Zhiyong Qian

Summary

Country: China

Publications

  1. ncbi request reprint Synthesis, characterization and hydrolytic degradation of degradable poly(butylene terephthalate)/poly(ethylene glycol) (PBT/PEG) copolymers
    Guotao Chao
    State Key Laborotary of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China
    J Mater Sci Mater Med 18:449-55. 2007
  2. ncbi request reprint Synthesis, characterization and hydrolytic degradation study of polyetheresteramide copolymers based on epsilon-caprolactone, 6-aminocaproic acid, and poly(ethylene glycol)
    Caibing Liu
    State Key Laborotary of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    J Mater Sci Mater Med 18:2085-91. 2007
  3. ncbi request reprint Basic fibroblast growth factor loaded biodegradable PCL-PEG-PCL copolymeric nanoparticles: preparation, in vitro release and immunogenicity study
    MaLing Gou
    State Key Laboratory of Biotherapy and Cancer Center West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    J Nanosci Nanotechnol 8:2357-61. 2008
  4. ncbi request reprint Recent Advances of Poly(ether-ether) and Poly(ether-ester) Block Copolymers in Biomedical Applications
    Zhi Yao He
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    Curr Drug Metab 17:168-86. 2016
  5. pmc Preparation and characterization of microporous poly(D,L-lactic acid) film for tissue engineering scaffold
    Shuai Shi
    State Key Lab of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan, University, Chengdu, PR China
    Int J Nanomedicine 5:1049-55. 2010
  6. pmc Synthesis and properties of a novel biodegradable poly(ester amine) copolymer based on poly(L-lactide) and low molecular weight polyethylenimine for gene delivery
    Qing Fa Guo
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, People s Republic of China
    Int J Nanomedicine 6:1641-9. 2011
  7. pmc Camptothecin nanocolloids based on N,N,N-trimethyl chitosan: efficient suppression of growth of multiple myeloma in a murine model
    Zhengguang Li
    Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, PR China
    Oncol Rep 27:1035-40. 2012
  8. pmc Synthesis, characterization, and acute oral toxicity evaluation of pH-sensitive hydrogel based on MPEG, poly(ε-caprolactone), and itaconic acid
    Liwei Tan
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Biomed Res Int 2013:239838. 2013
  9. ncbi request reprint Thermosensitive polymeric hydrogels as drug delivery systems
    C Gong
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    Curr Med Chem 20:79-94. 2013
  10. doi request reprint Double "plug and play" templates technology for photo controllable drug release polyelectrolyte multilayers
    Ming Wu
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Chem Commun (Camb) 48:9846-8. 2012

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Synthesis, characterization and hydrolytic degradation of degradable poly(butylene terephthalate)/poly(ethylene glycol) (PBT/PEG) copolymers
    Guotao Chao
    State Key Laborotary of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China
    J Mater Sci Mater Med 18:449-55. 2007
    ..The non-isothermal crystallization behavior of these copolymers was studied by differential scanning calorimetry (DSC). The water absorption and hydrolytic degradation behavior of PBT/PEG copolymers were also studied in detail...
  2. ncbi request reprint Synthesis, characterization and hydrolytic degradation study of polyetheresteramide copolymers based on epsilon-caprolactone, 6-aminocaproic acid, and poly(ethylene glycol)
    Caibing Liu
    State Key Laborotary of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    J Mater Sci Mater Med 18:2085-91. 2007
    ..For the hydrolytic degradation behavior, with the increase in PEG content or caprolactone content, the degradation rate increased then...
  3. ncbi request reprint Basic fibroblast growth factor loaded biodegradable PCL-PEG-PCL copolymeric nanoparticles: preparation, in vitro release and immunogenicity study
    MaLing Gou
    State Key Laboratory of Biotherapy and Cancer Center West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    J Nanosci Nanotechnol 8:2357-61. 2008
    ..For some success in controlling tumor growth had been met by neutralizing bFGF reported previously, the bFGF loaded PCEC nanoparticles prepared in this paper might have potential application as anti-tumor vaccine...
  4. ncbi request reprint Recent Advances of Poly(ether-ether) and Poly(ether-ester) Block Copolymers in Biomedical Applications
    Zhi Yao He
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    Curr Drug Metab 17:168-86. 2016
    ..This review focuses on active targeting theranostic systems, gene delivery systems and tissue engineering based on poly(ether-ether) and poly(ether-ester) block copolymers...
  5. pmc Preparation and characterization of microporous poly(D,L-lactic acid) film for tissue engineering scaffold
    Shuai Shi
    State Key Lab of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan, University, Chengdu, PR China
    Int J Nanomedicine 5:1049-55. 2010
    ..Meanwhile, in vitro culture experiments revealed the great biocompatibility of the scaffold for adsorption and proliferation of fibroblasts...
  6. pmc Synthesis and properties of a novel biodegradable poly(ester amine) copolymer based on poly(L-lactide) and low molecular weight polyethylenimine for gene delivery
    Qing Fa Guo
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, People s Republic of China
    Int J Nanomedicine 6:1641-9. 2011
    ..Polyethyleneimine, a cationic polymer, is one of the most successful and widely used vectors for nonviral transfection in vitro and in vivo...
  7. pmc Camptothecin nanocolloids based on N,N,N-trimethyl chitosan: efficient suppression of growth of multiple myeloma in a murine model
    Zhengguang Li
    Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, PR China
    Oncol Rep 27:1035-40. 2012
    ..These findings suggest that N,N,N-trimethyl chitosan could increase the stability and the antitumor effect of CPT and CPT-TMC is a potential approach for the effective treatment of multiple myeloma...
  8. pmc Synthesis, characterization, and acute oral toxicity evaluation of pH-sensitive hydrogel based on MPEG, poly(ε-caprolactone), and itaconic acid
    Liwei Tan
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Biomed Res Int 2013:239838. 2013
    ..All the results demonstrated that this hydrogel was nontoxic after gavage. Thus, the hydrogel might be the biocompatible potential candidate for oral drug delivery system...
  9. ncbi request reprint Thermosensitive polymeric hydrogels as drug delivery systems
    C Gong
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    Curr Med Chem 20:79-94. 2013
    ....
  10. doi request reprint Double "plug and play" templates technology for photo controllable drug release polyelectrolyte multilayers
    Ming Wu
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Chem Commun (Camb) 48:9846-8. 2012
    ..These multilayers exhibited a reversible drug loading and release achieved by the photoinduced isomerization...
  11. ncbi request reprint Recent advances in formation, properties, and applications of polymersomes
    Jinfeng Liao
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Curr Pharm Des 18:3432-41. 2012
    ..Polymersomes offer superior advantages for future clinical therapeutic and diagnostic imaging applications...
  12. ncbi request reprint Pharmacokinetics and disposition of nanomedicine using biodegradable PEG/PCL polymers as drug carriers
    Yujun Wang
    State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, PR China
    Curr Drug Metab 13:338-53. 2012
    ..In this review, we discussed the safety of the copolymers, release behavior of PEG/PCL micelles in vitro, and pharmacokinetic profiles referring to the optimized fate in vascular system and targeting biodistribution...
  13. ncbi request reprint Pharmacokinetics and in vivo fate of drug loaded chitosan nanoparticles
    XiaWei Wei
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Curr Drug Metab 13:364-71. 2012
    ..Here we crucially discuss the in vivo fate of chitosan nanoparticles. And finally, toxicity issue is discussed and conclusions are drawn...
  14. ncbi request reprint Absorption, pharmacokinetics and disposition of biodegradable nanoscale preparations
    Cheng Wang
    State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No 14 3rd Sec Ren Min Nan Road, Chengdu P R China
    Curr Drug Metab 13:429-39. 2012
    ..It may be significant for successful use of more nanoscale preparations in clinical practice...
  15. pmc Comparisons of three polyethyleneimine-derived nanoparticles as a gene therapy delivery system for renal cell carcinoma
    Zhizhong Xu
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, P R China
    J Transl Med 9:46. 2011
    ....
  16. pmc Anti-tumor activity of N-trimethyl chitosan-encapsulated camptothecin in a mouse melanoma model
    Xian ping Liu
    Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, China
    J Exp Clin Cancer Res 29:76. 2010
    ..But the clinical application is largely hampered by its extreme water insolubility and unpredictable side effect. It is essential to establish an efficient and safe protocol for the administration of CPT versus melanoma...
  17. pmc Identification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen
    Ze Jun Lu
    Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, 37 Guoxue Xiang Street, Chengdu 610041, Sichuan, PR China
    BMC Cancer 9:16. 2009
    ..It is essential to identify more immunogenic antigens (especially cellular membrane markers) for tumor diagnosis and therapy...
  18. pmc In vitro drug release behavior from a novel thermosensitive composite hydrogel based on Pluronic f127 and poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) copolymer
    Chang Yang Gong
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China
    BMC Biotechnol 9:8. 2009
    ..Thus, a suitable controlled drug delivery system is extremely important for chemotherapy...
  19. doi request reprint Preparation of MPEG-PLA nanoparticle for honokiol delivery in vitro
    XiuLing Zheng
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
    Int J Pharm 386:262-7. 2010
    ..The described honokiol loaded MPEG-PLA nanoparticles in this paper might be a novel formulation for honokiol delivery...
  20. ncbi request reprint Enhanced gene delivery using biodegradable poly(ester amine)s (PEAs) based on low-molecular-weight polyethylenimine and poly(epsilon-caprolactone)-pluronic-poly(epsilon-caprolactone)
    Tingting Liu
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    J Biomed Nanotechnol 6:351-9. 2010
    ..Therefore these PEAs might be a novel safe and efficient polymeric gene delivery vectors...
  21. doi request reprint Safety evaluation of amphiphilic three-armed star-shaped copolymer micelles
    Xiuhong Wang
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Pharm Sci 99:2830-8. 2010
    ..All results indicated that the biodegradable self-assembled SPCE micelles were nontoxic; therefore, it might be used as a safe candidate for drug delivery system...
  22. doi request reprint Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel. Part 2: sol-gel-sol transition and drug delivery behavior
    ChangYang Gong
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, and School of Life Sciences, Sichuan University, Chengdu 610041, China
    Acta Biomater 5:3358-70. 2009
    ..Therefore, PCEC hydrogel is promising for use as an injectable local drug delivery system...
  23. doi request reprint A novel transdermal honokiol formulation based on Pluronic F127 copolymer
    XiuLing Zheng
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China
    Drug Deliv 17:138-44. 2010
    ..In in vitro permeation studies, honokiol could be absorbed per cutem. The described drug delivery system might have great potential application for transdermal delivery of hydrophobic drugs such as honokiol...
  24. doi request reprint Biodegradable self-assembled PEG-PCL-PEG micelles for hydrophobic honokiol delivery: I. Preparation and characterization
    ChangYang Gong
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and School of Life Sciences, Sichuan University, Chengdu, 610041, People s Republic of China
    Nanotechnology 21:215103. 2010
    ....
  25. doi request reprint Self-assembled honokiol-loaded micelles based on poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) copolymer
    XiaWei Wei
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Int J Pharm 369:170-5. 2009
    ..These results suggested that we have successfully prepared honokiol-loaded micelles in an improved method which is safer and more efficient. The prepared micelles might be potential carriers for honokiol delivery in cancer chemotherapy...
  26. doi request reprint Polymeric matrix for drug delivery: honokiol-loaded PCL-PEG-PCL nanoparticles in PEG-PCL-PEG thermosensitive hydrogel
    MaLing Gou
    West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Biomed Mater Res A 93:219-26. 2010
    ..Such biodegradable smart drug-delivery system might have great potential application in injectable hydrophobic drug local delivery system...
  27. doi request reprint Curcumin loaded polymeric micelles inhibit breast tumor growth and spontaneous pulmonary metastasis
    Lei Liu
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Int J Pharm 443:175-82. 2013
    ....
  28. doi request reprint Characterization, pharmacokinetics and disposition of novel nanoscale preparations of paclitaxel
    Cheng Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Int J Pharm 414:251-9. 2011
    ..All results suggested that we had contrived a simple, biodegradable, effective and controllable drug delivery system for paclitaxel...
  29. ncbi request reprint A novel composite drug delivery system: honokiol nanoparticles in thermosensitive hydrogel based on chitosan
    XingYi Li
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Nanosci Nanotechnol 9:4586-92. 2009
    ..The described injectable hydrogels based on chitosan (CS) and beta-glycerophosphate (beta-GP) might have potential application as local drug delivery for honokiol...
  30. pmc Gene therapy for C-26 colon cancer using heparin-polyethyleneimine nanoparticle-mediated survivin T34A
    Ling Zhang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, People s Republic of China
    Int J Nanomedicine 6:2419-27. 2011
    ..Recently, we developed a novel nonviral gene carrier, ie, heparin-polyethyleneimine (HPEI) nanoparticles for this purpose...
  31. doi request reprint Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel
    ChangYang Gong
    State Key Laboratory of Biotherapy, West China Hospital, and School of Life Sciences, Sichuan University, Chengdu 610041, China
    Int J Pharm 365:89-99. 2009
    ..Therefore, owing to great thermosensitivity and biodegradability of these copolymers, PECE hydrogel is believed to be promising for in situ gel-forming controlled drug delivery system...
  32. ncbi request reprint Co-delivery honokiol and doxorubicin in MPEG-PLA nanoparticles
    BiLan Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Nanosci Nanotechnol 10:4166-72. 2010
    ..Meanwhile, honokiol and doxorubicin in MPEG-PLA nanoparticle could efficiently suppress cancer cell proliferation in vitro. The described honokiol and doxorubicin co-loaded MPEG-PLA nanoparticle might be a novel anticancer agent...
  33. doi request reprint Preparation and in vitro characterization of dexamethasone-loaded poly(D,L-lactic acid) microspheres embedded in poly(ethylene glycol)-poly({varepsilon}-caprolactone)-poly(ethylene glycol) hydrogel for orthopedic tissue engineering
    Min Fan
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    J Biomater Appl 28:288-97. 2013
    ....
  34. doi request reprint Efficient inhibition of colorectal peritoneal carcinomatosis by drug loaded micelles in thermosensitive hydrogel composites
    ChangYang Gong
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Nanoscale 4:3095-104. 2012
    ..Thus, the results suggested the micelles-hydrogel DDDS may have great potential clinical applications...
  35. ncbi request reprint PCL/PEG copolymeric nanoparticles: potential nanoplatforms for anticancer agent delivery
    MaLing Gou
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Curr Drug Targets 12:1131-50. 2011
    ....
  36. pmc Chitosan-alginate sponge: preparation and application in curcumin delivery for dermal wound healing in rat
    Mei Dai
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Biomed Biotechnol 2009:595126. 2009
    ..An in vivo animal test using SD rat showed that sponge had better effect than cotton gauze, and adding curcumin into the sponge enhanced the therapeutic healing effect...
  37. doi request reprint Synthesis and characterization of poly(methoxyl ethylene glycol-caprolactone-co-methacrylic acid-co-poly(ethylene glycol) methyl ether methacrylate) pH-sensitive hydrogel for delivery of dexamethasone
    Ke Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Int J Pharm 389:130-8. 2010
    ..Finally, the hydrogels demonstrated that the sharp change in different pH value, thus believing to be promising the suitability of the candidate for oral drug-delivery systems...
  38. doi request reprint A novel composite hydrogel based on chitosan and inorganic phosphate for local drug delivery of camptothecin nanocolloids
    XingYi Li
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Pharm Sci 100:232-41. 2011
    ..Furthermore, in vitro cytotoxicity of CPT nanocolloids on SKOV3 human ovarian cancer cells suggested the well anti-tumor cell efficiency could be gained at a lower concentration...
  39. ncbi request reprint Delivering instilled hydrophobic drug to the bladder by a cationic nanoparticle and thermo-sensitive hydrogel composite system
    Ke Men
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China
    Nanoscale 4:6425-33. 2012
    ..These results suggested that DMP-F was a good intravesical drug delivery system and D/DMP-F may have promising applications in intravesical therapy of bladder cancer...
  40. doi request reprint Improving anti-tumor activity with polymeric micelles entrapping paclitaxel in pulmonary carcinoma
    ChangYang Gong
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    Nanoscale 4:6004-17. 2012
    ..The biodegradable MPEG-PCL micelles entrapping PTX may have promising applications in pulmonary carcinoma therapy...
  41. doi request reprint Polysorbate 80 coated poly (ɛ-caprolactone)-poly (ethylene glycol)-poly (ɛ-caprolactone) micelles for paclitaxel delivery
    Yujun Wang
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Int J Pharm 434:1-8. 2012
    ..The results indicated that polysorbate 80 coated PCEC micelles might be a candidate for PTX delivery for brain tumor chemotherapy...
  42. doi request reprint Treating colon cancer with a suicide gene delivered by self-assembled cationic MPEG-PCL micelles
    Xingmei Duan
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
    Nanoscale 4:2400-7. 2012
    ..These data suggest that DMP may be a novel gene carrier, and its delivery of the S-T34A gene may have promising applications in the treatment of colon cancer...
  43. ncbi request reprint Adenoviral vectors modified by heparin-polyethyleneimine nanogels enhance targeting to the lung and show therapeutic potential for pulmonary metastasis in vivo
    Wei Wei
    State Key Laboratory of Biotherapy and Cancer Center West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People s Republic of China
    J Biomed Nanotechnol 7:768-75. 2011
    ..Our results indicate that Ad vectors modified by HPEI nanogels to form HPEI-Ad complexes enhanced transfection efficiency in CT26 cells that lacked CAR, targeted to the lung and demostrated a potential therapy for pulmonary metastasis...
  44. pmc A novel poly(epsilon-caprolactone)-pluronic-poly(epsilon-caprolactone) grafted polyethyleneimine(PCFC-g-PEI), Part 1, synthesis, cytotoxicity, and in vitro transfection study
    Shuai Shi
    State Key Lab of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China
    BMC Biotechnol 9:65. 2009
    ..To improve its biocompatibility and transfection efficiency, PEI has been modified with PEG, folic acid, and chloroquine in order to improve biocompatibility and enhance targeting...
  45. doi request reprint Injectable biodegradable thermosensitive hydrogel composite for orthopedic tissue engineering. 1. Preparation and characterization of nanohydroxyapatite/poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) hydrogel nanocomposites
    Shaozhi Fu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    J Phys Chem B 113:16518-25. 2009
    ..From the results, n-HA/PECE hydrogel is believed to be promising for injectable orthopedic tissue engineering due to its good thermosensitivity and injectability...
  46. ncbi request reprint Preparation of core cross-linked PCL-PEG-PCL micelles for doxorubicin delivery in vitro
    Juan Zhang
    State Key Laboratory of Biotherapy and Cancer Center West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Nanosci Nanotechnol 11:5054-61. 2011
    ..5 than that at pH 7.4 was also observed. These results suggested that this new biodegradable Core Cross-linked PCL-PEG-PCL Micelles might be potential carriers for drug delivery in cancer chemotherapy...
  47. doi request reprint Poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) nanoparticles: preparation, characterization, and application in doxorubicin delivery
    MaLing Gou
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China
    J Phys Chem B 113:12928-33. 2009
    ..The doxorubicin-loaded PCL/PEG/PCL nanoparticles might be a novel doxorubicin formulation for cancer therapy...
  48. doi request reprint Honokiol nanoparticles in thermosensitive hydrogel: therapeutic effects on malignant pleural effusion
    Fang Fang
    West China Medical School, Sichuan University, Chengdu, 610041, People s Republic of China
    ACS Nano 3:4080-8. 2009
    ..05). Histological analysis of pleural tumors exhibited that HK-hydrogel led to the increased rate of apoptosis. This work is important for the further application of HK-hydrogel in the treatment of MPE...
  49. doi request reprint In vivo antitumor and antimetastatic activities of camptothecin encapsulated with N-trimethyl chitosan in a preclinical mouse model of liver cancer
    Lina Zhou
    Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, People s Republic of China
    Cancer Lett 297:56-64. 2010
    ..Thus, CPT-TMC may provide a novel and effective therapeutic strategy against human advanced hepatic cancer without conspicuous systemic toxic effects...
  50. pmc Self-assembled mPEG-PCL-g-PEI micelles for simultaneous codelivery of chemotherapeutic drugs and DNA: synthesis and characterization in vitro
    Shuai Shi
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, People s Republic of China
    Int J Nanomedicine 7:1749-59. 2012
    ....
  51. ncbi request reprint Hydrolytic degradation behavior of biodegradable polyetheresteramide-based polyurethane copolymers
    Caibing Liu
    College of Material Science and Engineering, Sichuan University, Chengdu, 610065, People s Republic of China
    J Biomed Mater Res A 75:465-71. 2005
    ..Also, DSC, (1)H-NMR, and inherent viscosity were used to characterize the degradation behavior of the copolymers...
  52. doi request reprint Synthesis of a novel biodegradable poly(ester amine) (PEAs) copolymer based on low-molecular-weight polyethyleneimine for gene delivery
    Qingfa Guo
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    Int J Pharm 379:82-9. 2009
    ..Compared with low-molecular-PEI (Mn=1800), the obtained PEAs exhibited higher transfection efficiency as well as lower cytotoxicity. These results indicated that such PEAs might have great potential application in gene delivery system...
  53. doi request reprint A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing
    ChangYang Gong
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Biomaterials 34:6377-87. 2013
    ..Histopathologic examination also implied that Cur-M-H could enhance cutaneous wound repair. In conclusion, biodegradable Cur-M-H composite might have great application for wound healing...
  54. ncbi request reprint Two novel nanoscale preparations of micelle and thermosensitive hydrogel for docetaxel to treat malignant tumor
    Cheng Wang
    State Key Laboratory of Biotherapy and Cancer Center West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    J Biomed Nanotechnol 9:357-66. 2013
    ..Thus, the experiments signified that the combination therapy of intravenous (i.v.) and intratumoral administration using the two formulations maybe an effective way to treat malignant tumor...
  55. ncbi request reprint Micelles of methoxy poly(ethylene glycol)-poly(epsilon-caprolactone) as a novel drug delivery vehicle for tacrolimus
    Yingjing Wang
    State Key Laboratory of Biotherapy and Cancer Center West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, P R China
    J Biomed Nanotechnol 9:147-57. 2013
    ..Therefore, micelles of MPEG-PCL could be a very promising novel vehicle for tacrolimus...
  56. ncbi request reprint Synthesis, characterization, and application of amino-terminated poly(ethylene glycol)-block-poly(epsilon-caprolactone) copolymer for paclitaxel
    Cheng Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Nanosci Nanotechnol 13:68-76. 2013
    ..In particular, the NH2-PEG-PCL polymer has potential value for modifying with ligands to work as active targeting drug delivery carriers, which has great significance for cancer therapeutics...
  57. doi request reprint In vivo biocompatibility and osteogenesis of electrospun poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone)/nano-hydroxyapatite composite scaffold
    Shaozhi Fu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Biomaterials 33:8363-71. 2012
    ..It suggested that the composite scaffold had better activity of guided bone regeneration than that of self-healing. So the electrospun PCEC/n-HA fibrous scaffold had the great potential application in bone tissue engineering...
  58. doi request reprint Gel-sol-gel thermo-gelation behavior study of chitosan-inorganic phosphate solutions
    XingYi Li
    State Key Laboratory of Biotherapy and Cancer Center, Sichuan University, Chengdu, China
    Eur J Pharm Biopharm 75:388-92. 2010
    ..And the gel obtained at approximately 4 degrees C is reversible, but the gel obtained at approximately 43 degrees C is irreversible...
  59. doi request reprint Improving anticancer activity and reducing systemic toxicity of doxorubicin by self-assembled polymeric micelles
    MaLing Gou
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, People s Republic of China
    Nanotechnology 22:095102. 2011
    ....
  60. doi request reprint Antitumor activity of monomethoxy poly(ethylene glycol)-poly (ε-caprolactone) micelle-encapsulated doxorubicin against mouse melanoma
    Lan Zheng
    Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, No 20, Section 3, South People s Road, Chengdu, Sichuan, PR China
    Oncol Rep 25:1557-64. 2011
    ..Our data indicate that the encapsulation of doxorubicin in MPEG-PCL micelle improved the anti-tumor activity in vivo without conspicuous systemic toxic effects...
  61. pmc Preventing postoperative abdominal adhesions in a rat model with PEG-PCL-PEG hydrogel
    Bing Yang
    State Key Laboratory of Biotherapy, West China University Hospital, Sichuan University, Chengdu, People s Republic of China
    Int J Nanomedicine 7:547-57. 2012
    ..In this study, its potential efficacy and mechanisms of preventing postsurgical abdominal adhesions were investigated...
  62. doi request reprint Novel composite drug delivery system for honokiol delivery: self-assembled poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) micelles in thermosensitive poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) hydrogel
    ChangYang Gong
    State Key Laboratory of Biotherapy, West China Hospital, and School of Life Sciences, Sichuan University, Chengdu, 610041, PR China
    J Phys Chem B 113:10183-8. 2009
    ..The results suggested that the CDDS might have great potential applications in cancer chemotherapy...
  63. pmc Preparation, characterization and application of star-shaped PCL/PEG micelles for the delivery of doxorubicin in the treatment of colon cancer
    Xiang Gao
    Department of Pathophysiology, College of Preclinical and Forensic Medical Sciences, and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, People s Republic of China
    Int J Nanomedicine 8:971-82. 2013
    ..These results suggested that SSMPEG-PCL micelles have promising application in doxorubicin delivery for the enhancement of anticancer effect...
  64. doi request reprint Preparation and characterization of poly(pluronic-co-L-lactide) nanofibers for tissue engineering
    Qingfa Guo
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Int J Biol Macromol 58:79-86. 2013
    ..These results suggested that such Pluronic-PLLA nanofibers membranes might have prospective applications in tissue engineering field...
  65. doi request reprint Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer
    Xiang Gao
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People s Republic of China
    Nanoscale 4:7021-30. 2012
    ..Our data suggested that QU/MPEG-PCL micelles were a novel nano-formulation of quercetin with a potential clinical application in ovarian cancer therapy...
  66. ncbi request reprint Biodegradable self-assembled MPEG-PCL micelles for hydrophobic oridonin delivery in vitro
    Bingxin Xue
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Biomed Nanotechnol 8:80-9. 2012
    ..The prepared ORI-micelles have great potential for both direct intravascular administration and being further developed as a transdermal drug delivery system in cancer chemotherapy...
  67. doi request reprint Preparation, characterization, and in vitro cytotoxicity study of cationic PCL-pluronic-PCL (PCFC) nanoparticles for gene delivery
    Jian Zhao
    State Key Labaoratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People s Republic of China
    J Biomed Mater Res A 90:506-13. 2009
    ..Release behavior of pGFP from the pGFP/PCFC nanoparticles complex was also studied in vitro. The obtained cationic PCEC nanoparticles might have great potential application in DNA delivery...
  68. doi request reprint Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) copolymers as drug delivery system
    XiaWei Wei
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
    Int J Pharm 381:1-18. 2009
    ..This review introduced several aspects of PCL-PEG copolymers, including synthetic chemistry, PCL-PEG micro/nanoparticles, PCL-PEG hydrogels, and physicochemical and toxicological properties...
  69. ncbi request reprint Transdermal anaesthesia with lidocaine nano-formulation pretreated with low-frequency ultrasound in rats model
    MaLing Gou
    State Key Laboratory of Biotherapy and Cancer Center West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    J Nanosci Nanotechnol 9:6360-5. 2009
    ..It provided a novel path to develop rapid transdermal anaesthesia by combination of ultrasound pretreatment and lidocaine nano-formulation based on polymeric nanoparticles...
  70. doi request reprint Preparation of camptothecin-loaded PCEC microspheres for the treatment of colorectal peritoneal carcinomatosis and tumor growth in mice
    Mei Dai
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Cancer Lett 312:189-96. 2011
    ..05). The CPT-loaded PCEC microspheres were considered potentially useful to treat the abdominal metastases of colon carcinoma...
  71. doi request reprint Poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL) nanoparticles for honokiol delivery in vitro
    MaLing Gou
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People s Republic of China
    Int J Pharm 375:170-6. 2009
    ..The PCL-PEG-PCL nanoparticle was suitable for honokiol delivery, and such honokiol loaded PCL-PEG-PCL nanoparticle was a novel honokiol formulation...
  72. doi request reprint Preparation of honokiol-loaded chitosan microparticles via spray-drying method intended for pulmonary delivery
    XingYi Li
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
    Drug Deliv 16:160-6. 2009
    ..In vitro drug release profile was also observed. The content of mannitol in powders significantly influenced the release rate of honokiol from matrices...
  73. pmc Prevention of post-surgical abdominal adhesions by a novel biodegradable thermosensitive PECE hydrogel
    Bing Yang
    Department of Gynecology and Obstetrics, Second West China Hospital, and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    BMC Biotechnol 10:65. 2010
    ..In this work, we investigated the effect of PECE hydrogel on preventing post-surgical abdominal adhesions in mouse and rat models...
  74. pmc Preparation of poly(ethylene glycol)/polylactide hybrid fibrous scaffolds for bone tissue engineering
    Peiyan Ni
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People s Republic of China
    Int J Nanomedicine 6:3065-75. 2011
    ....
  75. doi request reprint Injectable thermosensitive PEG-PCL-PEG hydrogel/acellular bone matrix composite for bone regeneration in cranial defects
    Peiyan Ni
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China
    Biomaterials 35:236-48. 2014
    ..All the results suggested that the ABM/PECE composite presented enhanced bone regeneration guidance in rabbit cranial defects...
  76. doi request reprint PLA/F68/dexamethasone implants prepared by hot-melt extrusion for controlled release of anti-inflammatory drug to implantable medical devices: I. Preparation, characterization and hydrolytic degradation study
    Dexia Li
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Int J Pharm 441:365-72. 2013
    ..The degradation behavior was confirmed by mass loss and scanning electron microscopy. In addition, the in vivo biocompatibility study indicated that the implants had no negative influence as a foreign material in the body response...
  77. doi request reprint Improving intraperitoneal chemotherapeutic effect and preventing postsurgical adhesions simultaneously with biodegradable micelles
    ChangYang Gong
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Nanomedicine 8:963-73. 2012
    ..Thus, it is a promising strategy to combine the CDDS and barrier method to improve the intraperitoneal chemotherapeutic effect and prevent peritoneal adhesions simultaneously after surgery...
  78. ncbi request reprint Preparation and characterization of n-hydroxyapatite/PCL-pluronic-PCL nanocomposites for tissue engineering
    Shaozhi Fu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Nanosci Nanotechnol 10:711-8. 2010
    ..The microstructure and thermal properties of the composites were discussed in the paper too. The experimental results suggested that this polymeric nanocomposite might have great potential application in the field of tissue engineering...
  79. ncbi request reprint Preparation of magnetic microspheres based on poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) copolymers by modified solvent diffusion method
    Ke Men
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    J Biomed Nanotechnol 6:287-92. 2010
    ..This study described a novel method to prepare magnetic microspheres. The obtained magnetic polymeric microspheres might have potential application in drug delivery system or disease diagnosis field...
  80. pmc Preparation of alginate coated chitosan microparticles for vaccine delivery
    XingYi Li
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China
    BMC Biotechnol 8:89. 2008
    ....
  81. doi request reprint Controlled release of cisplatin from pH-thermal dual responsive nanogels
    Jinrong Peng
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
    Biomaterials 34:8726-40. 2013
    ..have also been reduced by nanogels loading. The in vitro and in vivo results demonstrated that the dual responsible nanogel is a suitable CDDP delivery candidate. ..
  82. ncbi request reprint Preparation and characterization of poly(vinyl alcohol)/poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone)/nano-hydroxyapatite composite membranes for tissue engineering
    Jinrong Peng
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    J Nanosci Nanotechnol 11:2354-60. 2011
    ..The PVA/PCEC/n-HA composite membranes may be applied in the field of tissue engineering...
  83. doi request reprint Injectable and thermo-sensitive PEG-PCL-PEG copolymer/collagen/n-HA hydrogel composite for guided bone regeneration
    Shaozhi Fu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Biomaterials 33:4801-9. 2012
    ..Thus the thermal-response PECE/Collagen/n-HA hydrogel composite had the great potential in bone tissue engineering...
  84. doi request reprint VEGF-targeted short hairpin RNA inhibits intraperitoneal ovarian cancer growth in nude mice
    Yu Bai
    Department of Gynecology and Obstetrics, West China Second Hospital, Chengdu, PR China
    Oncology 77:385-94. 2009
    ..In this study, we inhibited the expression of VEGF by short hairpin RNA (shRNA) in SKOV3 ovarian cancer cells in vitro and in vivo to explore the antitumor efficacy of shRNA in ovarian cancer cells...
  85. ncbi request reprint Preparation of biodegradable polycaprolactone/poly (ethylene glycol)/polycaprolactone (PCEC) nanoparticles
    Wenjuan Jia
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Drug Deliv 15:409-16. 2008
    ..The hydrolytic degradation behavior of the PCEC nanoparticles was also studied...
  86. ncbi request reprint [Synthesis and characterization of thermosensitive hydrogel based on PEG-PCL-PEG block copolymers]
    ChangYang Gong
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 25:1121-5. 2008
    ..As a result, the gel-sol transition temperature range could be altered, which might be very useful for its application as injectable drug delivery system...
  87. doi request reprint Toxicity evaluation of biodegradable and thermosensitive PEG-PCL-PEG hydrogel as a potential in situ sustained ophthalmic drug delivery system
    Hongbo Yin
    Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China
    J Biomed Mater Res B Appl Biomater 92:129-37. 2010
    ..Therefore, PECE hydrogel may be a safe candidate for sustained ophthalmic drug delivery system...
  88. doi request reprint Preparation and characterization of vitamin-12 loaded biodegradable pH-sensitive microgels
    Xu Xu
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, PR China
    J Microencapsul 26:642-8. 2009
    ..Then the blank microgels were loaded with hydrophilic model drug vitamin-12 (VB-12) and in vitro drug release behaviour was also studied here...
  89. doi request reprint Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo
    MaLing Gou
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China
    Nanoscale 3:1558-67. 2011
    ..In conclusion, Cur/MPEG-PCL micelles are an excellent intravenously injectable aqueous formulation of curcumin; this formulation can inhibit the growth of colon carcinoma through inhibiting angiogenesis and directly killing cancer cells...
  90. doi request reprint Comparison of the protective effects of truncated bFGF and native bFGF against murine lung carcinoma
    Zichao Luo
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
    Int J Mol Med 28:3-8. 2011
    ..These data suggested that tbFGF can be used in the immunotherapy of tumors, without the risks associated with bFGF, which induces neovascularization in normal tissues...
  91. ncbi request reprint Preparation and release characteristic of quercetin loaded poly(lactic acid) ultrafine fibers
    Jinrong Peng
    State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    J Nanosci Nanotechnol 11:3659-68. 2011
    ....
  92. doi request reprint Preparation of curcumin loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) nanofibers and their in vitro antitumor activity against Glioma 9L cells
    Gang Guo
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
    Nanoscale 3:3825-32. 2011
    ..These results strongly suggested that the curcumin/PCEC composite nanofibers might have potential application for postoperative chemotherapy of brain cancers...
  93. doi request reprint Therapeutic application of injectable thermosensitive hydrogel in preventing local breast cancer recurrence and improving incision wound healing in a mouse model
    Na Lei
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    Nanoscale 4:5686-93. 2012
    ..05), and days 4 and 14 (P > 0.05), in agreement with histopathological examinations. This novel DDSs represents a promising approach for local adjuvant therapy in malignant disease...
  94. ncbi request reprint Intravenous liposomal delivery of the short hairpin RNAs against Plk1 controls the growth of established human hepatocellular carcinoma
    HongXin Deng
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China
    Cancer Biol Ther 11:401-9. 2011
    ..Our study suggested that shRNA-mediated silencing of Plk1 might be a novel therapeutic approach against human hepatocellular carcinoma by inhibiting tumor cells proliferation and inducing apoptosis...
  95. pmc 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice
    Yongsheng Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, China
    BMC Cancer 10:402. 2010
    ..Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal chemotherapy...
  96. doi request reprint Synthesis and characterization of novel dual-responsive nanogels and their application as drug delivery systems
    Jinrong Peng
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China
    Nanoscale 4:2694-704. 2012
    ..The results indicated that such PNMP nanogels might have potential applications in drug delivery and other medical applications, but that the drug loading mechanism must be further developed...
  97. doi request reprint A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel
    MaLing Gou
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Int J Pharm 359:228-33. 2008
    ..The described injectable drug delivery system might have great potential application for local delivery of hydrophobic drugs such as honokiol...
  98. doi request reprint Preparation of Tacrolimus loaded micelles based on poly(ɛ-caprolactone)-poly(ethylene glycol)-poly(ɛ-caprolactone)
    Yingjing Wang
    State Key Lab of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
    Int J Pharm 407:184-9. 2011
    ..The prepared micelles might be potential carriers for Tacrolimus delivery in immunosuppressive therapy...
  99. doi request reprint Efficient inhibition of C-26 colon carcinoma by VSVMP gene delivered by biodegradable cationic nanogel derived from polyethyleneimine
    MaLing Gou
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People s Republic of China
    ACS Nano 4:5573-84. 2010
    ..The HPEI nanogels delivering pVSVMP have promising application in treating colon carcinoma...
  100. doi request reprint Targeting CD24 for treatment of ovarian cancer by short hairpin RNA
    Dan Su
    Department of Gynecology and Obstetrics, West China Second Hospital, Chengdu, People s Republic of China
    Cytotherapy 11:642-52. 2009
    ..Using short hairpin RNA (shRNA) targeting CD24, we aimed to investigate the anti-tumor efficacy of CD24 knockdown in ovarian cancer cells in vitro and in vivo...
  101. ncbi request reprint Preparation of anti-CD40 antibody modified magnetic PCL-PEG-PCL microspheres
    Xiang Gao
    State Key Laboratory of Biotherapy and Cancer Center West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, P R China
    J Biomed Nanotechnol 7:285-91. 2011
    ..These anti-CD40 antibody modified magnetic PCL-PEG-PCL microspheres may have potential application in cell separation...