Bing Hua Jiang

Summary

Affiliation: Nanjing Medical University
Country: China

Publications

  1. ncbi request reprint PI3K/PTEN signaling in tumorigenesis and angiogenesis
    Bing Hua Jiang
    Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu, China
    Biochim Biophys Acta 1784:150-8. 2008
  2. ncbi request reprint AKT signaling in regulating angiogenesis
    Bing Hua Jiang
    Lab of Reproductive Medicine, Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu, China
    Curr Cancer Drug Targets 8:19-26. 2008
  3. pmc Insulin promotes glucose consumption via regulation of miR-99a/mTOR/PKM2 pathway
    Wei Li
    Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, China
    PLoS ONE 8:e64924. 2013
  4. pmc MicroRNA-143 inhibits tumor growth and angiogenesis and sensitizes chemosensitivity to oxaliplatin in colorectal cancers
    Xu Qian
    Department of Pathology, State Key Lab of Reproductive Medicine and Cancer Center, Nanjing Medical University, Nanjing, China
    Cell Cycle 12:1385-94. 2013
  5. pmc Roles and mechanism of miR-199a and miR-125b in tumor angiogenesis
    Jun He
    State Key lab of Reproductive Medicine, Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, People s Republic of China
    PLoS ONE 8:e56647. 2013
  6. doi request reprint MicroRNA-26a promotes tumor growth and angiogenesis in glioma by directly targeting prohibitin
    Xu Qian
    Department of Pathology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
    CNS Neurosci Ther 19:804-12. 2013
  7. doi request reprint NADPH oxidase subunit p22(phox)-mediated reactive oxygen species contribute to angiogenesis and tumor growth through AKT and ERK1/2 signaling pathways in prostate cancer
    Qi Li
    State Key lab of Reproductive Medicine, and Department of Pathology, Cancer Center, Nanjing Medical, Nanjing 210029, China
    Biochim Biophys Acta 1833:3375-85. 2013
  8. pmc A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1
    Qing Xu
    State Key lab of Reproductive Medicine, and Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing 210029, China
    J Mol Cell Biol 5:3-13. 2013
  9. doi request reprint Downregulation of miR-145 associated with cancer progression and VEGF transcriptional activation by targeting N-RAS and IRS1
    Yu Yin
    Department of Pathology, Nanjing Medical University, Nanjing, China
    Biochim Biophys Acta 1829:239-47. 2013
  10. pmc Deficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility
    Xu Qian
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China
    Sci Rep 6:39318. 2016

Collaborators

Detail Information

Publications70

  1. ncbi request reprint PI3K/PTEN signaling in tumorigenesis and angiogenesis
    Bing Hua Jiang
    Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu, China
    Biochim Biophys Acta 1784:150-8. 2008
    ....
  2. ncbi request reprint AKT signaling in regulating angiogenesis
    Bing Hua Jiang
    Lab of Reproductive Medicine, Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu, China
    Curr Cancer Drug Targets 8:19-26. 2008
    ..Thus, inhibition of AKT and its downstream targets offers a new approach for targeting angiogenesis, which could be important for the development of new cancer therapeutics in the future...
  3. pmc Insulin promotes glucose consumption via regulation of miR-99a/mTOR/PKM2 pathway
    Wei Li
    Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, China
    PLoS ONE 8:e64924. 2013
    ..Meanwhile, knockdown of HIF-1α inhibited PKM2 expression and insulin-induced glucose consumption. Taken together, these findings will reveal the role and mechanism of insulin in regulating glycolytic activities via miR-99a/mTOR...
  4. pmc MicroRNA-143 inhibits tumor growth and angiogenesis and sensitizes chemosensitivity to oxaliplatin in colorectal cancers
    Xu Qian
    Department of Pathology, State Key Lab of Reproductive Medicine and Cancer Center, Nanjing Medical University, Nanjing, China
    Cell Cycle 12:1385-94. 2013
    ....
  5. pmc Roles and mechanism of miR-199a and miR-125b in tumor angiogenesis
    Jun He
    State Key lab of Reproductive Medicine, Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, People s Republic of China
    PLoS ONE 8:e56647. 2013
    ..This study provides a rationale for new therapeutic approach to suppress tumor angiogenesis using miR-199a, miR-125b, or their mimics for ovarian cancer treatment in the future...
  6. doi request reprint MicroRNA-26a promotes tumor growth and angiogenesis in glioma by directly targeting prohibitin
    Xu Qian
    Department of Pathology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
    CNS Neurosci Ther 19:804-12. 2013
    ..Upregulation of microRNA-26a (miR-26a) has been observed in glioma. However, the biological function and molecular mechanism of miR-26a in glioma remain to be elucidated...
  7. doi request reprint NADPH oxidase subunit p22(phox)-mediated reactive oxygen species contribute to angiogenesis and tumor growth through AKT and ERK1/2 signaling pathways in prostate cancer
    Qi Li
    State Key lab of Reproductive Medicine, and Department of Pathology, Cancer Center, Nanjing Medical, Nanjing 210029, China
    Biochim Biophys Acta 1833:3375-85. 2013
    ..These findings reveal a new function of p22(phox) in tumor angiogenesis and tumor growth, and suggest that p22(phox) is a potential novel target for prostate cancer treatment. ..
  8. pmc A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1
    Qing Xu
    State Key lab of Reproductive Medicine, and Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing 210029, China
    J Mol Cell Biol 5:3-13. 2013
    ....
  9. doi request reprint Downregulation of miR-145 associated with cancer progression and VEGF transcriptional activation by targeting N-RAS and IRS1
    Yu Yin
    Department of Pathology, Nanjing Medical University, Nanjing, China
    Biochim Biophys Acta 1829:239-47. 2013
    ....
  10. pmc Deficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility
    Xu Qian
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China
    Sci Rep 6:39318. 2016
    ..This result indicates that our finding is clinically relevant. The results of our study provided insights into a new mechanism of male infertility caused by the MKRN2 downregulation...
  11. pmc MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1
    Lin Wang
    State Key lab of Reproductive Medicine, Collaborative Innovation Center for Cancer Personalized Medicine, Department of Pathology, Nanjing Medical University, Nanjing, China
    Oncotarget 7:2660-71. 2016
    ..Lower miR-497 levels may be a potential biomarker for CRC advanced stages and treatment response. ..
  12. pmc MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas
    Zhu Mei Shi
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
    RNA 19:552-60. 2013
    ..Taken together, our results indicate that miR-181b functions in gliomas to suppress growth by targeting the IGF-1R oncogene and that miR-181b may serve as a novel therapeutic target for gliomas...
  13. pmc MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis
    Qing Xu
    State Key lab of Reproductive Medicine, and Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, China
    Nucleic Acids Res 40:761-74. 2012
    ..The miR-145 rescue could be a rationale for therapeutic applications in colon cancer in the future...
  14. pmc P70S6K 1 regulation of angiogenesis through VEGF and HIF-1alpha expression
    Chuan xiu Bian
    Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing 210029, China
    Biochem Biophys Res Commun 398:395-9. 2010
    ..Our results suggest that p70S6K1 is required for tumor growth and angiogenesis through HIF-1alpha and VEGF expression, providing a molecular mechanism of human ovarian cancer mediated by p70S6K1 signaling...
  15. pmc GSK-3β regulates tumor growth and angiogenesis in human glioma cells
    Peng Zhao
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Oncotarget 6:31901-15. 2015
    ..Glioma accounts for the majority of primary malignant brain tumors in adults...
  16. pmc Oral administration of apigenin inhibits metastasis through AKT/P70S6K1/MMP-9 pathway in orthotopic ovarian tumor model
    Jun He
    State Key lab of Reproductive Medicine, and Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, 210029, China E Mails J H Q X M W C L X Q Z S
    Int J Mol Sci 13:7271-82. 2012
    ..Our results demonstrate for the first time that oral uptake of apigenin can inhibit tumor metastasis through MMP-9 expression using the orthotopic ovarian tumor model...
  17. pmc MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma
    Lin Wang
    State Key lab of Reproductive Medicine, Department of Pathology, Nanjing Medical University, Nanjing, China These authors contributed equally to this work
    Oncotarget 5:5416-27. 2014
    ....
  18. pmc Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation
    Jun He
    State Key lab of Reproductive Medicine, Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing 210029, PR China
    EMBO Rep 13:1116-22. 2012
    ..These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR-199a and miR-125b downregulation and DNA hypermethylation...
  19. pmc Insulin regulates glucose consumption and lactate production through reactive oxygen species and pyruvate kinase M2
    Qi Li
    Department of Pathology, State Key lab of Reproductive Medicine, Cancer Center, Nanjing Medical University, Nanjing 210029, China
    Oxid Med Cell Longev 2014:504953. 2014
    ..Taken together, this study would provide a new insight into the mechanism of insulin-induced glycolysis. ..
  20. ncbi request reprint AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway
    Ling Zhi Liu
    Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China
    Cancer Res 67:6325-32. 2007
    ....
  21. pmc MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1
    Zhu Mei Shi
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    PLoS ONE 7:e32709. 2012
    ..Taken together, these findings will shed light to the role and mechanism of miR-128 in regulating glioma tumor angiogenesis via miR-128/p70S6K1 axis, and miR-128 may serve as a potential therapeutic target in glioma in the future...
  22. doi request reprint Regulation of survivin by PI3K/Akt/p70S6K1 pathway
    Peng Zhao
    Department of Neurosurgery, The First Affiliated Hospital, Cancer Center, Nanjing Medical University, Nanjing 210029, China
    Biochem Biophys Res Commun 395:219-24. 2010
    ..Taken together, these results demonstrated that PI3K/Akt/p70S6K1 pathway is essential for regulating survivin mRNA expression...
  23. pmc Role and mechanism of miR-222 in arsenic-transformed cells for inducing tumor growth
    Min Wang
    State Key Laboratory of Reproductive Medicine, Department of Pathology, and Collaborative Innovation Center for Cancer Personalized Medicine, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China
    Oncotarget 7:17805-14. 2016
    ..These results indicate that miR-222 plays an important role in arsenic-induced tumor growth. ..
  24. pmc Estrogen regulates miRNA expression: implication of estrogen receptor and miR-124/AKT2 in tumor growth and angiogenesis
    Cheng Fei Jiang
    State Key Laboratory of Reproductive Medicine, Department of Pathology, Nanjing Medical University, Nanjing, China
    Oncotarget 7:36940-36955. 2016
    ..Our results provide a mechanistic insight into a functional role of new ERα/miR-124/AKT2 signaling pathway in BC development. miR-124 and AKT2 may be used as biomarkers for ERα positive BC and therapeutic effect in the future...
  25. pmc MiR-124 governs glioma growth and angiogenesis and enhances chemosensitivity by targeting R-Ras and N-Ras
    Zhumei Shi
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Z S, X W, Y Y, N L State Key Lab of Reproductive Medicine, Department of Pathology, and Cancer Center, Nanjing Medical University, Nanjing, China Z S, Q C, C L, L W, X Q, C J, X L, B H J Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China H L Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China C K Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China T J Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania L Z L, B H J
    Neuro Oncol 16:1341-53. 2014
    ..Previous studies reported that miR-124 levels were downregulated in glioma specimens. Here, we further investigate the potential role of miR-124 in glioma...
  26. doi request reprint Low miR-145 expression level is associated with poor pathological differentiation and poor prognosis in non-small cell lung cancer
    Hua Shen
    Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, 210029 Jiangsu Province, China
    Biomed Pharmacother 69:301-5. 2015
    ..These findings indicated that miR-145 expression may be a useful prognostic marker that could be used for predicting poor differentiation, chemo-resistance and shore DFS. ..
  27. pmc Chronic arsenic exposure and angiogenesis in human bronchial epithelial cells via the ROS/miR-199a-5p/HIF-1α/COX-2 pathway
    Jun He
    State Key lab of Reproductive Medicine, Department of Pathology, Nanjing Medical University, Nanjing, People s Republic of China
    Environ Health Perspect 122:255-61. 2014
    ..Environmental and occupational exposure to arsenic is a major public health concern. Although it has been identified as a human carcinogen, the molecular mechanism underlying the arsenic-induced carcinogenesis is not well understood...
  28. ncbi request reprint Mechanism of vascular endothelial growth factor expression mediated by cisplatin in human ovarian cancer cells
    Xiao Song Zhong
    Laboratory of Reproductive Medicine, Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu, China
    Biochem Biophys Res Commun 358:92-8. 2007
    ..These results suggest a novel mechanism of CDDP's anti-tumor activity in ovarian cancer cells via HIF-1 expression and VEGF transcriptional activation...
  29. pmc MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1α expression
    Ling Zhi Liu
    Lab of Reproductive Medicine, Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China
    PLoS ONE 6:e19139. 2011
    ....
  30. doi request reprint Lentivirus-mediated overexpression of microRNA-199a inhibits cell proliferation of human hepatocellular carcinoma
    Xiao Qin Jia
    Cancer Center and Department of Pathology, Nanjing Medical University, Nanjing, China
    Cell Biochem Biophys 62:237-44. 2012
    ..Thus, these studies provide an important new insight into the pathogenesis of human HCC and it may open a new perspective for the development of effective gene therapy for human HCC...
  31. doi request reprint Endothelial p70 S6 kinase 1 in regulating tumor angiogenesis
    Ling Zhi Liu
    Department of Pathology, Lab of Reproductive Medicine, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China
    Cancer Res 68:8183-8. 2008
    ..This study helps to understand the role and molecular mechanism of p70S6K1 in regulating angiogenesis and tumor growth, and the role of endothelial p70S6K1/HIF-1 signaling in the regulation of tumor microenvironment and angiogenesis...
  32. ncbi request reprint Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
    Jing Fang
    The Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    FASEB J 19:342-53. 2005
    ..These findings reveal a novel role of apigenin in inhibiting HIF-1 and VEGF expression that is important for tumor angiogenesis and growth, identifying new signaling molecules that mediate this regulation...
  33. ncbi request reprint SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway
    Xiao Song Zhong
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Biochem Biophys Res Commun 324:471-80. 2004
    ..These results indicate that SU5416 may be an effective agent for ovarian cancer treatment through the inhibition of VEGF and HIF-1 expression, and the activation of PI3K/AKT/p70S6K1 signaling pathway...
  34. ncbi request reprint G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells
    Ning Gao
    1820 MBR Cancer Center and Dept of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Am J Physiol Cell Physiol 287:C281-91. 2004
    ..These results indicate that PI3K mediates G(1) progression and cyclin expression through activation of an AKT/mTOR/p70S6K1 signaling pathway in the ovarian cancer cells...
  35. ncbi request reprint The role of phosphatidylinositol-3 kinase in vanadate-promoted S phase entry
    Zhuo Zhang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 255:239-45. 2004
    ..The results obtained show that vanadate is able to increase PI3K activity through phosphorylation. PI3K activated p70S6K, which phosphated protein S6, and promoted S phase entry...
  36. pmc Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment
    Bing Hua Jiang
    Department of Microbiology, Mary Babb Randolph Cancer Center, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA
    Drug Resist Updat 11:63-76. 2008
    ..We then discuss the potential therapeutic opportunities for using mTOR inhibitors rapamycin, CCI-779, RAD001, and AP-23573 in cancer therapy as single agents or in combinations to reverse drug resistance...
  37. ncbi request reprint Arsenite induces p70S6K1 activation and HIF-1alpha expression in prostate cancer cells
    Heath D Skinner
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26505 9300, USA
    Mol Cell Biochem 255:19-23. 2004
    ..We have also shown that arsenite specifically induces HIF-1alpha, but not HIF-1beta, protein levels in prostate cancer cells in a mTOR-dependent manner...
  38. pmc PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis
    Jing Fang
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Cell Signal 19:2487-97. 2007
    ....
  39. ncbi request reprint p38 Signaling-mediated hypoxia-inducible factor 1alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells
    Ning Gao
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Biol Chem 277:45041-8. 2002
    ..These results suggest that the expression of HIF-1 and VEGF induced by Cr(VI) may be an important signaling pathway in the Cr(VI)-induced carcinogenesis...
  40. ncbi request reprint PI3K activation is required for PMA-directed activation of cSrc by AFAP-110
    Valerie G Walker
    The Mary Babb Randolph Cancer Center, Dept of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Am J Physiol Cell Physiol 293:C119-32. 2007
    ..Thus PI3K activity is required for PMA-induced colocalization between AFAP-110 and cSrc and subsequent cSrc activation, and this signaling pathway promotes cell migration...
  41. ncbi request reprint Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis
    Beibei Fu
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Cancer Ther 6:220-6. 2007
    ..Taken together, these results suggest that chrysin is a potent inhibitor of HIF-1alpha and provide a new sight into the mechanisms of chrysin against cancers...
  42. ncbi request reprint ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26506, USA
    Oncogene 24:3154-65. 2005
    ..Taken together, our results identify a mechanism through which ILK can regulate both integrin-associated rearrangements of actin filaments and cell migration and invasion at the integrin receptor-proximal region...
  43. ncbi request reprint Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling
    Heath D Skinner
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Biol Chem 279:45643-51. 2004
    ..It also indicates the important role of VEGF and HIF-1 in ovarian tumorigenesis and angiogenesis, which is mediated by the PI3K/AKT/HDM2 and AKT/p70S6K1 pathways in ovarian cancer cells...
  44. ncbi request reprint trans-3,4,5'-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells
    Zongxian Cao
    Department of Microbiology, Immunology and Cell Biology, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, USA
    Clin Cancer Res 10:5253-63. 2004
    ..Our data suggested that resveratrol may inhibit human ovarian cancer progression and angiogenesis by inhibiting HIF-1alpha and VEGF expression and thus provide a novel potential mechanism for the anticancer action of resveratrol...
  45. ncbi request reprint 9-beta-D-arabinofuranosyl-2-fluoroadenine inhibits expression of vascular endothelial growth factor through hypoxia-inducible factor-1 in human ovarian cancer cells
    Jing Fang
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Mol Pharmacol 66:178-86. 2004
    ..These results demonstrate a new function of Fara-A in inhibiting VEGF and HIF-1alpha expression and identify a potential molecular mechanism of the regulation...
  46. ncbi request reprint Phosphatidylinositol 3-kinase signaling is involved in neurogenesis during Xenopus embryonic development
    Ying Peng
    Department of Neurology, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China
    J Biol Chem 279:28509-14. 2004
    ....
  47. ncbi request reprint PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health NIH, Morgantown, WV 26506, USA
    Am J Physiol Cell Physiol 286:C153-63. 2004
    ..These results demonstrate that activation of PI3K activity alone is sufficient to remodel actin filaments to increase cell migration through the activation of Akt and p70S6K1 in CEF cells...
  48. ncbi request reprint Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C
    Chuanshu Huang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA
    Cancer Res 62:5689-97. 2002
    ..The role of H(2)O(2) in p70(S6k) phosphorylation at Thr(389) and Thr(421)/Ser(424) was further supported by the findings that treatment of cells with H(2)O(2) also caused p70(S6k) phosphorylation at Thr(389) and Thr(421)/Ser(424)...
  49. ncbi request reprint Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells
    Ning Gao
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA
    Mol Cell Biochem 255:33-45. 2004
    ..These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis...
  50. ncbi request reprint The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src
    Justin M Summy
    Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, PO Box 9300, Morgantown 26506, USA
    J Cell Sci 116:2585-98. 2003
    ..These data indicate that c-Yes may not modulate signals associated with c-Src-induced changes in actin filament integrity and may explain why c-Yes fails to compensate for c-Src signaling in src-/- cells...
  51. ncbi request reprint Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells
    Jingxia Li
    Nelson Institute of Environmental Medicine, New York University, School of Medicine, Tuxedo, New York 10987, USA
    Cancer Res 64:94-101. 2004
    ..This study should help us understand the signal transduction pathways involved in the carcinogenic effects of nickel compounds...
  52. ncbi request reprint Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
    Ning Gao
    Institute for Nutritional Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, China
    Biochem Biophys Res Commun 310:1124-32. 2003
    ..These results suggest that PI3K mediates G(1) cell cycle progression and cyclin expression through the activation of AKT/mTOR/p70(S6K) signaling pathway in the prostate cancer cells...
  53. pmc Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells
    Zongxian Cao
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Cell Signal 19:1542-53. 2007
    ....
  54. ncbi request reprint Mdm2 and HIF-1alpha interaction in tumor cells during hypoxia
    Anna Liisa Nieminen
    Department of Anatomy and Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    J Cell Physiol 204:364-9. 2005
    ..These results point toward a novel and p53-independent function of Mdm2 to promote tumor cell adaptations to hypoxia by interacting with and promoting HIF-1 activation...
  55. ncbi request reprint PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1
    Weiming Ouyang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    J Cell Biochem 101:969-78. 2007
    ..Given the importance of aberrant cell proliferation in cell transformation, we propose that the activation of PI-3K/Akt pathway and cyclin D1 induction may be the important mediators of human skin carcinogenic effect of arsenite...
  56. ncbi request reprint Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species
    Dan Meng
    The Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Free Radic Biol Med 42:1651-60. 2007
    ..These results suggest that (1) IGF-I induces EGFR activation through production of ROS and ROS-mediated Src activation in VSMCs, and (2) EGFR transactivation is required for IGF-I-induced VSMC proliferation...
  57. ncbi request reprint Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression
    Jing Fang
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 28:858-64. 2007
    ..The inhibition of tumor angiogenesis was associated with the decrease of HIF-1 and VEGF in tumor tissues. Taken together, our results show that apigenin suppresses tumor angiogenesis through HIF-1 and VEGF expression...
  58. ncbi request reprint Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells
    Ling Zhi Liu
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Free Radic Biol Med 41:1521-33. 2006
    ..This study also indicates that p70S6K1 and H2O2 are important in tumor angiogenesis. The results of the study could have an important implication in ovarian cancer therapy...
  59. ncbi request reprint Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor
    Chang Xia
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, USA
    Cancer Res 67:10823-30. 2007
    ..This information may be useful to understand the new mechanism of cancer cells in inducing tumorigenesis and to develop new therapeutic strategy by targeting ROS signaling in human cancer in the future...
  60. pmc Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal
    Pai Hao Yang
    Joint State Key Laboratory in Oncology in South China, Sun Yat Sen University, Guangzhou, China
    J Biol Chem 283:8486-95. 2008
    ..Moreover, mkrn2 up-regulated the mRNA and protein levels of GSK-3beta. These results revealed for the first time the important role of mkrn2 as a new player in PI3K/Akt-mediated neurogenesis during Xenopus embryonic development...
  61. ncbi request reprint A downstream kinase of the mammalian target of rapamycin, p70S6K1, regulates human double minute 2 protein phosphorylation and stability
    Jing Fang
    Department of Microbiology, Immunology and Cell Biology, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Cell Physiol 209:261-5. 2006
    ..Overexpression of p70S6K1 enhanced HDM2 phosphorylation and led to an increase in HDM2 protein turnover. Our results suggest that p70S6K1 regulates turnover of HDM2 protein for cancer development...
  62. ncbi request reprint Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide
    Qiong Zhou
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    FEBS Lett 580:5161-6. 2006
    ..IGF-1 did not induced production of H(2)O(2) in DU145 cells. Our results suggest that transactivation of EGFR by IGF-1 requires basal intracellular H(2)O(2) in DU145 cells...
  63. pmc Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression
    Xiang Hong Peng
    Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:25903-14. 2006
    ..Understanding key molecular events in EGFR signaling-induced apoptosis resistance should provide new information for the development of novel therapeutic agents targeting EGFR, HIF-1alpha, and/or survivin...
  64. ncbi request reprint Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway
    Qiao Meng
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA
    Cell Signal 18:2262-71. 2006
    ..This study demonstrates the important role of the PI3K/AKT/mTOR/p70S6K1 pathway in cell proliferation, migration, and invasion in ovarian cancer cells by using siRNA-mediated gene silencing as a reverse genetic method...
  65. ncbi request reprint Nitric oxide regulates cell sensitivity to cisplatin-induced apoptosis through S-nitrosylation and inhibition of Bcl-2 ubiquitination
    Pithi Chanvorachote
    Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, WV 26506, USA
    Cancer Res 66:6353-60. 2006
    ..These findings indicate a novel pathway for NO regulation of Bcl-2, which provides a key mechanism for cisplatin resistance and its potential modulation for improved cancer chemotherapy...
  66. ncbi request reprint Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression
    Chang Xia
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Cell Physiol 209:56-66. 2006
    ..This work provides a better understanding of the molecular mechanism of human cancer induced by the activation of PI3K signaling...
  67. ncbi request reprint Reactive oxygen species regulate insulin-induced VEGF and HIF-1alpha expression through the activation of p70S6K1 in human prostate cancer cells
    Qiong Zhou
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 28:28-37. 2007
    ..These results provide some useful information for prostate cancer therapy in the future...
  68. ncbi request reprint Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity
    Min Ding
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 281:17359-68. 2006
    ..These finding demonstrate for the first time that a purified compound of anthocyanin inhibits tumor promoter-induced carcinogenesis and tumor metastasis in vivo...
  69. ncbi request reprint Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer
    Ling Zhi Liu
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Mol Pharmacol 68:635-43. 2005
    ..Our data suggested that apigenin may inhibit human lung cancer angiogenesis by inhibiting HIF-1alpha and VEGF expression, thus providing a novel explanation for the anticancer action of apigenin...
  70. ncbi request reprint Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species
    Ning Gao
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Biol Chem 277:31963-71. 2002
    ..These results suggest that the expression of HIF-1 and VEGF induced by vanadate through PI3K/Akt may be an important signaling pathway in the vanadate-induced carcinogenesis, and ROS may play an important role...