Liu Hong

Summary

Country: China

Publications

  1. doi request reprint Keratinocyte growth factor receptor: a therapeutic target in solid cancer
    Liu Hong
    a 1 Fourth Military Medical University, Xijing Hospital of Digestive Diseases, Xi an 710032, Shaanxi Province, China 86 29 84771531 86 29 82539041
    Expert Opin Ther Targets 19:1411-8. 2015
  2. doi request reprint Effect of early oral feeding on short-term outcome of patients receiving laparoscopic distal gastrectomy: a retrospective cohort study
    Liu Hong
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China Electronic address
    Int J Surg 12:637-9. 2014
  3. doi request reprint Prognosis-related microRNAs in esophageal cancer
    Liu Hong
    Fourth Military Medical University, Xijing Hospital, Xijing Hospital of Digestive Diseases, Xi an 710032, Shaanxi Province, China 86 29 84773974 86 29 82539041
    Expert Opin Biol Ther 14:483-9. 2014
  4. doi request reprint Relation of excess body weight and survival in patients with esophageal adenocarcinoma: a meta-analysis
    L Hong
    Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Dis Esophagus 26:623-7. 2013
  5. doi request reprint The short-term outcome in esophagogastric junctional adenocarcinoma patients receiving total gastrectomy: laparoscopic versus open gastrectomy--a retrospective cohort study
    Liu Hong
    State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, 710032 Shaanxi Province, China Electronic address
    Int J Surg 11:957-61. 2013
  6. doi request reprint The short-term outcome of three-field minimally invasive esophagectomy for Siewert type I esophagogastric junctional adenocarcinoma
    Liu Hong
    Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China Electronic address
    Ann Thorac Surg 96:1826-31. 2013
  7. doi request reprint Epidermal growth factor receptor: an important target in esophageal cancer
    Liu Hong
    Fourth Military Medical University, Xijing Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi an, 710032, Shaanxi Province, China 86 29 84773974 86 29 82539041
    Expert Opin Ther Targets 17:1179-85. 2013
  8. doi request reprint Prognostic value of epidermal growth factor receptor in patients with gastric cancer: a meta-analysis
    Liu Hong
    State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, 710032 Shaanxi Province, China Electronic address
    Gene 529:69-72. 2013
  9. doi request reprint MicroRNA-21: a therapeutic target for reversing drug resistance in cancer
    Liu Hong
    Fourth Military Medical University, State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xi an, 710032, Shaanxi Province, China
    Expert Opin Ther Targets 17:1073-80. 2013
  10. doi request reprint DNA methylation biomarkers of stool and blood for early detection of colon cancer
    Liu Hong
    Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an, China
    Genet Test Mol Biomarkers 17:401-6. 2013

Collaborators

Detail Information

Publications84

  1. doi request reprint Keratinocyte growth factor receptor: a therapeutic target in solid cancer
    Liu Hong
    a 1 Fourth Military Medical University, Xijing Hospital of Digestive Diseases, Xi an 710032, Shaanxi Province, China 86 29 84771531 86 29 82539041
    Expert Opin Ther Targets 19:1411-8. 2015
    ..KGFR may play important roles in epithelial cell proliferation and differentiation, epithelial wound repair, embryonic development, immunity, tumor formation and development...
  2. doi request reprint Effect of early oral feeding on short-term outcome of patients receiving laparoscopic distal gastrectomy: a retrospective cohort study
    Liu Hong
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China Electronic address
    Int J Surg 12:637-9. 2014
    ..To evaluate the effect of early oral feeding on postoperative short-term outcome of gastric cancer patients receiving laparoscopic distal gastrectomy...
  3. doi request reprint Prognosis-related microRNAs in esophageal cancer
    Liu Hong
    Fourth Military Medical University, Xijing Hospital, Xijing Hospital of Digestive Diseases, Xi an 710032, Shaanxi Province, China 86 29 84773974 86 29 82539041
    Expert Opin Biol Ther 14:483-9. 2014
    ..Despite improvements in detection, surgical resection and adjuvant therapy, the prognosis of esophageal cancer (EC) patients is dismal. A number of microRNAs (miRNAs) are related with the prognosis of EC...
  4. doi request reprint Relation of excess body weight and survival in patients with esophageal adenocarcinoma: a meta-analysis
    L Hong
    Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Dis Esophagus 26:623-7. 2013
    ..65-0.95, P = 0.108) and 0.80 (95% confidence interval 0.68-0.93, P = 1.00), respectably. Taken together, the excess body weight did not have the value of predicting survival for patients with esophageal adenocarcinoma...
  5. doi request reprint The short-term outcome in esophagogastric junctional adenocarcinoma patients receiving total gastrectomy: laparoscopic versus open gastrectomy--a retrospective cohort study
    Liu Hong
    State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, 710032 Shaanxi Province, China Electronic address
    Int J Surg 11:957-61. 2013
    ..This study aimed to compare the quality of life in Siewert type II esophagogastric junctional adenocarcinoma patients receiving either laparoscopic total gastrectomy or open total gastrectomy...
  6. doi request reprint The short-term outcome of three-field minimally invasive esophagectomy for Siewert type I esophagogastric junctional adenocarcinoma
    Liu Hong
    Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China Electronic address
    Ann Thorac Surg 96:1826-31. 2013
    ..This study aims to evaluate whether three-field minimally invasive surgery promotes outcome as compared with three-incision open surgery...
  7. doi request reprint Epidermal growth factor receptor: an important target in esophageal cancer
    Liu Hong
    Fourth Military Medical University, Xijing Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi an, 710032, Shaanxi Province, China 86 29 84773974 86 29 82539041
    Expert Opin Ther Targets 17:1179-85. 2013
    ..Epidermal growth factor receptor (EGFR) is a molecular target for antibody-based therapy in various cancer types, and it may play important roles in the development of esophageal cancer...
  8. doi request reprint Prognostic value of epidermal growth factor receptor in patients with gastric cancer: a meta-analysis
    Liu Hong
    State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, 710032 Shaanxi Province, China Electronic address
    Gene 529:69-72. 2013
    ..The epidermal growth factor receptor (EGFR) plays important roles in the development of gastric cancer. This study aims to analyze the prognostic value of EGFR in patients with gastric cancer...
  9. doi request reprint MicroRNA-21: a therapeutic target for reversing drug resistance in cancer
    Liu Hong
    Fourth Military Medical University, State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xi an, 710032, Shaanxi Province, China
    Expert Opin Ther Targets 17:1073-80. 2013
    ..Drug resistance is a major clinical obstacle to the successful treatment of human cancer. The microRNAs-21 (miR-21), an oncomiR, may play an important role in the progress of drug resistance...
  10. doi request reprint DNA methylation biomarkers of stool and blood for early detection of colon cancer
    Liu Hong
    Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an, China
    Genet Test Mol Biomarkers 17:401-6. 2013
    ..More investigations should be performed to promote both basic and clinical research of DNA methylation markers in patients with colon cancer...
  11. doi request reprint High expression of epidermal growth factor receptor might predict poor survival in patients with colon cancer: a meta-analysis
    Liu Hong
    Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Genet Test Mol Biomarkers 17:348-51. 2013
    ..Here we aimed to analyze the relation between high expression of EGFR and postoperational survival in patients with colon cancer...
  12. doi request reprint Angiogenesis-related microRNAs in colon cancer
    Liu Hong
    Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Shaanxi Province, China
    Expert Opin Biol Ther 13:77-84. 2013
    ..A number of angiogenesis-related microRNAs (miRNAs) are under investigation and they can affect the cancerous phenotype of malignant cells...
  13. doi request reprint miR-210: a therapeutic target in cancer
    Liu Hong
    Fourth Military Medical University, Xijing Hospital of Digestive Diseases, Xijing Hospital, State Key Laboratory of Cancer Biology, Xi an, 710032, Shaanxi Province, China
    Expert Opin Ther Targets 17:21-8. 2013
    ..miR-210 may play important roles in regulation of cell growth, angiogenesis and apoptosis in different human tumor models, indicating that it can be used as a therapeutic target...
  14. doi request reprint Angiogenesis-related molecular targets in esophageal cancer
    Liu Hong
    Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi an, Shaanxi Province, China
    Expert Opin Investig Drugs 20:637-44. 2011
    ..The effort to present and discuss the current status of the research on the angiogenesis-related molecular targets will lead to improved clinical strategies and outcomes for patients with esophageal cancer (EC)...
  15. doi request reprint High expression of miR-210 predicts poor survival in patients with breast cancer: a meta-analysis
    Liu Hong
    Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, China
    Gene 507:135-8. 2012
    ..Here we aimed to summarize the recent advances in miR-210 involvement in human breast cancer and analyze the predicting role of miR-210 for survival...
  16. doi request reprint miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells
    Lin Xia
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, People s Republic of China
    Int J Cancer 123:372-9. 2008
    ..Taken together, our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2...
  17. ncbi request reprint A new apoptosis inhibitor, CIAPIN1 (cytokine-induced apoptosis inhibitor 1), mediates multidrug resistance in leukemia cells by regulating MDR-1, Bcl-2, and Bax
    Xiaohua Li
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, 17 Changle Western Road, Xi an 710032, China
    Biochem Cell Biol 85:741-50. 2007
    ..Further study of CIAPIN1's function may reveal more of the mechanisms of leukemia MDR and result in the development of strategies to treat leukemia...
  18. doi request reprint Down-regulation of miR-27a might reverse multidrug resistance of esophageal squamous cell carcinoma
    Hongwei Zhang
    Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032, Xi an, Shaanxi Province, China
    Dig Dis Sci 55:2545-51. 2010
    ..So far, the miRNAs involved in multidrug resistance of esophageal cancer have not been reported...
  19. ncbi request reprint Reversal of multidrug resistance of adriamycin-resistant gastric adenocarcinoma cells through the up-regulation of DARPP-32
    Liu Hong
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, China
    Dig Dis Sci 53:101-7. 2008
    ..Further study of the biological functions of DARPP-32 may be helpful for understanding the mechanisms of MDR of gastric cancer cells and developing possible strategies to treat gastric cancer...
  20. ncbi request reprint DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1
    Liu Hong
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Cancer Invest 25:699-705. 2007
    ..The DARPP-32 siRNA-mediated MDR could be reversed by inhibitor of P-gp or siRNA of ZNRD1, indicating DARPP-32 might mediate MDR of gastric cancer through regulation of P-gp and ZNRD1...
  21. doi request reprint The prognostic and chemotherapeutic value of miR-296 in esophageal squamous cell carcinoma
    Liu Hong
    Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Shaanxi Province, China
    Ann Surg 251:1056-63. 2010
    ..The role of target miRNAs in the development of esophageal cancer was further detected...
  22. ncbi request reprint Reversal of multidrug resistance of vincristine-resistant gastric adenocarcinoma cells through up-regulation of DARPP-32
    Liu Hong
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Changlexi ST 15, Xi an 710032, Shaanxi Province, China
    Cell Biol Int 31:1010-5. 2007
    ..DARPP-32 could also significantly decrease the anti-apoptotic activity of SGC7901/VCR cells. Further study of the biological functions of DARPP-32 might be helpful for understanding the mechanisms of MDR in gastric cancer...
  23. pmc p75 neurotrophin receptor suppresses the proliferation of human gastric cancer cells
    Haifeng Jin
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province 710032, China
    Neoplasia 9:471-8. 2007
    ..Therefore, we provided evidence that p75NTR was a potential tumor suppressor and may be used as a therapeutic target for gastric cancer...
  24. ncbi request reprint Inhibition of osteopontin would suppress angiogenesis in gastric cancer
    Hongwei Tang
    State Key Laboratory of Cancer Biology and Institute of Digestive Disease, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shannxi Province, China
    Biochem Cell Biol 85:103-10. 2007
    ..e., angiogenesis, in transplanted tumors of mice. These data confirm the positive role of OPN in gastric-cancer-associated angiogenesis...
  25. ncbi request reprint ZNRD1 mediates resistance of gastric cancer cells to methotrexate by regulation of IMPDH2 and Bcl-2
    Liu Hong
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Biochem Cell Biol 84:199-206. 2006
    ..Taken together, the findings suggest that ZNRD1 could act as a modulator of methotrexate chemotherapy in gastric cancer cells through the regulation of IMPDH2 and Bcl-2...
  26. doi request reprint Calcyclin-binding protein inhibits proliferation, tumorigenicity, and invasion of gastric cancer
    Xiaoxuan Ning
    Department of Geriatrics, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Mol Cancer Res 5:1254-62. 2007
    ....
  27. ncbi request reprint Inhibitory effects of a specific phage-displayed peptide on high peritoneal metastasis of gastric cancer
    Feihu Bai
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province 710032, China
    J Mol Med (Berl) 85:169-80. 2007
    ..In conclusion, the selected peptide PIII was a biologically active peptide and could effectively inhibit peritoneal dissemination of gastric cancer...
  28. doi request reprint Preparation of a novel monoclonal antibody specific to DARPP-32
    Jianjun Yang
    Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University of China, Xi an, Shaanxi Province, China
    Hybridoma (Larchmt) 29:351-4. 2010
    ..The results showed that DARPP-32 might play an important role in carcinogenesis and multidrug resistance of gastric cancer...
  29. doi request reprint Akt1/protein kinase B alpha is involved in gastric cancer progression and cell proliferation
    Zheyi Han
    The State Key Laboratory for Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi 710032, PR China
    Dig Dis Sci 53:1801-10. 2008
    ..We have therefore identified Akt1 as an active kinase that contributes to gastric cancer progression and promotes proliferation of gastric cancer cells...
  30. ncbi request reprint CIAPIN1 confers multidrug resistance by upregulating the expression of MDR-1 and MRP-1 in gastric cancer cells
    Zhiming Hao
    State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province, China
    Cancer Biol Ther 5:261-6. 2006
    ..In addition, Western blotting revealed that CIAPIN1 decreased the expression of Bcl-2, Bax and p53. Therefore, it is concluded that CIAPIN1 confers MDR in gastric cancer cells, likely by upregulating MDR-1 and MRP-1...
  31. ncbi request reprint p75 neurotrophin receptor inhibits invasion and metastasis of gastric cancer
    Haifeng Jin
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, 17 Changle Western Road, Xi an 710032, Shaanxi Province, P R China
    Mol Cancer Res 5:423-33. 2007
    ..Our studies suggested that p75NTR may be used as a new potential therapeutic target in metastatic gastric cancer...
  32. doi request reprint Monoclonal antibody MG7 as a screening tool for gastric cancer
    Zheng Chen
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Hybridoma (Larchmt) 29:27-30. 2010
    ..The use of qIPCR assays enabled the detection of MG7Ag in complex biological samples that were poorly accessible by conventional immunoassays...
  33. doi request reprint Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC
    Xiaoli Hui
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    J Control Release 131:86-93. 2008
    ..It would be promising to further develop GX1 peptide-based assay for tumor angiogenesis imaging to improve diagnosis and internal radiotherapy...
  34. doi request reprint Decreased expression of CIAPIN1 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma
    Xiushan Zheng
    State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 710032, Xi an, Shaanxi Province, People s Republic of China
    Dig Dis Sci 55:3408-14. 2010
    ..Neither CIAPIN1 expression nor its clinical significance has been previously examined in esophageal squamous cell carcinoma (ESCC), and the present immunohistochemical analysis is the first study on CIAPIN1 distribution in ESCC...
  35. doi request reprint miR-483-3p plays an oncogenic role in esophageal squamous cell carcinoma by targeting tumor suppressor EI24
    Jiaojiao Ma
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, No 127 West Changle Road, Xi an, 710032, Shaanxi Province, China
    Cell Biol Int 40:448-55. 2016
    ..Collectively, our study demonstrated that miR-483-3p could promote ESCC progression at least in part through directly targeting EI24, supplying a potential strategy for miRNA-based ESCC therapy. ..
  36. ncbi request reprint Screening and identification of vascular-endothelial-cell-specific binding peptide in gastric cancer
    Shuhui Liang
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, People s Republic of China
    J Mol Med (Berl) 84:764-73. 2006
    ..Meanwhile, GEBP11 was found to be able to target the gastric cancer vascular endothelial cells. Therefore, GEBP11 may be a potential candidate for targeted drug delivery in antivascular therapy and diagnosis of gastric cancer...
  37. ncbi request reprint Depression of MAD2 inhibits apoptosis of gastric cancer cells by upregulating Bcl-2 and interfering mitochondrion pathway
    Yulei Du
    State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Biochem Biophys Res Commun 345:1092-8. 2006
    ..These results indicate that down regulation of MAD2 could promote the drug resistance of gastric cancer cells and inhibit anticancer drugs induced-apoptosis by upregulating Bcl-2 and interfering the mitochondrion apoptosis pathway...
  38. ncbi request reprint Zinc ribbon domain-containing 1 (ZNRD1) mediates multidrug resistance of leukemia cells through regulation of P-glycoprotein and Bcl-2
    Liu Hong
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi, China
    Mol Cancer Ther 4:1936-42. 2005
    ..The further study of the biological functions of ZNRD1 may be helpful for understanding the mechanisms of MDR of leukemia and developing possible strategies to treat leukemia...
  39. doi request reprint BMP7 expression in esophageal squamous cell carcinoma and its potential role in modulating metastasis
    Guanghui Xu
    State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 15 Changle Western Road, Xi an 710032, People s Republic of China
    Dig Dis Sci 58:1871-9. 2013
    ..The roles of BMP7 in ESCC is not fully understood...
  40. doi request reprint Role of ZNRD1 (zinc ribbon domain-containing 1) in angiogenesis of leukaemia cells
    Liu Hong
    State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China
    Cell Biol Int 35:321-4. 2011
    ..Taken together, ZNRD1 might inhibit tumour angiogenesis and could be considered as a target for leukaemia therapy...
  41. pmc The function and mechanism of COX-2 in angiogenesis of gastric cancer cells
    Liping Yao
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 15 West Changle Road, Xi an, 710032, PR China
    J Exp Clin Cancer Res 30:13. 2011
    ..Here we aimed to investigate the effect of COX-2 siRNA on proliferation and angiogenesis of gastric cancer cells...
  42. doi request reprint The malignant phenotype-associated microRNA in gastroenteric, hepatobiliary and pancreatic carcinomas
    Liu Hong
    Fourth Military Medical University, State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xi an, Shaanxi Province, China
    Expert Opin Biol Ther 10:1693-701. 2010
    ..MicroRNA (miRNA) is a newly discovered class of small and endogenous non-coding RNAs. Many miRNAs exhibit altered expression levels in cancer, and they can affect the cancerous phenotype of malignant cells...
  43. doi request reprint Up-regulation of Nob1 in the rat auditory system with noise-induced hearing loss
    Yu Han
    Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, 17 Changle Western Road, Xi an, 710032, Shaanxi Province, China
    Neurosci Lett 491:79-82. 2011
    ..Therefore, Nob1 may play an important role in auditory function following acoustic trauma and can be used as a new target for the treatment of noise-induced hearing loss...
  44. doi request reprint Preparation and characterization of a novel monoclonal antibody specific to human CAD protein
    Mengbin Li
    Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Hybridoma (Larchmt) 28:129-32. 2009
    ..The CAD protein was also detected in gastric cancer and colon cancer tissues by immunohistochemical analysis. Thus, Z12 binds to native CAD protein and should be useful in studies of CAD protein function and expression...
  45. ncbi request reprint Establishment and characterization of calcyclin binding protein (CacyBP) monoclonal antibody
    Huihong Zhai
    State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, PR China
    Hybridoma (Larchmt) 25:91-4. 2006
    ..This MAb would act as a useful tool for the detection of CacyBP protein in future studies...
  46. doi request reprint A role for MHBst167/HBx in hepatitis B virus-induced renal tubular cell apoptosis
    Liu Hong
    Department of Pathology, Xijing Hospital, Fourth Military Medical University, 15 Changle Western Road, 710032, Xi an, People s Republic of China
    Nephrol Dial Transplant 25:2125-33. 2010
    ..We previously showed that nuclear factor kappaB (NF-kappaB) was activated in HBVGN renal tissues, especially in tubular cells. We therefore investigated the role of NF-kappaB in tubular epithelial cells with HBV infection...
  47. ncbi request reprint Expression of delayed rectifier potassium channels and their possible roles in proliferation of human gastric cancer cells
    Mei Lan
    State Key Laboratory of Cancer Biology and Institute of Digestive Disease, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Cancer Biol Ther 4:1342-7. 2005
    ..Kv1.5 may be involved in tumor cells proliferation by controlling Ca(2+) entry, and the interference of K(D) channels expression and/or activity could provide a novel strategy to reverse the malignant phenotype of gastric cancer cells...
  48. ncbi request reprint Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene
    Liu Hong
    Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an 710032, People s Republic of China
    Biochem Biophys Res Commun 321:611-6. 2004
    ..These results provide new insights into the function of ZNRD1 and further validate ZNRD1 as a potential therapeutic target in gastric cancer...
  49. ncbi request reprint Phage display selection of peptides that inhibit metastasis ability of gastric cancer cells with high liver-metastatic potential
    Shengjuan Hu
    State Key Laboratory of GI Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi an, Shanxi Province 710032, PR China
    Biochem Biophys Res Commun 341:964-72. 2006
    ..In conclusion, the phage display is an effective method to screen for the new molecules associated with organ-specific metastasis. The selected peptide20 can reverse the liver metastasis behavior of the gastric cancer cells...
  50. ncbi request reprint Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells
    Liu Hong
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, 710032 Shaanxi Province, China
    Carcinogenesis 28:1622-8. 2007
    ..In addition, ZNRD1 could reduce tumor microvessel densities through inhibition of VEGF. Taken together, these results suggested that ZNRD1 might inhibit cell growth by targeting cell cycle-related genes and reducing tumor angiogenesis...
  51. doi request reprint ATRA-inhibited proliferation in glioma cells is associated with subcellular redistribution of beta-catenin via up-regulation of Axin
    Jianrong Lu
    Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province 710032, PR China
    J Neurooncol 87:271-7. 2008
    ..Our results suggested that Axin might play an important role in RA-mediated anti-proliferative effects of glioma cell lines...
  52. ncbi request reprint Harvest of at Least 23 Lymph Nodes is Indispensable for Stage N3 Gastric Cancer Patients
    Gaozan Zheng
    Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi an, Shaanxi, China
    Ann Surg Oncol . 2016
    ..The National Comprehensive Cancer Network (NCCN) recommends that at least 15 lymph nodes (LNs) be removed during radical gastrectomy. This study aims to investigate the optimal number of LNs resected for radical gastrectomy...
  53. ncbi request reprint Function of miRNA in controlling drug resistance of human cancers
    Liu Hong
    State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, China
    Curr Drug Targets 14:1118-27. 2013
    ..In the future, more investigations should be performed to promote the success of therapeutic-clinical use of microRNAs in cancer. ..
  54. ncbi request reprint Expression and prognostic value of MG7-Ag in patients with surgically resectable esophageal squamous cell carcinoma
    Yunping Zhao
    State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, PR China
    Ann Surg Oncol 14:2621-7. 2007
    ..In this study, we examined the expression of MG7-Ag in esophageal squamous cell carcinomas to assess its value as a prognostic indicator...
  55. ncbi request reprint Reversal of multidrug resistance of gastric cancer cells by downregulation of TSG101 with TSG101siRNA
    Huiqin Shen
    Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, People s Republic of China
    Cancer Biol Ther 3:561-5. 2004
    ..The preliminary study suggested that TSG101 might play an important role in multidrug resistance of gastric carcinoma...
  56. doi request reprint Totally laparoscopic Billroth II gastrectomy with a novel, safe, simple, and time-saving anastomosis by only stapling devices
    Jianjun Du
    Department of Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, No 127 Changle West Road, 710032, Xian, China
    J Gastrointest Surg 16:738-43. 2012
    ..The feasibility and early surgical outcomes of totally laparoscopic Billroth II gastrectomy with stapling anastomosis and with hand-sewn anastomosis were introduced in this study...
  57. ncbi request reprint [Expression and significance of DARPP-32 in gastric carcinoma]
    Jin Wang
    Institute of Digestive Disease, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Zhonghua Bing Li Xue Za Zhi 33:350-3. 2004
    ..To investigate the significance of DARPP-32 protein expression in gastric carcinoma tissue and cell lines...
  58. ncbi request reprint ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase
    Liu Hong
    Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an 710032, People s Republic of China
    Cancer Biol Ther 4:60-4. 2005
    ..These results showed that ZNRD1 may play an important role in the regulation of gastric carcinogenesis and could be used as a new target in treatment of stomach cancer...
  59. ncbi request reprint Expression of Jagged1 and its association with hepatitis B virus X protein in hepatocellular carcinoma
    Juan Gao
    Institute of Digestive Diseases, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, PR China
    Biochem Biophys Res Commun 356:341-7. 2007
    ..Moreover, Jagged1 was found to co-localize and directly interact with HBx in HCC tissues and HBx expressed HCC cell lines. Our results reveal that Jagged1, which is regulated by HBx, may contribute to the development of HCC...
  60. doi request reprint Identification of new altered genes in rat cochleae with noise-induced hearing loss
    Yu Han
    Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, China
    Gene 499:318-22. 2012
    ..Future experiments will focus on several of these new candidate genes and may provide insight into the underlying auditory pathophysiology...
  61. doi request reprint Expression and prognostic value of ZNRD1 in esophageal squamous cell carcinoma
    Yunping Zhao
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, China
    Dig Dis Sci 54:586-92. 2009
    ..ZNRD1 expression was also confirmed to be down-regulated in esophageal cancer tissues compared to adjacent non-neoplastic tissues. The results showed that ZNRD1 might play an important role in esophageal carcinogenesis...
  62. ncbi request reprint [Analysis of risk factors and prognosis of esophagojejunal anastomotic leakage in gastric cancer patients after curative total gastrectomy]
    Jinqiang Liu
    Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi an 710032, China
    Zhonghua Wei Chang Wai Ke Za Zhi 19:756-62. 2016
    ..To identify the risk factors of esophagojejunal anastomotic leakage (EJAL) and its impact on prognosis of gastric cancer patients after curative total gastrectomy...
  63. pmc Tumor volume increases the predictive accuracy of prognosis for gastric cancer: A retrospective cohort study of 3409 patients
    Zhen Liu
    Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 710032, Xi an, Shaanxi Province, China
    Oncotarget . 2017
    ..In comparison with TNM staging system, VNM staging system could improve the predictive accuracy and prognostic discriminatory ability for gastric cancer...
  64. ncbi request reprint Expressions and clinical significances of angiopoietin-1, -2 and Tie2 in human gastric cancer
    Jun Wang
    State Key Laboratory of Cancer Biology and Institute of Digestive Disease, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Biochem Biophys Res Commun 337:386-93. 2005
    ..Among them, AGS expressed both Ang-2 and a relatively moderate amount of Ang-2(443), a novel splice form of Ang-2, while others showed only Ang-2 mRNA expression...
  65. doi request reprint CIDE-3 interacts with lipopolysaccharide-induced tumor necrosis factor, and overexpression increases apoptosis in hepatocellular carcinoma
    Jie Min
    State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, The Fourth Military Medical University, 710032 Xi an, China
    Med Oncol 28:S219-27. 2011
    ..This is the first demonstrated interaction between CIDE-3 and LITAF, and the first report that CIDE-3 induces apoptosis in hepatocellular carcinoma...
  66. doi request reprint The value of MG7-Ag and COX-2 for predicting malignancy in gastric precancerous lesions
    Liu Hong
    State Key Laboratory of Tumor Biology, Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian, 710032, Shaanxi Province, Peoples Republic of China
    Cell Biol Int 34:873-6. 2010
    ..MG7-Ag and COX-2 might play an important role in the process of carcinogenesis and progression of gastric cancer. Combined detection of MG7-Ag and COX-2 was of value of predicting early gastric cancer from precancerous lesions...
  67. pmc Surgical resection should be taken into consideration for the treatment of small gastric gastrointestinal stromal tumors
    Jianjun Yang
    Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 West Changle Road, 710032, Xi an, Shaanxi, China
    World J Surg Oncol 11:273. 2013
    ..The aim of the present study was to investigate the clinical and pathological features of small gastric GISTs, re-evaluate the risk potential, and discuss the treatment strategy of small gastric GISTs...
  68. ncbi request reprint Preparation and characterization of a novel monoclonal antibody specific to human ZNRD1 protein
    Liu Hong
    Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, People s Republic of China
    Hybrid Hybridomics 23:65-8. 2004
    ..The results showed that ZNRD1 might be a novel modifier in gastric carcinogenesis...
  69. ncbi request reprint Enhanced immune response to gastric cancer specific antigen Peptide by coencapsulation with CpG oligodeoxynucleotides in nanoemulsion
    Rui Shi
    Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Shaanxi Province, People s Republic of China
    Cancer Biol Ther 4:218-24. 2005
    ..Our experiments suggest that a vaccinal approach using nano-delivery system carrying in tumoral epitope and CpG ODN as adjuvant may have important implications for cancer therapy...
  70. ncbi request reprint [Intracorporeal hand-sewn technique used in totally laparoscopic colectomy]
    Jian Jun Du
    Department of Surgery, The Fourth Military Medical University, Xi an, China
    Zhonghua Wei Chang Wai Ke Za Zhi 14:772-4. 2011
    ..To evaluate the safety and feasibility of hand-sewn anastomosis in totally laparoscopic colectomy...
  71. ncbi request reprint Reversal of migraine symptoms by Helicobacter pylori eradication therapy in patients with hepatitis-B-related liver cirrhosis
    Liu Hong
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Helicobacter 12:306-8. 2007
    ..pylori has been eradicated. Thus, the study pushed further insight into the mechanisms of migraine pathogenesis...
  72. doi request reprint Detection of serum gastric cancer-associated MG7-Ag from gastric cancer patients using a sensitive and convenient ELISA method
    Bin Jin
    State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Shannxi, P R China
    Cancer Invest 27:227-33. 2009
    ..To seek a high sensitive and convenient method for early diagnosis of gastric cancer by testing MG7-Ag in serum of gastric cancer patients and some other control groups using a convenient ELISA method...
  73. ncbi request reprint Expression of MG7-Ag in patients with gastric cancer correlates with weaker T cell immune response and more proinflammatory cytokine secretion
    Xiaoyin Zhang
    State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, 4th Military Medical University, Xian, PR China
    Biochem Cell Biol 84:135-41. 2006
    ..This likely contributes to the poor prognosis in MG7-Ag-positive gastric-cancer patients...
  74. ncbi request reprint Preparation and characterization of four novel monoclonal antibodies specific to N51(L6)C46 polypeptide simulating fusogenic core structure of GP41 subunit of HIV-1
    Zheng Chen
    Department of Microbiology, State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Xi an, Shaanxi Province, China
    Hybridoma (Larchmt) 25:278-82. 2006
    ..Taken together, these MAbs would be effective tools in selecting anti-HIV polypeptide and analyzing the characteristics of gp41 epitopes...
  75. doi request reprint The expression of NOB1 in spiral ganglion cells of guinea pig
    Yu Han
    Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Int J Pediatr Otorhinolaryngol 73:315-9. 2009
    ..NOB1 was a transcription-associated protein, consisting of one zinc ribbon domain. This study aimed to investigate the NOB1 expression in spiral ganglion cells of normal guinea pigs and deaf ones...
  76. doi request reprint Drug resistance-related microRNAs in esophageal cancer
    Liu Hong
    Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi an, 710032, Shaanxi Province, China
    Expert Opin Biol Ther 12:1487-94. 2012
    ..The research on drug resistance-related microRNAs (miRNAs) may eventually lead to improved clinical strategies and outcomes for patients with esophageal cancer (EC)...
  77. doi request reprint Preparation and characterization of a novel monoclonal antibody specific to human NOB1 protein
    Yu Han
    Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Hybridoma (Larchmt) 27:187-90. 2008
    ..By using the MAb, we found NOB1 protein was expressed in human lung, liver, spleen, and kidney tissues. Taken together, the MAb H11 would be helpful for understanding the distribution and functions of NOB1...
  78. doi request reprint Effect of c-myc on the ultrastructural structure of cochleae in guinea pigs with noise induced hearing loss
    Yu Han
    Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032 Shaanxi Province, China
    Biochem Biophys Res Commun 390:458-62. 2009
    ..Also, the ultrastructure changes were severe in the Ad.EGFP group, but not obvious in the Ad.c-myc-EGFP group. Therefore, c-myc gene might play an unexpected role in hearing functional and morphological protection from acoustic trauma...
  79. ncbi request reprint Peripheral blood monocytes from patients with HBV related decompensated liver cirrhosis can differentiate into functional hepatocytes
    Li Yan
    Department of Gastroenterology, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province, China
    Am J Hematol 82:949-54. 2007
    ....
  80. doi request reprint A novel monoclonal antibody specific to mouse IL-17
    Jianjun Yang
    Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University of China, Xi an, Shaanxi Province, China
    Hybridoma (Larchmt) 30:287-9. 2011
    ..Then the MAb was used to detect the expression of IL-17 in rat intestine graft tissues by immunohistochemical analysis. Thus, Y11 could be considered a useful tool for studies of IL-17 expression and function...
  81. ncbi request reprint Cancer mucosa antigens: novel immunotherapeutic targets
    Liu Hong
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, China
    Expert Opin Ther Targets 12:749-56. 2008
    ..It is of no surprise that cancer mucosa antigens (CMAs) may serve as attractive targets for cancer immunotherapy...
  82. doi request reprint Nuclear expression of Twist promotes lymphatic metastasis in esophageal squamous cell carcinoma
    Taiqian Gong
    State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi an, China
    Cancer Biol Ther 13:606-13. 2012
    ..The combination of twist and VEGF-C detection could be a reliable prediction of LN metastasis in ESCC...
  83. ncbi request reprint [Totally laparoscopic Billroth II( gastrectomy without intracorporeal hand-sewn sutures]
    Jian Jun Du
    Department of Surgery, Fourth Military Medical University, Xi an 710032, China
    Zhonghua Wei Chang Wai Ke Za Zhi 14:611-3. 2011
    ..To evaluate the safety and feasibility of a novel totally laparoscopic Billroth II gastrectomy...
  84. pmc Interleukin-17 plays a critical role in the acute rejection of intestinal transplantation
    Jian jun Yang
    Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    World J Gastroenterol 19:682-91. 2013
    ..To investigate the role of interleukin (IL)-17 in small bowel allograft rejection...