Jun Ming Tang

Summary

Country: China

Publications

  1. ncbi request reprint Mesenchymal stem cells participate in angiogenesis and improve heart function in rat model of myocardial ischemia with reperfusion
    Junming Tang
    Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, People s Republic of China
    Eur J Cardiothorac Surg 30:353-61. 2006
  2. doi request reprint VEGF-A promotes cardiac stem cell engraftment and myocardial repair in the infarcted heart
    Jun Ming Tang
    Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China Department of Physiology and Key Lab of human Embryonic Stem Cell of Hubei Province, Hubei University of Medicine, Hubei 442000, China Center for Medical Research and Department of Physiology, School of Basic Medical Sciences, Wuhan University, Hubei 430071, China Electronic address
    Int J Cardiol 183:221-31. 2015
  3. pmc Acetylcholine induces mesenchymal stem cell migration via Ca2+ /PKC/ERK1/2 signal pathway
    Jun Ming Tang
    Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Hubei 442000, China
    J Cell Biochem 113:2704-13. 2012
  4. pmc Adenovirus-mediated stromal cell-derived factor-1 alpha gene transfer improves cardiac structure and function after experimental myocardial infarction through angiogenic and antifibrotic actions
    Junming Tang
    Institute of Clinical Medicine, Renmin Hospital, Yunyang Medical College, 442000, Shiyan, Hubei, People s Republic of China
    Mol Biol Rep 37:1957-69. 2010
  5. pmc VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart
    Jun Ming Tang
    Institute of Clinical Medicine Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, PR China
    Cardiovasc Res 91:402-11. 2011
  6. doi request reprint Combination of chemokine and angiogenic factor genes and mesenchymal stem cells could enhance angiogenesis and improve cardiac function after acute myocardial infarction in rats
    Junming Tang
    Department of Cardiology, Institute of Clinical Medicine, Renmin Hospital, Yunyang Medical College, Shiyan, Hubei 442000, People s Republic of China
    Mol Cell Biochem 339:107-18. 2010
  7. doi request reprint Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction
    Junming Tang
    Institute of Clinical Medicine, Renmin Hospital, Yunyang Medical College, Shiyan, Hubei, 442000, People s Republic of China
    Mol Cells 29:9-19. 2010
  8. doi request reprint Vascular endothelial growth factor promotes cardiac stem cell migration via the PI3K/Akt pathway
    Junming Tang
    Center for Medical Research and Department of Physiology, School of Basic Medical Sciences, Wuhan University, Hubei 430071, PR China
    Exp Cell Res 315:3521-31. 2009
  9. doi request reprint Mesenchymal stem cells over-expressing SDF-1 promote angiogenesis and improve heart function in experimental myocardial infarction in rats
    Junming Tang
    Institute of Clinical Medicine, Renmin Hospital, Yunyang Medical College, Shiyan, Hubei 442000, People s Republic of China
    Eur J Cardiothorac Surg 36:644-50. 2009
  10. ncbi request reprint [Incorporation and integration of mesenchymal stem cell-derived myocardial cells into host cardiac myocytes: an experimental study in rats]
    Jun Ming Tang
    Institute of Clinical Medicine Research, People s Hospital of Shiyan City, Shiyan 44200, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:38-42. 2007

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Mesenchymal stem cells participate in angiogenesis and improve heart function in rat model of myocardial ischemia with reperfusion
    Junming Tang
    Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, People s Republic of China
    Eur J Cardiothorac Surg 30:353-61. 2006
    ..The effect of transplanted mesenchymal stem cells (MSCs) on the left ventricular (LV) function and morphology in a rat myocardial infarct heart with reperfusion model were analyzed...
  2. doi request reprint VEGF-A promotes cardiac stem cell engraftment and myocardial repair in the infarcted heart
    Jun Ming Tang
    Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China Department of Physiology and Key Lab of human Embryonic Stem Cell of Hubei Province, Hubei University of Medicine, Hubei 442000, China Center for Medical Research and Department of Physiology, School of Basic Medical Sciences, Wuhan University, Hubei 430071, China Electronic address
    Int J Cardiol 183:221-31. 2015
    ..The objective of this study was to determine whether vascular endothelial growth factor (VEGF)-A subtypes improve cardiac stem cell (CSC) engraftment and promote CSC-mediated myocardial repair in the infarcted heart...
  3. pmc Acetylcholine induces mesenchymal stem cell migration via Ca2+ /PKC/ERK1/2 signal pathway
    Jun Ming Tang
    Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Hubei 442000, China
    J Cell Biochem 113:2704-13. 2012
    ..These results indicate that ACh induces MSC migration via Ca(2+), PKC, and ERK1/2 signal pathways...
  4. pmc Adenovirus-mediated stromal cell-derived factor-1 alpha gene transfer improves cardiac structure and function after experimental myocardial infarction through angiogenic and antifibrotic actions
    Junming Tang
    Institute of Clinical Medicine, Renmin Hospital, Yunyang Medical College, 442000, Shiyan, Hubei, People s Republic of China
    Mol Biol Rep 37:1957-69. 2010
    ..Furthermore, the expression of collagen type I and type III mRNA, and collagen accumulation in the infarcted area was lower, which was associated with decreased TGF-beta1, TIMP-1 and TIMP-2 expression in AdV-SDF-1 group...
  5. pmc VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart
    Jun Ming Tang
    Institute of Clinical Medicine Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, PR China
    Cardiovasc Res 91:402-11. 2011
    ....
  6. doi request reprint Combination of chemokine and angiogenic factor genes and mesenchymal stem cells could enhance angiogenesis and improve cardiac function after acute myocardial infarction in rats
    Junming Tang
    Department of Cardiology, Institute of Clinical Medicine, Renmin Hospital, Yunyang Medical College, Shiyan, Hubei 442000, People s Republic of China
    Mol Cell Biochem 339:107-18. 2010
    ..These results demonstrated that combination of chemokine and angiogenic factor gene and stem cells could enhance angiogenesis and improves cardiac function after acute myocardial infarction in rats...
  7. doi request reprint Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction
    Junming Tang
    Institute of Clinical Medicine, Renmin Hospital, Yunyang Medical College, Shiyan, Hubei, 442000, People s Republic of China
    Mol Cells 29:9-19. 2010
    ....
  8. doi request reprint Vascular endothelial growth factor promotes cardiac stem cell migration via the PI3K/Akt pathway
    Junming Tang
    Center for Medical Research and Department of Physiology, School of Basic Medical Sciences, Wuhan University, Hubei 430071, PR China
    Exp Cell Res 315:3521-31. 2009
    ..The CSC accumulation was inhibited by either the VEGF receptor blocker SU5416 or the PI3K/Ak inhibitor wortmannin. VEGF signaling may mediate the migration of CSCs via activation of PI3K/Akt...
  9. doi request reprint Mesenchymal stem cells over-expressing SDF-1 promote angiogenesis and improve heart function in experimental myocardial infarction in rats
    Junming Tang
    Institute of Clinical Medicine, Renmin Hospital, Yunyang Medical College, Shiyan, Hubei 442000, People s Republic of China
    Eur J Cardiothorac Surg 36:644-50. 2009
    ..The stromal-derived factor-1 alpha (SDF-1alpha) plays an important role in the homing of stem cells to the injured tissues of the heart. Therefore, the MSCs over-expressing SDF-1alpha could augment the angiogenesis pathway...
  10. ncbi request reprint [Incorporation and integration of mesenchymal stem cell-derived myocardial cells into host cardiac myocytes: an experimental study in rats]
    Jun Ming Tang
    Institute of Clinical Medicine Research, People s Hospital of Shiyan City, Shiyan 44200, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:38-42. 2007
    ..To investigate the anatomical bases for electrical coupling of mesenchymal stem cells (MSCs)-derived myocardial cells with host cardiac myocytes...
  11. pmc The combined transduction of copper, zinc-superoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury
    Guang Qing Huang
    Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China
    J Transl Med 9:73. 2011
    ..The aim of this study is to explore whether combined use of PEP-1-SOD1 and PEP-1-CAT enhances their protective effects...
  12. pmc PEP-1-CAT-transduced mesenchymal stem cells acquire an enhanced viability and promote ischemia-induced angiogenesis
    Lei Zhang
    Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, People s Republic of China
    PLoS ONE 7:e52537. 2012
    ..The aim of this study is to investigate the role of PEP-1-CAT transduction in MSC survival and its effect on ischemia-induced angiogenesis...
  13. pmc PEP-1-CAT protects hypoxia/reoxygenation-induced cardiomyocyte apoptosis through multiple sigaling pathways
    Lei Zhang
    Institute of Clinical Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China
    J Transl Med 11:113. 2013
    ..This study is aimed to investigate if PEP-1-CAT fusion protein can effectively protect cardiomyocytes from oxidative stress due to hypoxia/reoxygenation (H/R)-induced injury...
  14. pmc VEGF is essential for the growth and migration of human hepatocellular carcinoma cells
    Lei Zhang
    Department of Cardiology and Institute of Clinical Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China
    Mol Biol Rep 39:5085-93. 2012
    ..Knockdown of VEGF165 decreased the expression of NF-κB p65 and PKCα while increased the expression of p53 signaling molecules, suggesting that VEGF functions in HCC proliferation and migration are mediated by P65, PKCα and/or p53...
  15. ncbi request reprint [Adenovirus-mediated stromal cell-derived factor-1 alpha gene transfer promotes mesenchymal stem cell migration]
    Yi Ping Wang
    Institute of Clinical Medicine, Shiyan People s Hospital Affiliated toYunyang Medical College, Shiyan 442000, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:1190-4. 2008
    ..To explore the role of stromal-derived factor-1 (SDF-1) in the migration of mesenchymal stem cells (MSCs) and the underlying signal transduction mechanism...
  16. ncbi request reprint [VEGF promotes the proliferation of bone marrow derived mesenchymal stem cells through ERK1/2 signal pathway]
    Xia Kong
    Institute of Clinical Medicine, Department of Cardiology, Peolpe Hospital, Yunyang Medical College, Shiyan 442000, Hubei Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1292-6. 2010
    ..Furthermore, the inhibitory effect of PD98059 on MSC proliferation was obviously higher than that of SB203580. It is concluded that the VEGF can promote MSC proliferation, and its possible mechanism may relate to ERK1/2 pathway...
  17. doi request reprint Vascular endothelial growth factor-C protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis
    Xu Guang Chen
    Institute of Clinical Medicine and Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China
    Mol Cell Biochem 413:9-23. 2016
    ..VEGF-C exerts its cardiac protection following I/R injury via its anti-apoptotic effect. ..
  18. ncbi request reprint [Effect of adenovirus-mediated stromal cell-derived factor-alpha gene transfer on ventricular remodeling in rats with myocardial infarction]
    Jian Ye Yang
    Institute of Clinical Medicine, Shiyan People s Hospital, Department of Physiology, Yunyang Medical College, Shiyan 442000, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:38-42. 2010
    ..To explore the effect of adenovirus-mediated human stromal cell-derived factor-1alpha (hSDF-1alpha) on ventricular remodeling in rats with myocardial infarction...
  19. pmc PEP-1-SOD1 protects brain from ischemic insult following asphyxial cardiac arrest in rats
    You En Zhang
    Department of Emergency, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China
    Resuscitation 82:1081-6. 2011
    ..However, exogenous SOD1 can not be delivered into living cells because of the poor permeability and selectivity of the cell membrane, thus its application for protecting cells/tissues from oxidative stress damage is greatly limited...
  20. ncbi request reprint [Effect of conditioned medium of mesenchymal stem cells on proliferation, migration and adhesion of human umbilical vein endothelial cells]
    Fei Zheng
    Institute of Clinical Medicine, Hubei Medical and Medicinal College, Shiyan, Hubei Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 20:154-8. 2012
    ..It is concluded that MSC-CM promotes the migration and adhesion ability of CRL1730 cells through SDF-1 expressed by MSC...
  21. ncbi request reprint [The effect of recombinant human erythropoietin on the migration of bone marrow derived mesenchymal stem cells in vitro]
    Long Chen
    Affiliated Dongfeng Hospital, Yunyang Medical College, Shiyan 442000, China
    Zhonghua Xue Ye Xue Za Zhi 29:811-4. 2008
    ..To explore the effects of rhEPO on the migration of bone marrow(BM) derived mesenchymal stem cells(MSCs) and its probable signal transduction mechanism...
  22. ncbi request reprint [Protective effect of preconditioning with PEP-1-CAT fusion protein against myocardial ischemia-reperfusion injury in rats]
    Yong Jun Zhang
    Institute of Clinical Medicine, People s Hospital Affiliated to Yunyang Medical College, Shiyan 442000, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2429-32. 2009
    ..To investigate the transduction efficiency of purified PEP-1-CAT fusion protein into rat heart and the protective effect of the fusion protein against myocardial ischemia-reperfusion injury...
  23. ncbi request reprint [Effect of vascular endothelial growth factor on bone marrow-derived mesenchymal stem cell proliferation and the signaling mechanism]
    Jun Zhang
    Institute of Clinical Medicine, Hubei University of Medicine, Shiyan, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1697-700. 2011
    ..To observe the effect of vascular endothelial growth factor (VEGF) on bone marrow-derived mesenchymal stem cell (MSC) proliferation and explore the signaling mechanism involved...
  24. pmc PEP-1-SOD1 fusion proteins block cardiac myofibroblast activation and angiotensin II-induced collagen production
    Li Guo Tan
    Institute of Clinical Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, P R China
    BMC Cardiovasc Disord 15:116. 2015
    ..This study was aimed to investigate the effect of PEP-1-SOD1 fusion protein on angiotensin II (ANG II)-induced collagen metabolism in rat cardiac myofibroblasts (MCFs)...
  25. doi request reprint In vivo protein transduction: delivery of PEP-1-SOD1 fusion protein into myocardium efficiently protects against ischemic insult
    You En Zhang
    Institute of Clinical Medicine, Renmin Hospital, Yunyang Medical College, Shiyan, 442000, China
    Mol Cells 27:159-66. 2009
    ..These results suggest that the biologically active intact forms of PEP-1-SOD1 fusion protein will provide an efficient strategy for therapeutic delivery in various diseases related to SOD1 or to OFR...
  26. pmc Dual effects of VEGF-B on activating cardiomyocytes and cardiac stem cells to protect the heart against short- and long-term ischemia-reperfusion injury
    Guo Hua Li
    School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei Province, China
    J Transl Med 14:116. 2016
    ..To investigate whether vascular endothelial growth factor B (VEGF-B) improves myocardial survival and cardiac stem cell (CSC) function in the ischemia-reperfusion (I/R) heart and promotes CSC mobilization and angiogenesis...
  27. ncbi request reprint [The role of PEP-1-SOD1 fusion protein on ischemia-reperfusion injury in isolated perfused rat hearts.]
    Zun Ping Ke
    Institute of Clinical Medicine, Renmin Hospital, Yunyang Medical College, Shiyan 442000, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:268-74. 2009
    ..The transduction efficiency of the purified PEP-1-SOD1 fusion protein and the effects of PEP-1-SOD1 fusion protein on ischemia reperfusion injury in the isolated perfused rat hearts were investigated...
  28. ncbi request reprint [Effects of different doses of thrombopoietin on proliferation of bone marrow mesenchymal stem cells in mice]
    Hai Xia Chai
    Department of Hematology, DongFeng Hospital, Yunyang Medical College, Shiyan 442000, Hubei Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:859-62. 2008
    ..It means that TPO can enhance MSCs to proliferate in bone marrow. However, the number of BMNCs and CFU-F can not increase with the increase of TPO dose...
  29. ncbi request reprint [Mechanism of granulocyte colony-stimulating factor for promoting cell viability of bone marrow mesenchymal stem cells.]
    Long Chen
    Department of Hematology, Yunyang Medical College, Shiyan, China
    Sheng Li Xue Bao 61:169-74. 2009
    ..It is thus suggested that the promoting effect of G-CSF on MSCs viability was closely related to AKT-mTOR-PKC signal pathway, and PKC maybe the central role in the signal pathway...
  30. ncbi request reprint [Effects of rhG-CSF on mobilization of mouse mesenchymal stem cells]
    Qi Huan Liu
    Department of Hematology, DongFeng Hospital, Yunyang Medical College, Shiyan 442008, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:790-4. 2007
    ..rhG-CSF have the mini-mobilization effect on murine MSCs derived from bone marrow...
  31. doi request reprint Enhanced recovery after surgery programs versus traditional perioperative care in laparoscopic hepatectomy: A meta-analysis
    Rui Yang
    Department of Hepatobiliary and Pancreatic Surgery, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China Electronic address
    Int J Surg 36:274-282. 2016
    ..This meta-analysis is aimed to evaluate the efficacy and safety of ERAS programs versus traditional care in laparoscopic hepatectomy...