Yiguang Jin

Summary

Affiliation: Beijing Institute of Radiation Medicine
Location: Beijing, China
Summary:
Focusing on a novel drug delivery technology: self-assembled drug delivery systems (SADDS) involving prodrug, molecular self-assembly, and nanotechnology. SADDS can be defined as the nanoscale self-assemblies of amphiphilic prodrugs. Now we have performed the SADDS research about antivirals, anticancer drugs, anti-tuberculosis agent. One of them, CPZ, showed a very high anti-HIV activity and macrophage-targeting effect.

Publications

  1. ncbi request reprint Wound Healing Effect of an in Situ Forming Hydrogel Loading Curcumin-Phospholipid Complex
    Lina Du
    Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, PR China
    Curr Drug Deliv 13:76-82. 2016
  2. doi request reprint Molecular self-assembly of amphiphilic cyclic phosphoryl gemcitabine with different N-fatty acyl tails and enhanced anticancer effects of the self-assembled nanostructures
    Yiguang Jin
    Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China Institute of Pharmacy, Pharmaceutical College of Henan University, Kaifeng 475004, China Electronic address
    Colloids Surf B Biointerfaces 133:356-61. 2015
  3. doi request reprint Nanostructures of an amphiphilic zinc phthalocyanine polymer conjugate for photodynamic therapy of psoriasis
    Yiguang Jin
    Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China Institute of Pharmacy, Pharmaceutical College of Henan University, Kaifeng 475004, China Electronic address
    Colloids Surf B Biointerfaces 128:405-9. 2015
  4. doi request reprint Rational design of didodecyldimethylammonium bromide-based nanoassemblies for gene delivery
    Yiguang Jin
    Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China Anhui Medical University, Hefei 230001, China Electronic address
    Colloids Surf B Biointerfaces 126:257-64. 2015
  5. doi request reprint Nanoassemblies containing a fluorouracil/zidovudine glyceryl prodrug with phospholipase A2-triggered drug release for cancer treatment
    Yiguang Jin
    Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China Institute of Pharmacy, Pharmaceutical College of Henan University, Kaifeng 475004, China Electronic address
    Colloids Surf B Biointerfaces 112:421-8. 2013
  6. doi request reprint Self-assembled drug delivery systems. Part 6: in vitro/in vivo studies of anticancer N-octadecanoyl gemcitabine nanoassemblies
    Yiguang Jin
    Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China
    Int J Pharm 430:276-81. 2012

Collaborators

  • Lina Du
  • Xiaoqin Xiang
  • Xue Feng

Detail Information

Publications6

  1. ncbi request reprint Wound Healing Effect of an in Situ Forming Hydrogel Loading Curcumin-Phospholipid Complex
    Lina Du
    Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, PR China
    Curr Drug Deliv 13:76-82. 2016
    ..The epidermal recovery was highly improved by the CPC ISG compared to the control. The CPC ISG is a promising formulation as an effective wound healing dressing. ..
  2. doi request reprint Molecular self-assembly of amphiphilic cyclic phosphoryl gemcitabine with different N-fatty acyl tails and enhanced anticancer effects of the self-assembled nanostructures
    Yiguang Jin
    Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China Institute of Pharmacy, Pharmaceutical College of Henan University, Kaifeng 475004, China Electronic address
    Colloids Surf B Biointerfaces 133:356-61. 2015
    ..The nanostructures showed higher anticancer effects on HepG2 cells than GEM. The nanostructures are promising anticancer nanomedicines. ..
  3. doi request reprint Nanostructures of an amphiphilic zinc phthalocyanine polymer conjugate for photodynamic therapy of psoriasis
    Yiguang Jin
    Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China Institute of Pharmacy, Pharmaceutical College of Henan University, Kaifeng 475004, China Electronic address
    Colloids Surf B Biointerfaces 128:405-9. 2015
    ..The ZPB nanostructure is a promising anti-psoriasis nanomedicine based on photodynamic therapy...
  4. doi request reprint Rational design of didodecyldimethylammonium bromide-based nanoassemblies for gene delivery
    Yiguang Jin
    Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China Anhui Medical University, Hefei 230001, China Electronic address
    Colloids Surf B Biointerfaces 126:257-64. 2015
    ..CPNA could mainly enter cell plasma based on endocytosis. The rational design method is useful for the design and optimization of DDAB-based gene carriers and other cationic lipid-based carriers...
  5. doi request reprint Nanoassemblies containing a fluorouracil/zidovudine glyceryl prodrug with phospholipase A2-triggered drug release for cancer treatment
    Yiguang Jin
    Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China Institute of Pharmacy, Pharmaceutical College of Henan University, Kaifeng 475004, China Electronic address
    Colloids Surf B Biointerfaces 112:421-8. 2013
    ..Enzyme-sensitive amphiphilic combinatorial prodrugs and prodrug-loaded nanoassemblies may represent a new strategy for anticancer drug design. ..
  6. doi request reprint Self-assembled drug delivery systems. Part 6: in vitro/in vivo studies of anticancer N-octadecanoyl gemcitabine nanoassemblies
    Yiguang Jin
    Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China
    Int J Pharm 430:276-81. 2012
    ..The nanoassemblies had similar anticancer efficacy to free gemcitabine solutions when the former contained about 1/3 dose of the latter in gemcitabine form. The nanoassemblies would be a promising anticancer nanomedicine...