Luis María Schang

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. pmc Development of kinomic analyses to identify dysregulated signaling pathways in cells expressing cytoplasmic PrP
    Rory H Shott
    Department of Biochemistry and Centre for Prions and Protein Folding Diseases CPPFD, University of Alberta, Edmonton, AB T6G 2E1, Canada
    Virol J 11:175. 2014
  2. pmc Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease
    Rory H Shott
    Department of Biochemistry and Centre for Prions and Protein Folding Diseases CPPFD, University of Alberta, Edmonton, AB, Canada
    Virol J 11:160. 2014
  3. pmc The differential mobilization of histones H3.1 and H3.3 by herpes simplex virus 1 relates histone dynamics to the assembly of viral chromatin
    Kristen L Conn
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS Pathog 9:e1003695. 2013
  4. pmc Core histones H2B and H4 are mobilized during infection with herpes simplex virus 1
    Kristen L Conn
    Department of Biochemistry, University of Alberta, 6 142G KATZ, Edmonton, Alberta T6G 2E1, Canada
    J Virol 85:13234-52. 2011
  5. ncbi request reprint Five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs
    Luis M Schang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Antivir Chem Chemother 17:293-320. 2006
  6. ncbi request reprint First demonstration of the effectiveness of inhibitors of cellular protein kinases in antiviral therapy
    Luis M Schang
    University of Alberta, Department of Biochemistry, 315C Heritage Medical Research Center, Edmonton, Alberta, Canada
    Expert Rev Anti Infect Ther 4:953-6. 2006
  7. ncbi request reprint Herpes simplex viruses in antiviral drug discovery
    Luis M Schang
    Department of Biochemistry and Department of Medical Microbiology and Immunology, Signal Transduction Research Group, Molecular Mechanisms of Growth Control Research Group, University of Alberta, Canada
    Curr Pharm Des 12:1357-70. 2006
  8. ncbi request reprint Cdk inhibitory nucleoside analogs prevent transcription from viral genomes
    L M Schang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Nucleosides Nucleotides Nucleic Acids 24:829-37. 2005
  9. ncbi request reprint Advances on cyclin-dependent kinases (CDKs) as novel targets for antiviral drugs
    L M Schang
    315C Heritage Medical Research Center Edmonton, Alberta T6G 2S2, Canada
    Curr Drug Targets Infect Disord 5:29-37. 2005
  10. ncbi request reprint Antiviral drugs that target cellular proteins may play major roles in combating HIV resistance
    Véronic Marie Isabelle Provencher
    Heritage Medical Research Center, Edmonton, Alberta T6G 2S2 Canada
    Curr Pharm Des 10:4081-101. 2004

Collaborators

  • Nathanael S Gray
  • Michael J Hendzel
  • Michael H Malim
  • Rory H Shott
  • Kristen L Conn
  • Jonathan J Lacasse
  • Véronic Marie Isabelle Provencher
  • Kathy L Frost
  • Anna Majer
  • Guillaume Tremblay
  • Cathy Appanah
  • Catherine Grenier
  • Xavier Roucou
  • Stephanie A Booth
  • Jonathan Jacques Lacasse
  • Ersilia Coccaro

Detail Information

Publications16

  1. pmc Development of kinomic analyses to identify dysregulated signaling pathways in cells expressing cytoplasmic PrP
    Rory H Shott
    Department of Biochemistry and Centre for Prions and Protein Folding Diseases CPPFD, University of Alberta, Edmonton, AB T6G 2E1, Canada
    Virol J 11:175. 2014
    ..We tested the global assays for their sensitivity to detect changes in signaling pathways in cells expressing cytoplasmic PrP mutants...
  2. pmc Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease
    Rory H Shott
    Department of Biochemistry and Centre for Prions and Protein Folding Diseases CPPFD, University of Alberta, Edmonton, AB, Canada
    Virol J 11:160. 2014
    ..Here, we used this approach to identify signaling pathways dysregulated during prion pathogenesis in vivo...
  3. pmc The differential mobilization of histones H3.1 and H3.3 by herpes simplex virus 1 relates histone dynamics to the assembly of viral chromatin
    Kristen L Conn
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS Pathog 9:e1003695. 2013
    ..These data therefore relate nuclear histone dynamics to the composition of viral chromatin and provide the first evidence that histone mobilization relates to viral chromatin assembly. ..
  4. pmc Core histones H2B and H4 are mobilized during infection with herpes simplex virus 1
    Kristen L Conn
    Department of Biochemistry, University of Alberta, 6 142G KATZ, Edmonton, Alberta T6G 2E1, Canada
    J Virol 85:13234-52. 2011
    ..Moreover, this mobilization is consistent with the assembly of H2A-H2B and H3-H4 dimers into unstable nucleosomes with HSV-1 genomes...
  5. ncbi request reprint Five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs
    Luis M Schang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Antivir Chem Chemother 17:293-320. 2006
    ..We also highlight the major issues that still need to be addressed before PCIs or other drugs targeting cellular proteins can be developed as clinical antivirals...
  6. ncbi request reprint First demonstration of the effectiveness of inhibitors of cellular protein kinases in antiviral therapy
    Luis M Schang
    University of Alberta, Department of Biochemistry, 315C Heritage Medical Research Center, Edmonton, Alberta, Canada
    Expert Rev Anti Infect Ther 4:953-6. 2006
    ..The three papers discussed herein demonstrate that inhibitors of cellular protein kinases are indeed effective for the treatment of virus-induced disease in animal models and human clinical trials...
  7. ncbi request reprint Herpes simplex viruses in antiviral drug discovery
    Luis M Schang
    Department of Biochemistry and Department of Medical Microbiology and Immunology, Signal Transduction Research Group, Molecular Mechanisms of Growth Control Research Group, University of Alberta, Canada
    Curr Pharm Des 12:1357-70. 2006
    ..Herein, we will review the roles of HSV as model viruses in the discovery and development of antiviral drugs. The major focus will be on the recent discovery on the activities of PCIs against HSV and other viruses...
  8. ncbi request reprint Cdk inhibitory nucleoside analogs prevent transcription from viral genomes
    L M Schang
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Nucleosides Nucleotides Nucleic Acids 24:829-37. 2005
    ..This inhibition is promoter independent, but genome dependent, and requires no viral proteins. This is a novel antiviral mechanism and a previously unknown activity for purine PCIs...
  9. ncbi request reprint Advances on cyclin-dependent kinases (CDKs) as novel targets for antiviral drugs
    L M Schang
    315C Heritage Medical Research Center Edmonton, Alberta T6G 2S2, Canada
    Curr Drug Targets Infect Disord 5:29-37. 2005
    ..In fact, no PCI-resistant viral mutant has been reported. PCIs are scheduled to enter clinical trials as antivirals in 2005...
  10. ncbi request reprint Antiviral drugs that target cellular proteins may play major roles in combating HIV resistance
    Véronic Marie Isabelle Provencher
    Heritage Medical Research Center, Edmonton, Alberta T6G 2S2 Canada
    Curr Pharm Des 10:4081-101. 2004
    ..Recent and exciting studies indicate that PCIs ameliorate the pathogenesis of an animal model of HIV-induced nephropathy. We can expect that the full potential of PCIs as antiretroviral drugs will be explored in the coming years...
  11. ncbi request reprint Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication
    Luis M Schang
    Department of Biochemistry and Department of Medical Microbiology and Immunology, Signal Transduction Research Group, Molecular Mechanisms of Growth Control Research Group, University of Alberta, Canada
    Biochim Biophys Acta 1697:197-209. 2004
    ..Herein, we will review the involvement of CDKs in viral replication and the antiviral properties of the most extensively characterized PCIs, with special emphasis on the mechanisms of inhibition of viral transcription...
  12. ncbi request reprint Cyclin-dependent kinases as cellular targets for antiviral drugs
    Luis M Schang
    Department of Biochemistry, Signal Transduction Research Group, University of Alberta, 315C Heritage Medical Research Center, Edmonton, Alberta T6G 2S2, Canada
    J Antimicrob Chemother 50:779-92. 2002
    ....
  13. pmc Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins
    Luis M Schang
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Virol 76:7874-82. 2002
    ..Lastly, the spectrum of proteins that bound to P-PCIs in extracts of mock- and HSV-infected cells was the same. Based on these observations, we conclude that P-PCIs inhibit virus replication by targeting cellular, not viral, proteins...
  14. pmc Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4
    Luis M Schang
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Virol 76:7724-35. 2002
    ..We conclude that neuronal levels of cdk2 are among the factors that determine the outcome of HSV infections of neurons...
  15. ncbi request reprint Cellular proteins (cyclin dependent kinases) as potential targets for antiviral drugs
    L M Schang
    Department of Biochemistry, University of Alberta, Heritage Medical Research Centre, Edmonton, Canada
    Antivir Chem Chemother 12:157-78. 2001
    ..In this review, the biochemical, cellular and antiviral activities of PCIs in vitro and their toxicity in vivo are discussed. Other cellular proteins that are required for viral replication could also be targets for new antiviral drugs...
  16. pmc During lytic infections, herpes simplex virus type 1 DNA is in complexes with the properties of unstable nucleosomes
    Jonathan J Lacasse
    Signal Transduction Research Group, Molecular Mechanisms of Growth Control Research Group, University of Alberta, 327C Heritage Medical Research Center, Edmonton, Alberta T6G 2S2, Canada
    J Virol 84:1920-33. 2010
    ..The HSV-1 DNAs in complexes fractionating as mono- to dinucleosomes were stabilized by cross-linking. Therefore, most HSV-1 DNA forms particularly unstable nucleosome-like complexes at 5 h of lytic infection...