Liang Shen

Summary

Affiliation: Shandong University of Technology
Country: China

Publications

  1. doi request reprint Intestinal Microbiota and Metabolic Diseases: Pharmacological Implications
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, PR China Electronic address
    Trends Pharmacol Sci 37:169-71. 2016
  2. pmc Associations between B Vitamins and Parkinson's Disease
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, China
    Nutrients 7:7197-208. 2015
  3. pmc Mutational Spectrum Analysis of Neurodegenerative Diseases and Its Pathogenic Implication
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
    Int J Mol Sci 16:24295-301. 2015
  4. pmc Associations between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: A Meta-Analysis Assessment
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, China
    Nutrients 7:4817-27. 2015
  5. doi request reprint Photophysical and photosensitizing characters of 2-phenylbenzimidazole-5-sulfonic acid. A theoretical study
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, PR China Electronic address
    Spectrochim Acta A Mol Biomol Spectrosc 150:187-9. 2015
  6. pmc A DFT study on deactivation of triplet excited state riboflavin by polyphenols
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, P R China
    Int J Mol Sci 9:1908-14. 2008
  7. ncbi request reprint The multiple pharmaceutical potential of curcumin in Parkinson's disease
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, P R China
    CNS Neurol Disord Drug Targets 13:369-73. 2014
  8. doi request reprint Vitamin E: supplement versus diet in neurodegenerative diseases
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, P R China
    Trends Mol Med 18:443-5. 2012
  9. doi request reprint The pharmacology of curcumin: is it the degradation products?
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, PR China
    Trends Mol Med 18:138-44. 2012
  10. pmc Theoretical study on reactions of triplet excited state thioxanthone with indole
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, China
    Int J Mol Sci 10:4284-9. 2009

Collaborators

Detail Information

Publications49

  1. doi request reprint Intestinal Microbiota and Metabolic Diseases: Pharmacological Implications
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, PR China Electronic address
    Trends Pharmacol Sci 37:169-71. 2016
    ..This helps elucidate the intriguing pharmacology of polyphenols and optimize the treatment of metabolic diseases. ..
  2. pmc Associations between B Vitamins and Parkinson's Disease
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, China
    Nutrients 7:7197-208. 2015
    ..As the number of included studies is limited, more studies are needed to confirm the findings and elucidate the underpinning underlying these associations. ..
  3. pmc Mutational Spectrum Analysis of Neurodegenerative Diseases and Its Pathogenic Implication
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
    Int J Mol Sci 16:24295-301. 2015
    ..These findings help to understand how mutations may cause NDs. ..
  4. pmc Associations between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: A Meta-Analysis Assessment
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, China
    Nutrients 7:4817-27. 2015
    ..62, 95% CI: 0.35 to 0.90). Outdoor work was also related to reduced risk of PD (OR: 0.72, 95% CI: 0.63 to 0.81). The findings may stimulate larger, well-designed studies to further verify the associations between vitamin D and PD risk. ..
  5. doi request reprint Photophysical and photosensitizing characters of 2-phenylbenzimidazole-5-sulfonic acid. A theoretical study
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, PR China Electronic address
    Spectrochim Acta A Mol Biomol Spectrosc 150:187-9. 2015
    ..This offers some deeper insights into the photosensitizing mechanisms of PBSA. ..
  6. pmc A DFT study on deactivation of triplet excited state riboflavin by polyphenols
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, P R China
    Int J Mol Sci 9:1908-14. 2008
    ..The findings are helpful to understand the protective effect of polyphenols against the riboflavin induced photosensitizing damage...
  7. ncbi request reprint The multiple pharmaceutical potential of curcumin in Parkinson's disease
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, P R China
    CNS Neurol Disord Drug Targets 13:369-73. 2014
    ....
  8. doi request reprint Vitamin E: supplement versus diet in neurodegenerative diseases
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, P R China
    Trends Mol Med 18:443-5. 2012
    ..Potential reasons for why α-tocopherol supplements exhibit disappointing effects, especially compared with dietary intake, are put forward and implications for future studies are discussed...
  9. doi request reprint The pharmacology of curcumin: is it the degradation products?
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, PR China
    Trends Mol Med 18:138-44. 2012
    ..This possibility should be given full attention when elucidating the pharmacology of this promising natural product for various diseases...
  10. pmc Theoretical study on reactions of triplet excited state thioxanthone with indole
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, China
    Int J Mol Sci 10:4284-9. 2009
    ..to TX(.-), and H-atom transfer from nitrogen of INH to keto oxygen of T(1) state TX, were proposed theoretically to be involved in T(1) state TX deactivation by INH...
  11. ncbi request reprint Photosensitization mechanisms of triplet excited state beta-lapachone. A density functional theory study
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, P R China
    Nat Prod Commun 6:1677-8. 2011
    ..Starting from triplet excited state beta-lapachone, the possible generating pathways of 1O2 and O2*- are elucidated and the solvent effects on the photosensitizing reactions are also discussed...
  12. ncbi request reprint Theoretical study on the photophysical and photochemical properties of elsinochrome A
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, P R China
    J Biomol Struct Dyn 25:321-6. 2007
    ..However, EA gives birth to O(2)(.-) only in DMSO, and it is E(A)(.-) generated from autoionization reactions that is responsible for the O(2)(.-)-generation, which gains some deeper insights into the photosensitive behaviors of EA...
  13. doi request reprint Interactions of curcumin with the PfATP6 model and the implications for its antimalarial mechanism
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    Bioorg Med Chem Lett 19:2453-5. 2009
    ..Moreover, the theoretically predicted binding affinity implies that curcumin can efficiently inhibit PfATP6, which gains some deeper insights into the antimalarial mechanism of curcumin...
  14. pmc Molecular basis of inhibitory activities of berberine against pathogenic enzymes in Alzheimer's disease
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
    ScientificWorldJournal 2012:823201. 2012
    ..These results have important implications for the berberine-based anti-AD drug design...
  15. ncbi request reprint Anion of hypericin is crucial to understanding the photosensitive features of the pigment
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    Bioorg Med Chem Lett 16:1414-7. 2006
    ..It is revealed that the stronger electron-donating power of HYP anion than that of HA is responsible for the HYP's photosensitive features...
  16. doi request reprint Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer's disease: a meta-analysis
    Feng Jiao Li
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, PR China
    J Alzheimers Dis 31:253-8. 2012
    ..The findings will be of significance to the prevention and interventional treatment of AD...
  17. ncbi request reprint How to understand the dichotomy of antioxidants
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    Biochem Biophys Res Commun 362:543-5. 2007
    ....
  18. doi request reprint The mechanisms of ROS-photogeneration by berberine, a natural isoquinoline alkaloid
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    J Photochem Photobiol B 99:154-6. 2010
    ..formed through autoionization reactions) to 3O2. The findings also provide clues to explaining the much higher 1O2-yield of BER in nonpolar than in polar solvents...
  19. ncbi request reprint Theoretical study on physicochemical properties of curcumin
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    Spectrochim Acta A Mol Biomol Spectrosc 67:619-23. 2007
    ....
  20. doi request reprint Insights into the inhibition of xanthine oxidase by curcumin
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    Bioorg Med Chem Lett 19:5990-3. 2009
    ....
  21. doi request reprint Theoretical investigation of the photosensitization mechanisms of urocanic acid
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    J Photochem Photobiol B 91:96-8. 2008
    ..Secondly, UA gives birth to O(2)(-) through two pathways: (i) direct electron transfer between triplet state UA and (3)O(2); (ii) electron transfer between anion radical of UA (generated through autoionization reactions) and (3)O(2)...
  22. doi request reprint Vitamin D levels in Alzheimer's and Parkinson's diseases: a meta-analysis
    Yan Zhao
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, PR China
    Nutrition 29:828-32. 2013
    ..The purpose of the present study is to perform a meta-analysis on the 25-hydroxyvitamin D (25(OH)D) status in this population of patients...
  23. ncbi request reprint Density functional theory methods as powerful tools to elucidate amino acid oxidation mechanisms. A case study on methionine model peptide
    Wen Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, P R China
    J Phys Chem B 111:485-9. 2007
    ..All of these findings strongly suggest that DFT methodology has great potential in investigating amino acid oxidation mechanisms...
  24. doi request reprint Berberine: a potential multipotent natural product to combat Alzheimer's disease
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
    Molecules 16:6732-40. 2011
    ....
  25. ncbi request reprint Successful application of TD-DFT in transient absorption spectra assignment
    Liang Shen
    Laboratory for Computational Biology and Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, PR China
    Org Lett 7:243-6. 2005
    ....
  26. doi request reprint Why Is the C-terminus of Abeta(1-42) more unfolded than that of Abeta(1-40)? Clues from hydrophobic interaction
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo, People s Republic of China
    J Phys Chem B 112:3164-7. 2008
    ....
  27. pmc Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    Genome Biol 8:R176. 2007
    ..Extant life depends greatly on the binding of small molecules (such as ligands) with macromolecules (such as proteins), and one ligand can bind multiple proteins. However, little is known about the global patterns of ligand-protein mapping...
  28. doi request reprint Molecular basis for cis-urocanic acid as a 5-HT(2A) receptor agonist
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    Bioorg Med Chem Lett 19:5307-9. 2009
    ..Moreover, the molecular basis for the distinct binding affinities between the trans- and cis-UA with 5-HT(2A) receptor was also provided...
  29. ncbi request reprint A theoretical elucidation on the solvent-dependent photosensitive behaviors of C60
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo, PR China
    Photochem Photobiol 82:798-800. 2006
    ..and (.)OH are primarily responsible for the photoinduced DNA cleavage by C(60) under physiological conditions, whereas (1)O(2) plays a critical role in nonpolar solvents...
  30. pmc Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, People s Republic of China
    PLoS ONE 6:e22494. 2011
    ..Furthermore, the present findings have significant implication for exploring the composition of primitive RNA, i.e., adenine base as principal building blocks...
  31. pmc How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, P R China
    Sci Rep 6:20872. 2016
    ..Our novel findings not only provide novel insights into the complex pharmacology of curcumin due to its poor bioavailability, but also open new avenues for developing therapeutic applications of this natural product. ..
  32. doi request reprint A theoretical study on the quenching mechanisms of triplet state riboflavin by tryptophan and tyrosine
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zhangzhou Road, Zibo 255049, PR China
    J Photochem Photobiol B 92:10-2. 2008
    ....
  33. doi request reprint Osteoporosis risk and bone mineral density levels in patients with Parkinson's disease: a meta-analysis
    Yan Zhao
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, PR China
    Bone 52:498-505. 2013
    ..The purpose of the present study is to perform a meta-analysis on the risk of osteoporosis and bone mineral density (BMD) levels in PD patients...
  34. doi request reprint On photoprotective mechanisms of carotenoids in light harvesting complex
    Fu Gui Xiao
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, PR China
    Biochem Biophys Res Commun 414:1-4. 2011
    ..Moreover, being as good antioxidants, carotenoids' potential protective effects against LHC photo-oxidation by quenching active oxygen species or triplet excited state chlorophyll are also discussed...
  35. ncbi request reprint The role of electrostatic interaction in triggering the unraveling of stable helix 1 in normal prion protein. A molecular dynamics simulation investigation
    Hong Fang Ji
    Laboratory for Computational Biology, Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, PR China
    J Biomol Struct Dyn 22:563-70. 2005
    ..This finding not only help to reconcile the existing debate on the role of helix 1 in the PrPC-->PrPSc transition, but also reveals a possible mechanism for triggering the PrPC-->PrPSc conversion...
  36. ncbi request reprint Proton dissociation is important to understanding structure-activity relationships of gallic acid antioxidants
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    Bioorg Med Chem Lett 16:4095-8. 2006
    ....
  37. doi request reprint Assessment of vitamin D levels in type 1 and type 2 diabetes patients: Results from metaanalysis
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, P R China
    Mol Nutr Food Res 60:1059-67. 2016
    ..The present study aims to assess 25-hydroxyvitamin D [25(OH)D] levels in T1D and T2D patients compared with controls through a metaanalysis...
  38. pmc Alzheimer's disease and risk of hip fracture: a meta-analysis study
    Yan Zhao
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
    ScientificWorldJournal 2012:872173. 2012
    ..Considering that bone mineral density (BMD) acts as a strong predictor of bone fracture, we also studied the hip BMD in AD patients...
  39. doi request reprint Effect of vitamin E supplementation on aminotransferase levels in patients with NAFLD, NASH, and CHC: results from a meta-analysis
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, P R China Electronic address
    Nutrition 30:986-91. 2014
    ....
  40. ncbi request reprint The effect of heme on the conformational stability of micro-myoglobin
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo, China
    FEBS J 275:89-96. 2008
    ....
  41. doi request reprint Insights into the region responding to ΔpH change in major light harvesting complex
    Fu Gui Xiao
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, PR China
    J Photochem Photobiol B 111:35-8. 2012
    ....
  42. ncbi request reprint Beta-lactam antibiotics are multipotent agents to combat neurological diseases
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    Biochem Biophys Res Commun 333:661-3. 2005
    ..This is partially supported by our theoretical calculations...
  43. doi request reprint Triplet excited state characters and photosensitization mechanisms of alpha-terthienyl: a theoretical study
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China
    J Photochem Photobiol B 94:51-3. 2009
    ..can only be formed in water through the electron transfer from the T(1) state alpha-T or alpha-T(-) to 3O2...
  44. pmc Genetic overlap between type 2 diabetes and major depressive disorder identified by bioinformatics analysis
    Hong Fang Ji
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, P R China
    Oncotarget 7:17410-4. 2016
    ..The findings will have potential implications for future interventional studies of the two diseases. ..
  45. pmc Vitamin D deficiency is associated with increased risk of Alzheimer's disease and dementia: evidence from meta-analysis
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, 255049, P R China
    Nutr J 14:76. 2015
    ..The present meta-analysis was designed to estimate the association between vitamin D deficiency and risk of developing AD and dementia...
  46. pmc A meta-analysis of tea drinking and risk of Parkinson's disease
    Feng Jiao Li
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
    ScientificWorldJournal 2012:923464. 2012
    ..Many studies have reported an association between tea drinking and Parkinson's disease (PD). Our purpose is to summarize the available information and evaluate the risk of PD associated with tea drinking...
  47. doi request reprint Mutation directional selection sheds light on prion pathogenesis
    Liang Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, PR China
    Biochem Biophys Res Commun 410:159-63. 2011
    ..g., lipid and polyanion, we proposed that the mutation-induced changes may strengthen the interaction between PrP and facilitating factors, which will accelerate PrP conversion and cause PrDs...
  48. ncbi request reprint Comparative study of copper(II)-curcumin complexes as superoxide dismutase mimics and free radical scavengers
    Atanu Barik
    Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India
    Eur J Med Chem 42:431-9. 2007
    ..In addition, quantum chemical calculations with density functional theory have been performed to support the experimental observations...
  49. ncbi request reprint Bis(2-amino-6-methylpyridinium) tetrachlorozincate(II)
    Zhi Min Jin
    College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, People s Republic of China
    Acta Crystallogr C 61:m43-5. 2005
    ..The molecules are associated by two different pi-pi interactions between identical antiparallel AMP cations, with face-to-face distances of 3.627 (4) and 3.342 (3) A, to form a one-dimensional chain...