Jinhua Liu

Summary

Affiliation: China Agricultural University
Country: China

Publications

  1. pmc Emergence of European avian influenza virus-like H1N1 swine influenza A viruses in China
    Jinhua Liu
    China Agricultural University, Beijing, People s Republic of China
    J Clin Microbiol 47:2643-6. 2009
  2. ncbi request reprint Phylogenetic analysis of neuraminidase gene of H9N2 influenza viruses prevalent in chickens in China during 1995-2002
    Jin Hua Liu
    Laboratory of Microbiology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, P R China
    Virus Genes 27:197-202. 2003
  3. ncbi request reprint [Sequence analysis of NS1 gene of some H9N2 subtype influenza viruses isolated from chickens in China]
    Jinhua Liu
    College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
    Wei Sheng Wu Xue Bao 43:547-53. 2003
  4. ncbi request reprint Genetic conservation of hemagglutinin gene of H9 influenza virus in chicken population in Mainland China
    Jin Hua Liu
    Department of Infectious Disease, College of Veterinary Medicine, China Agricultural University, Beijing, People s Republic of China
    Virus Genes 29:329-34. 2004
  5. ncbi request reprint Interregional transmission of the internal protein genes of H2 influenza virus in migratory ducks from North America to Eurasia
    Jin Hua Liu
    Laboratory of Microbiology, College of Veterinary Medicine, China Agricultural University, Beijing, 100094, People s Republic of China
    Virus Genes 29:81-6. 2004
  6. ncbi request reprint Phylogenetic analysis of hemagglutinin and neuraminidase genes of H9N2 viruses isolated from migratory ducks
    Jin Hua Liu
    Laboratory of Microbiology, College of Veterinary Medicine, China Agricultural University, Beijing, 100094, People s Republic of China
    Virus Genes 27:291-6. 2003
  7. ncbi request reprint H9N2 influenza viruses prevalent in poultry in China are phylogenetically distinct from A/quail/Hong Kong/G1/97 presumed to be the donor of the internal protein genes of the H5N1 Hong Kong/97 virus
    Jinhua Liu
    Laboratory of Microbiology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, People s Republic of China
    Avian Pathol 32:551-60. 2003
  8. pmc Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice
    Yuhai Bi
    Center for Molecular Virology, Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Virol J 8:505. 2011
  9. pmc Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence
    JingJing Wang
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    PLoS ONE 7:e40752. 2012
  10. pmc Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice
    Yipeng Sun
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    J Virol 88:4600-4. 2014

Collaborators

Detail Information

Publications63

  1. pmc Emergence of European avian influenza virus-like H1N1 swine influenza A viruses in China
    Jinhua Liu
    China Agricultural University, Beijing, People s Republic of China
    J Clin Microbiol 47:2643-6. 2009
    ..Our study revealed the emergence of avian-origin European H1N1 swine influenza virus in China, which highlights the necessity of swine influenza surveillance for potential pandemic preparedness...
  2. ncbi request reprint Phylogenetic analysis of neuraminidase gene of H9N2 influenza viruses prevalent in chickens in China during 1995-2002
    Jin Hua Liu
    Laboratory of Microbiology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, P R China
    Virus Genes 27:197-202. 2003
    ..The present results indicate that the NA of H9N2 strains isolated in mainland China during the past 8 years were well preserved and the geographical distribution play a significant role in the evolution of the H9N2 influenza viruses...
  3. ncbi request reprint [Sequence analysis of NS1 gene of some H9N2 subtype influenza viruses isolated from chickens in China]
    Jinhua Liu
    College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
    Wei Sheng Wu Xue Bao 43:547-53. 2003
    ....
  4. ncbi request reprint Genetic conservation of hemagglutinin gene of H9 influenza virus in chicken population in Mainland China
    Jin Hua Liu
    Department of Infectious Disease, College of Veterinary Medicine, China Agricultural University, Beijing, People s Republic of China
    Virus Genes 29:329-34. 2004
    ..The available evidence indicates that HA genes of H9 influenza virus circulating in Mainland China during the past years were well conserved...
  5. ncbi request reprint Interregional transmission of the internal protein genes of H2 influenza virus in migratory ducks from North America to Eurasia
    Jin Hua Liu
    Laboratory of Microbiology, College of Veterinary Medicine, China Agricultural University, Beijing, 100094, People s Republic of China
    Virus Genes 29:81-6. 2004
    ..The fact that reassortants could be generated in the migratory ducks between North American and Eurasian avian virus lineage further stresses the importance of global surveillance among the migratory ducks...
  6. ncbi request reprint Phylogenetic analysis of hemagglutinin and neuraminidase genes of H9N2 viruses isolated from migratory ducks
    Jin Hua Liu
    Laboratory of Microbiology, College of Veterinary Medicine, China Agricultural University, Beijing, 100094, People s Republic of China
    Virus Genes 27:291-6. 2003
    ..The present results further emphasize the importance of carrying out molecular epidemiological surveillance of H9N2 viruses in wild ducks to obtain more information for the future human influenza pandemics preparedness...
  7. ncbi request reprint H9N2 influenza viruses prevalent in poultry in China are phylogenetically distinct from A/quail/Hong Kong/G1/97 presumed to be the donor of the internal protein genes of the H5N1 Hong Kong/97 virus
    Jinhua Liu
    Laboratory of Microbiology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, People s Republic of China
    Avian Pathol 32:551-60. 2003
    ....
  8. pmc Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice
    Yuhai Bi
    Center for Molecular Virology, Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Virol J 8:505. 2011
    ..H9N2 influenza A viruses have undergone extensive reassortments in different host species, and could lead to the epidemics or pandemics with the potential emergence of novel viruses...
  9. pmc Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence
    JingJing Wang
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    PLoS ONE 7:e40752. 2012
    ..Thus, our results show that the combination of PB2 amino acids at position 147 and 627 is critical for the increased pathogenicity of H9N2 influenza virus in mammalian host...
  10. pmc Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice
    Yipeng Sun
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    J Virol 88:4600-4. 2014
    ..In particular, the PA-P224S mutation when combined with PA-A70V in CA04 drastically reduced the virus's 50% mouse lethal dose (LD50), by almost 1,000-fold. ..
  11. pmc Identification of swine influenza A virus and Stenotrophomonas maltophilia co-infection in Chinese pigs
    Dongjun Hou
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People s Republic of China
    Virol J 9:169. 2012
    ..Influenza virus virulence can be exacerbated by bacterial co-infections. Swine influenza virus (SIV) infection together with some bacteria is found to enhance pathogenicity...
  12. pmc Amino acid 316 of hemagglutinin and the neuraminidase stalk length influence virulence of H9N2 influenza virus in chickens and mice
    Yipeng Sun
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    J Virol 87:2963-8. 2013
    ..Single mutations or combinations of these mutations strengthened the virulence of H9N2 virus in chickens and mice...
  13. doi request reprint Identification and characterization of avian-origin H3N2 canine influenza viruses in northern China during 2009-2010
    Yipeng Sun
    Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No 2 Yuanmingyuan West Road, Beijing 100193, China
    Virology 435:301-7. 2013
    ..Our findings show the continued evolution of avian-origin H3N2 CIVs and emphasize the necessity of continued surveillance of influenza virus in dogs...
  14. pmc Characterization of an artificial swine-origin influenza virus with the same gene combination as H1N1/2009 virus: a genesis clue of pandemic strain
    Xueli Zhao
    Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    PLoS ONE 6:e22091. 2011
    ..The present results reveal that not only gene segment reassortment but also amino acid mutation were needed for the generation of the pandemic influenza virus...
  15. pmc Duck Hepatitis A virus possesses a distinct type IV internal ribosome entry site element of picornavirus
    Meng Pan
    Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, ChinaAgricultural University, Beijing, People s Republic of China
    J Virol 86:1129-44. 2012
    ..Therefore, we propose that DHAV possesses a distinct type IV IRES element of picornavirus...
  16. doi request reprint Synergism of co-mutation of two amino acid residues in NS1 protein increases the pathogenicity of influenza virus in mice
    Juan Pu
    Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China
    Virus Res 151:200-4. 2010
    ..Our findings demonstrate that co-mutation of amino acid residues at multiple positions in the NS1 protein can increase the pathogenicity of influenza virus in mice...
  17. pmc Acute respiratory distress syndrome induced by a swine 2009 H1N1 variant in mice
    Yi Zhang
    Key Laboratory of Animal Epidemiology and Zoonosis, College of Veterinary Medicine, China Agricultural University, Ministry of Agriculture, Beijing, China
    PLoS ONE 7:e29347. 2012
    ..However, no animal model has been developed for ARDS caused by infection with 2009 H1N1 virus. Here, we present a mouse model of ARDS induced by 2009 H1N1 virus...
  18. doi request reprint Characterization of a highly pathogenic avian influenza H5N1 clade 2.3.4 virus isolated from a tree sparrow
    Qinfang Liu
    Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, PR China
    Virus Res 147:25-9. 2010
    ....
  19. pmc Transmission and pathogenicity of novel reassortants derived from Eurasian avian-like and 2009 pandemic H1N1 influenza viruses in mice and guinea pigs
    Weili Kong
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China
    Sci Rep 6:27067. 2016
    ..The present study revealed high reassortment compatibility between EA and pdm/09 viruses in pigs, which could give rise to progeny reassortant viruses with enhanced virulence and transmissibility in mice and guinea pig models. ..
  20. doi request reprint PA-X is a virulence factor in avian H9N2 influenza virus
    Huijie Gao
    1 Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, PR China
    J Gen Virol 96:2587-94. 2015
    ....
  21. pmc Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity
    Huijie Gao
    1 Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, PR China
    J Gen Virol 96:2036-49. 2015
    ..Furthermore, aa 233-252 at the C terminus of PA-X strongly suppressed co-transfected gene expression by ∼ 50%, suggesting that these terminal 20 aa could play a role in enhancing viral replication and contribute to virulence...
  22. pmc Novel swine influenza virus reassortants in pigs, China
    Yuhai Bi
    China Agricultural University, Beijing, People s Republic of China
    Emerg Infect Dis 16:1162-4. 2010
    ..These reassortment events raise concern about generation of novel viruses in pigs, which could have pandemic potential...
  23. pmc Cryptoporus volvatus extract inhibits porcine reproductive and respiratory syndrome virus (PRRSV) in vitro and in vivo
    Li Gao
    State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China
    PLoS ONE 8:e63767. 2013
    ..Collectively, our findings imply that the aqueous extract from the fruiting body of Cryptoporus volvatus has the potential to be used for anti-PRRSV therapies...
  24. doi request reprint A multiplex RT-PCR assay for detection and differentiation of avian H3, H5, and H9 subtype influenza viruses and Newcastle disease viruses
    Qingdong Tang
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
    J Virol Methods 181:164-9. 2012
    ..The mRT-PCR assay was established successfully for the detection and differentiation of avian H3, H5, and H9 subtype AIVs and NDVs. The method should, therefore, provide a valuable diagnostic tool for these infections...
  25. pmc Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model Ferrets
    Honglei Sun
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China
    J Virol 90:6235-43. 2016
    ..The present results highlight the threat of emergent H5N6 viruses to poultry and human health and the need to closely track their continual adaptation in humans...
  26. pmc Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and Pathogenicity
    Guanlong Xu
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China
    J Virol 90:8105-14. 2016
    ....
  27. pmc Truncation of C-terminal 20 amino acids in PA-X contributes to adaptation of swine influenza virus in pigs
    Guanlong Xu
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, 100193, China
    Sci Rep 6:21845. 2016
    ..Furthermore, we found that truncation of PA-X improved the inhibition of IFN-I mRNA expression. Hereby, our results imply that truncation of PA-X may contribute to the adaptation of SIV in pigs. ..
  28. pmc Serological survey of canine H3N2, pandemic H1N1/09, and human seasonal H3N2 influenza viruses in cats in northern China, 2010-2014
    Xuxiao Zhang
    State Key Laboratory of Agrobiotechnology, College of Veterinary Medicine and Key Laboratory of Animal Epidemiology and Zoonosis of the Ministry of Agriculture, China Agricultural University, No 2 Yuanmingyuan West Road, Beijing, 100193, China
    Virol J 12:50. 2015
    ..Therefore, we examined the seroprevalence of pandemic H1N1/09, canine H3N2, and human H3N2 viruses in pet cats in northern China from 2010 to 2014...
  29. pmc Influenza A virus acquires enhanced pathogenicity and transmissibility after serial passages in swine
    Kai Wei
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    J Virol 88:11981-94. 2014
    ....
  30. doi request reprint Evaluation of the protective efficacy of a commercial vaccine against different antigenic groups of H9N2 influenza viruses in chickens
    Yipeng Sun
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
    Vet Microbiol 156:193-9. 2012
    ..Furthermore, the avian influenza vaccination policy also needs to be re-assessed, and increased veterinary biosecurity on farms, rather than vaccine application alone, should be implemented to prevent and control avian influenza...
  31. doi request reprint Establishment of a multiplex RT-PCR assay to detect different lineages of swine H1 and H3 influenza A viruses
    Guanghua Fu
    Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, People s Republic of China
    Virus Genes 41:236-40. 2010
    ..This multiplex RT-PCR method provides a rapid and specific swine influenza diagnostic tool that also has the potential for investigating the epidemiology of different lineages of swine influenza virus prevalent currently in China...
  32. pmc Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference
    Fei Wang
    College of Veterinary Medicine China Agricultural University, Beijing, China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences, Beijing, China
    EMBO J 34:1661-73. 2015
    ..Further structural analysis revealed how the P186L substitution in the receptor-binding site of HA determines the receptor-binding preference change. We conclude that the human-infecting H6N1 evolved into a human receptor preference. ..
  33. pmc High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses
    Yipeng Sun
    Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
    Proc Natl Acad Sci U S A 108:4164-9. 2011
    ....
  34. doi request reprint Genotypic evolution and antigenic drift of H9N2 influenza viruses in China from 1994 to 2008
    Yipeng Sun
    Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China
    Vet Microbiol 146:215-25. 2010
    ..The continuing evolution of H9N2 influenza viruses in China emphasizes the importance of H9N2 influenza virus surveillance throughout this region to aid pandemic prediction and prevention...
  35. pmc Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses
    Honglei Sun
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    J Virol 88:725-9. 2014
    ..3.4 viruses produced significantly more viruses than those infected with the other two clades. Likewise, clade 2.3.4-infected macrophages caused the most severe cellular damage and strongest proinflammatory response. ..
  36. doi request reprint Hemagglutinin mutation D222N of the 2009 pandemic H1N1 influenza virus alters receptor specificity without affecting virulence in mice
    Weili Kong
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, 17 Qinghua Donglu, Beijing 100193, China
    Virus Res 189:79-86. 2014
    ..The D222N HA mutation resulted in slight weight loss, lower lung titers, inflammatory cytokines and alveolar inflammation in mice than the WT virus. This may or may not be associated with severe clinical outcomes reported in humans. ..
  37. doi request reprint A serological survey of canine H3N2, pandemic H1N1/09 and human seasonal H3N2 influenza viruses in dogs in China
    Yipeng Sun
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    Vet Microbiol 168:193-6. 2014
    ..Our findings emphasize the necessity for continued surveillance of influenza viruses in dogs in China. ..
  38. pmc Generation and protective efficacy of a cold-adapted attenuated avian H9N2 influenza vaccine
    Yandi Wei
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, 100193, China
    Sci Rep 6:30382. 2016
    ..These results demonstrated that the cold-adapted attenuated H9N2 virus would be selected as a vaccine to control the infection of prevalent H9N2 influenza viruses in chickens. ..
  39. doi request reprint Characterization of clade 2.3.4.4 highly pathogenic H5 avian influenza viruses in ducks and chickens
    Honglei Sun
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China
    Vet Microbiol 182:116-22. 2016
    ..Antigenicity analysis revealed that the current vaccines that are widely used in China may fail to confer protection against the H5 reassortants. ..
  40. doi request reprint Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus
    Min Wang
    1 College of Veterinary Medicine, China Agricultural University, Beijing 100193, China 2 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Nat Commun 6:5600. 2015
    ..We conclude that the H10N8 virus is a typical avian influenza virus. ..
  41. pmc A single amino acid at the hemagglutinin cleavage site contributes to the pathogenicity and neurovirulence of H5N1 influenza virus in mice
    Yi Zhang
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    J Virol 86:6924-31. 2012
    ..Our results demonstrate that an amino acid substitution at the P6 cleavage site alone could modulate the virulence of H5N1 in mice...
  42. pmc The infection of turkeys and chickens by reassortants derived from pandemic H1N1 2009 and avian H9N2 influenza viruses
    Honglei Sun
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China
    Sci Rep 5:10130. 2015
    ..Our results indicate that turkeys and chickens are susceptible to pH1N1-H9N2 reassortant viruses, and mixing breeding of different avian species would facilitate the transmission of these reassortant viruses. ..
  43. pmc Antigenic evolution of H9N2 chicken influenza viruses isolated in China during 2009-2013 and selection of a candidate vaccine strain with broad cross-reactivity
    Yandi Wei
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China
    Vet Microbiol 182:1-7. 2016
    ..Systematic surveillance and timely updating of vaccine strains are important for viral prevention and control in the future. ..
  44. pmc The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses
    Huijie Gao
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China
    Sci Rep 5:8262. 2015
    ..Our study highlights the effects of PA-X on the moderation of viral pathogenesis and pathogenicity. ..
  45. pmc Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus
    Juan Pu
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105
    Proc Natl Acad Sci U S A 112:548-53. 2015
    ..The prevalence and variation of H9N2 influenza virus in farmed poultry could provide an important early warning of the emergence of novel reassortants with pandemic potential. ..
  46. ncbi request reprint Full genome sequences of two reticuloendotheliosis viruses contaminating commercial vaccines
    Qinfang Liu
    Department of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China
    Avian Dis 53:341-6. 2009
    ..The results further indicated that the prototype CSV may be the most-important REV contaminant in the commercial vaccines, and distinct genotypes of REVs may cocirculate in chicken flocks of China at the present time...
  47. doi request reprint Natural and experimental infection of dogs with pandemic H1N1/2009 influenza virus
    Degui Lin
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China
    J Gen Virol 93:119-23. 2012
    ..The present findings indicate that human H1N1/2009 can infect dogs, but is transmitted inefficiently between dogs...
  48. pmc A Multiplex RT-PCR Assay for Detection and Differentiation of Avian-Origin Canine H3N2, Equine-Origin H3N8, Human-Origin H3N2, and H1N1/2009 Canine Influenza Viruses
    Chenxi Wang
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    PLoS ONE 12:e0170374. 2017
    ..Additionally, mRT-PCR results obtained from 420 clinical samples were consistent with those obtained by the conventional virus isolation method. Our mRT-PCR assay is reliable for clinical diagnosis and rapid identification of CIVs...
  49. pmc Cryptoporus volvatus extract inhibits influenza virus replication in vitro and in vivo
    Li Gao
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 9:e113604. 2014
    ..Our results suggest that the Cryptoporus volvatus extract could be a potential candidate for the development of a new anti-influenza virus therapy. ..
  50. doi request reprint C-terminal elongation of NS1 of H9N2 influenza virus induces a high level of inflammatory cytokines and increases transmission
    Weili Kong
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China
    J Gen Virol 96:259-68. 2015
    ..These findings suggest that the NS1 extension conferred a gain of fitness to some extent. ..
  51. doi request reprint Different quasispecies with great mutations hide in the same subgroup J field strain of avian leukosis virus
    Yaqing Mao
    College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
    Sci China Life Sci 56:414-20. 2013
    ..The amino acid sequence homology of gp37 and gp85 among the nine clones was 98.5%-100.0% and 96.6%-100.0% respectively, suggesting that the gp85 region of the env gene can better display the quasispecies diversity of ALV-J than gp37...
  52. doi request reprint Recovery of duck hepatitis A virus 3 from a stable full-length infectious cDNA clone
    Meng Pan
    Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, People s Republic of China
    Virus Res 160:439-43. 2011
    ..Our present studies provide a useful tool for future research on genomic functions and molecular pathogenesis of DHAV-3...
  53. doi request reprint Differential nucleocytoplasmic shuttling of the nucleoprotein of influenza a viruses and association with host tropism
    Jing Li
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    Cell Microbiol . 2016
    ..The present study demonstrated the dissimilarity in subcellular NP transport processes between H1N1 virus WSN and other influenza A virus strains, as well as uncovered the mechanism responsible for this difference...
  54. pmc Guinea pig model for evaluating the potential public health risk of swine and avian influenza viruses
    Yipeng Sun
    Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    PLoS ONE 5:e15537. 2010
    ..The influenza viruses circulating in animals sporadically transmit to humans and pose pandemic threats. Animal models to evaluate the potential public health risk potential of these viruses are needed...
  55. pmc Risk perceptions for avian influenza virus infection among poultry workers, China
    Qi Yu
    Beijing General Station of Animal Husbandry and Veterinary Medicine, Beijing, China
    Emerg Infect Dis 19:313-6. 2013
    ..We found that poultry workers had considerable risk for infection with H9 subtypes. Increasing their knowledge could prevent future infections...
  56. doi request reprint Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
    Yi Shi
    Research Network of Immunity and Health, Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China
    Science 342:243-7. 2013
    ..The structures of SH-H7N9 HA, AH-H7N9 HA, and its mutant in complex with either avian or human receptor analogs show how AH-H7N9 can bind human receptors while still retaining the avian receptor-binding property. ..
  57. doi request reprint Inhibition of porcine reproductive and respiratory syndrome virus replication by flavaspidic acid AB
    Qian Yang
    State Key Laboratories of Agrobiotechnology, China Agricultural University, Beijing, China
    Antiviral Res 97:66-73. 2013
    ..In conclusion, we provide a foundation for the possibility to develop a new therapeutic agent to control PRRSV infection...
  58. doi request reprint Neutrophils may be a vehicle for viral replication and dissemination in human H5N1 avian influenza
    Yingying Zhao
    Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, China
    Clin Infect Dis 47:1575-8. 2008
    ..Viral RNA was detected in neutrophils by in situ hybridization and enhanced real-time polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza...
  59. doi request reprint Divergence in centromere structure distinguishes related genomes in Coix lacryma-jobi and its wild relative
    Yonghua Han
    National Maize Improvement Center of China, Key Laboratory of Crop Genetic Improvement and Genome of Ministry of Agriculture, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, People s Republic of China
    Chromosoma 119:89-98. 2010
    ..The evolution of centromeric repeats of C. lacryma-jobi during the polyploidization was discussed...
  60. pmc H9N2 influenza virus in China: a cause of concern
    Yipeng Sun
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, 100083, China
    Protein Cell 6:18-25. 2015
    ..The contribution of H9N2 genes, especially RNP genes, to the infection of humans needs to be investigated in the future. ..
  61. pmc Assessment of the internal genes of influenza A (H7N9) virus contributing to high pathogenicity in mice
    Yuhai Bi
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    J Virol 89:2-13. 2015
    ..Our results indicate that PB2, M, and NP are the key virulence genes, together with the surface hemagglutinin (HA) and neuraminidase (NA) proteins, contributing to the high infectivity of the H7N9 virus in humans...
  62. ncbi request reprint H5N1 infection of the respiratory tract and beyond: a molecular pathology study
    Jiang Gu
    Infectious Disease Centre, Peking University, Beijing, China
    Lancet 370:1137-45. 2007
    ..Previous studies have shown that the human infection with avian influenza H5N1 could also target organs apart from the lungs...