Kurt A Schalper

Summary

Country: Chile

Publications

  1. ncbi Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases
    Kurt A Schalper
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, P O Box 114 D, Santiago, Chile
    Curr Vasc Pharmacol 7:486-505. 2009
  2. pmc Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses
    Kurt A Schalper
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Mol Biol Cell 19:3501-13. 2008
  3. doi Currently used methods for identification and characterization of hemichannels
    Kurt A Schalper
    Departamento de Ciencias Fisiologicas, Núcleo de Immunología e inmuroterapía, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Cell Commun Adhes 15:207-18. 2008
  4. pmc Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization
    Kurt A Schalper
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Alameda 340, 4 to Piso, Santiago, 8331150 Chile
    Am J Physiol Cell Physiol 299:C1504-15. 2010
  5. doi Modulation of gap junction channels and hemichannels by growth factors
    Kurt A Schalper
    Clinica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile
    Mol Biosyst 8:685-98. 2012
  6. pmc Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochem Biophys Res Commun 409:603-9. 2011
  7. ncbi Cell membrane permeabilization via connexin hemichannels in living and dying cells
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Exp Cell Res 316:2377-89. 2010
  8. doi Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels
    Juan A Orellana
    Departamento de Neurologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 391, 8330024, Santiago, Chile
    Adv Exp Med Biol 740:777-94. 2012
  9. ncbi Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion
    Mauricio A Retamal
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Membr Biol 218:49-63. 2007
  10. pmc Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration
    Juan A Orellana
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Antioxid Redox Signal 11:369-99. 2009

Detail Information

Publications11

  1. ncbi Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases
    Kurt A Schalper
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, P O Box 114 D, Santiago, Chile
    Curr Vasc Pharmacol 7:486-505. 2009
    ....
  2. pmc Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses
    Kurt A Schalper
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Mol Biol Cell 19:3501-13. 2008
    ..The cell density of Cx26 and Cx43 HeLa transfectants cultured in serum-free medium was differentially affected by FGF-1. Thus, the FGF-1-induced cell permeabilization and derived consequences depend on the Cx composition of HCs...
  3. doi Currently used methods for identification and characterization of hemichannels
    Kurt A Schalper
    Departamento de Ciencias Fisiologicas, Núcleo de Immunología e inmuroterapía, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Cell Commun Adhes 15:207-18. 2008
    ..Although the available in vitro evidence is substantial, further studies and possibly new experimental approaches are required to understand the role and properties of connexin and pannexin hemichannels in vivo...
  4. pmc Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization
    Kurt A Schalper
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Alameda 340, 4 to Piso, Santiago, 8331150 Chile
    Am J Physiol Cell Physiol 299:C1504-15. 2010
    ..These studies identify a membrane pathway for Ca(2+) influx and provide a potential explanation for the activation of cellular events induced by extracellular alkalinization...
  5. doi Modulation of gap junction channels and hemichannels by growth factors
    Kurt A Schalper
    Clinica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile
    Mol Biosyst 8:685-98. 2012
    ..The functional consequence of variation in cell-cell communication via these membrane channels is implicated in disease as well as normal cellular responses...
  6. pmc Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochem Biophys Res Commun 409:603-9. 2011
    ..Thus, competitive inhibition of permeation through hemichannels might contribute to cellular retention of essential molecules and/or uptake inhibition of toxic compounds...
  7. ncbi Cell membrane permeabilization via connexin hemichannels in living and dying cells
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Exp Cell Res 316:2377-89. 2010
    ....
  8. doi Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels
    Juan A Orellana
    Departamento de Neurologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 391, 8330024, Santiago, Chile
    Adv Exp Med Biol 740:777-94. 2012
    ..Here, we review evidence supporting the role of Ca(2+) in the regulation of GJCs and HCs formed by connexins. Also it is speculated how these connexin-based channels could contribute to the propagation of intercellular Ca(2+) signals...
  9. ncbi Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion
    Mauricio A Retamal
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Membr Biol 218:49-63. 2007
    ....
  10. pmc Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration
    Juan A Orellana
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Antioxid Redox Signal 11:369-99. 2009
    ..These changes are likely to occur in diverse cell types of the CNS and contribute to neurodegeneration during inflammatory process...
  11. pmc Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential
    Mauricio A Retamal
    Núcleo Milenio Inmunología e Inmunoterapia, Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago 4860, Chile
    Proc Natl Acad Sci U S A 104:8322-7. 2007
    ..These findings suggest that lowering intracellular redox potential increases the opening of Cx43 and Cx43-EGFP hemichannels, possibly by action on cytoplasmic cysteine residues in the connexin C terminus...