 2013
    ..Developing therapeutic strategies aimed at modulating amylin receptor function may prove useful for treatment of neurodegenerative diseases such as Alzheimer's disease. ..
  3. pmc Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation
    Jack H Jhamandas
    Division of Neurology, Department of Medicine, Centre for Neuroscience, University of Alberta Edmonton, AB, Canada
    Front Endocrinol (Lausanne) 4:8. 2013
    ..Finally, the presence of NPFF system in the human brain and its alterations within the hypertensive brain are discussed...
  4. ncbi Novel excitatory actions of galanin on rat cholinergic basal forebrain neurons: implications for its role in Alzheimer's disease
    Jack H Jhamandas
    Division of Neurology, Department of Medicine, University of Alberta, 530 Heritage Medical Research Centre, Edmonton, Alberta T6G 2S2, Canada
    J Neurophysiol 87:696-704. 2002
    ..This action might serve to delay the progression of AD pathology linked to a reduction in central cholinergic tone...
  5. ncbi Neuropeptide FF and neuropeptide VF inhibit GABAergic neurotransmission in parvocellular neurons of the rat hypothalamic paraventricular nucleus
    Jack H Jhamandas
    Heritage Medical Research Centre, Dept of Medicine Neurology, Univ of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Regul Integr Comp Physiol 292:R1872-80. 2007
    ....
  6. ncbi Fucoidan inhibits cellular and neurotoxic effects of beta-amyloid (A beta) in rat cholinergic basal forebrain neurons
    Jack H Jhamandas
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Eur J Neurosci 21:2649-59. 2005
    ..These results show that Fucoidan is able to block A beta-induced reduction in whole-cell currents in basal forebrain neurons and has neuroprotective effects against A beta-induced neurotoxicity in basal forebrain neuronal cultures...
  7. ncbi Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons
    Jack H Jhamandas
    Division of Neurology, Department of Medicine, Centre for Alzheimer and Neurodegenerative Research, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Neurosci 24:5579-84. 2004
    ..These data are the first to show that expression of Abeta toxicity may occur through the amylin receptor and suggest a novel therapeutic target for the treatment of AD...
  8. pmc Actions of β-amyloid protein on human neurons are expressed through the amylin receptor
    Jack H Jhamandas
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    Am J Pathol 178:140-9. 2011
    ....
  9. ncbi Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects
    Jack H Jhamandas
    Department of Medicine Neurology and Centre for Alzheimer and Neurodegenerative Research, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Neurophysiol 89:2923-30. 2003
    ..Furthermore, the two peptides may share a common mechanism of action. The ability of an amylin antagonist to block the responses evoked by hAmylin and A beta may provide a novel therapeutic approach for Alzheimer's disease...
  10. doi β-Amyloid protein (Aβ) and human amylin regulation of apoptotic genes occurs through the amylin receptor
    Jack H Jhamandas
    Division of Neurology, Department of Medicine, Centres for Neuroscience and for Prions and Protein Folding Diseases, University of Alberta, Heritage Medical Research Centre, Edmonton, AB, Canada
    Apoptosis 17:37-47. 2012
    ..These data allow us to identify key elements in the Aβ-induced apoptosis that are blocked by antagonism of the amylin receptor and further support the potential for amylin receptor blockade as a potential therapeutic avenue in AD...
  11. ncbi Neuropeptide FF (NPFF) control of magnocellular neurosecretory cells of the rat hypothalamic paraventricular nucleus (PVN)
    Jack H Jhamandas
    Department of Medicine Neurology and Centre for Neuroscience, University of Alberta, Edmonton, Alta, Canada T6G 2B7
    Peptides 27:973-9. 2006
    ..These findings provide a cellular and anatomic basis for the NPFF-induced inhibition of vasopressin release has been reported consequent to hypovolemia and hyperosmolar stimulation...
  12. ncbi New central projections of neuropeptide FF: colateral branching pathways in the brainstem and hypothalamus in the rat
    J H Jhamandas
    Division of Neurology, Department of Medicine, 530 Heritage Medical Research Centre, University of Alberta, Alta, T6G 2S2, Edmonton, Canada
    J Chem Neuroanat 21:171-9. 2001
    ..This coordinated signalling may lead to synchronized responses of NPFF target sites and provide insights into the role of this peptide in cardiovascular and nociceptive responses...
  13. ncbi Cellular mechanisms for amyloid beta-protein activation of rat cholinergic basal forebrain neurons
    J H Jhamandas
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Neurophysiol 86:1312-20. 2001
    ..These observations provide a cellular basis for the selectivity of Abeta neurotoxicity toward cholinergic basal forebrain neurons that are at the epicenter of AD pathology...
  14. ncbi Central administration of neuropeptide FF (NPFF) causes increased neuronal activation and up-regulation of NPFF gene expression in the rat brainstem
    Jack H Jhamandas
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Comp Neurol 447:300-7. 2002
    ..c.v. at the higher dose. The up-regulation of NPFF may play a homeostatic role in response to specific cardiovascular challenges, such as hypotension...
  15. doi Aβ inhibition of ionic conductance in mouse basal forebrain neurons is dependent upon the cellular prion protein PrPC
    Kwai Alier
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta T6G2S2, Canada
    J Neurosci 31:16292-7. 2011
    ..While prior studies give broad support for a neuroprotective function for PrP(C), our data define a latent pro-pathogenic role in the presence of amyloid assemblies...
  16. ncbi Beta-amyloid enhances intracellular calcium rises mediated by repeated activation of intracellular calcium stores and nicotinic receptors in acutely dissociated rat basal forebrain neurons
    James H Chin
    Department of Medicine, Division of Neurology, University of Alberta, 530 Heritage Medical Research Centre, Edmonton, AB, Canada T6G 2S2
    Brain Cell Biol 35:173-86. 2006
    ....
  17. doi Ionic mechanisms of action of prion protein fragment PrP(106-126) in rat basal forebrain neurons
    Kwai Alier
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
    J Neurosci Res 88:2217-27. 2010
    ..These findings suggest novel links between PrP signalling partners inferred from genetic experiments, K(+) channels, and PrP-mediated neurotoxicity...
  18. doi Prolactin-releasing peptide effects in the rat brain are mediated through the Neuropeptide FF receptor
    Li Ma
    Department of Medicine Neurology and Centre for Neuroscience, University of Alberta, Edmonton, AB, Canada
    Eur J Neurosci 30:1585-93. 2009
    ..These observations may assume clinical relevance as RF amide peptides such NPFF and PrRP become therapeutic targets for a variety of autonomically related disorders...
  19. ncbi Autonomic and neuroendocrine actions of adrenomedullin in the brain: mechanisms for homeostasis
    Jing Shan
    Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, T6G 2H7, Edmonton, AB, Canada
    Regul Pept 112:33-40. 2003
    ....
  20. ncbi Amyloid beta protein modulates glutamate-mediated neurotransmission in the rat basal forebrain: involvement of presynaptic neuronal nicotinic acetylcholine and metabotropic glutamate receptors
    James H Chin
    Department of Medicine Neurology and Center for Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Neurosci 27:9262-9. 2007
    ..These observations provide further insight into the mechanisms whereby Abeta affects synaptic function in the brain and may be relevant in the context of synaptic failure observed in AD...
  21. doi Distinct morphological and electrophysiological properties of an elk prion peptide
    John Paul Glaves
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Peptides 40:49-56. 2013
    ..In addition, the elk PrP(127-147) peptide is unique in its ability to enhance Thioflavin T fluorescence and its ability to modulate neuronal ion channel conductances...
  22. ncbi Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease
    Amir Afkhami-Goli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 179:5493-503. 2007
    ....
  23. ncbi Beta-amyloid peptide activates non-alpha7 nicotinic acetylcholine receptors in rat basal forebrain neurons
    Wen Fu
    Department of Medicine, Centre for Alzheimer and Neurodegenerative Research, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Neurophysiol 90:3130-6. 2003
    ..Thus non-alpha7 nAChRs may also represent a novel target in mediating the effects of Abeta in AD...
  24. ncbi Nociceptin/orphanin FQ modulation of ionic conductances in rat basal forebrain neurons
    J H Chin
    Department of Medicine Neurology, Centre for Neuroscience, University of Alberta, Edmonton, Canada
    J Pharmacol Exp Ther 303:188-95. 2002
    ....
  25. pmc The P's and Q's of cellular PrP-Aβ interactions
    David Westaway
    Department of Medicine Neurology, University of Alberta, Edmonton, AB Canada
    Prion 6:359-63. 2012
    ..16) Here we discuss confounds, consensus and conflict associated with parameters that apply to these experimental settings...
  26. pmc Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity
    Pornpun Vivithanaporn
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 5:e12856. 2010
    ..Herein, we investigate HCV infectivity and effects on neuronal survival and neuroinflammation in conjunction with HIV infection...
  27. ncbi Hypertensive rats exhibit heightened expression of corticotropin-releasing factor in activated central neurons in response to restraint stress
    T L Krukoff
    Department of Cell Biology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Brain Res Mol Brain Res 65:70-9. 1999
    ....
  28. ncbi Central administration of neuropeptide FF causes activation of oxytocin paraventricular hypothalamic neurones that project to the brainstem
    J H Jhamandas
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Neuroendocrinol 15:24-32. 2003
    ..Oxytocin released from terminals within the NTS oxytocin thus modulate the activity of ascending visceral autonomic pathways that synapse initially within the NTS...
  29. doi Role of calpain and caspase in beta-amyloid-induced cell death in rat primary septal cultured neurons
    Z Wei
    Department of Psychiatry, Alberta Centre for Prion and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada
    Neuropharmacology 54:721-33. 2008
    ..Additionally, evidence that inhibitors of caspase and calpains can partially protect the cultured basal forebrain neurons raised the possibility that their inhibitors could be of therapeutic relevance in the treatment of AD pathology...
  30. ncbi Activation by hypotension of neurons in the hypothalamic paraventricular nucleus that project to the brainstem
    T L Krukoff
    Department of Cell Biology and Anatomy, Faculty of Medicine, University of Alberta, Edmonton, Canada
    J Comp Neurol 385:285-96. 1997
    ..These results support the contention that descending projections from the PVN to the brainstem play an important role in the physiological response to decreases in arterial pressure and suggest that NO may participate in this response...
  31. doi Beta amyloid-induced depression of hippocampal long-term potentiation is mediated through the amylin receptor
    Ryoichi Kimura
    Department of Medicine, Hyogo College of Medicine, Nishinomiya, 663 8501 Hyogo, Japan
    J Neurosci 32:17401-6. 2012
    ..Amylin receptor antagonists could serve as potentially useful therapeutic agents in AD...
  32. pmc Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration
    David Vergote
    Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Proc Natl Acad Sci U S A 103:19182-7. 2006
    ..05) were prevented by a CXCR3 antagonist. These studies reveal additive neuropathogenic properties exerted by a proteolytically cleaved chemokine as consequences of a change in receptor specificity, culminating in neurodegeneration...
  33. doi Histamine induces the production of matrix metalloproteinase-9 in human astrocytic cultures via H1-receptor subtype
    Aarti Patel
    Division of Neurology, Department of Medicine, Institute of Neuroscience and Mental Health, 530 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, T6G 2S2, Canada
    Brain Struct Funct 221:1845-60. 2016
    ..Furthermore, MMP-9 appears to cleave soAβ into less toxic monomeric species. Given the key role of histamine in MMP-9 release, this neurotransmitter may serve as a potential therapeutic target for AD. ..
  34. pmc Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity
    Wen Fu
    From the Division of Neurology, Department of Medicine, Institute of Neuroscience and Mental Health, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 290:12504-13. 2015
    ..These studies shed light on the unique bioenergetic mechanisms within astrocytes that may contribute to the development of AD pathology. ..
  35. pmc Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways
    Wen Fu
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Biol Chem 287:18820-30. 2012
    ....
  36. doi Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain
    Aarti N Patel
    Division of Neurology, Department of Medicine, Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada
    Expert Rev Mol Med 14:e2. 2012
    ..Aβ interactions with other receptors such as the p75 neurotrophin receptors, which are highly expressed on cholinergic basal forebrain neurons lost in AD, are also highlighted...
  37. doi Role of astrocytic glycolytic metabolism in Alzheimer's disease pathogenesis
    Wen Fu
    Division of Neurology, Department of Medicine and Institute for Neuroscience and Mental Health, University of Alberta, Edmonton, AB, T6G 2S2, Canada
    Biogerontology 15:579-86. 2014
    ....
  38. ncbi Cardiovascular influences on rat parabrachial nucleus: an electrophysiological study
    J H Jhamandas
    Department of Medicine, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Am J Physiol 260:R225-31. 1991
    ..These findings also support the notion of a diversity of cardiovascular inputs to topographically segregated regions within the parabrachial nucleus...
  39. ncbi Single transmembrane domain insulin-like growth factor-II/mannose-6-phosphate receptor regulates central cholinergic function by activating a G-protein-sensitive, protein kinase C-dependent pathway
    Cheryl Hawkes
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3A 2B4, Canada
    J Neurosci 26:585-96. 2006
    ....
  40. doi Neuropeptide FF2 receptor distribution in the human brain. An immunohistochemical study
    Valeri Goncharuk
    Russian Cardiology Research Centre, 121552 Moscow, Russia
    Peptides 29:1544-53. 2008
    ..The distribution of hFF2 may help in identifying the role of amidated neuropeptides in the human brain within the context of central autonomic and neuroendocrine regulation...
  41. ncbi Distribution of the neuropeptide FF1 receptor (hFF1) in the human hypothalamus and surrounding basal forebrain structures: immunohistochemical study
    Valeri Goncharuk
    Russian Cardiology Research Centre, 121552 Moscow, Russia
    J Comp Neurol 474:487-503. 2004
    ..Localization of hFF1 in discrete regions of the hypothalamus and extended amygdala may provide important insights into the role of amidated neuropeptides in central autonomic and neuroendocrine control in the human brain...
  42. pmc RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia
    Frederic Simonin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 103:466-71. 2006
    ..Our data indicate that NPFF receptors are part of a bona fide antiopioid system and that selective antagonists of these receptors could represent useful therapeutic agents for improving the efficacy of opioids in chronic pain treatment...
  43. ncbi Neuropeptide FF distribution in the human and rat forebrain: a comparative immunohistochemical study
    Valeri D Goncharuk
    Russian Cardiology Research Center, 121552 Moscow, Russia
    J Comp Neurol 496:572-93. 2006
    ....