Nicholas Mrosovsky

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Diurnal mice (Mus musculus) and other examples of temporal niche switching
    N Mrosovsky
    Department of Zoology, University of Toronto, ON, M5S3G5, Canada
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 191:1011-24. 2005
  2. ncbi Responses to light after retinal degeneration
    N Mrosovsky
    Department of Zoology, University of Toronto, Ont, Canada
    Vision Res 40:575-8. 2000
  3. ncbi Further characterization of the phenotype of mCry1/mCry2-deficient mice
    N Mrosovsky
    Department of Zoology, University of Toronto, Ontario, Canada
    Chronobiol Int 18:613-25. 2001
  4. ncbi Cycle of period gene expression in a diurnal mammal (Spermophilus tridecemlineatus): implications for nonphotic phase shifting
    N Mrosovsky
    Department of Zoology, University of Toronto, Ontario, Canada
    J Biol Rhythms 16:471-8. 2001
  5. ncbi Masking in waved-2 mice: EGF receptor control of locomotion questioned
    N Mrosovsky
    Department of Zoology, University of Toronto, Toronto, Ontario, Canada
    Chronobiol Int 22:963-74. 2005
  6. ncbi Learned arbitrary responses to light in mice without rods or cones
    N Mrosovsky
    Department of Zoology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada
    Naturwissenschaften 89:525-7. 2002
  7. ncbi Contribution of classic photoreceptors to entrainment
    N Mrosovsky
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 189:69-73. 2003
  8. ncbi Aschoff's rule in retinally degenerate mice
    N Mrosovsky
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 189:75-8. 2003
  9. ncbi Beyond the suprachiasmatic nucleus
    N Mrosovsky
    Department of Zoology, University of Toronto, Toronto, Ontario, Canada
    Chronobiol Int 20:1-8. 2003
  10. ncbi Impaired masking responses to light in melanopsin-knockout mice
    N Mrosovsky
    Department of Zoology, University of Toronto, Toronto, Ontario, Canada
    Chronobiol Int 20:989-99. 2003

Detail Information

Publications33

  1. ncbi Diurnal mice (Mus musculus) and other examples of temporal niche switching
    N Mrosovsky
    Department of Zoology, University of Toronto, ON, M5S3G5, Canada
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 191:1011-24. 2005
    ..e. masking). An emerging theme from this review is the suggestion that retinal inputs have a greater role in switching than suspected previously...
  2. ncbi Responses to light after retinal degeneration
    N Mrosovsky
    Department of Zoology, University of Toronto, Ont, Canada
    Vision Res 40:575-8. 2000
    ..Enhanced inhibition of activity around twilight may be adaptive for mice in some circumstances and so help maintain genes for retinal degeneration in natural populations...
  3. ncbi Further characterization of the phenotype of mCry1/mCry2-deficient mice
    N Mrosovsky
    Department of Zoology, University of Toronto, Ontario, Canada
    Chronobiol Int 18:613-25. 2001
    ..One possible explanation of such predark activity is that some damped endogenous process is spared in mCry1/mCry2 double-knockout mice...
  4. ncbi Cycle of period gene expression in a diurnal mammal (Spermophilus tridecemlineatus): implications for nonphotic phase shifting
    N Mrosovsky
    Department of Zoology, University of Toronto, Ontario, Canada
    J Biol Rhythms 16:471-8. 2001
    ..These results have implications for understanding nonphotic phase response curves in diurnal species and thereby for guiding research on nonphotic phase shifting in people...
  5. ncbi Masking in waved-2 mice: EGF receptor control of locomotion questioned
    N Mrosovsky
    Department of Zoology, University of Toronto, Toronto, Ontario, Canada
    Chronobiol Int 22:963-74. 2005
    ..No evidence suggested that normal functioning of epidermal growth factor receptors was required, or even involved, in masking...
  6. ncbi Learned arbitrary responses to light in mice without rods or cones
    N Mrosovsky
    Department of Zoology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada
    Naturwissenschaften 89:525-7. 2002
    ..When the lights were covered with opaque material, the performance of rodless-coneless mice dropped to chance level, indicating that they had been using the light as a cue for avoidance...
  7. ncbi Contribution of classic photoreceptors to entrainment
    N Mrosovsky
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 189:69-73. 2003
    ..Thresholds for entrainment appear to be a more sensitive test of deficits in entrainment than phase shifts in response to light pulses...
  8. ncbi Aschoff's rule in retinally degenerate mice
    N Mrosovsky
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 189:75-8. 2003
    ..The sparing of Aschoff's rule in retinally degenerate mice is further evidence that circadian photoreception depends on mechanisms other than rods and cones...
  9. ncbi Beyond the suprachiasmatic nucleus
    N Mrosovsky
    Department of Zoology, University of Toronto, Toronto, Ontario, Canada
    Chronobiol Int 20:1-8. 2003
    ..Yet extensive temporal restructuring of behavior can occur without participation of the suprachiasmatic nucleus. This raises questions about current thinking about how to cope with jet lag and shift work...
  10. ncbi Impaired masking responses to light in melanopsin-knockout mice
    N Mrosovsky
    Department of Zoology, University of Toronto, Toronto, Ontario, Canada
    Chronobiol Int 20:989-99. 2003
    ..This suggests that melanopsin in retinal ganglion cells is involved in masking, as it is in pupil contraction and phase shifts. Melanopsin is especially important in maintaining masking responses over long periods...
  11. ncbi Masking: history, definitions, and measurement
    N Mrosovsky
    Department of Zoology, University of Toronto, Ontario, Canada
    Chronobiol Int 16:415-29. 1999
    ..This paper discusses the origin and definition of terminology (positive and negative masking, paradoxical masking) and methods of quantifying masking. How masking is scored can greatly influence the interpretation of results...
  12. ncbi Further experiments on the relationship between the period of circadian rhythms and locomotor activity levels in hamsters
    N Mrosovsky
    Department of Zoology, University of Toronto, Ontario
    Physiol Behav 66:797-801. 1999
    ..The effects of possible changes in activity on circadian period should be considered when interpreting experiments on physiological manipulations of the circadian period...
  13. ncbi Thresholds for masking responses to light in three strains of retinally degenerate mice
    N Mrosovsky
    Department of Zoology, University of Toronto, Ontario, Canada
    J Comp Physiol A 184:423-8. 1999
    ..With very dim light pulses, mutants did not change their activity, but wildtypes actually became more active (positive masking). Positive and negative masking appear to depend on different sensory and central processes...
  14. ncbi Distorting gene pools by conservation: Assessing the case of doomed turtle eggs
    N Mrosovsky
    Department of Zoology, University of Toronto, Toronto, Ontario, M5S 3G5 Canada
    Environ Manage 38:523-31. 2006
    ..Options are outlined for the management of nesting beaches where a high proportion of turtle eggs is subject to destruction by flooding...
  15. ncbi Spatial responses to light in mice with severe retinal degeneration
    N Mrosovsky
    Department of Zoology, University of Toronto, Ontario, Canada
    Neurosci Lett 222:204-6. 1997
    ..This was true of mutant mice over a year old, when retinal degeneration is very severe, and also of a transgenic strain of mice whose rods are destroyed as they begin to develop in the first few weeks after birth...
  16. doi Against oversimplifying the issues on relocating turtle eggs
    Nicholas Mrosovsky
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, M5S 3B2, Toronto, Ontario, Canada
    Environ Manage 41:465-7. 2008
    ....
  17. doi Negative and positive masking responses to light in retinal degenerate slow (rds/rds) mice during aging
    N Mrosovsky
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ont, Canada M5S 3G5
    Vision Res 48:1270-3. 2008
    ....
  18. doi Divergent phenotypes of vision and accessory visual function in mice with visual cycle dysfunction (Rpe65 rd12) or retinal degeneration (rd/rd)
    Stewart Thompson
    Department of Cell and Systems Biology, The University of Toronto, Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 49:2737-42. 2008
    ..A novel assay of vision was used to determine how the form and extent of retinal disease affects visual phenotype in mice...
  19. ncbi Behavioral arousal blocks light-induced phase advances in locomotor rhythmicity but not light-induced Per1 and Fos expression in the hamster suprachiasmatic nucleus
    K Edelstein
    Department of Zoology, University of Toronto, 25 Harbord Street, M5S 3G5, Toronto, Canada
    Neuroscience 118:253-61. 2003
    ..Photic regulation of clock genes and spontaneous rhythmic expression of clock genes are probably mediated by different mechanisms...
  20. ncbi Enhanced masking response to light in hamsters with IGL lesions
    U Redlin
    Department of Zoology, University of Toronto, Ontario, Canada
    J Comp Physiol A 184:449-56. 1999
    ..It is concluded that the intergeniculate leaflet in the Syrian hamster cannot be of paramount importance for masking of locomotor activity by light but may play a modulating role...
  21. ncbi Scheduled wheel access during daytime: A method for studying conflicting zeitgebers
    R Dallmann
    Department of Zoology, University of Toronto, Ontario, Canada
    Physiol Behav 88:459-65. 2006
    ..This approximates the situation in people subjected to shift work or jet lag...
  22. ncbi Inter-seasonal maintenance of individual nest site preferences in hawksbill sea turtles
    Stephanie J Kamel
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Ecology 87:2947-52. 2006
    ..By taking an individual-based approach to the study of maternal behavior we reveal previously overlooked individual variation and hope to provide some impetus for more detailed studies of nest site choice...
  23. ncbi Deforestation: risk of sex ratio distortion in hawksbill sea turtles
    Stephanie Jill Kamel
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario MSS 3G5, Canada
    Ecol Appl 16:923-31. 2006
    ....
  24. doi Leatherback turtles: the menace of plastic
    N Mrosovsky
    Department of Ecology and Evolutionary Biology, University of Toronto, Ontario, Canada M5S 3G5
    Mar Pollut Bull 58:287-9. 2009
    ..Blockage of the gut by plastic was mentioned in some accounts. These findings are discussed in the context of removal of top predators from poorly understood food chains...
  25. ncbi Behavioral responses to light in mice with dorsal lateral geniculate lesions
    K Edelstein
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Canada M5S 3G5
    Brain Res 918:107-12. 2001
    ....
  26. ncbi Masking by light in hamsters with SCN lesions
    U Redlin
    Department of Zoology, University of Toronto, Ontario, Canada
    J Comp Physiol A 184:439-48. 1999
    ..Evidently the direct effects of light can substitute for the endogenous control by the suprachiasmatic nucleus to maintain appropriate behaviour in time and space...
  27. ncbi Persistence of nonphotic phase shifts in hamsters after serotonin depletion in the suprachiasmatic nucleus
    K J Bobrzynska
    Department of Zoology, University of Toronto, Ont, Canada
    Brain Res 741:205-14. 1996
    ..The results suggest that the 5-HT projection from the raphe to the SCN is not essential for activity-induced phase shifts in hamsters...
  28. ncbi Serotonergic stimulation and nonphotic phase-shifting in hamsters
    K J Bobrzynska
    Department of Zoology, University of Toronto, Ontario, Canada
    Physiol Behav 59:221-30. 1996
    ..Suprisingly, quipazine (a non specific 5-HT agonist), when injected in the middle of subjective day did not phase shift the activity rhythm of hamsters, as it has been reported to do in rats...
  29. ncbi Masking of locomotor activity in hamsters
    U Redlin
    Department of Zoology, University of Toronto, Ontario, Canada
    J Comp Physiol A 184:429-37. 1999
    ..The suppressive effect of light was maximal around the onset of activity, which normally coincides with dusk in hamsters. This may have adaptive value in limiting foraging to the hours of darkness...
  30. ncbi Phase shifting by novelty-induced running: activity dose-response curves at different circadian times
    K J Bobrzynska
    Department of Zoology, University of Toronto, Ontario, Canada
    J Comp Physiol A 182:251-8. 1998
    ..Possibly, there are two different mechanisms of nonphotic phase shifting that can be activated by being placed in a novel wheel, but the results can also be explained in terms of a single mechanism...
  31. ncbi Phase response curves for social entrainment
    N Mrosovsky
    Department of Zoology, University of Toronto, Canada
    J Comp Physiol A 162:35-46. 1988
    ..The effects of social interactions and of other disturbances may be mediated through an oscillator phased by general arousal. The present findings have implications for the interpretation of drug-induced changes in biological rhythms...
  32. ncbi Large phase-shifts of circadian rhythms caused by induced running in a re-entrainment paradigm: the role of pulse duration and light
    S G Reebs
    Department of Zoology, University of Toronto, Ontario, Canada
    J Comp Physiol A 165:819-25. 1989
    ..In a second experiment, the re-entrainment design of Mrosovsky and Salmon (1987) was repeated with the light portion of the shifted LD cycle eliminated.(ABSTRACT TRUNCATED AT 250 WORDS)..
  33. ncbi Running activity mediates the phase-advancing effects of dark pulses on hamster circadian rhythms
    S G Reebs
    Department of Zoology, University of Toronto, Ontario, Canada
    J Comp Physiol A 165:811-8. 1989
    ..CT 10 and CT 13. These results support the idea that, in hamsters at least, dark pulses affect the circadian system mostly by altering behavioural states rather than by altering photic input to the internal clock...