Hong Fan

Summary

Affiliation: Southeast University
Country: China

Publications

  1. doi request reprint Genome-wide profiling of DNA methylation reveals preferred sequences of DNMTs in hepatocellular carcinoma cells
    Hong Fan
    Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, 87 Ding Jiaqiao Road, Nanjing, 210009, China
    Tumour Biol 37:877-85. 2016
  2. doi request reprint MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma
    H Fan
    The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China
    Oncogene 31:2298-308. 2012
  3. pmc A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma
    Hong Fan
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, China
    BMC Med 8:12. 2010
  4. pmc Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma
    Hong Fan
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing, Jiangsu Province, China
    World J Gastroenterol 15:2020-6. 2009
  5. pmc Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study
    Hong Fan
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, 210009, Nanjing, PR China
    J Exp Clin Cancer Res 27:24. 2008
  6. pmc DNMT3B 579 G>T promoter polymorphism and risk of esophagus carcinoma in Chinese
    Hong Fan
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, Jiangsu Province, China
    World J Gastroenterol 14:2230-4. 2008
  7. ncbi request reprint DNA methyltransferase 1 knockdown induces silenced CDH1 gene reexpression by demethylation of methylated CpG in hepatocellular carcinoma cell line SMMC-7721
    Hong Fan
    Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu Province, China
    Eur J Gastroenterol Hepatol 19:952-61. 2007
  8. ncbi request reprint Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine
    Hong Fan
    Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, China
    Chin Med J (Engl) 120:1626-31. 2007
  9. doi request reprint DNMT3B promoter polymorphism and risk of gastric cancer
    Jiabo Hu
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, 210009, Nanjing, Jiangsu, China
    Dig Dis Sci 55:1011-6. 2010
  10. pmc Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell
    Zhujiang Zhao
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, China
    J Biomed Biotechnol 2010:737535. 2010

Collaborators

Detail Information

Publications39

  1. doi request reprint Genome-wide profiling of DNA methylation reveals preferred sequences of DNMTs in hepatocellular carcinoma cells
    Hong Fan
    Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, 87 Ding Jiaqiao Road, Nanjing, 210009, China
    Tumour Biol 37:877-85. 2016
    ..Meanwhile, the analysis of preference sequences provides an alternative way to find out the individual function of DNMTs. ..
  2. doi request reprint MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma
    H Fan
    The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China
    Oncogene 31:2298-308. 2012
    ..MTSS1 was further characterized as a novel tumor suppressor gene in HCC. These findings highlight how DNMT3B regulates MTSS1, and such data may be useful for the development of new treatment options for HCC...
  3. pmc A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma
    Hong Fan
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, China
    BMC Med 8:12. 2010
    ....
  4. pmc Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma
    Hong Fan
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing, Jiangsu Province, China
    World J Gastroenterol 15:2020-6. 2009
    ..To explore the relationship between DNA methyltransferase 1 (DNMT1) and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and its biological significance in primary HCC...
  5. pmc Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study
    Hong Fan
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, 210009, Nanjing, PR China
    J Exp Clin Cancer Res 27:24. 2008
    ..Polymorphisms of the DNMT3B gene may influence DNMT3B activity on DNA methylation in several cancers, thereby modulating the susceptibility to cancer...
  6. pmc DNMT3B 579 G>T promoter polymorphism and risk of esophagus carcinoma in Chinese
    Hong Fan
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, Jiangsu Province, China
    World J Gastroenterol 14:2230-4. 2008
    ..To investigate the relationship between 579 G>T polymorphisms in the DNMT3B gene, which is involved in de novo methylation and associated with the risk of esophagus cancer (EC) in Chinese...
  7. ncbi request reprint DNA methyltransferase 1 knockdown induces silenced CDH1 gene reexpression by demethylation of methylated CpG in hepatocellular carcinoma cell line SMMC-7721
    Hong Fan
    Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu Province, China
    Eur J Gastroenterol Hepatol 19:952-61. 2007
    ..DNA methyltransferase 1 (DNMT1) is the predominant maintenance methyltransferase gene required to maintain DNA methylation patterns in mammalian cells...
  8. ncbi request reprint Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine
    Hong Fan
    Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, China
    Chin Med J (Engl) 120:1626-31. 2007
    ..This study explored the mechanism of 5-aza-2'-deoxycytidine targeting transcriptional repressor complexes affecting global gene expression in hepatocellular carcinoma cell line...
  9. doi request reprint DNMT3B promoter polymorphism and risk of gastric cancer
    Jiabo Hu
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, 210009, Nanjing, Jiangsu, China
    Dig Dis Sci 55:1011-6. 2010
    ..49; 95% CI, 0.17-17.94) in the studied Chinese population. In addition, data suggested that DNMT3B genetic polymorphism varied among different races, ethnic groups, and geographic areas...
  10. pmc Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell
    Zhujiang Zhao
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, China
    J Biomed Biotechnol 2010:737535. 2010
    ..Demethylation of PTEN promoter was observed in DNMT3A-depleted cells implying that DNMT3A silenced PTEN via DNA methylation. These results provide insights into the mechanisms of DNMT3A to regulate TSGs by an epigenetic approach in HCC...
  11. doi request reprint DNMT3A rs36012910 A>G polymorphism and gastric cancer susceptibility in a Chinese population
    Qunying Wu
    Department of Genetic and Developmental, Medical School of Southeast University and Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Nanjing, 210009, China
    Mol Biol Rep 39:10949-55. 2012
    ..DNMT3A rs36012910 A>G might become a potential biomarker for use in GC prediction, although further studies in larger groups and different populations are needed for confirmation...
  12. ncbi request reprint Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma
    Xianwei Su
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, P R China
    Oncol Rep 23:819-26. 2010
    ..pylori infection. Elevated DNMT3B variants may influence the progression of gastric cancer and may possibly be a powerful indicator for the disease...
  13. ncbi request reprint Identification of potential genes regulated by DNA methyltransferase 3B in a hepatocellular carcinoma cell line by RNA interference and microarray analysis
    Jun Xu
    State Education Ministry Laboratory of Developmental Genes and Human Diseases, Jiangsu Provincial Key Laboratory of Gene Diagnosis and Therapy, Genetics Research Center, Southeast University Medical School, Nanjing 210009, China
    Yi Chuan Xue Bao 32:1115-27. 2005
    ..An array of candidate genes that are involved in the action of DNMT3B have been identified,including those related to development...
  14. pmc Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer
    He Cui
    Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing, 210009, China
    PLoS ONE 10:e0123926. 2015
    ..This finding reveals that DNA methylation-associated silencing of miR-29b/c is critical for GC development and thus may be a therapeutic target. ..
  15. pmc Reduced miR-29a-3p expression is linked to the cell proliferation and cell migration in gastric cancer
    Zhujiang Zhao
    Department of Genetics and Developmental Biology, the Medical School of Southeast University and Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, 2 Sipailou, Xuanwu, Nanjing, 210009, China
    World J Surg Oncol 13:101. 2015
    ..Alteration expression patterns of miRNAs in gastric cancer (GC) are associated with cancer initiation and progression. In the present study, we evaluated miR-29a-3p expression pattern and its function in gastric carcinogenesis...
  16. doi request reprint Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cells
    Fengchang Qiao
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Institute of Life Science, and Department of Genetics and Developmental Biology, Medical School of Southeast University, Nanjing 210009, PR China
    Oncol Rep 28:1475-81. 2012
    ..RASAL1 may be a functional tumor suppressor involved in gastric cancer. This study provides novel insights into the biological role of RASAL1 in gastric carcinogenesis...
  17. pmc DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18INK4C in gastric carcinogenesis
    He Cui
    Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing 210009, China
    Sci Rep 5:13781. 2015
    ..These findings provide new insights into gastric carcinogenesis and a potential therapeutic target for GC that may be further investigated in the future...
  18. doi request reprint Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis
    Fengchang Qiao
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Department of Genetics and Developmental Biology, The Medical School of Southeast University and the Institute of Life Science, Southeast University, Nanjing, 210009, China
    Mol Biol Rep 41:5693-700. 2014
    ..Overexpression of miR-30b-5p inhibited cell migration. Thus, miR-30b-5p may represent a potential therapeutic target for gastric cancer therapy...
  19. doi request reprint Reduced miR-29a-3p expression is linked to the cell proliferation and cell migration in gastric cancer
    Zhujiang Zhao
    Department of Genetics and Developmental Biology, the Medical School of Southeast University and Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, 2 Sipailou, Xuanwu, Nanjing, 210009, China
    World J Surg Oncol 13:513. 2015
    ..Alteration expression patterns of miRNAs in gastric cancer (GC) are associated with cancer initiation and progression. In the present study, we evaluated miR-29a-3p expression pattern and its function in gastric carcinogenesis...
  20. doi request reprint Upregulation of DNMT1 mediated by HBx suppresses RASSF1A expression independent of DNA methylation
    Xuemei Qiu
    Department of Medical Genetics and Developmental Biology, Medical School of Southeast University and the Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing, Jiangsu, P R China
    Oncol Rep 31:202-8. 2014
    ....
  21. pmc HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling
    Jiao Jiao Hu
    Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing, China
    Sci Rep 6:23521. 2016
    ..Our findings demonstrate an important mechanism of hepatocarcinogenesis through the signaling of HBx-UCA1/EZH2-p27Kip1 axis, and a potential target of HCC. ..
  22. doi request reprint Upregulation of long noncoding RNA PEG10 associates with poor prognosis in diffuse large B cell lymphoma with facilitating tumorigenicity
    Wei Peng
    Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing Medical University, No 42 Baiziting Road, Nanjing, 210009, China
    Clin Exp Med 16:177-82. 2016
    ..Our results suggested that PEG10 could represent a novel indicator of poor prognosis and might be served as a potential target for the diagnosis and gene therapy of DLBCL. ..
  23. pmc A novel functional TagSNP Rs7560488 in the DNMT3A1 promoter is associated with susceptibility to gastric cancer by modulating promoter activity
    Huazhang Wu
    The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China
    PLoS ONE 9:e92911. 2014
    ....
  24. ncbi request reprint Hypermethylation and clinicopathological significance of RASAL1 gene in gastric cancer
    Hong Chen
    Department of Gastroenterology, Affiliated Zhongda Hospital, Southeast University, Nanjing, China E mail
    Asian Pac J Cancer Prev 14:6261-5. 2013
    ..However, the exact mechanism which induces down-regulation of the RASAL1 gene remains unclear. This study aimed to determine the methylation status and regulation of RASAL1 in gastric cancer...
  25. doi request reprint Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer
    Wei Peng
    Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing Medical University, No 42 Baiziting Road, Nanjing, 210009, China
    Tumour Biol 36:6751-8. 2015
    ..Our data suggest that SPRY4-IT1 plays a critical role in GC tumorigenesis and may represent a novel prognostic marker and potential therapeutic target in patients with GC...
  26. doi request reprint Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer
    Jian Yang
    Department of Oncology, Affiliated Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, PR China
    Mol Med Rep 4:1139-43. 2011
    ..035). DNMTs are overexpressed in gastric cancer, and may play a significant role in the development of aberrant promoter methylation during tumorigenesis...
  27. doi request reprint LncRNA NEAT1 Impacts Cell Proliferation and Apoptosis of Colorectal Cancer via Regulation of Akt Signaling
    Wei Peng
    Department of Medical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, No 42 Baiziting Road, Nanjing, 210009, China
    Pathol Oncol Res . 2016
    ..Taken together, this work support the first evidence that NEAT1 can be used to be a promising biomarker and target for novel treatment for human CRC...
  28. ncbi request reprint Genetic profile of two Tibetan populations from China by analysis of 15 STR loci
    Binwu Ying
    Department of Respiratory Medicine and National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People s Republic of China
    Hum Biol 78:757-70. 2006
    ..These findings suggest that these STR loci could be particularly powerful tools in forensic medicine and could provide the necessary fundamental population genetic data for the reconstruction of recent human evolutionary history...
  29. ncbi request reprint [Cloning and mapping analysis of cDNA fragment OPB7-1 gene in human lung adenocarcinoma]
    Hong Fan
    Laboratory of Medical Genetics, Harbin Medical University, Harbin, Helongjiang, 150086 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:156-9. 2003
    ..To search the candidate gene in the development and metastasis of lung adenocarcinoma and shed light on the possible molecular mechanism of the development of lung carcinoma...
  30. doi request reprint Three cases of community-associated meticillin-resistant Staphylococcus aureus infection in China
    Hong Fan
    J Med Microbiol 57:1178-9. 2008
  31. doi request reprint Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo
    Julia K Kurash
    Epigenetics, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA
    Mol Cell 29:392-400. 2008
    ..We provide the first genetic evidence demonstrating that lysine methylation of p53 by Set7/9 is important for p53 activation in vivo and suggest a mechanistic link between methylation and acetylation of p53 through Tip60...
  32. doi request reprint Population genetic study of 15 STR loci in a Chinese population
    Ga Liao
    Biomedical Engineering Department, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    J Forensic Sci 53:252-3. 2008
  33. ncbi request reprint The application of mitochondrial DNA cytochrome oxidase II gene for the identification of forensically important blowflies in Western China
    Bin Wu Ying
    Department of Lab Medicine, West China Hospital, People s Republic of China
    Am J Forensic Med Pathol 28:308-13. 2007
    ....
  34. ncbi request reprint Population genetics for five STR loci in Tibetan group of Chinese population
    Jin Huang
    Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
    J Forensic Sci 51:697-8. 2006
  35. ncbi request reprint Radiolabeled small-molecule ligands for prostate-specific membrane antigen: in vivo imaging in experimental models of prostate cancer
    Catherine A Foss
    Johns Hopkins University, Baltimore, Maryland 21287 2182, USA
    Clin Cancer Res 11:4022-8. 2005
    ..Our goal in this study was to develop a series of PSMA-based imaging agents for clinical use...
  36. ncbi request reprint [Determination of human RHD gene rhesus box and its significance]
    Hua you Zhou
    Department of Blood Transfusion, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:130-4. 2005
    ..It is concluded that the method is suitable for clinical application with its simplicity and veracity. There are many noneffective RHD genes (44.9%) in Chinese Hans with RhD(-) phenotype...
  37. ncbi request reprint [Exon polymorphism of human RHD gene]
    Hua you Zhou
    Department of Blood Transfusion, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:513-6. 2004
    ..To study exon polymorphism of human RHD gene and investigate the genetic mechanism of RhD-negative individuals...
  38. ncbi request reprint Science as ideology: the rejection and reception of sociobiology in China
    Li Jianhui
    Department of Philosophy, Beijing Normal University, China
    J Hist Biol 36:567-78. 2003
    ..A review of the process of reception of sociobiology in China is helpful for understanding this theory as well as the society of China...
  39. ncbi request reprint [Mapping and expression analysis of a different expression cDNA fragment from lung adenocarcinoma cell line]
    Hong Fan
    Laboratory of Medical Genetics, Ha erbin Medical University, Ha erbin 150086, China
    Yi Chuan Xue Bao 29:476-80. 2002
    ..It will be helpful to investigate the expression in lung cancer cases and other tumor tissues for further determining the function of OPB7-1 gene in development of tumor...