Christopher Power

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. doi request reprint Current issues in clinical neurovirology: pathogenesis, diagnosis and treatment. Preface
    Christopher Power
    Department of Medicine Neurology, Medical Microbiology, Immunology, and Psychiatry, University of Alberta, 6 11 Heritage Medical Research Centre, Edmonton, Alberta, T6G 2S2, Canada
    Neurol Clin 26:xiii-xv. 2008
  2. pmc Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS
    John G Walsh
    Department of Medicine Neurology, Heritage Medical Research Centre 6 11, University of Alberta, Edmonton T6G 2S2, Canada
    Retrovirology 11:35. 2014
  3. pmc Inflammasome induction in Rasmussen's encephalitis: cortical and associated white matter pathogenesis
    Vijay Ramaswamy
    Department of Psychiatry, University of Alberta, Edmonton, AB, Canada
    J Neuroinflammation 10:152. 2013
  4. doi request reprint Delineating HIV-associated neurocognitive disorders using transgenic models: the neuropathogenic actions of Vpr
    Christopher Power
    Department of Medicine Neurology, University of Alberta, Heritage Medical Research Center, Edmonton, AB, Canada
    J Neuroimmune Pharmacol 7:319-31. 2012
  5. pmc Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence
    Hong Na
    Department of Medicine University of Alberta, Edmonton, AB, T6G 2S2, Canada
    Retrovirology 8:44. 2011
  6. doi request reprint MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival
    Farshid Noorbakhsh
    Department of Medicine Neurology, University of Alberta, Edmonton, AB, Canada
    FASEB J 24:1799-812. 2010
  7. doi request reprint Regulation of lentivirus neurovirulence by lipopolysaccharide conditioning: suppression of CXCL10 in the brain by IL-10
    Ferdinand Maingat
    Division of Neurology, University of Alberta, Edmonton, Canada
    J Immunol 184:1566-74. 2010
  8. pmc Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis
    Farshid Noorbakhsh
    Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Exp Med 203:425-35. 2006
  9. pmc Differential type 1 interferon-regulated gene expression in the brain during AIDS: interactions with viral diversity and neurovirulence
    Maria J Polyak
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    FASEB J 27:2829-44. 2013
  10. doi request reprint HIV-1 viral protein R causes peripheral nervous system injury associated with in vivo neuropathic pain
    Shaona Acharjee
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    FASEB J 24:4343-53. 2010

Detail Information

Publications83

  1. doi request reprint Current issues in clinical neurovirology: pathogenesis, diagnosis and treatment. Preface
    Christopher Power
    Department of Medicine Neurology, Medical Microbiology, Immunology, and Psychiatry, University of Alberta, 6 11 Heritage Medical Research Centre, Edmonton, Alberta, T6G 2S2, Canada
    Neurol Clin 26:xiii-xv. 2008
  2. pmc Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS
    John G Walsh
    Department of Medicine Neurology, Heritage Medical Research Centre 6 11, University of Alberta, Edmonton T6G 2S2, Canada
    Retrovirology 11:35. 2014
    ..Induction of inflammasomes causes cleavage and release of IL-1β and IL-18, representing pathogenic processes that underlie inflammatory diseases although their contribution HIV-associated brain disease is unknown...
  3. pmc Inflammasome induction in Rasmussen's encephalitis: cortical and associated white matter pathogenesis
    Vijay Ramaswamy
    Department of Psychiatry, University of Alberta, Edmonton, AB, Canada
    J Neuroinflammation 10:152. 2013
    ..Herein, the pathogenesis of RE was investigated focusing on inflammasome activation in the brain...
  4. doi request reprint Delineating HIV-associated neurocognitive disorders using transgenic models: the neuropathogenic actions of Vpr
    Christopher Power
    Department of Medicine Neurology, University of Alberta, Heritage Medical Research Center, Edmonton, AB, Canada
    J Neuroimmune Pharmacol 7:319-31. 2012
    ..The availability of different transgenic models to study HIV neuropathogenesis represents exciting and innovative approaches to understanding disease mechanisms and perhaps developing new therapeutic strategies in the future...
  5. pmc Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence
    Hong Na
    Department of Medicine University of Alberta, Edmonton, AB, T6G 2S2, Canada
    Retrovirology 8:44. 2011
    ....
  6. doi request reprint MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival
    Farshid Noorbakhsh
    Department of Medicine Neurology, University of Alberta, Edmonton, AB, Canada
    FASEB J 24:1799-812. 2010
    ..Overall, these data point to previously unrecognized alterations in miRNA profile in the brain during HIV infection, which contribute to cell death through dysregulation of cell death machinery...
  7. doi request reprint Regulation of lentivirus neurovirulence by lipopolysaccharide conditioning: suppression of CXCL10 in the brain by IL-10
    Ferdinand Maingat
    Division of Neurology, University of Alberta, Edmonton, Canada
    J Immunol 184:1566-74. 2010
    ....
  8. pmc Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis
    Farshid Noorbakhsh
    Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Exp Med 203:425-35. 2006
    ..001) in WT animals. These findings reveal previously unreported pathogenic interactions between CNS PAR2 expression and neuroinflammation with ensuing demyelination and axonal injury...
  9. pmc Differential type 1 interferon-regulated gene expression in the brain during AIDS: interactions with viral diversity and neurovirulence
    Maria J Polyak
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    FASEB J 27:2829-44. 2013
    ..05). Lentiviral infections induce type 1 interferon-regulated gene expression in microglia in a viral diversity-dependent manner, representing a mechanism by which immune responses might be exploited to limit neurovirulence...
  10. doi request reprint HIV-1 viral protein R causes peripheral nervous system injury associated with in vivo neuropathic pain
    Shaona Acharjee
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    FASEB J 24:4343-53. 2010
    ..05). Herein, Vpr caused DRG neuronal damage, likely through cytosolic calcium activation and cytokine perturbation, highlighting Vpr's contribution to HIV-associated peripheral neuropathy and ensuing neuropathic pain...
  11. pmc Proteinase-activated receptor-1 mediates dorsal root ganglion neuronal degeneration in HIV/AIDS
    Shaona Acharjee
    Department of Medicine, University of Alberta, Edmonton, AB T6G 2S2, Canada
    Brain 134:3209-21. 2011
    ....
  12. ncbi request reprint Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease
    Amir Afkhami-Goli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 179:5493-503. 2007
    ....
  13. ncbi request reprint Peripheral nerve-derived HIV-1 is predominantly CCR5-dependent and causes neuronal degeneration and neuroinflammation
    Gareth Jones
    University of Calgary, Calgary, Canada
    Virology 334:178-93. 2005
    ..Our results suggest that HIV-1 infection of the peripheral nervous system causes axonal degeneration, possibly through the induction of pro-inflammatory cytokines...
  14. ncbi request reprint The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: a role for endoplasmic reticulum chaperones in astrocytes
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Immunol 179:1210-24. 2007
    ..These studies provide new insights into the role of HERV-mediated neuroinflammation and its contribution to an autoimmune disease...
  15. doi request reprint Neurobehavioral performance in feline immunodeficiency virus infection: integrated analysis of viral burden, neuroinflammation, and neuronal injury in cortex
    Ferdinand Maingat
    Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Neurosci 29:8429-37. 2009
    ..05). The present studies indicated that specific motor and neurocognitive abilities were impaired in FIV infection and that these effects were closely coupled with viral burden, neuroinflammation, and neuronal loss...
  16. ncbi request reprint HIV and other lentiviral infections cause defects in neutrophil chemotaxis, recruitment, and cell structure: immunorestorative effects of granulocyte-macrophage colony-stimulating factor
    Bryan Heit
    Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive Northwest, Calgary, Alberta, Canada T2N 4N1
    J Immunol 177:6405-14. 2006
    ..Together, our findings underscore the fundamental defects in innate immunity caused by lentivirus infections, while also indicating that GM-CSF may be a potential immunorestorative therapy for HIV-infected patients...
  17. doi request reprint Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells
    Kristofor K Ellestad
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Immunol 183:298-309. 2009
    ..These findings support the concept of early-life microbial exposure influencing the generation of neuroprotective regulatory T cells and may provide insights into new immunotherapeutic strategies for MS...
  18. doi request reprint Dual lentivirus infection potentiates neuroinflammation and neurodegeneration: viral copassage enhances neurovirulence
    Amir Afkhami-Goli
    Departments of Medicine and Medical Microbiology and Immunology, University of Alberta, Alberta, Canada
    J Neurovirol 15:139-52. 2009
    ..Dual lentivirus infections caused an escalation in neuroinflammation and ensuing neurodegeneration, underscoring the contribution of infection by multiple viruses to neuropathogenesis...
  19. ncbi request reprint Didanosine causes sensory neuropathy in an HIV/AIDS animal model: impaired mitochondrial and neurotrophic factor gene expression
    Yu Zhu
    Department of Medicine, University of Alberta, Edmonton AB, Canada T6G 2S2
    Brain 130:2011-23. 2007
    ....
  20. pmc Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity
    Pornpun Vivithanaporn
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 5:e12856. 2010
    ..Herein, we investigate HCV infectivity and effects on neuronal survival and neuroinflammation in conjunction with HIV infection...
  21. pmc CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy
    Yu Zhu
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    FASEB J 23:2928-41. 2009
    ....
  22. pmc Clinical outcomes and immune benefits of anti-epileptic drug therapy in HIV/AIDS
    Kathy Lee
    Southern Alberta Clinic, Alberta Health Services, Calgary, AB, Canada
    BMC Neurol 10:44. 2010
    ..Herein, AED usage, associated toxicities and immune consequences were investigated...
  23. ncbi request reprint Lentivirus infection causes neuroinflammation and neuronal injury in dorsal root ganglia: pathogenic effects of STAT-1 and inducible nitric oxide synthase
    Yu Zhu
    Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada
    J Immunol 175:1118-26. 2005
    ..The present studies indicate that FIV infection of DRGs directly contributes to axonal and neuronal injury through a mechanism involving macrophage immune activation, which is mediated by STAT-1 and iNOS activation...
  24. pmc Inflammation and epithelial cell injury in AIDS enteropathy: involvement of endoplasmic reticulum stress
    Ferdinand Maingat
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    FASEB J 25:2211-20. 2011
    ..Lentivirus infections cause gut inflammation and ensuing damage to intestinal epithelial cells, likely through induction of ER stress pathways, resulting in disruption of gut functional integrity...
  25. ncbi request reprint Comparative expression of human endogenous retrovirus-W genes in multiple sclerosis
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    AIDS Res Hum Retroviruses 23:1251-6. 2007
    ..Similarly, ERVWE1 env transcripts were inducible in glial cells (p < 0.05), while comparable changes in MSRV abundance were not observed. These results indicate that individual HERVs might have distinct roles in MS pathogenesis...
  26. ncbi request reprint Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection
    Farshid Noorbakhsh
    Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    J Immunol 174:7320-9. 2005
    ..001). Thus, neuroinflammation can exert protective effects by which it induces PAR-2 expression with the ensuing abrogation of neuronal death...
  27. doi request reprint Neurosteroid-mediated regulation of brain innate immunity in HIV/AIDS: DHEA-S suppresses neurovirulence
    Ferdinand G Maingat
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    FASEB J 27:725-37. 2013
    ..Neurosteroid-derived therapies could be effective in the treatment of virus- or inflammation-mediated neurodegeneration...
  28. doi request reprint Neuroinflammation and endoplasmic reticulum stress are coregulated by crocin to prevent demyelination and neurodegeneration
    Andre M Deslauriers
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Immunol 187:4788-99. 2011
    ..05). These findings underscored the convergent roles of pathogenic ER stress and immune pathways in neuroinflammatory disease and point to potential therapeutic applications for crocin...
  29. ncbi request reprint Growth hormone prevents human immunodeficiency virus-induced neuronal p53 expression
    Claudia Silva
    Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Ann Neurol 54:605-14. 2003
    ..01). GH prevents neuronal death through its actions on neurons involving a p53-mediated pathway and also improved in vivo neurological function, indicating that GH may have a role in the treatment of HIV-induced neurodegeneration...
  30. ncbi request reprint CD8+ lymphocyte-mediated injury of dorsal root ganglion neurons during lentivirus infection: CD154-dependent cell contact neurotoxicity
    Yu Zhu
    Department of Medicine, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
    J Neurosci 26:3396-403. 2006
    ..05). These findings indicated that CD8+ T cells were principal effectors of DRG neuronal injury after FIV infection through a CD40-CD154 interaction in a cell contact-dependent manner...
  31. pmc Brain microbial populations in HIV/AIDS: α-proteobacteria predominate independent of host immune status
    William G Branton
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 8:e54673. 2013
    ..Thus, α-proteobacteria represented the major bacterial component of the primate brain's microbiome regardless of underlying immune status, which could be transferred into naïve hosts leading to microbial persistence in the brain...
  32. ncbi request reprint Sensory neuropathy in human immunodeficiency virus/acquired immunodeficiency syndrome patients: protease inhibitor-mediated neurotoxicity
    Jacqueline A Pettersen
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Ann Neurol 59:816-24. 2006
    ..We investigated the clinical features and associated pathogenic determinants of HIV-SN in a neurological cohort of HIV-infected patients, together with a novel model of HIV-SN...
  33. ncbi request reprint Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Nat Neurosci 7:1088-95. 2004
    ..Thus, syncytin's proinflammatory properties in the nervous system demonstrate a novel role for an endogenous retrovirus protein, which may be a target for therapeutic intervention...
  34. pmc Age- and disease-dependent HERV-W envelope allelic variation in brain: association with neuroimmune gene expression
    Rakesh K Bhat
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 6:e19176. 2011
    ..Herein, HERV-W env diversity together with Syncytin-1 abundance and host immune gene profiles were examined in the nervous system using a multiplatform approach...
  35. pmc Impaired neurosteroid synthesis in multiple sclerosis
    Farshid Noorbakhsh
    Department of Medicine Neurology, 6 11 Heritage Medical Research Centre, University of Alberta, Edmonton, AB T6G 2S2, Canada
    Brain 134:2703-21. 2011
    ..The findings also indicate that allopregnanolone and perhaps other neurosteroid-like compounds might represent potential biomarkers or therapies for multiple sclerosis...
  36. doi request reprint HIV infection of the central nervous system: clinical features and neuropathogenesis
    Lysa Boisse
    Division of Neurology, Queen s University, 76 Stuart Street, Kingston, ON K7L 2V7, Canada
    Neurol Clin 26:799-819, x. 2008
    ..This review summarizes the clinical manifestations, diagnosis, treatment, and pathogenesis of the primary HIV-associated central nervous system disorders...
  37. ncbi request reprint RON-regulated innate immunity is protective in an animal model of multiple sclerosis
    Shigeki Tsutsui
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Ann Neurol 57:883-95. 2005
    ..Thus, the MSP-RON pathway represents a novel regulatory mechanism within the CNS by which innate immunity and its pathogenic effects could be targeted for future therapeutic interventions...
  38. ncbi request reprint Comparative neurovirulence in lentiviral infections: The roles of viral molecular diversity and select proteases
    Christopher Power
    Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    J Neurovirol 10:113-7. 2004
    ....
  39. doi request reprint HIV-1 Nef expression in microglia disrupts dopaminergic and immune functions with associated mania-like behaviors
    Shaona Acharjee
    Department of Medicine, University of Alberta, Edmonton, Canada Department of Physiology and Pharmacology and Hotchkiss Brain Institute, University of Calgary, Bangkok, Thailand
    Brain Behav Immun 40:74-84. 2014
    ..Herein, an in vivo transgenic mouse model was generated in which the HIV-1 Nef protein was expressed in microglia cells, permitting investigation of neurobehavioral phenotypes and associated cellular and molecular properties...
  40. doi request reprint The regulation of reactive changes around multiple sclerosis lesions by phosphorylated signal transducer and activator of transcription
    Jian Qiang Lu
    From the Departments of Laboratory Medicine and Pathology JQL, and Medicine Neurology CP, GB, FG, University of Alberta, Edmonton, Alberta, Canada and Departments of Clinical Neurosciences and Oncology, University of Calgary, Calgary, Alberta, Canada VWY
    J Neuropathol Exp Neurol 72:1135-44. 2013
    ..Our findings show that pSTAT3 does not correlate with inflammatory activity in MS lesions, but that it may play an important role in regulating reactive changes proximal to MS lesions...
  41. ncbi request reprint Glucocorticoids regulate innate immunity in a model of multiple sclerosis: reciprocal interactions between the A1 adenosine receptor and beta-arrestin-1 in monocytoid cells
    Shigeki Tsutsui
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    FASEB J 22:786-96. 2008
    ....
  42. ncbi request reprint Human immunodeficiency virus type 1 genetic diversity in the nervous system: evolutionary epiphenomenon or disease determinant?
    Guido van Marle
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    J Neurovirol 11:107-28. 2005
    ....
  43. ncbi request reprint Neuropsychiatric disorders in HIV infection: impact of diagnosis on economic costs of care
    Helen Yeung
    Department of Psychiatry, University of Calgary, Calgary, Canada
    AIDS 20:2005-9. 2006
    ..HAART is associated with a growing prevalence of HIV-associated neuropsychiatric disorders (NPD) despite improved overall survival...
  44. pmc West Nile virus-induced neuroinflammation: glial infection and capsid protein-mediated neurovirulence
    Guido van Marle
    Departments of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    J Virol 81:10933-49. 2007
    ..These studies underscore the important interactions between the WNV capsid protein and neuroinflammation in the pathogenesis of WNV-induced neurological disorders...
  45. pmc Regulation of eotaxin-3/CCL26 expression in human monocytic cells
    Victoria E L Stubbs
    Department of Physiology, University of Calgary, Alberta, Canada
    Immunology 130:74-82. 2010
    ..These data show that IL-4 and pro-inflammatory cytokines such as TNF-alpha, IL-1beta and IFN-gamma regulate CCL26 synthesis in human monocytic cells, which may be important in regulating monocyte inflammatory responses...
  46. doi request reprint Hepatitis C virus co-infection increases neurocognitive impairment severity and risk of death in treated HIV/AIDS
    Pornpun Vivithanaporn
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    J Neurol Sci 312:45-51. 2012
    ....
  47. ncbi request reprint A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis
    Shigeki Tsutsui
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 24:1521-9. 2004
    ..Thus, modulation of neuroinflammation by the A1AR represents a novel mechanism that provides new therapeutic opportunities for MS and other demyelinating diseases...
  48. ncbi request reprint HIV-1 Vpr causes neuronal apoptosis and in vivo neurodegeneration
    Gareth J Jones
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 27:3703-11. 2007
    ..05). Thus, HIV-1 Vpr caused neuronal death through convergent pathogenic mechanisms with ensuing in vivo neurodegeneration, yielding new insights into the mechanisms by which HIV-1 injures the nervous system...
  49. ncbi request reprint The human microbiome in multiple sclerosis: pathogenic or protective constituents?
    Christopher Power
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Can J Neurol Sci 37:S24-33. 2010
    ..The human microbiome has potential impact on future diagnostic and therapeutic issues in MS...
  50. ncbi request reprint Regulation of neural cell survival by HIV-1 infection
    Gareth Jones
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Neurobiol Dis 21:1-17. 2006
    ..Lastly, strategies are examined for treating or preventing HAD by targeting specific neurotoxic mechanisms...
  51. pmc Domain- and nucleotide-specific Rev response element regulation of feline immunodeficiency virus production
    Hong Na
    Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Virology 404:246-60. 2010
    ....
  52. ncbi request reprint HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation
    Manmeet K Mamik
    Department of Medicine, University of Alberta, T6G 2S2, Edmonton, AB, Canada
    J Neuroimmune Pharmacol . 2016
    ..Thus, Vpr-induced NLRP3 inflammasome activation, which contributed to neuroinflammation and was abrogated by caspase-1 inhibition. This study provides a new therapeutic perspective for HIV-associated neuropsychiatric disease...
  53. doi request reprint Metagenomic and metabolomic characterization of rabies encephalitis: new insights into the treatment of an ancient disease
    Stacey N Reinke
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    J Infect Dis 207:1451-6. 2013
    ..These multiplatform studies highlight the extent of ongoing viral replication coupled with inflammation in treated rabies, indicative of a neurological immune reconstitution inflammatory syndrome...
  54. doi request reprint Inflammasomes in the CNS
    John G Walsh
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Nat Rev Neurosci 15:84-97. 2014
    ..Here, we review the current understanding of the functions of different inflammasomes in the CNS and their roles in neurological diseases. ..
  55. ncbi request reprint Peripheral neuropathy in lentivirus infection: evidence of inflammation and axonal injury
    James M Kennedy
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    AIDS 18:1241-50. 2004
    ..CONCLUSION: FIV infection results in the rapid onset of peripheral neuropathy, defined by axonal injury and macrophage activation, together with abundant virus within the nerve, indicating that it may serve as a model of HIV-related DSP...
  56. ncbi request reprint HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration
    Kunyan Zhang
    Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Nat Neurosci 6:1064-71. 2003
    ..Hence, this study identifies a new in vivo neurotoxic pathway in which cleavage of a chemokine by an induced metalloproteinase results in neuronal apoptosis that leads to neurodegeneration...
  57. doi request reprint Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology
    Farshid Noorbakhsh
    Department of Medicine, 6 11 Heritage Medical Research Centre, 87 Avenue, University of Alberta, Edmonton, Alberta, T6G2S2, Canada
    Trends Neurosci 32:88-100. 2009
    ....
  58. doi request reprint Plasma microRNA profiling predicts HIV-associated neurocognitive disorder
    Eugene L Asahchop
    aDepartment of Medicine Neurology bDepartment of Mathematical and Statistical Sciences cDepartment of Psychiatry, University of Alberta, Edmonton, Alberta dSouthern Alberta Clinic eDepartment of Medicine, University of Calgary, Calgary fDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    AIDS 30:2021-31. 2016
    ..Host-encoded microRNAs (miRNA) regulate both host and viral gene expression contributing to HAND pathogenesis and can also serve as disease biomarkers. Herein, plasma miRNA profiles were investigated in HIV/AIDS patients with HAND...
  59. pmc Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration
    David Vergote
    Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Proc Natl Acad Sci U S A 103:19182-7. 2006
    ..05) were prevented by a CXCR3 antagonist. These studies reveal additive neuropathogenic properties exerted by a proteolytically cleaved chemokine as consequences of a change in receptor specificity, culminating in neurodegeneration...
  60. pmc Human immunodeficiency virus type 1 envelope-mediated neuronal death: uncoupling of viral replication and neurotoxicity
    Kunyan Zhang
    Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    J Virol 77:6899-912. 2003
    ..These findings underscore the importance of HIV-1 envelope protein expression in neurotoxic pathways associated with HIV-induced brain disease and highlight the envelope as a target for neuroprotective therapeutic interventions...
  61. pmc Human endogenous retrovirus-K(II) envelope induction protects neurons during HIV/AIDS
    Rakesh K Bhat
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 9:e97984. 2014
    ..These findings imply that HERV gene products might exert adaptive effects in circumstances of pathophysiological stress, perhaps underlying the conservation of HERVs within the human genome. ..
  62. ncbi request reprint Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases
    Christopher Power
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Ann Neurol 53:731-42. 2003
    ..Thus, select MMPs exhibit increased expression after ICH, whereas minocycline is neuroprotective after ICH by suppressing monocytoid cell activation and downregulating MMP-12 expression...
  63. doi request reprint Multifocal inflammatory demyelination in a patient with rheumatoid arthritis and treatment complications
    Jian Qiang Lu
    Neuropathology Section, Department of Laboratory Medicine and Pathology, University of Alberta, 8440 112 Street, Edmonton, Alberta T6G 2B7, Canada Electronic address
    J Neurol Sci 367:305-7. 2016
    ..Our present case, in combination with literature review, suggests that the RA treatment especially with hydroxychloroquine and methotrexate is likely to alter the characteristics of inflammatory demyelination and disease course. ..
  64. doi request reprint Neuroinflammation Preceding and Accompanying Primary Central Nervous System Lymphoma: Case Study and Literature Review
    Jian Qiang Lu
    Neuropathology Section, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada Electronic address
    World Neurosurg 88:692.e1-8. 2016
    ..However, the pathologic relationship between the inflammatory lesions and subsequent PCNSL is still unknown...
  65. doi request reprint Decision making under explicit risk is impaired in individuals with human immunodeficiency virus (HIV)
    Esther Fujiwara
    a Department of Psychiatry, University of Alberta, Edmonton, AB, Canada
    J Clin Exp Neuropsychol 37:733-50. 2015
    ..Decision making under explicit risk has very rarely been examined in HIV+ individuals and was tested here using the Game of Dice Task (GDT)...
  66. pmc HIV protease inhibitors disrupt astrocytic glutamate transporter function and neurobehavioral performance
    Pornpun Vivithanaporn
    aDepartments of Medicine bDepartments of Psychiatry cNeuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada dDepartment of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand eDepartment of Physiology, University of Calgary, Calgary, Alberta, Canada
    AIDS 30:543-52. 2016
    ..The neurotoxic actions of the HIV protease inhibitors, amprenavir (APV) and lopinavir (LPV) were investigated...
  67. ncbi request reprint NeuroAIDS: an evolving epidemic
    Christopher Power
    Department of Medicine Neurology, 6 11 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Can J Neurol Sci 36:285-95. 2009
    ..Herein, we review the clinical presentations, underlying pathogenesis and treatments of this burgeoning group of neurological disorders...
  68. ncbi request reprint HIV-related neurological syndromes reduce health-related quality of life
    Rupang Pandya
    Department of Psychiatry, University of Calgary, Calgary, AB, Canada
    Can J Neurol Sci 32:201-4. 2005
    ..Human immunodeficiency virus (HIV) infection frequently results in neurological complications but the impact of different neurological syndromes on patients' quality of life remains unknown...
  69. ncbi request reprint Interleukin-1beta promotes oligodendrocyte death through glutamate excitotoxicity
    Jennifer L Takahashi
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Ann Neurol 53:588-95. 2003
    ....
  70. ncbi request reprint In vivo impairment of neutrophil recruitment during lentivirus infection
    Paul Kubes
    Department of Physiology and Biophysics, University of Calgary, Alberta, Canada
    J Immunol 171:4801-8. 2003
    ..These in vivo studies also indicate that neutrophil dysfunction should be taken into account when treating infections and tissue injury...
  71. ncbi request reprint The promise of minocycline in neurology
    V Wee Yong
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Lancet Neurol 3:744-51. 2004
    ..The encouraging results of minocycline in experimental neurology bode well for its therapeutic use in human neurological diseases...
  72. ncbi request reprint Human immunodeficiency virus type 1 envelope-mediated neuropathogenesis: targeted gene delivery by a Sindbis virus expression vector
    Guido van Marle
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    Virology 309:61-74. 2003
    ..Thus SIN expression vectors represent novel tools for studying in vitro and in vivo HIV-1 neuropathogenesis because of their high levels of transgene expression in specific cell types within the brain...
  73. pmc Decision-making under explicit risk is impaired in multiple sclerosis: relationships with ventricular width and disease disability
    Ashley D Radomski
    Department of Psychiatry, University of Alberta, 1E1 01 WCM Health Sciences Centre, Edmonton, Alberta, T6G 2R7, Canada
    BMC Neurol 15:61. 2015
    ..We expected performance in decision-making under risk to be lowered in MS patients, and negatively correlated with disease-related disability, cognition, and ventricular width...
  74. doi request reprint Acute disseminated encephalomyelitis: clinical and pathogenesis features
    Farshid Noorbakhsh
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
    Neurol Clin 26:759-80, ix. 2008
    ..Neuropathological examination of the CNS in ADEM reveals involvement of white matter, with infiltration of monocytoid cells and perivenous demyelination...
  75. doi request reprint Rapid Multifocal Neurologic Decline in an Immunocompromised Patient
    Julie Anne Kromm
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada2Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA Neurol 73:226-31. 2016
    ..The approach to the immunosuppressed patient with progressive neurologic decline, neuropathologic findings, and final diagnosis are discussed. ..
  76. ncbi request reprint Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis
    Leonie A Boven
    Neuroscience Research Group, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Immunol 170:2638-46. 2003
    ....
  77. ncbi request reprint NeuroAIDS in West Africa: a full circle
    Christopher Power
    Can J Neurol Sci 34:118-9. 2007
  78. ncbi request reprint HIV dementia patients exhibit reduced viral neutralization and increased envelope sequence diversity in blood and brain
    Guido van Marle
    Department of Clinical Neurosciences, University of Calgary, Canada
    AIDS 16:1905-14. 2002
    ..To examine the relationship between the humoral immune response and viral envelope diversity among HIV/AIDS patients with or without HIV-associated dementia (HAD)...
  79. doi request reprint Emerging issues in neurovirology: new viruses, diagnostic tools, and therapeutics
    Richard T Johnson
    Department of Neurology, The Johns Hopkins Hospital, Pathology 627, Baltimore, MD 21287, USA
    Neurol Clin 26:855-64, xi. 2008
    ....
  80. ncbi request reprint Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10
    Guido van Marle
    Department of Clinical Neurosciences, University of Calgary, Calgary AB, Canada
    Virology 329:302-18. 2004
    ..Furthermore, Nef molecular diversity was evident in brain tissue among patients with neurological disease and which may influence IP-10 production by astrocytes...
  81. ncbi request reprint Fatigue in HIV/AIDS is associated with depression and subjective neurocognitive complaints but not neuropsychological functioning
    Colleen P Millikin
    Mental Health Service and Inner City Health Research Unit, St Michael s Hospital, Toronto, Ont, Canada
    J Clin Exp Neuropsychol 25:201-15. 2003
    ..Such research will further the development of effective treatments for fatigue associated with HIV-infection...
  82. ncbi request reprint Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patients
    Lucette A Cysique
    St Vincent s Hospital Clinical School, University of New South Wales, Darlinghurst, Sydney, Australia
    J Acquir Immune Defic Syndr 39:426-9. 2005
    ....
  83. ncbi request reprint Brain-derived human immunodeficiency virus-1 Tat exerts differential effects on LTR transactivation and neuroimmune activation
    Leonie A Boven
    Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurovirol 13:173-84. 2007
    ..Thus, mutations within the HIV-1 tat gene may exert pathogenic effects contributing to the development of HAD, which are independent of its effects on LTR transactivation...

Research Grants3

  1. LENTIVIRUS-INDUCED NEUROPATHY: VIRAL DIVERSITY AND HOST*
    Christopher Power; Fiscal Year: 2004
    ..From these studies, we expect to gain insights into this common neurological complication in terms of lentivirus-induced neurovirulence and pathogenic host responses. ..
  2. NEUROTOXIC MECHANISMS MEDIATED BY LENTIVIRUS-INDUCED PROTEOLYSIS
    Christopher Power; Fiscal Year: 2008
    ..The information derived from this proposal will be applicable to the prevention and treatment of HIV-associated brain disease. [unreadable] [unreadable]..
  3. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
    ..Many of the scientific techniques and models to be employed in the experiments described herein are unique to the laboratories of this team of investigators who have worked together for many years. ..