Hui Yao Lan

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. doi The incidence, risk factors and in-hospital mortality of acute kidney injury in patients after abdominal aortic aneurysm repair surgery
    Ying Tang
    Department of Nephrology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, 107 Yan Jiang West Road, Guangzhou, China
    BMC Nephrol 18:184. 2017
  2. doi MicroRNA and nephropathy: emerging concepts.
    Arthur Ck Chung
    Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, People s Republic of China CUHK Shenzhen Research Institute, Shenzhen, People s Republic of China
    Int J Nephrol Renovasc Dis 6:169-79. 2013
  3. pmc Chaihuang-Yishen granule inhibits diabetic kidney disease in rats through blocking TGF-β/Smad3 signaling
    Ting Ting Zhao
    Department of Pharmacology, Institute of Clinical Medical Sciences, China Japan Friendship Hospital, Beijing, China
    PLoS ONE 9:e90807. 2014
  4. pmc Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice
    Guan xian Liu
    Department of Nephrology, Central Municipal Hospital of Huizhou, Guangdong, China
    PLoS ONE 8:e53573. 2013
  5. pmc Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro
    Li xia Tang
    Institute of Medical Research, The First People s Hospital of Foshan, Foshan, Guangdong, China
    PLoS ONE 7:e31350. 2012
  6. doi TGF-β/Smad signaling in kidney disease
    Hui Y Lan
    Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China
    Semin Nephrol 32:236-43. 2012
  7. doi Transforming growth factor-β/Smad signalling in diabetic nephropathy
    Hui Yao Lan
    Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Clin Exp Pharmacol Physiol 39:731-8. 2012
  8. doi Smad3 mediates ANG II-induced hypertensive kidney disease in mice
    Zhen Liu
    Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Am J Physiol Renal Physiol 302:F986-97. 2012
  9. pmc Diverse roles of TGF-β/Smads in renal fibrosis and inflammation
    Hui Yao Lan
    Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Int J Biol Sci 7:1056-67. 2011
  10. doi Transforming growth factor-β and Smads
    Hui Yao Lan
    Department of Medicine and Therapeutics, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
    Contrib Nephrol 170:75-82. 2011

Collaborators

Detail Information

Publications50

  1. doi The incidence, risk factors and in-hospital mortality of acute kidney injury in patients after abdominal aortic aneurysm repair surgery
    Ying Tang
    Department of Nephrology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, 107 Yan Jiang West Road, Guangzhou, China
    BMC Nephrol 18:184. 2017
    ..Acute kidney injury (AKI) is a severe complication associated with abdominal aortic aneurysm (AAA) repair. In this study, we evaluated the incidence, risk factors and in-hospital mortality of AKI in patients after the AAA repair surgery...
  2. doi MicroRNA and nephropathy: emerging concepts.
    Arthur Ck Chung
    Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, People s Republic of China CUHK Shenzhen Research Institute, Shenzhen, People s Republic of China
    Int J Nephrol Renovasc Dis 6:169-79. 2013
    ..Thus, understanding the function of miRNAs in the pathogenesis of kidney diseases may offer an innovative approach for both early diagnosis and treatment of renal diseases...
  3. pmc Chaihuang-Yishen granule inhibits diabetic kidney disease in rats through blocking TGF-β/Smad3 signaling
    Ting Ting Zhao
    Department of Pharmacology, Institute of Clinical Medical Sciences, China Japan Friendship Hospital, Beijing, China
    PLoS ONE 9:e90807. 2014
    ..However, treatment of DN by blocking the TGF-β/Smad pathway remains limited. The present study investigated the anti-fibrotic effect of a traditional Chinese medicine, Chaihuang-Yishen granule (CHYS), on DN...
  4. pmc Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice
    Guan xian Liu
    Department of Nephrology, Central Municipal Hospital of Huizhou, Guangdong, China
    PLoS ONE 8:e53573. 2013
    ..Thus, Smad7 may play a protective role in ANG II-induced hypertensive kidney disease...
  5. pmc Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro
    Li xia Tang
    Institute of Medical Research, The First People s Hospital of Foshan, Foshan, Guangdong, China
    PLoS ONE 7:e31350. 2012
    ..In conclusion, AA may be a novel therapeutic agent for liver fibrosis. Induction of Smad7-dependent inhibition of TGF-beta/Smad-mediated fibrogenesis may be a central mechanism by which AA protects liver from injury...
  6. doi TGF-β/Smad signaling in kidney disease
    Hui Y Lan
    Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China
    Semin Nephrol 32:236-43. 2012
    ..Advances in understanding of the mechanisms of TGF-β/Smad signaling in renal fibrosis and inflammation during chronic kidney diseases should provide a better therapeutic strategy to combat kidney diseases...
  7. doi Transforming growth factor-β/Smad signalling in diabetic nephropathy
    Hui Yao Lan
    Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Clin Exp Pharmacol Physiol 39:731-8. 2012
    ..Targeting downstream TGF-β/Smad signalling by overexpressing Smad7- or Smad3-dependent microRNA related to fibrosis may represent a novel and effective strategy for the treatment of DN...
  8. doi Smad3 mediates ANG II-induced hypertensive kidney disease in mice
    Zhen Liu
    Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Am J Physiol Renal Physiol 302:F986-97. 2012
    ..Results from this study suggest that inhibition of Smad3 or overexpression of Smad7 may be a novel therapeutic strategy for hypertensive nephropathy...
  9. pmc Diverse roles of TGF-β/Smads in renal fibrosis and inflammation
    Hui Yao Lan
    Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Int J Biol Sci 7:1056-67. 2011
    ..Thus, targeting the downstream TGF-β/Smad3 signaling pathway by gene transfer of either Smad7 or Smad3-dependent microRNAs may represent a specific and effective therapeutic strategy for kidney disease...
  10. doi Transforming growth factor-β and Smads
    Hui Yao Lan
    Department of Medicine and Therapeutics, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
    Contrib Nephrol 170:75-82. 2011
    ..In conclusion, TGF-β/Smad signaling plays a critical role in DN. A better understanding of the role of TGF-β/Smad signaling in the development of DN should provide an effective therapeutic strategy to combat DN...
  11. doi Smad7 inhibits angiotensin II-induced hypertensive cardiac remodelling
    Li Hua Wei
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, China
    Cardiovasc Res 99:665-73. 2013
    ..The present study tested the hypothesis that overexpression of Smad7 may have therapeutic potential for angiotensin II (Ang II)-mediated hypertensive cardiac remodelling...
  12. doi Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro
    Xiao ming Meng
    Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR China
    Kidney Int 81:266-79. 2012
    ..Thus, Smad4 may be a key regulator for the diverse roles of TGF-β1 in inflammation and fibrogenesis by interacting with Smad7 and Smad3 to influence their transcriptional activities in renal inflammation and fibrosis...
  13. pmc miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-β/Smad3 signaling
    Yang Zhang
    1 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China 2 Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Mol Ther 22:974-85. 2014
    ..In conclusion, miR-29b plays a protective role in AngII-mediated cardiac remodeling and may be a therapeutic agent for cardiac fibrosis by targeting the TGF-β/Smad3 pathway. ..
  14. doi Deletion of Angiotensin-Converting Enzyme-2 Promotes Hypertensive Nephropathy by Targeting Smad7 for Ubiquitin Degradation
    Zhen Liu
    From the Division of Nephrology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, China Z L, J L Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Shatin, Hong Kong SAR, China Z L, X R H, H y C, E F, H Y L and Shenzhen Research Institute, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China Z L, X R H, H y C, E F, H Y L
    Hypertension 70:822-830. 2017
    ..Overexpression of renal Smad7 protects against hypertensive nephropathy by inactivating angiotensin II-induced TGF-β/Smad3 and NF-κB pathways and by targeting the Smad3-dependent microRNA-21 axis...
  15. doi Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy
    Zhen Liu
    Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Lab Invest 92:650-61. 2012
    ..Smad7 ubiquitin degradation mediated by Smurf2 may be a central mechanism by which Ace2(-/y) mice promote TGF-β/Smad2/3-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of UUO nephropathy...
  16. doi Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro
    Xiao ming Meng
    Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Pathol 227:175-88. 2012
    ..In addition, deletion of TβRII also enhances NF-κB signalling along with up-regulation of renal pro-inflammatory cytokines, which may be associated with the impairment of anti-inflammatory properties of TGF-β1...
  17. pmc Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension
    Li Hua Wei
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 8:e70195. 2013
    ..In conclusions, Smad7 plays a protective role in AngII-mediated cardiac remodeling via mechanisms involving the Sp1-TGF-β/Smad3-NF.κB-miR-29 regulatory network. ..
  18. pmc TGF-β/Smad3 signalling regulates the transition of bone marrow-derived macrophages into myofibroblasts during tissue fibrosis
    Shuang Wang
    Li Ka Shing Institute of Health Sciences, Departments of Medicine and Therapeutics, Chemical Pathology, and Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Oncotarget 7:8809-22. 2016
    ..This process contributes to progressive renal tissue fibrosis and is regulated by TGF-β/Smad3 signalling. ..
  19. pmc microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway
    Jia Wang
    Institute of Digestive Disease and The Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong
    Oncotarget 6:7325-38. 2015
    ..In conclusion, miR-29b prevents liver fibrogenesis by inhibiting HSC activation and inducing HSC apoptosis through inhibiting PI3K/AKT pathway. These results provide novel mechanistic insights for the anti-fibrotic effect of miR-29b. ..
  20. pmc Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis
    Xiao ming Meng
    Department of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Am Soc Nephrol 21:1477-87. 2010
    ..In conclusion, in contrast to Smad3, Smad2 protects against TGF-beta-mediated fibrosis by counteracting TGF-beta/Smad3 signaling...
  21. doi Essential role for Smad3 in angiotensin II-induced tubular epithelial-mesenchymal transition
    Fuye Yang
    Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Shatin, NT, Hong Kong
    J Pathol 221:390-401. 2010
    ..Smad3, but not Smad2, may be a mediator of EMT, while Smad7 may play a protective role in EMT in response to Ang II...
  22. pmc Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis
    Xiao ming Meng
    Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Cell Death Dis 7:e2495. 2016
    ..In conclusion, these findings provide substantial new data to support the postulate that macrophages can directly transdifferentiate into collagen-producing myofibroblasts in human and experimental kidney disease...
  23. pmc The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential
    Hai Yong Chen
    Department of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Diabetes 60:590-601. 2011
    ..The current study tests the hypothesis that Smad7 may play a protective role and has therapeutic potential for diabetic kidney disease...
  24. doi Latent transforming growth factor-β1 protects against bleomycin-induced lung injury in mice
    Yong Jiang Tang
    1 Department of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Am J Respir Cell Mol Biol 51:761-71. 2014
    ....
  25. doi The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring
    Patrick Ming Kuen Tang
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China Li Ka Shing Institute of Health Sciences, and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Kidney Int . 2017
    ..Thus, macrophage-myofibroblast transition contributes to Src-mediated tissue fibrosis. Hence, targeting Src may represent as a precision therapeutic strategy for macrophage-myofibroblast transition-driven fibrotic diseases...
  26. doi TGF-β Mediates Renal Fibrosis via the Smad3-Erbb4-IR Long Noncoding RNA Axis
    Min Feng
    Department of Nephrology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, China Departments of Medicine and Therapeutics, Anatomical and Cellular Pathology, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China
    Mol Ther . 2017
    ..Targeting Erbb4-IR may represent a precise therapeutic strategy for progressive renal fibrosis...
  27. doi Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3
    Fuye Yang
    Department of Medicine and Therapeutic, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Hypertension 54:877-84. 2009
    ..In conclusion, Ang II induces tubular CTGF expression and renal fibrosis via the TGF-beta-dependent and -independent Smad3 signaling pathways, suggesting that targeting Smad3 may have therapeutic potential for hypertensive nephropathy...
  28. doi MicroRNA-29b inhibits peritoneal fibrosis in a mouse model of peritoneal dialysis
    Jian Wen Yu
    1 Department of Nephrology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China 2 Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Lab Invest 94:978-90. 2014
    ..In conclusion, treatment with miR-29b may represent a novel and effective therapy for PD-associated peritoneal fibrosis. ..
  29. doi Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro
    Wen Juan Duan
    Department of Nephrology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Am J Pathol 184:2275-84. 2014
    ..These findings provide a mechanistic basis for future therapies targeting TGF-β/Smad signaling in peritoneal fibrosis. ..
  30. doi Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro
    Jia Wang
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
    J Pathol 230:441-52. 2013
    ..Smad7 suppresses HCC cell growth by inhibiting proliferation and G1 -S phase transition and inducing apoptosis through attenuation of NF-κB and TGFβ signalling. Smad7 acts as a potential tumour suppressor in liver...
  31. doi Mechanism of chronic aristolochic acid nephropathy: role of Smad3
    Li Zhou
    1Department of Medicine, University of Hong Kong, Hong Kong SAR, China
    Am J Physiol Renal Physiol 298:F1006-17. 2010
    ..In conclusion, TGF-beta/Smad3 may be an essential mediator for chronic AAN. Results from this study indicate that specific blockade of the TGF-beta/Smad3 signaling pathway may have therapeutic potential for chronic AAN...
  32. pmc Dragon (repulsive guidance molecule RGMb) inhibits E-cadherin expression and induces apoptosis in renal tubular epithelial cells
    WenJing Liu
    From the Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    J Biol Chem 288:31528-39. 2013
    ..Our results suggest that Dragon may impair tubular epithelial integrity and induce epithelial apoptosis both in vitro and in vivo. ..
  33. pmc Serum levels of WNT1-inducible signaling pathway protein-1 (WISP-1): a noninvasive biomarker of renal fibrosis in subjects with chronic kidney disease
    Xiang Zhong
    Department of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, School of Medicine, University of Electronic Science and Technology of ChinaChengdu, China
    Am J Transl Res 9:2920-2932. 2017
    ..475, P=0.0001). Thus, serum WISP-1 levels may be used as a potential noninvasive biomarker of renal fibrosis in patients with CKD...
  34. pmc Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin
    Xiao ming Meng
    Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR
    Oncotarget 6:36984-97. 2015
    ..Thus, rebalancing the disorder of TGF-β/Smad signaling by treatment with AA and NG may represent as a novel and effective therapy for chronic kidney disease associated with fibrosis. ..
  35. pmc Smad7 protects against chronic aristolochic acid nephropathy in mice
    Xiao Yu Dai
    Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China
    Oncotarget 6:11930-44. 2015
    ..In conclusion, Smad7 plays a protective role in the pathogenesis of chronic AAN and overexpression of Smad7 may represent a novel therapeutic potential for chronic AAN...
  36. doi Ribosomal protein S19 is a novel therapeutic agent in inflammatory kidney disease
    Jun Lv
    Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    Clin Sci (Lond) 124:627-37. 2013
    ..01). These results demonstrate that RPS19 is a potent anti-inflammatory agent, which appears to work primarily by inhibiting MIF signalling...
  37. pmc Validity of leptin receptor-deficiency (db/db) type 2 diabetes mellitus mice as a model of secondary osteoporosis
    Le Huang
    Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Sci Rep 6:27745. 2016
    ..The leptin-receptor mice is not a proper model for secondary osteoporosis associated with T2DM. ..
  38. doi The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation
    Lin L Lv
    Li Ka Shing Institute of Health Sciences, and Department of Medicine and Therapeutics, and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China Institute of Nephrology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China
    Kidney Int . 2016
    ..Hence, targeting Mincle may be a novel therapy for acute kidney injury associated with M1 macrophages...
  39. ncbi Helicobacter pylori infection is associated with increased expression of macrophage migratory inhibitory factor--by epithelial cells, T cells, and macrophages--in gastric mucosa
    Harry Hua Xiang Xia
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, S A R, China
    J Infect Dis 190:293-302. 2004
    ..pylori infection...
  40. doi Transforming growth factor-β1 mediates psoriasis-like lesions via a Smad3-dependent mechanism in mice
    Yun Zhang
    Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of HongKong, Hong Kong, China School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
    Clin Exp Pharmacol Physiol 41:921-32. 2014
    ..In conclusion, TGF-β1 mediates the development of psoriasis-like lesions via a Smad3-dependent, Th17-mediated mechanism. Targeting TGF-β/Smad3 signalling with a Smad3 inhibitor may represent a novel and effective therapy for psoriasis...
  41. doi Partial loss of Smad7 function impairs bone remodeling, osteogenesis and enhances osteoclastogenesis in mice
    Nan Li
    Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Bone 67:46-55. 2014
    ..Our results indicate that partial loss of Smad7 function in mice leads to compromised bone formation and enhanced bone resorption. Thus, Smad7 is acknowledged as a novel key regulator between osteogenesis and osteoclastogenesis. ..
  42. doi Impaired TGF-beta signalling enhances peritoneal inflammation induced by E. coli in rats
    Xin Wang
    Department of Nephrology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Nephrol Dial Transplant 25:399-412. 2010
    ..Peritonitis is a common and severe complication of peritoneal dialysis (PD). Although TGF-beta is a key mediator in peritoneal fibrosis with chronic PD, its role in acute peritoneal inflammation remains unclear...
  43. doi Peritoneal inflammation and fibrosis in C-reactive protein transgenic mice undergoing peritoneal dialysis solution treatment
    Peter Yam Kau Poon
    Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Nephrology (Carlton) 22:125-132. 2017
    ..Peritoneal dialysis (PD) is known to cause peritoneal inflammation and fibrosis. We compare the degree of peritoneal inflammation and fibrosis in wild-type (WT) and CRP-transgenic (Tg) mice after PD treatment...
  44. pmc Treatment of established peritoneal fibrosis by gene transfer of Smad7 in a rat model of peritoneal dialysis
    Yanyan Sun
    Department of Nephrology, The First Affiliated Hospital, Sun Yat Sen University, Guangdong, PR China
    Am J Nephrol 30:84-94. 2009
    ..The present study investigated whether Smad7 has a therapeutic effect on established peritoneal fibrosis associated with peritoneal dialysis (PD)...
  45. doi Transforming growth factor beta1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells
    Wen Deng
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR, China
    Cancer Res 68:7200-9. 2008
    ..These results together suggest an important role of TGF-beta1 in the early process of cervical carcinogenesis...
  46. pmc Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression
    Jian Li
    Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e21816. 2011
    ..The aim of this study is to investigate the effect of IL-17A on the progression of hepatocellular carcinoma (HCC)...
  47. pmc TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29
    Wei Qin
    Department of Medicine and Therapeutics, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, NT, Hong Kong, China
    J Am Soc Nephrol 22:1462-74. 2011
    ..In conclusion, miR-29 is a downstream inhibitor of TGF-β/Smad3-mediated fibrosis and may have therapeutic potential for diseases involving fibrosis...
  48. doi Chemokines in renal injury
    Arthur C K Chung
    Department of Medicine and Therapeutics, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    J Am Soc Nephrol 22:802-9. 2011
    ..As chemokine receptor blockade inches toward clinical use, the field remains an attractive area with potential for unexpected opportunity in the future...
  49. pmc Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling
    Arthur C K Chung
    Department of Medicine and Therapeutics, and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    J Am Soc Nephrol 21:249-60. 2010
    ..These data suggest that overexpression of Smad7 or targeting Smad3 may have therapeutic potential for diabetic nephropathy...
  50. pmc Activation of p53 promotes renal injury in acute aristolochic acid nephropathy
    Li Zhou
    Division of Nephrology, West China Hospital of Sichuan University, Chengdu, China
    J Am Soc Nephrol 21:31-41. 2010
    ..Taken together, these results suggest that AA induces TEC death via apoptosis by dephosphorylation of STAT3 and posttranslational activation of p53, supporting the hypothesis that p53 promotes renal injury in acute AAN...