Juan A Orellana

Summary

Country: Chile

Publications

  1. ncbi Physiological Functions of Glial Cell Hemichannels
    Juan A Orellana
    Departamento de Neurologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 391, Santiago, Chile
    Adv Exp Med Biol 949:93-108. 2016
  2. ncbi Role of connexins and pannexins in ischemic stroke
    J A Orellana
    Departamento de Neurologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 391, Santiago, Chile
    Curr Med Chem 21:2165-82. 2014
  3. doi Gap junction channels and hemichannels in the CNS: regulation by signaling molecules
    Juan A Orellana
    Departamento de Neurologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 391, Santiago, Chile Electronic address
    Neuropharmacology 75:567-82. 2013
  4. doi Glial hemichannels and their involvement in aging and neurodegenerative diseases
    Juan A Orellana
    Facultad de Medicina, Departamento de Neurologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Neurosci 23:163-77. 2012
  5. doi Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels
    Juan A Orellana
    Departamento de Neurologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 391, 8330024, Santiago, Chile
    Adv Exp Med Biol 740:777-94. 2012
  6. pmc Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Glia 60:53-68. 2012
  7. pmc Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochem Biophys Res Commun 409:603-9. 2011
  8. doi Amyloid β-induced death in neurons involves glial and neuronal hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago 6513677, Chile
    J Neurosci 31:4962-77. 2011
  9. pmc ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Neurochem 118:826-40. 2011
  10. ncbi Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    CNS Neurol Disord Drug Targets 10:404-14. 2011

Collaborators

Detail Information

Publications27

  1. ncbi Physiological Functions of Glial Cell Hemichannels
    Juan A Orellana
    Departamento de Neurologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 391, Santiago, Chile
    Adv Exp Med Biol 949:93-108. 2016
    ..Here, we briefly review the current findings regarding the effects of the hemichannel-dependent release of gliotransmitters on the physiology of the CNS...
  2. ncbi Role of connexins and pannexins in ischemic stroke
    J A Orellana
    Departamento de Neurologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 391, Santiago, Chile
    Curr Med Chem 21:2165-82. 2014
    ..Development of new drug modulators using in silico devices for connexin and pannexin-based channels will be crucial for future therapies against stroke. ..
  3. doi Gap junction channels and hemichannels in the CNS: regulation by signaling molecules
    Juan A Orellana
    Departamento de Neurologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 391, Santiago, Chile Electronic address
    Neuropharmacology 75:567-82. 2013
    ..This article is part of the Special Issue Section entitled 'Current Pharmacology of Gap Junction Channels and Hemichannels'. ..
  4. doi Glial hemichannels and their involvement in aging and neurodegenerative diseases
    Juan A Orellana
    Facultad de Medicina, Departamento de Neurologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Neurosci 23:163-77. 2012
    ..Therefore, blockade of hemichannels expressed by glial cells and/or neurons during neuroinflammation might prevent neurodegeneration...
  5. doi Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels
    Juan A Orellana
    Departamento de Neurologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 391, 8330024, Santiago, Chile
    Adv Exp Med Biol 740:777-94. 2012
    ..Here, we review evidence supporting the role of Ca(2+) in the regulation of GJCs and HCs formed by connexins. Also it is speculated how these connexin-based channels could contribute to the propagation of intercellular Ca(2+) signals...
  6. pmc Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Glia 60:53-68. 2012
    ..It also establishes that Cx43 hemichannels can be rapidly activated under physiological conditions by the sequential activation of glucosensing proteins in normal tanycytes...
  7. pmc Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochem Biophys Res Commun 409:603-9. 2011
    ..Thus, competitive inhibition of permeation through hemichannels might contribute to cellular retention of essential molecules and/or uptake inhibition of toxic compounds...
  8. doi Amyloid β-induced death in neurons involves glial and neuronal hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago 6513677, Chile
    J Neurosci 31:4962-77. 2011
    ..Consequently, this work opens novel avenues for alternative treatments that target glial cells and neurons to maintain neuronal survival in the presence of Aβ...
  9. pmc ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Neurochem 118:826-40. 2011
    ....
  10. ncbi Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    CNS Neurol Disord Drug Targets 10:404-14. 2011
    ..Therefore, blocking hemichannels expressed by glial cells and/or neurons of the inflamed central nervous system might prevent neurovascular unit dysfunction and neurodegeneration...
  11. pmc Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels
    Juan A Orellana
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Glia 58:329-43. 2010
    ..Cx43 hemichannels may be a novel therapeutic target to reduce cell death following stroke, particularly in hyperglycemic conditions...
  12. pmc Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration
    Juan A Orellana
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Antioxid Redox Signal 11:369-99. 2009
    ..These changes are likely to occur in diverse cell types of the CNS and contribute to neurodegeneration during inflammatory process...
  13. pmc Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice
    Pablo J Sáez
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 8:e71361. 2013
    ..Therefore, Npc1⁻/⁻ astrocytes present features of connexin based channels compatible with those of reactive astrocytes and hemichannels might be a novel therapeutic target to reduce neuroinflammation in NPC disease...
  14. doi Cell membrane permeabilization via connexin hemichannels in living and dying cells
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Exp Cell Res 316:2377-89. 2010
    ....
  15. ncbi Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion
    Mauricio A Retamal
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Membr Biol 218:49-63. 2007
    ....
  16. doi Astrocytes inhibit nitric oxide-dependent Ca(2+) dynamics in activated microglia: involvement of ATP released via pannexin 1 channels
    Juan A Orellana
    Departamento de Neurología Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Glia 61:2023-37. 2013
    ..The understanding of mechanisms underlying glial cell regulatory crosstalk could contribute to the development of new treatments to reduce inflammatory cytotoxicity in several brain pathologies...
  17. doi Understanding risk factors for Alzheimer's disease: interplay of neuroinflammation, connexin-based communication and oxidative stress
    Rodrigo A Quintanilla
    Departamento de Neurologia, Laboratorio de Neurociencias, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Arch Med Res 43:632-44. 2012
    ..Understanding how they cooperate as pathogenic mechanisms of AD is promising for the discovery of new therapeutic strategies against neurodegenerative disorders...
  18. doi Currently used methods for identification and characterization of hemichannels
    Kurt A Schalper
    Departamento de Ciencias Fisiologicas, Núcleo de Immunología e inmuroterapía, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Cell Commun Adhes 15:207-18. 2008
    ..Although the available in vitro evidence is substantial, further studies and possibly new experimental approaches are required to understand the role and properties of connexin and pannexin hemichannels in vivo...
  19. pmc Modulation of interferon-γ-induced glial cell activation by transforming growth factor β1: a role for STAT1 and MAPK pathways
    Rodrigo Herrera-Molina
    Departamento de Neurologia, Laboratorio de Neurosciencias, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Neurochem 123:113-23. 2012
    ..Our results indicate that the cross-talk between IFNγ and TGFβ1 might regulate the activation of glial cells and that TGFβ1 modulated IFNγ-induced production of neurotoxic oxidant molecules through STAT1, ERK, and P38 pathways...
  20. pmc Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells
    Helmuth A Sánchez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Am J Physiol Cell Physiol 297:C665-78. 2009
    ..Thus HC blockade could reduce the increase in free [Ca(2+)](i) and cell death induced by ischemia-like conditions in cells expressing Cx32 HCs...
  21. ncbi Chlorpromazine reduces the intercellular communication via gap junctions in mammalian cells
    Juan A Orellana
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Toxicol Appl Pharmacol 213:187-97. 2006
    ..If Cx43 were the only connexin expressed, MAPK-dependent phosphorylation of this connexin would induce closure of gap junction channels...
  22. ncbi Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases
    Kurt A Schalper
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, P O Box 114 D, Santiago, Chile
    Curr Vasc Pharmacol 7:486-505. 2009
    ....
  23. pmc Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases
    Juan A Orellana
    Departamento de Neurologia, Escuela de Medicina, Pontificia Universidad Católica de Chile Santiago, Chile
    Front Integr Neurosci 10:26. 2016
    ....
  24. doi Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels: A neuroprotective mechanism
    Rosario Gajardo-Gómez
    Departamento de Neurología Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Glia 65:122-137. 2017
    ..Consequently, this work opens novel avenues for alternative treatments that target astrocytes to maintain neuronal function and survival during AD. GLIA 2016 GLIA 2017;65:122-137...
  25. pmc Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions
    Rosario Gajardo-Gómez
    Departamento de Neurologia, Escuela de Medicina, Pontificia Universidad Católica de Chile Santiago, Chile
    Front Mol Neurosci 9:86. 2016
    ..Specifically, we focus on the possible implications of these channels in microglia-to-microglia, microglia-to-astrocyte and neuron-to-microglia interactions in the inflamed brain...
  26. doi Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival
    Beatriz C Avendaño
    Departamento de Neurolog a, Escuela de Medicina, Pontificia Universidad Cat lica de Chile, Santiago, Chile
    Glia . 2015
    ..The understanding of the mechanism underlying astrocyte-neuron crosstalk could contribute to the development of new strategies to ameliorate the brain abnormalities induced in the offspring by prenatal inflammation. GLIA 2015...
  27. doi Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala
    Jimmy Stehberg
    Laboratorio de Neurobiologia, Departamento de Ciencias Biologicas, Facultad de Ciencias Biologicas and Facultad de Medicina, Universidad Andres Bello, Santiago, Chile
    FASEB J 26:3649-57. 2012
    ....