J C Saez

Summary

Country: Chile

Publications

  1. ncbi Regulation of gap junctions by protein phosphorylation
    J C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Braz J Med Biol Res 31:593-600. 1998
  2. ncbi Gap junctions in cells of the immune system: structure, regulation and possible functional roles
    J C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Braz J Med Biol Res 33:447-55. 2000
  3. ncbi Plasma membrane channels formed by connexins: their regulation and functions
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Physiol Rev 83:1359-400. 2003
  4. ncbi Arachidonic acid-induced dye uncoupling in rat cortical astrocytes is mediated by arachidonic acid byproducts
    A D Martinez
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago
    Brain Res 816:411-23. 1999
  5. ncbi Regulation of astrocyte gap junctions by hypoxia-reoxygenation
    A D Martinez
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago
    Brain Res Brain Res Rev 32:250-8. 2000
  6. pmc Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes
    J A Orellana
    Departamento de Neurologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Leukoc Biol 94:399-407. 2013
  7. pmc Gap junction hemichannels in astrocytes of the CNS
    J C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Acta Physiol Scand 179:9-22. 2003
  8. pmc Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha
    E A Eugenin
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 340, Chile
    Proc Natl Acad Sci U S A 98:4190-5. 2001
  9. doi [Biological mechanisms involved in the spread of traumatic brain damage]
    M Rovegno
    Laboratorio de Neurociencias y Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Chile
    Med Intensiva 36:37-44. 2012

Collaborators

Detail Information

Publications9

  1. ncbi Regulation of gap junctions by protein phosphorylation
    J C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Braz J Med Biol Res 31:593-600. 1998
    ..Changes in intercellular communication mediated by protein phosphorylation are believed to control various physiological tissue and cell functions as well as to be altered under pathological conditions...
  2. ncbi Gap junctions in cells of the immune system: structure, regulation and possible functional roles
    J C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Braz J Med Biol Res 33:447-55. 2000
    ..Studies designed to elucidate their physiological roles suggest that they might permit coordination of cellular events which favor the effective and timely response of the immune system...
  3. ncbi Plasma membrane channels formed by connexins: their regulation and functions
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Physiol Rev 83:1359-400. 2003
    ..The observed phenotypes range from specific tissue dysfunction to embryonic lethality...
  4. ncbi Arachidonic acid-induced dye uncoupling in rat cortical astrocytes is mediated by arachidonic acid byproducts
    A D Martinez
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago
    Brain Res 816:411-23. 1999
    ..It is proposed that the AA-induced dye uncoupling is mediated by byproducts that induce rapid channel closure or slow removal of connexin43 gap junctions...
  5. ncbi Regulation of astrocyte gap junctions by hypoxia-reoxygenation
    A D Martinez
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago
    Brain Res Brain Res Rev 32:250-8. 2000
    ..Thus, these results strongly suggest that reoxygenation-induced uncoupling is mediated by arachidonic acid byproducts that induce, at least, disorganization of Cx43 gap junction channels...
  6. pmc Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes
    J A Orellana
    Departamento de Neurologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Leukoc Biol 94:399-407. 2013
    ..Blocking Panx1 hemichannels by reducing their opening or protein expression inhibited HIV replication in CD4(+) T lymphocytes. Thus, our findings demonstrate that Panx1 hemichannels play an essential role in HIV infection. ..
  7. pmc Gap junction hemichannels in astrocytes of the CNS
    J C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Acta Physiol Scand 179:9-22. 2003
    ..Exacerbated hemichannel opening occurs in metabolically inhibited cells, including cortical astrocytes, which contributes to the loss of chemical gradients across the plasma membrane and speeds cell death...
  8. pmc Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha
    E A Eugenin
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 340, Chile
    Proc Natl Acad Sci U S A 98:4190-5. 2001
    ..This report demonstrates that microglia can communicate with each other through gap junctions that are induced by inflammatory cytokines, a process that may be important in the elaboration of the inflammatory response...
  9. doi [Biological mechanisms involved in the spread of traumatic brain damage]
    M Rovegno
    Laboratorio de Neurociencias y Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Chile
    Med Intensiva 36:37-44. 2012
    ..Therapeutic approaches related to the described mechanisms have been included. The discussion is completed with a working model showing the convergence of the main topics...