Xavier F Figueroa

Summary

Country: Chile

Publications

  1. pmc Pannexin channel and connexin hemichannel expression in vascular function and inflammation
    Daniela Begandt
    Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA
    BMC Cell Biol 18:2. 2017
  2. doi request reprint Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels
    Xavier F Figueroa
    Departamento de Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Casilla 114 D, Santiago, Chile Electronic address
    Neuropharmacology 75:471-8. 2013
  3. pmc Dissection of two Cx37-independent conducted vasodilator mechanisms by deletion of Cx40: electrotonic versus regenerative conduction
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Am J Physiol Heart Circ Physiol 295:H2001-7. 2008
  4. pmc Gap junctions in the control of vascular function
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Antioxid Redox Signal 11:251-66. 2009
  5. doi request reprint NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Casilla, Santiago, Chile
    Am J Physiol Heart Circ Physiol 297:H134-43. 2009
  6. pmc Coordinated endothelial nitric oxide synthase activation by translocation and phosphorylation determines flow-induced nitric oxide production in resistance vessels
    Xavier F Figueroa
    Departamento de Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Vasc Res 50:498-511. 2013
  7. ncbi request reprint Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Am J Physiol Heart Circ Physiol 293:H1371-83. 2007
  8. doi request reprint Ca2+-activated K+ channels of small and intermediate conductance control eNOS activation through NAD(P)H oxidase
    Pablo S Gaete
    Departamento de Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Free Radic Biol Med 52:860-70. 2012
  9. ncbi request reprint Central role of connexin40 in the propagation of electrically activated vasodilation in mouse cremasteric arterioles in vivo
    Xavier F Figueroa
    Dept of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, PO Box 800736, Charlottesville, VA 22908 0736, USA
    Circ Res 92:793-800. 2003
  10. ncbi request reprint Vascular gap junctions in hypertension
    Xavier F Figueroa
    Unidad de Regulación Neurohumoral, Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Hypertension 48:804-11. 2006

Collaborators

Detail Information

Publications16

  1. pmc Pannexin channel and connexin hemichannel expression in vascular function and inflammation
    Daniela Begandt
    Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA
    BMC Cell Biol 18:2. 2017
    ..In addition, this review will touch on recent evidence implicating a role for these proteins in regulating red blood cell and platelet function...
  2. doi request reprint Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels
    Xavier F Figueroa
    Departamento de Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Casilla 114 D, Santiago, Chile Electronic address
    Neuropharmacology 75:471-8. 2013
    ..This article is part of the Special Issue Section entitled 'Current Pharmacology of Gap Junction Channels and Hemichannels'...
  3. pmc Dissection of two Cx37-independent conducted vasodilator mechanisms by deletion of Cx40: electrotonic versus regenerative conduction
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Am J Physiol Heart Circ Physiol 295:H2001-7. 2008
    ..Connexin40 is essential for the ACh-activated regenerative vasodilator mechanism. However, neither connexin40 nor connexin37 is indispensable for the electrotonic spread of hyperpolarizing signals...
  4. pmc Gap junctions in the control of vascular function
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Antioxid Redox Signal 11:251-66. 2009
    ..In this review, we discuss the participation of connexin-based channels in the control of vascular function in physiologic and pathologic conditions, with a special emphasis on hypertension and diabetes...
  5. doi request reprint NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Casilla, Santiago, Chile
    Am J Physiol Heart Circ Physiol 297:H134-43. 2009
    ....
  6. pmc Coordinated endothelial nitric oxide synthase activation by translocation and phosphorylation determines flow-induced nitric oxide production in resistance vessels
    Xavier F Figueroa
    Departamento de Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Vasc Res 50:498-511. 2013
    ..We tested the hypothesis that eNOS activation by shear stress in resistance vessels depends on synchronized phosphorylation, dissociation from Cav-1 and translocation of the membrane-bound enzyme to Golgi and cytosol...
  7. ncbi request reprint Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Am J Physiol Heart Circ Physiol 293:H1371-83. 2007
    ..2 channels. The resultant Ca(2+) influx activates endothelial nitric oxide synthase and Ca(2+)-activated K(+) channels, triggering vasodilation...
  8. doi request reprint Ca2+-activated K+ channels of small and intermediate conductance control eNOS activation through NAD(P)H oxidase
    Pablo S Gaete
    Departamento de Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Free Radic Biol Med 52:860-70. 2012
    ..These findings disclose a novel mechanism involved in the control of NO production...
  9. ncbi request reprint Central role of connexin40 in the propagation of electrically activated vasodilation in mouse cremasteric arterioles in vivo
    Xavier F Figueroa
    Dept of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, PO Box 800736, Charlottesville, VA 22908 0736, USA
    Circ Res 92:793-800. 2003
    ..Moreover, electrical stimulation activates a nonneuronal, Cx40-dependent vasodilator response that spreads along the vessel length without decay...
  10. ncbi request reprint Vascular gap junctions in hypertension
    Xavier F Figueroa
    Unidad de Regulación Neurohumoral, Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Hypertension 48:804-11. 2006
  11. ncbi request reprint Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad, Catolica de Chile, Chile
    Microvasc Res 68:247-57. 2004
    ..Hence, the histamine-induced reduction in gap junctional communication between HUTEC is mediated by cytoskeleton-dependent and -independent mechanisms and might contribute to modulate endothelial function in lymphoid tissue...
  12. pmc De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy
    Luis A Cea
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago 6513677, Chile
    Proc Natl Acad Sci U S A 110:16229-34. 2013
    ..Consequently, Cx hemichannels are potential targets for new therapeutic agents to prevent or reduce muscle atrophy induced by denervation of diverse etiologies. ..
  13. ncbi request reprint Connexins: gaps in our knowledge of vascular function
    Xavier F Figueroa
    Department of Molecular Physiology and Biological Physics, Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Physiology (Bethesda) 19:277-84. 2004
    ....
  14. pmc ACh-induced endothelial NO synthase translocation, NO release and vasodilatation in the hamster microcirculation in vivo
    Xavier F Figueroa
    Unidad de Regulación Neurohumoral, Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Physiol 544:883-96. 2002
    ....
  15. ncbi request reprint Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    CNS Neurol Disord Drug Targets 10:404-14. 2011
    ..Therefore, blocking hemichannels expressed by glial cells and/or neurons of the inflamed central nervous system might prevent neurovascular unit dysfunction and neurodegeneration...
  16. doi request reprint Functional role of connexins and pannexins in the interaction between vascular and nervous system
    Pablo S Gaete
    Departamento de Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 229:1336-45. 2014
    ..In this review, we discuss the importance of connexin-based channels in the control of BBB integrity and the functional interaction of vascular connexins and pannexins with the peripheral nervous system...