L Hu

Summary

Country: China

Publications

  1. pmc Resveratrol attenuates the Na(+)-dependent intracellular Ca(2+) overload by inhibiting H(2)O(2)-induced increase in late sodium current in ventricular myocytes
    Chunping Qian
    Cardio Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, People s Republic of China
    PLoS ONE 7:e51358. 2012
  2. ncbi request reprint [Involvement of veratridine-induced increase of reverse Na(+)/Ca(2+) exchange current in intracellular Ca(2+) overload and extension of action potential duration in rabbit ventricular myocytes]
    Ling Hao Kong
    Medical College of Wuhan University of Science and Technology, Wuhan 430065, China
    Sheng Li Xue Bao 64:433-43. 2012
  3. doi request reprint Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes
    Jihua Ma
    Cardio Electrophysiological Research Laboratory, Medical College of Wuhan University of Science and Technology, China
    Am J Physiol Cell Physiol 302:C1141-51. 2012
  4. ncbi request reprint [Nitric oxide increases persistent sodium current of ventricular myocytes in guinea pig during normoxia and hypoxia]
    Ji Hua Ma
    Cardio Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, China
    Sheng Li Xue Bao 56:603-8. 2004
  5. ncbi request reprint Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytes
    Ji Hua Ma
    Cardio Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan 430080, China
    Acta Pharmacol Sin 26:828-34. 2005
  6. ncbi request reprint [Low extracellular pH increases the persistent sodium current in guinea pig ventricular myocytes]
    Ji Hua Ma
    Cardio Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, China
    Sheng Li Xue Bao 59:233-9. 2007
  7. ncbi request reprint Extracellular hypotonicity induces disturbance of sodium currents in rat ventricular myocytes
    L Hu
    Cardio Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, China
    Physiol Res 58:807-15. 2009

Collaborators

  • Lin Wu
  • Xian Pei Wang
  • Chao Wang
  • Ji Hua Ma
  • Pei Hua Zhang
  • Chunping Qian
  • Shuo Zhang
  • Jihua Ma
  • An Tao Luo
  • Ling Hao Kong
  • Peihua Zhang
  • Antao Luo
  • Zhiqiang Ren
  • Luiz Belardinelli
  • Wei Wan
  • Linghao Kong
  • Jiu Ling Chen
  • John C Shryock
  • Zhi Qiang Ren
  • Juan Feng
  • Ying Wu
  • Wei Ping Wang

Detail Information

Publications7

  1. pmc Resveratrol attenuates the Na(+)-dependent intracellular Ca(2+) overload by inhibiting H(2)O(2)-induced increase in late sodium current in ventricular myocytes
    Chunping Qian
    Cardio Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, People s Republic of China
    PLoS ONE 7:e51358. 2012
    ..L)) which augmented the reverse Na(+)-Ca(2+) exchanger current (I(NCX)), and the diastolic intracellular Ca(2+) concentration in ventricular myocytes...
  2. ncbi request reprint [Involvement of veratridine-induced increase of reverse Na(+)/Ca(2+) exchange current in intracellular Ca(2+) overload and extension of action potential duration in rabbit ventricular myocytes]
    Ling Hao Kong
    Medical College of Wuhan University of Science and Technology, Wuhan 430065, China
    Sheng Li Xue Bao 64:433-43. 2012
    ..P). Based on this study, it is concluded that as the I(Na.P) agonist, VER can enhance reverse I(NCX) by increasing I(Na.P), leading to intracellular Ca(2+) overload and APD abnormal extension...
  3. doi request reprint Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes
    Jihua Ma
    Cardio Electrophysiological Research Laboratory, Medical College of Wuhan University of Science and Technology, China
    Am J Physiol Cell Physiol 302:C1141-51. 2012
    ..L) in ventricular myocytes. Inhibition of CaMKII and/or PKC pathways may be a therapeutic target to reduce myocardial dysfunction and cardiac arrhythmias caused by calcium overload...
  4. ncbi request reprint [Nitric oxide increases persistent sodium current of ventricular myocytes in guinea pig during normoxia and hypoxia]
    Ji Hua Ma
    Cardio Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, China
    Sheng Li Xue Bao 56:603-8. 2004
    ..P) of ventricular myocytes, which is induced by raised NO oxidating sodium channel protein in myocardial membrane during hypoxia. The activity of I(Na.P) in normoxia is related to the oxidation state of the channel protein...
  5. ncbi request reprint Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytes
    Ji Hua Ma
    Cardio Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan 430080, China
    Acta Pharmacol Sin 26:828-34. 2005
    ..To study the effect of hydrogen peroxide (H2O2) on persistent sodium current (I(Na.P)) in guinea pig ventricular myocytes...
  6. ncbi request reprint [Low extracellular pH increases the persistent sodium current in guinea pig ventricular myocytes]
    Ji Hua Ma
    Cardio Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, China
    Sheng Li Xue Bao 59:233-9. 2007
    ..025+/-0.006 and (0.914+/-0.070) ms, respectively (both P<0.01 vs pH 6.5, n=6). The results demonstrate that low extracellular pH markedly increases I(Na.P) in guinea pig ventricular myocytes, in which activation of PKC may be involved...
  7. ncbi request reprint Extracellular hypotonicity induces disturbance of sodium currents in rat ventricular myocytes
    L Hu
    Cardio Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, China
    Physiol Res 58:807-15. 2009
    ..Therefore we conclude that hypotonic solution inhibits I(NaT), enhances I(NaP) and I(IM) with the effects being reversible. TRPV4 and intracellular Ca(2+), PKC and Ca/CaMKII participate in the hypotonic modifications of sodium currents...