Shuang Yang

Summary

Affiliation: Nankai University
Country: China

Publications

  1. doi request reprint ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM.
    Xiang Zhang
    Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China
    Cell Death Dis 9:57. 2018
  2. pmc MKL1 inhibits cell cycle progression through p21 in podocytes
    Shuang Yang
    Medical School, Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Nankai University, 94 Weijin Road, Tianjin, 300071, China
    BMC Mol Biol 16:1. 2015
  3. pmc BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells
    Shuang Yang
    Medical College of Nankai University, Tianjin, China
    BMC Cancer 7:211. 2007
  4. doi request reprint Dual mechanism of deltaEF1 expression regulated by bone morphogenetic protein-6 in breast cancer
    Shuang Yang
    Medical College of Nankai University, 94 Weijin Road, Tianjin 300071, China
    Int J Biochem Cell Biol 41:853-61. 2009
  5. doi request reprint DeltaEF1 promotes breast cancer cell proliferation through down-regulating p21 expression
    Fen Hu
    Medical College of Nankai University, Tianjin, China
    Biochim Biophys Acta 1802:301-12. 2010
  6. doi request reprint BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1
    Jun Du
    Laboratory of Medical Molecular Biology, Medical College of Nankai University, 94 Weijin Road, Tianjin 300071, China
    Cell Res 19:487-96. 2009
  7. doi request reprint δEF1 promotes osteolytic metastasis of MDA-MB-231 breast cancer cells by regulating MMP-1 expression
    Fen Hu
    Medical College of Nankai University, 94 Weijin Road, Tianjin, China
    Biochim Biophys Acta 1809:200-10. 2011
  8. doi request reprint PTHrP inhibits BMP-6 expression through the PKA signaling pathway in breast cancer cells
    Dong Mi
    Laboratory of Molecular Genetics, Medical College, Nankai University, Tianjin 300071, People s Republic of China
    J Cancer Res Clin Oncol 137:295-303. 2011
  9. doi request reprint Identification of DeltaEF1 as a novel target that is negatively regulated by LMO2 in T-cell leukemia
    Wei Sun
    Laboratory of Molecular Genetics, College of Medicine, Nankai University, Tianjin, China
    Eur J Haematol 85:508-19. 2010
  10. doi request reprint BMP-6 inhibits cell proliferation by targeting microRNA-192 in breast cancer
    Fen Hu
    Medical College of Nankai University, Tianjin, China College of Life Sciences, Hebei United University, Tangshan, Hebei, China
    Biochim Biophys Acta 1832:2379-90. 2013

Collaborators

Detail Information

Publications36

  1. doi request reprint ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM.
    Xiang Zhang
    Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China
    Cell Death Dis 9:57. 2018
    ..Collectively, our findings suggest that ZEB1 is a crucial determinant of chemotherapeutic resistance in breast cancer...
  2. pmc MKL1 inhibits cell cycle progression through p21 in podocytes
    Shuang Yang
    Medical School, Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Nankai University, 94 Weijin Road, Tianjin, 300071, China
    BMC Mol Biol 16:1. 2015
    ..However, little is known about the genetic programs leading to this functionality or the final phenotype...
  3. pmc BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells
    Shuang Yang
    Medical College of Nankai University, Tianjin, China
    BMC Cancer 7:211. 2007
    ..Bone morphogenetic protein-6 (BMP-6) is critically involved in many developmental processes. Recent studies indicate that BMP-6 is closely related to tumor differentiation and metastasis...
  4. doi request reprint Dual mechanism of deltaEF1 expression regulated by bone morphogenetic protein-6 in breast cancer
    Shuang Yang
    Medical College of Nankai University, 94 Weijin Road, Tianjin 300071, China
    Int J Biochem Cell Biol 41:853-61. 2009
    ..Our study has provided novel findings of a dual mechanism for BMP-6-regulated deltaEF1 expression in breast cancer cells, involving cross-talks between AP-1-mediated transcriptional repression and miRs-mediated translational inhibition...
  5. doi request reprint DeltaEF1 promotes breast cancer cell proliferation through down-regulating p21 expression
    Fen Hu
    Medical College of Nankai University, Tianjin, China
    Biochim Biophys Acta 1802:301-12. 2010
    ..Taken together, these observations suggest a dual effect of deltaEF1 in promoting breast cancer cell proliferation, by differentially regulating the cell cycle regulatory proteins...
  6. doi request reprint BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1
    Jun Du
    Laboratory of Medical Molecular Biology, Medical College of Nankai University, 94 Weijin Road, Tianjin 300071, China
    Cell Res 19:487-96. 2009
    ..In conclusion, BMP-6-induced inhibition of miR-21 suggests that BMP-6 may function as an anti-metastasis factor by a mechanism involving transcriptional repression of miR-21 in breast cancer...
  7. doi request reprint δEF1 promotes osteolytic metastasis of MDA-MB-231 breast cancer cells by regulating MMP-1 expression
    Fen Hu
    Medical College of Nankai University, 94 Weijin Road, Tianjin, China
    Biochim Biophys Acta 1809:200-10. 2011
    ..In conclusion, these observations suggest a potent role of δEF1 to promote breast cancer metastasis to bone by regulating secretion of growth factors in the tumor microenvironment...
  8. doi request reprint PTHrP inhibits BMP-6 expression through the PKA signaling pathway in breast cancer cells
    Dong Mi
    Laboratory of Molecular Genetics, Medical College, Nankai University, Tianjin 300071, People s Republic of China
    J Cancer Res Clin Oncol 137:295-303. 2011
    ..BMP-6, as a member of TGF-β superfamily, is closely correlated with tumor differentiation and skeletal metastasis...
  9. doi request reprint Identification of DeltaEF1 as a novel target that is negatively regulated by LMO2 in T-cell leukemia
    Wei Sun
    Laboratory of Molecular Genetics, College of Medicine, Nankai University, Tianjin, China
    Eur J Haematol 85:508-19. 2010
    ..Taken together, our findings revealed that ectopically expressed LMO2 impaired the function of DeltaEF1 in both transcriptional and protein levels and identified DeltaEF1 as a novel pathogenic target of LMO2 in T-cell leukemia...
  10. doi request reprint BMP-6 inhibits cell proliferation by targeting microRNA-192 in breast cancer
    Fen Hu
    Medical College of Nankai University, Tianjin, China College of Life Sciences, Hebei United University, Tangshan, Hebei, China
    Biochim Biophys Acta 1832:2379-90. 2013
    ..Furthermore, BMP-6/miR-192 was expressed at low levels in breast cancer specimens, indicating that this pathway might represent a promising therapeutic target for breast cancer treatment. ..
  11. doi request reprint miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β
    Wei Sun
    Laboratory of Molecular Genetics, College of Medicine, Nankai University, Tianjin 300071, China
    Cell Res 20:1158-69. 2010
    ..These results reveal a novel miR-223--CEBP-β--LMO2--miR-142 regulatory pathway, which has pivotal functions in hematopoiesis...
  12. doi request reprint BMP-6 inhibits MMP-9 expression by regulating heme oxygenase-1 in MCF-7 breast cancer cells
    Chuan Wang
    Medical College of Nankai University, 94 Weijin Road, Tianjin 300071, China
    J Cancer Res Clin Oncol 137:985-95. 2011
    ..Our recent research has implied that BMP-6 may suppress breast cancer metastasis. In the present study, we extended to elucidate the molecular mechanism by which BMP-6 exerts its anti-tumorigenic effect...
  13. ncbi request reprint [Identification of interaction partners and function analysis of new splicing product of human LMO2 gene]
    Wei Yuan
    Laboratory of Molecular Genetics, Medical College, Nankai University, Tianjin 300071, China
    Zhonghua Xue Ye Xue Za Zhi 29:325-8. 2008
    ..To identify the interaction partners of a new splicing product of LMO2 gene (LMO2-C), and study its function in K562 cells...
  14. pmc Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic-related target genes
    Wei Sun
    Laboratory of Molecular Genetics, College of Medicine, Nankai University, Tianjin 300071, PR China
    J Biomed Sci 17:22. 2010
    ..Both isoforms function as bridge molecules to assemble their partners together to regulate their target genes. A typical LMO2 binding site consists of two elements, a GATA site and an E-box, with an interval of 9 approximately 12 bp...
  15. ncbi request reprint Bone morphogenetic protein 6 inhibit stress-induced breast cancer cells apoptosis via both Smad and p38 pathways
    Jun Du
    Medical College of Nankai University, Tianjin, China
    J Cell Biochem 103:1584-97. 2008
    ..These results suggested that BMP6 induced cell cycle arrest in estrogen-insensitive breast cancer cells. BMP6 inhibits stress-induced apoptosis via both Smad and p38 signal pathways...
  16. ncbi request reprint Epigenetic regulation of bone morphogenetic protein-6 gene expression in breast cancer cells
    Ming Zhang
    Laboratory of Molecular Medicines, Medical College, Nankai University, Tianjin 300071, China
    J Steroid Biochem Mol Biol 105:91-7. 2007
    ....
  17. ncbi request reprint [Effect of different tags on pulldown assays implemented by LMO2 fusion protein]
    Wei Yuan
    Laboratory of Molecular Genetics, College of Medicine, Nankai University, Tianjin 300071, China
    Sheng Wu Gong Cheng Xue Bao 24:887-91. 2008
    ..These results suggest that using of MBP system is a helpful attempt in the case of studying small molecular weight, strong hydrophobic proteins...
  18. ncbi request reprint [Expression of recombinant human BMP6 in CHO cells by fused to the signal peptide and propeptide of another homologue protein]
    Ji Dong Yan
    Laboratory of Molecular Genetics, College of Medicine, Nankai University, Tianjin 300071, China
    Sheng Wu Gong Cheng Xue Bao 23:413-7. 2007
    ..The partially purified rhBMP6 by heparin affinity chromatography was shown to possess bone induction activity tested by the induction of alkaline phosphatase activity in C2C12 cells...
  19. pmc LMO2 attenuates tumor growth by targeting the Wnt signaling pathway in breast and colorectal cancer
    Ye Liu
    Laboratory of Molecular Genetics in School of Medicine, Nankai University, Tianjin, China
    Sci Rep 6:36050. 2016
    ....
  20. ncbi request reprint [Stability analysis of CHO cell line expressing heterologous rhBMP2]
    Chunli Zhai
    Laboratory of Molecular Genetics, College of Medicine, Nankai University, Tianjin 300071, China
    Sheng Wu Gong Cheng Xue Bao 24:862-6. 2008
    ..Moreover, we detected the temperature sensitivity of rhBMP2 in culture medium. This study will contribute to our understanding for further producing rhBMP2 by large-scale culture technology...
  21. pmc δEF1 down-regulates ER-α expression and confers tamoxifen resistance in breast cancer
    Shaocong Guo
    Medical College of Nankai University, Tianjin, China
    PLoS ONE 7:e52380. 2012
    ..Inhibiting δEF1 to restore ER-α expression might represent a potential therapeutic strategy for overcoming endocrine resistance in breast cancer...
  22. doi request reprint BMP6 attenuates oxidant injury in HK-2 cells via Smad-dependent HO-1 induction
    Jidong Yan
    Medical College of Nankai University, Tianjin, China
    Free Radic Biol Med 46:1275-82. 2009
    ..In summary, these findings suggest that induction of HO-1 through a Smad-dependent mechanism is responsible for the cytoprotective effect of BMP6 in H(2)O(2)-mediated renal cell injury...
  23. pmc BMP6 reverses TGF-beta1-induced changes in HK-2 cells: implications for the treatment of renal fibrosis
    Ji Dong Yan
    Medical College of Nankai University, Tianjin 300071, China
    Acta Pharmacol Sin 30:994-1000. 2009
    ..The aim of the study was to investigate the potential role of BMP6 in TGF-beta1-mediated changes in HK-2 cells...
  24. pmc ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast Cancer
    Lingjia Liu
    Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Medical College of Nankai University, Tianjin 300071, China
    PLoS ONE 11:e0148774. 2016
    ..Collectively, we found that ZEB1-expressing breast cancer cells increase VEGFA production and thus stimulate tumor growth and angiogenesis via a paracrine mechanism. ..
  25. doi request reprint LMO2 blocks the UBA6-USE1 interaction and downstream FAT10ylation by targeting the ubiquitin fold domain of UBA6
    Chao Wu
    Laboratory of Molecular Genetics in School of Medicine, Nankai University, Tianjin, China
    Biochem Biophys Res Commun 478:1442-8. 2016
    ..Taken together, this study revealed a novel function of LMO2 involving in the regulatory hierarchy of UBA6-USE1-FAT10ylation pathway by targeting the E1 enzyme UBA6. ..
  26. ncbi request reprint Protective effect of bone morphogenetic protein-6 on neurons from H2O2 injury
    Jun Du
    Medical College of Nankai University 94 Weijin Road, Tianjin 300071, China
    Brain Res 1163:10-20. 2007
    ....
  27. doi request reprint ZEB1 confers stem cell-like properties in breast cancer by targeting neurogenin-3
    Chen Zhou
    Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Medical School of Nankai University, Tianjin 300071, China
    Oncotarget 8:54388-54401. 2017
    ..Targeted therapies against the ZEB1/Ngn3 axis may be highly valuable for the prevention and treatment of breast cancer...
  28. doi request reprint Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-κB translocation and ROS production in synoviocytes
    Fen Hu
    Department of Biophysics, School of Physics and Key Laboratory of Bioactive Materials of Education Ministry, Nankai University, Tianjin 300071, PR China
    Biochem Biophys Res Commun 424:196-200. 2012
    ....
  29. ncbi request reprint deltaEF1 represses BMP-2-induced differentiation of C2C12 myoblasts into the osteoblast lineage
    Shuang Yang
    Medical College of Nankai University, 94 Weijin Road, Tianjin, 300071, China
    J Biomed Sci 14:663-79. 2007
    ..These results suggest that deltaEF1 acts as a potent inhibitor of BMP-2-induced osteogenesis in vitro, in part, by differentially regulating the AP-1 signaling pathway...
  30. ncbi request reprint [Soluble expression of recombinant human BMP6 in Escherichia coli and its purification and bioassay in vitro]
    Rongyue Lei
    Laboratory of Medical Molecular Genetics, College of Medicine, Nankai University, Tianjin 300071, China
    Sheng Wu Gong Cheng Xue Bao 24:452-9. 2008
    ..coli BL21trxB(DE3) cytoplasm, which is a thioredoxin reductase mutant strain, soluble homodimeric BMP6 can be formed. The overexpressed MBP-BMP6 fusion protein is purified by chromatography, and shown to be functionally active...
  31. pmc The novel VEGF receptor 2 inhibitor YLL545 inhibits angiogenesis and growth in breast cancer
    Jianbo Zhang
    Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Oncotarget 7:41067-41080. 2016
    ..These observations suggest YLL545 is a potentially useful anticancer drug candidate...
  32. doi request reprint Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway
    Haiying Niu
    Department of Gynecology and Obstetrics, Tianjin First Center Hospital, Tianjin, China
    Oncotarget 8:76266-76278. 2017
    ..These results demonstrate that silencing PPA1 inhibits EOC metastasis by suppressing the Wnt/β-catenin signaling pathway. Strategies for downregulating PPA1 may have therapeutic potential for the prevention and treatment of EOC...
  33. doi request reprint Involvement of transient receptor potential melastatin-8 (TRPM8) in menthol-induced calcium entry, reactive oxygen species production and cell death in rheumatoid arthritis rat synovial fibroblasts
    Shuyan Zhu
    School of Physics and TEDA Applied Physics Institute, Key Laboratory of Bioactive Materials of Education Ministry, Nankai University, Tianjin, China
    Eur J Pharmacol 725:1-9. 2014
    ..Taken together, our data indicated that menthol resulted in synoviocyte death associated with apoptosis via calcium entry and reactive oxygen species production depending on TRPM8 activation. ..
  34. pmc LMO2 promotes tumor cell invasion and metastasis in basal-type breast cancer by altering actin cytoskeleton remodeling
    Ye Liu
    Laboratory of Molecular Genetics in School of Medicine, Nankai University, Tianjin, China
    Oncotarget . 2016
    ..These findings suggest a subtype-dependent role of LMO2 in breast cancers and the potential of LMO2 as a subtype-specific biomarker for clinical practice...
  35. pmc Clinical significance and functional validation of PPA1 in various tumors
    Dehong Luo
    Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China
    Cancer Med 5:2800-2812. 2016
    ..PPA1 expression is significantly higher in many tumors, especially those of lung and ovarian origin, which suggests that PPA1 plays an important role in carcinogenesis and in the development of some tumors...
  36. ncbi request reprint [Indirubin inhibits ATP-induced phagocytosis attenuation, ROS production and cell death of macrophages]
    Yuan Man
    Department of Biophysics, School of Physics, Nankai University, Tianjin 300071, China
    Yao Xue Xue Bao 47:45-50. 2012
    ..These results suggested the inhibitory effects of indirubin on the activation of P2X7 receptors, which may underlying the effects on ATP induced ROS production, phagocytosis attenuation and cell death of macrophages...