H Castrop

Summary

Publications

  1. ncbi request reprint Mediators of tubuloglomerular feedback regulation of glomerular filtration: ATP and adenosine
    H Castrop
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Acta Physiol (Oxf) 189:3-14. 2007
  2. doi request reprint A role for AT1 receptor-associated proteins in blood pressure regulation
    Hayo Castrop
    Institute of Physiology, University of Regensburg, Germany Electronic address
    Curr Opin Pharmacol 21:43-7. 2015
  3. doi request reprint Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2)
    Hayo Castrop
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Am J Physiol Renal Physiol 307:F991-F1002. 2014
  4. pmc Superficial nephrons in BALB/c and C57BL/6 mice facilitate in vivo multiphoton microscopy of the kidney
    Ina Maria Schießl
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    PLoS ONE 8:e52499. 2013
  5. doi request reprint Angiotensin II AT2 receptor activation attenuates AT1 receptor-induced increases in the glomerular filtration of albumin: a multiphoton microscopy study
    Ina Maria Schießl
    Institute of Physiology, Univ of Regensburg, Universitätsstr 31, 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 305:F1189-200. 2013
  6. doi request reprint Dietary salt intake modulates differential splicing of the Na-K-2Cl cotransporter NKCC2
    Ina Maria Schiessl
    Institute of Physiology, Univ of Regensburg, Universitätsstr 31, 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 305:F1139-48. 2013
  7. doi request reprint Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse
    Katharina Mederle
    Institute of Physiology, Univ of Regensburg, Universitätsstr 31, 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 304:F1198-209. 2013
  8. doi request reprint Angiotensin receptor-associated proteins: local modulators of the renin-angiotensin system
    Hayo Castrop
    Institute of Physiology, University of Regensburg, Universitätsstr 31, 93040, Regensburg, Germany
    Pflugers Arch 465:111-9. 2013
  9. doi request reprint Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II
    Elisabeth Doblinger
    Institute of Physiology, Univ of Regensburg, Universitätsstr 31, 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 302:F1313-24. 2012
  10. ncbi request reprint Skeletal abnormalities and extra-skeletal ossification in mice with restricted Gsalpha deletion caused by a renin promoter-Cre transgene
    Hayo Castrop
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Cell Tissue Res 330:487-501. 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Mediators of tubuloglomerular feedback regulation of glomerular filtration: ATP and adenosine
    H Castrop
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Acta Physiol (Oxf) 189:3-14. 2007
    ....
  2. doi request reprint A role for AT1 receptor-associated proteins in blood pressure regulation
    Hayo Castrop
    Institute of Physiology, University of Regensburg, Germany Electronic address
    Curr Opin Pharmacol 21:43-7. 2015
    ..Two aspects of blood pressure regulation will be discussed in detail: angiotensin II-dependent volume homoeostasis and vascular resistance. ..
  3. doi request reprint Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2)
    Hayo Castrop
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Am J Physiol Renal Physiol 307:F991-F1002. 2014
    ....
  4. pmc Superficial nephrons in BALB/c and C57BL/6 mice facilitate in vivo multiphoton microscopy of the kidney
    Ina Maria Schießl
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    PLoS ONE 8:e52499. 2013
    ..In summary, due to significantly more superficial glomeruli compared to other commonly used strains, BALB/cAnN and C57BL/6N mice appear to be particularly suitable for the investigation of glomerular function using MPM...
  5. doi request reprint Angiotensin II AT2 receptor activation attenuates AT1 receptor-induced increases in the glomerular filtration of albumin: a multiphoton microscopy study
    Ina Maria Schießl
    Institute of Physiology, Univ of Regensburg, Universitätsstr 31, 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 305:F1189-200. 2013
    ..In summary, AT1 activation acutely increases the albumin GSC. This effect appears to be largely independent of changes in the renal perfusion pressure. The AT2 receptor partially attenuates the proteinuric effects of the AT1 receptor. ..
  6. doi request reprint Dietary salt intake modulates differential splicing of the Na-K-2Cl cotransporter NKCC2
    Ina Maria Schiessl
    Institute of Physiology, Univ of Regensburg, Universitätsstr 31, 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 305:F1139-48. 2013
    ..Differential splicing of NKCC2 appears to contribute to the adaptive capacity of the kidney to cope with changes in reabsorptive needs. ..
  7. doi request reprint Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse
    Katharina Mederle
    Institute of Physiology, Univ of Regensburg, Universitätsstr 31, 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 304:F1198-209. 2013
    ..Consequently, our data suggest that WNK3 may serve as a member of a kinase network that facilitates the fine-tuning of renal transepithelial NaCl transport...
  8. doi request reprint Angiotensin receptor-associated proteins: local modulators of the renin-angiotensin system
    Hayo Castrop
    Institute of Physiology, University of Regensburg, Universitätsstr 31, 93040, Regensburg, Germany
    Pflugers Arch 465:111-9. 2013
    ..A hypothesis will be discussed that integrates the existence of various angiotensin receptor-associated proteins into an overall functional model...
  9. doi request reprint Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II
    Elisabeth Doblinger
    Institute of Physiology, Univ of Regensburg, Universitätsstr 31, 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 302:F1313-24. 2012
    ..In summary, Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II. Thus Arap1 may serve as a local modulator of vascular AT(1) receptor function in vivo...
  10. ncbi request reprint Skeletal abnormalities and extra-skeletal ossification in mice with restricted Gsalpha deletion caused by a renin promoter-Cre transgene
    Hayo Castrop
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Cell Tissue Res 330:487-501. 2007
    ..Nevertheless, the present report reaffirms the importance of Gs alpha signaling for bone development and the suppression of ectopic ossification...
  11. doi request reprint Functional evidence confirmed by histological localization: overlapping expression of erythropoietin and HIF-2alpha in interstitial fibroblasts of the renal cortex
    Hayo Castrop
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Kidney Int 77:269-71. 2010
    ..Paliege and co-workers provide convincing morphological evidence that it is the HIF-2 isoform that essentially triggers EPO in the kidney, which is the primary source of EPO in the body...
  12. doi request reprint Genetically modified mice-successes and failures of a widely used technology
    Hayo Castrop
    Institute of Physiology, University of Regensburg, Universitätsstr 31, 93040 Regensburg, Germany
    Pflugers Arch 459:557-67. 2010
    ....
  13. ncbi request reprint Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene
    H Castrop
    Institute of Physiology, University of Regensburg, Germany
    Physiol Genomics 25:277-85. 2006
    ....
  14. pmc Isoforms of renal Na-K-2Cl cotransporter NKCC2: expression and functional significance
    Hayo Castrop
    Physiologisches Institut der Universität Regensburg, Universitätsstr 31, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 295:F859-66. 2008
    ....
  15. doi request reprint Localization and functional characterization of the human NKCC2 isoforms
    I Carota
    Institute of Physiology, University of Regensburg, Germany
    Acta Physiol (Oxf) 199:327-38. 2010
    ..The NKCC2 isoforms have specific localizations and transport characteristics, as assessed for rabbit, rat and mouse. In the present study, we aimed to address the localization and transport characteristics of the human NKCC2 isoforms...
  16. ncbi request reprint Macula densa control of renin secretion and preglomerular resistance in mice with selective deletion of the B isoform of the Na,K,2Cl co-transporter
    Mona Oppermann
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1370, USA
    J Am Soc Nephrol 17:2143-52. 2006
    ..Nevertheless, the high-affinity NKCC2B contributes to salt absorption and macula densa function in the low NaCl concentration range...
  17. pmc Development of vascular renin expression in the kidney critically depends on the cyclic AMP pathway
    Björn Neubauer
    Department of Physiology, Universitat Regensburg, Regensburg, Germany
    Am J Physiol Renal Physiol 296:F1006-12. 2009
    ....
  18. ncbi request reprint Renal function in mice with targeted disruption of the A isoform of the Na-K-2Cl co-transporter
    Mona Oppermann
    NIDDK, NIH, Building 10, Room 4 D51, 10 Center Drive MSC 1370, Bethesda, MD 20892 1370, USA
    J Am Soc Nephrol 18:440-8. 2007
    ..Coexpression of both high- and low-affinity isoforms of NKCC2 may permit transport and Cl-dependent tubuloglomerular feedback regulation to occur over a wider Cl concentration range...
  19. pmc Enhanced tubuloglomerular feedback in mice with vascular overexpression of A1 adenosine receptors
    Mona Oppermann
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 297:F1256-64. 2009
    ..These data indicate that A1AR expression in vascular smooth muscle cells is a critical component for TGF signaling and that changes in renal vascular A1AR expression may determine the magnitude of TGF responses...
  20. pmc Contribution of the basolateral isoform of the Na-K-2Cl- cotransporter (NKCC1/BSC2) to renin secretion
    Hayo Castrop
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 289:F1185-92. 2005
    ..Our data suggest that a functional NKCC1 suppresses basal renin release, at least in part, through a direct effect on JG cells...
  21. doi request reprint Physiology of kidney renin
    Hayo Castrop
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Physiol Rev 90:607-73. 2010
    ..The broad spectrum of biological actions of (pro)renin is mediated by receptors for (pro)renin, angiotensin II and angiotensin-(1-7)...
  22. ncbi request reprint Permissive role of nitric oxide in macula densa control of renin secretion
    Hayo Castrop
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 286:F848-57. 2004
    ..However, NO independent of its exact source permits the macula densa pathway of renin secretion to function normally...
  23. ncbi request reprint Role of renocortical cyclooxygenase-2 for renal vascular resistance and macula densa control of renin secretion
    H Castrop
    , Regensburg, Germany
    J Am Soc Nephrol 12:867-74. 2001
    ..These findings suggest that in states of increased renocortical expression of COX-2, overall renal vascular resistance and the macula densa control of renin secretion become dependent on COX-2-derived prostanoids...
  24. doi request reprint Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice
    Mona Oppermann
    National Institute of Digestive and Diabetes and Kidney Diseases, National Institute of Health, 10 Center Drive MSC 1370, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 294:F965-70. 2008
    ....
  25. ncbi request reprint Effect of carbonic anhydrase inhibition on GFR and renal hemodynamics in adenosine-1 receptor-deficient mice
    Seiji Hashimoto
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 4 D51, 10 Center Drive MSC 1370, Bethesda, MD 20892, USA
    Pflugers Arch 448:621-8. 2004
    ..Acute angiotensin II receptor blockade, on the other hand, diminishes the effect of CA inhibition on GFR and RBF. The causes for the GFR reduction appear to be complex and include an effect of the renin-angiotensin system...
  26. ncbi request reprint Blood pressure-dependent inhibition of Renin secretion requires A1 adenosine receptors
    Frank Schweda
    Institute of Physiology, University of Regensburg, 93040 Regensburg, Germany
    Hypertension 46:780-6. 2005
    ..In contrast, the stimulation of the renin system by a low blood pressure appears to follow different pathways...
  27. ncbi request reprint Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice
    Charlotte Wagner
    Department of Physiology, University of Regensburg, 93040 Regensburg, Germany
    Pflugers Arch 447:214-22. 2003
    ..Our data suggest a marked divergence of renin and Cox-2 expression in the kidney cortex of C57Bl/6 mice with no clear evidence for a role of Cox-2-derived prostanoids from the macula densa in the regulation of renin expression...
  28. ncbi request reprint Adenosine induces vasoconstriction through Gi-dependent activation of phospholipase C in isolated perfused afferent arterioles of mice
    Pernille B Hansen
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Am Soc Nephrol 14:2457-65. 2003
    ....
  29. pmc Impairment of tubuloglomerular feedback regulation of GFR in ecto-5'-nucleotidase/CD73-deficient mice
    Hayo Castrop
    National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 114:634-42. 2004
    ..We conclude that the generation of adenosine at the glomerular pole depends to a major extent on e-5'NT/CD73-mediated dephosphorylation of 5'-AMP, presumably generated from released ATP...
  30. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors
    Matthias Hautmann
    Institute for Physiology, University of Regensburg, 93040 Regensburg, Germany
    J Am Soc Nephrol 18:1150-6. 2007
    ..These data show that PACAP acting on PAC1 receptors potently stimulates renin release, serving as a tonic enhancer of the renin system in vivo...
  31. doi request reprint Generation of tubular superstructures by piling of renal stem/progenitor cells
    Will W Minuth
    Department of Molecular and Cellular Anatomy, University of Regensburg, Regensburg, Germany
    Tissue Eng Part C Methods 14:3-13. 2008
    ..This novel technique is an important step toward the generation of renal superstructures urgently needed for biomedical research and kidney regeneration...
  32. doi request reprint Allergen-induced airway hyperresponsiveness is absent in ecto-5'-nucleotidase (CD73)-deficient mice
    Rainer Schreiber
    Institut fur Physiologie, Universitat Regensburg, Universitatsstrasse 31, 93053, Regensburg, Germany
    Pflugers Arch 457:431-40. 2008
    ..Thus, ecto-5'-nucleotidase may provide a novel target for therapeutic intervention, probably by local application of ecto-5'-nucleotidase inhibitors through inhalation...
  33. ncbi request reprint Vasodilatation of afferent arterioles and paradoxical increase of renal vascular resistance by furosemide in mice
    Mona Oppermann
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 293:F279-87. 2007
    ..We suggest that generation of angiotensin II and/or a vasoconstrictor prostaglandin combined with compression of peritubular capillaries by the expanding tubular compartment are responsible for the reduction of RBF in vivo...
  34. pmc Atrap deficiency increases arterial blood pressure and plasma volume
    Mona Oppermann
    Children s Hospital, University Medical Center, Germany
    J Am Soc Nephrol 21:468-77. 2010
    ..In summary, Atrap-/- mice have increased arterial pressure and plasma volume. Atrap seems to modulate volume status by acting as a negative regulator of AT1 receptors in the renal tubules...
  35. ncbi request reprint General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system
    Hayo Castrop
    Institut für Physiologie und Pharmakologie der Universität Regensburg, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 284:F518-24. 2003
    ..Thus our data suggest a general inhibitory effect of the renin-angiotensin system on renocortical COX-2 expression...
  36. doi request reprint The formation of pores in the basal lamina of regenerated renal tubules
    Annette Blattmann
    Department of Molecular and Cellular Anatomy, University of Regensburg, University Street 31, D 93053 Regensburg, Germany
    Biomaterials 29:2749-56. 2008
    ..It remains to be evaluated whether these pores support physiological transport functions or if they indicate the site where extracellular matrix proteins are inserted into newly synthesized basal lamina...
  37. ncbi request reprint Cyclooxygenases in the collecting duct of neonatal rabbit kidney
    Karl Schumacher
    Department of Anatomy, University of Regensburg, Germany
    Cell Physiol Biochem 12:63-74. 2002
    ..The upregulation of COX 2 by a chronic NaCl load in embryonic epithelia suggests in part a constitutive and in part a facultative expression during CD cell differentiation...
  38. ncbi request reprint Low tonicity mediates a downregulation of cyclooxygenase-1 expression by furosemide in the rat renal papilla
    Hayo Castrop
    Institutes of Physiology and Anatomy, University Regensburg, Regensburg, Germany
    J Am Soc Nephrol 13:1136-44. 2002
    ..This effect could be related to the breakdown of the papillary osmotic gradient induced by loop diuretics...
  39. ncbi request reprint Parallel down-regulation of chloride channel CLC-K1 and barttin mRNA in the thin ascending limb of the rat nephron by furosemide
    Konrad Wolf
    Klinik und Poliklinik fur Innere Medizin II, Klinikum der Universitat Regensburg, 93042, Regensburg, Germany
    Pflugers Arch 446:665-71. 2003
    ..Our findings imply that during furosemide treatment selective down-regulation of ClC-K1 and barttin mRNAs in thin limb plays a role in maintaining salt and water homeostasis...