Li Guo

Summary

Country: China

Publications

  1. doi request reprint Consistent isomiR expression patterns and 3' addition events in miRNA gene clusters and families implicate functional and evolutionary relationships
    Li Guo
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
    Mol Biol Rep 39:6699-706. 2012
  2. doi request reprint An integrated evolutionary analysis of miRNA-lncRNA in mammals
    Li Guo
    Department of Epidemiology and Biostatistics and Ministry of Education Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, 211166, China
    Mol Biol Rep 41:201-7. 2014
  3. doi request reprint Selected isomiR expression profiles via arm switching?
    Li Guo
    Department of Epidemiology and Biostatistics and Ministry of Education Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, 211166, China Electronic address
    Gene 533:149-55. 2014
  4. doi request reprint A challenge for miRNA: multiple isomiRs in miRNAomics
    Li Guo
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 211166, China Electronic address
    Gene 544:1-7. 2014
  5. doi request reprint Dynamic evolution of mir-17-92 gene cluster and related miRNA gene families in vertebrates
    Li Guo
    Department of Epidemiology and Biostatistics and Ministry of Education Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, 210029 Nanjing, China
    Mol Biol Rep 40:3147-53. 2013
  6. doi request reprint Genome-wide screen for aberrantly expressed miRNAs reveals miRNA profile signature in breast cancer
    Li Guo
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 210029, China
    Mol Biol Rep 40:2175-86. 2013
  7. doi request reprint A genome-wide screen for non-template nucleotides and isomiR repertoires in miRNAs indicates dynamic and versatile microRNAome
    Li Guo
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China
    Mol Biol Rep 41:6649-58. 2014
  8. doi request reprint Global expression analysis of miRNA gene cluster and family based on isomiRs from deep sequencing data
    Li Guo
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
    Comput Biol Chem 34:165-71. 2010
  9. doi request reprint Tracking miRNA precursor metabolic products and processing sites through completely analyzing high-throughput sequencing data
    Li Guo
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
    Mol Biol Rep 39:2031-8. 2012
  10. doi request reprint Close association between paralogous multiple isomiRs and paralogous/orthologues miRNA sequences implicates dominant sequence selection across various animal species
    Li Guo
    Department of Epidemiology and Biostatistics and Ministry of Education Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, 210029, China
    Gene 527:624-9. 2013

Detail Information

Publications38

  1. doi request reprint Consistent isomiR expression patterns and 3' addition events in miRNA gene clusters and families implicate functional and evolutionary relationships
    Li Guo
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
    Mol Biol Rep 39:6699-706. 2012
    ..The consistent maturation mechanism may contribute to co-regulate biological processes, and may originate from ancestral miRNA genes through complex duplication history...
  2. doi request reprint An integrated evolutionary analysis of miRNA-lncRNA in mammals
    Li Guo
    Department of Epidemiology and Biostatistics and Ministry of Education Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, 211166, China
    Mol Biol Rep 41:201-7. 2014
    ..The phylogenetical conservation of the imprinted cluster may be also derived from the functional implications and evolutionary pressures. The study will enrich the study of potential crosstalk of miRNA-lncRNA and mRNA-ncRNA...
  3. doi request reprint Selected isomiR expression profiles via arm switching?
    Li Guo
    Department of Epidemiology and Biostatistics and Ministry of Education Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, 211166, China Electronic address
    Gene 533:149-55. 2014
    ..The diverged isomiR expression profiles further enrich the complexity of multiple isomiRs, and complicate the coding-non-coding RNA regulatory network. ..
  4. doi request reprint A challenge for miRNA: multiple isomiRs in miRNAomics
    Li Guo
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 211166, China Electronic address
    Gene 544:1-7. 2014
    ..This may enrich and complicate miRNA biogenesis and coding-non-coding RNA regulatory networks. ..
  5. doi request reprint Dynamic evolution of mir-17-92 gene cluster and related miRNA gene families in vertebrates
    Li Guo
    Department of Epidemiology and Biostatistics and Ministry of Education Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, 210029 Nanjing, China
    Mol Biol Rep 40:3147-53. 2013
    ..miRNA gene cluster should be a better phylogenetic marker than a single miRNA gene to reveal functional and evolutionary relationships...
  6. doi request reprint Genome-wide screen for aberrantly expressed miRNAs reveals miRNA profile signature in breast cancer
    Li Guo
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 210029, China
    Mol Biol Rep 40:2175-86. 2013
    ..Dynamic miRNA expression profiles, various abnormal miRNA profiles and complexity of the miRNA regulatory network reveal that the miRNA expression profile is a potential biomarker for classifying or detecting human disease...
  7. doi request reprint A genome-wide screen for non-template nucleotides and isomiR repertoires in miRNAs indicates dynamic and versatile microRNAome
    Li Guo
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China
    Mol Biol Rep 41:6649-58. 2014
    ..Collectively, multiple isomiR products and miRNA maturation processes provide opportunities to perform versatile roles in the regulatory network, which further enriches and complicates the regulation of biological processes...
  8. doi request reprint Global expression analysis of miRNA gene cluster and family based on isomiRs from deep sequencing data
    Li Guo
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
    Comput Biol Chem 34:165-71. 2010
    ....
  9. doi request reprint Tracking miRNA precursor metabolic products and processing sites through completely analyzing high-throughput sequencing data
    Li Guo
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
    Mol Biol Rep 39:2031-8. 2012
    ..Overall, a comprehensive analysis of sequencing data can be used to track pre-miRNA metabolic products and mechanism of pre-miRNA processing and metabolism...
  10. doi request reprint Close association between paralogous multiple isomiRs and paralogous/orthologues miRNA sequences implicates dominant sequence selection across various animal species
    Li Guo
    Department of Epidemiology and Biostatistics and Ministry of Education Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, 210029, China
    Gene 527:624-9. 2013
    ..Thus, dominant sequences emerge in response to functional and evolutionary pressures, allowing an organism to adapt to complex intra- and extra-cellular events...
  11. doi request reprint Integrated evolutionary analysis of human miRNA gene clusters and families implicates evolutionary relationships
    Li Guo
    Department of Epidemiology and Biostatistics, Ministry of Education Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, 211166, China Electronic address
    Gene 534:24-32. 2014
    ..The integrative evolutionary analysis will provide more potential evolutionary and functional relationships between homologous and clustered miRNAs. ..
  12. pmc nDNA-Prot: identification of DNA-binding proteins based on unbalanced classification
    Li Song
    School of Information Science and Technology, Xiamen University, Xiamen, Fujian 361005, China
    BMC Bioinformatics 15:298. 2014
    ..Because of this, the previous research has been limited by the relatively unbalanced accuracy rate and the low identification success of the current methods...
  13. pmc A comprehensive survey of miRNA repertoire and 3' addition events in the placentas of patients with pre-eclampsia from high-throughput sequencing
    Li Guo
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
    PLoS ONE 6:e21072. 2011
    ....
  14. doi request reprint A comprehensive survey of maternal plasma miRNAs expression profiles using high-throughput sequencing
    Hailing Li
    State Key Laboratory of Bioelectronics, Southeast University Nanjing, China
    Clin Chim Acta 413:568-76. 2012
    ..We thus set out to investigate maternal plasma miRNAs expression profile using genome-wide sequencing...
  15. pmc Next-generation sequencing of microRNAs for breast cancer detection
    Qian Wu
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, SiPaiLou 2, Nanjing 210096, China
    J Biomed Biotechnol 2011:597145. 2011
    ..SOLiD sequencing provides a promising method for cancer-related miRNA profiling. Serum miRNAs may be useful biomarkers for breast cancer detection...
  16. doi request reprint Identification and characterization of novel microRNA candidates from deep sequencing
    Qian Wu
    The State Key Laboratory of Reproductive Medicine, Department of Hygienic Analysis and Detection, School of Public Health, Nanjing Medical University, 140 Hanzhong Rd, Nanjing 210029, China
    Clin Chim Acta 415:239-44. 2013
    ..In the conclusion, novel-miR, named miR-3675b, is a true, functional and novel miRNA. Candidate novel miRNA from deep sequencing which will be qualified as a "real" miRNA must be validated by a series of functional experiments...
  17. doi request reprint Analysis of serum genome-wide microRNAs for breast cancer detection
    Qian Wu
    State Key Laboratory of Reproductive Medicine, Department of Hygienic Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, China
    Clin Chim Acta 413:1058-65. 2012
    ..In this paper, we investigated that whether specific miRNAs were co-expressed in the serum and tissue of breast cancer (BC) patients as novel biomarkers by SOLiD sequencing...
  18. doi request reprint Genome-wide analysis of aberrantly expressed circulating miRNAs in patients with coal workers' pneumoconiosis
    Li Guo
    Department of Epidemiology and Biostatistics and Ministry of Education Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China
    Mol Biol Rep 40:3739-47. 2013
    ..In addition, some significantly dysregulated miRNAs may be potential non-invasive diagnosis biomarkers based on further study...
  19. pmc Serum miRNA profiling identifies miR-150/30a as potential biomarker for workers with damaged nerve fibers from carbon disulfide
    Li Guo
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China
    Ind Health 53:38-47. 2015
    ..miR-150 and miR-30a may be potential noninvasive biomarkers for a damaged nervous system. ..
  20. pmc The fate of miRNA* strand through evolutionary analysis: implication for degradation as merely carrier strand or potential regulatory molecule?
    Li Guo
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
    PLoS ONE 5:e11387. 2010
    ..Recently, some miRNA* sequences were reported as guide miRNAs with abundant expression. Here, we intended to discover evolutionary implication of the fate of miRNA* strand by analyzing miRNA/miRNA* sequences across vertebrates...
  21. pmc Global analysis of miRNA gene clusters and gene families reveals dynamic and coordinated expression
    Li Guo
    Department of Epidemiology and Biostatistics and Ministry of Education Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
    Biomed Res Int 2014:782490. 2014
    ..miRNA gene clusters and families indicated important biological roles, and the specific distribution and expression further enrich and ensure the flexible and robust regulatory network. ..
  22. doi request reprint miRNA-miRNA interaction implicates for potential mutual regulatory pattern
    Li Guo
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China
    Gene 511:187-94. 2012
    ..We herein present systematic analysis of them in human, mouse and rat miRNAs, and their expression patterns based on deep sequencing datasets...
  23. pmc Cross-mapping events in miRNAs reveal potential miRNA-mimics and evolutionary implications
    Li Guo
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
    PLoS ONE 6:e20517. 2011
    ..We proposed that the cross-mapping events are more complex than we previously thought. Sequence similarity between other ncRNAs and pre-miRNAs and the specific stem-loop structures of pre-miRNAs may provide evolutionary implications...
  24. doi request reprint A comprehensive study of multiple mapping and feature selection for correction strategy in the analysis of small RNAs from SOLiD sequencing
    Li Guo
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China
    Biosystems 104:87-93. 2011
    ..Further studies should develop an approach to correct the widespread phenomenon of multiple mapping based on these features, and improve accuracy of profiling and discovering miRNAs...
  25. pmc A Systematic Evaluation of Feature Selection and Classification Algorithms Using Simulated and Real miRNA Sequencing Data
    Sheng Yang
    Department of Biostatistics, School of Public Health, Nanjing Medical University, 101 Longmian Road, Nanjing, Jiangsu 211166, China
    Comput Math Methods Med 2015:178572. 2015
    ..Taking these findings altogether and considering computational memory requirements, we propose a strategy that combines edgeR and DESeq for large sample sizes. ..
  26. doi request reprint Comparisons of isomiR patterns and classification performance using the rank-based MANOVA and 10-fold cross-validation
    Hui Zhang
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China
    Gene 569:21-6. 2015
    ..Collectively, we could recommend the rank-based MANOVA for comparing different isomiR patterns, and further investigation on isomiRs needs to be considered in miRNA sequencing research...
  27. doi request reprint Deregulated microRNA species in the plasma and placenta of patients with preeclampsia
    Sheng Yang
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, P R China
    Mol Med Rep 12:527-34. 2015
    ..Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified...
  28. pmc Integrative analysis of miRNA-mRNA and miRNA-miRNA interactions
    Li Guo
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China
    Biomed Res Int 2014:907420. 2014
    ..The integrative analysis of miRNA-mRNA based on biological characteristics of miRNA will further enrich miRNA study. ..
  29. pmc Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis
    Li Guo
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
    PLoS ONE 4:e7944. 2009
    ..In the paper, we intended to analyze miRNA haplotype distribution and evolutionary network by analyzing miRNA sequences of miR-17 and miR-124 families across animal species as special populations...
  30. pmc An integrated analysis of miRNA, lncRNA, and mRNA expression profiles
    Li Guo
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China
    Biomed Res Int 2014:345605. 2014
    ..Systematic and integrative analysis of different RNA molecules with potential cross-talk may make great contributions to the unveiling of the complex mechanisms underlying tumorigenesis. ..
  31. doi request reprint Reconstructing the coding and non-coding RNA regulatory networks of miRNAs and mRNAs in breast cancer
    Sheng Yang
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China
    Gene 548:6-13. 2014
    ..Taken together, this method gives new insight to building modules related to complex diseases and simultaneously can give a supplement to explain the mechanism of breast cancer (BC). ..
  32. pmc Maternal plasma miRNAs expression in preeclamptic pregnancies
    Hailing Li
    Department of Obstetrics and Gynecology, Zhongda Hospital, Southeast University, DingJiaqiao 87, Nanjing 210009, China State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, SiPaiLou 2, Nanjing 210096, China
    Biomed Res Int 2013:970265. 2013
    ..Recently, circulating miRNAs are considered as potential useful noninvasive biomarkers. The aim of this study was to identify differentially expressed plasma miRNAs in preeclamptic pregnancies compared with normal pregnancies...
  33. pmc miR-isomiRExp: a web-server for the analysis of expression of miRNA at the miRNA/isomiR levels
    Li Guo
    Department of Bioinformatics, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing, 210023, China
    Sci Rep 6:23700. 2016
    ..This comprehensive analysis will enrich experimental miRNA studies. miR-isomiRExp is available at http://mirisomirexp.aliapp.com. ..
  34. pmc Evolutionary and expression analysis of miR-#-5p and miR-#-3p at the miRNAs/isomiRs levels
    Li Guo
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China
    Biomed Res Int 2015:168358. 2015
    ..A comprehensive analysis and further experimental study at the miRNA/isomiR levels are quite necessary for miRNA study...
  35. pmc Analysis of the miRNA-mRNA-lncRNA networks in ER+ and ER- breast cancer cell lines
    Qian Wu
    The State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China
    J Cell Mol Med 19:2874-87. 2015
    ....
  36. pmc Genetic analysis of loop sequences in the let-7 gene family reveal a relationship between loop evolution and multiple isomiRs
    Tingming Liang
    Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, 210023, China
    PLoS ONE 9:e113042. 2014
    ..Overall, this study provides further insight into miRNA processing and maturation and further enriches our understanding of miRNA biogenesis. ..
  37. pmc An exploration of evolution, maturation, expression and function relationships in mir-23 ∼ 27 ∼ 24 cluster
    Tingming Liang
    Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, Jiangsu, China
    PLoS ONE 9:e106223. 2014
    ..The study reveals the close evolutionary, expression and functional relationships between related homologous/clustered miRNAs, which will further enrich miRNA studies and understand direct or indirect interactions between miRNAs...
  38. doi request reprint Effect of gene transfecting at different times on mandibular distraction osteogenesis
    Guoping Wu
    Department of Plastic Surgery, The Affiliated Friendship Plastic Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210029, China
    J Craniofac Surg 24:232-6. 2013
    ....