Po Sing Leung

Summary

Affiliation: The Chinese University of Hong Kong
Location: Hong Kong, China
URL: http://www.sbs.cuhk.edu.hk/TeachingStaffDetails.asp?TE_NAME=LEUNG%20Po%20Sing

Publications

  1. ncbi request reprint The upregulation of angiotensin II receptor AT(1) in human preeclamptic placenta
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin N T, Hong Kong
    Mol Cell Endocrinol 184:95-102. 2001
  2. ncbi request reprint Chronic hypoxia upregulates the expression and function of AT(1) receptor in rat carotid body
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Endocrinol 167:517-24. 2000
  3. ncbi request reprint Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets
    T Lau
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Diabetologia 47:240-8. 2004
  4. doi request reprint Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]
    Qianni Cheng
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Pharmacol Exp Ther 327:683-91. 2008
  5. ncbi request reprint Angiotensin II type 1 receptor-dependent nuclear factor-kappaB activation-mediated proinflammatory actions in a rat model of obstructive acute pancreatitis
    Yuk Cheung Chan
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    J Pharmacol Exp Ther 323:10-8. 2007
  6. ncbi request reprint Postnatal hypoxemia increases angiotensin II sensitivity and up-regulates AT1a angiotensin receptors in rat carotid body chemoreceptors
    - M-L Fung
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Endocrinol 173:305-13. 2002
  7. ncbi request reprint Prophylactic and therapeutic treatments with AT 1 and AT 2 receptor antagonists and their effects on changes in the severity of pancreatitis
    Siu Wai Tsang
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Shatin, PR China
    Int J Biochem Cell Biol 36:330-9. 2004
  8. doi request reprint Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic beta-cells via angiotensin II type 2 receptors
    Kwan Yi Chu
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Am J Physiol Cell Physiol 298:C313-23. 2010
  9. doi request reprint Involvement of redox-sensitive extracellular-regulated kinases in angiotensin II-induced interleukin-6 expression in pancreatic acinar cells
    Yuk Cheung Chan
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Pharmacol Exp Ther 329:450-8. 2009
  10. ncbi request reprint The role of the pancreatic renin-angiotensin system in acinar digestive enzyme secretion and in acute pancreatitis
    Siu Wai Tsang
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Regul Pept 119:213-9. 2004

Collaborators

Detail Information

Publications89

  1. ncbi request reprint The upregulation of angiotensin II receptor AT(1) in human preeclamptic placenta
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin N T, Hong Kong
    Mol Cell Endocrinol 184:95-102. 2001
    ..These data indicate that upregulation of placental RAS components, notably AT(1) receptor in the syncytiotrophoblasts, could play a pathophysiological role in patients with preeclampsia...
  2. ncbi request reprint Chronic hypoxia upregulates the expression and function of AT(1) receptor in rat carotid body
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Endocrinol 167:517-24. 2000
    ..This might be important in the modulation of cardiorespiratory functions as well as fluid and electrolyte homeostasis during chronic hypoxia...
  3. ncbi request reprint Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets
    T Lau
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Diabetologia 47:240-8. 2004
    ..This study aimed, primarily, to investigate the existence of a local angiotensin-generating system in the pancreatic islets and, secondly, to elucidate its role in regulating insulin secretion...
  4. doi request reprint Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]
    Qianni Cheng
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Pharmacol Exp Ther 327:683-91. 2008
    ....
  5. ncbi request reprint Angiotensin II type 1 receptor-dependent nuclear factor-kappaB activation-mediated proinflammatory actions in a rat model of obstructive acute pancreatitis
    Yuk Cheung Chan
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    J Pharmacol Exp Ther 323:10-8. 2007
    ..These data provide substantial evidence that angiotensin II is involved in AT1 receptor-mediated NADPH oxidase-dependent NF-kappaB activation; thus, it might ultimately promote proinflammatory actions during AP pathogenesis...
  6. ncbi request reprint Postnatal hypoxemia increases angiotensin II sensitivity and up-regulates AT1a angiotensin receptors in rat carotid body chemoreceptors
    - M-L Fung
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Endocrinol 173:305-13. 2002
    ..This modulation may be important for adaptation of carotid body functions in the hypoxic ventilatory response and in electrolyte and water homeostasis during perinatal and postnatal hypoxia...
  7. ncbi request reprint Prophylactic and therapeutic treatments with AT 1 and AT 2 receptor antagonists and their effects on changes in the severity of pancreatitis
    Siu Wai Tsang
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Shatin, PR China
    Int J Biochem Cell Biol 36:330-9. 2004
    ..Thus the protective role of AT(1) receptor antagonist, losartan, could be mediated by the inhibition of NAD(P)H oxidase-dependent generation of reactive oxygen species (ROS)...
  8. doi request reprint Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic beta-cells via angiotensin II type 2 receptors
    Kwan Yi Chu
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Am J Physiol Cell Physiol 298:C313-23. 2010
    ..These data suggest that hyperglycemia alters beta-cell function through modification of the K(v) channel which may be associated with the RAS...
  9. doi request reprint Involvement of redox-sensitive extracellular-regulated kinases in angiotensin II-induced interleukin-6 expression in pancreatic acinar cells
    Yuk Cheung Chan
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Pharmacol Exp Ther 329:450-8. 2009
    ....
  10. ncbi request reprint The role of the pancreatic renin-angiotensin system in acinar digestive enzyme secretion and in acute pancreatitis
    Siu Wai Tsang
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Regul Pept 119:213-9. 2004
    ..The differential actions of AT1 and AT2 receptors and their upregulation may have clinical relevance to the pathogenesis and management of acute pancreatitis...
  11. ncbi request reprint Pancreatic acinar cell: its role in acute pancreatitis
    Po Sing Leung
    Department of Physiology and School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Int J Biochem Cell Biol 38:1024-30. 2006
    ..Notwithstanding this promising development, most of these potential therapies are still in an experimental stage or clinical trial. Further investigation is needed to prove the efficacy of these novel treatment modalities...
  12. pmc Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush border membrane
    Tung Po Wong
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    J Physiol 584:613-23. 2007
    ..The detection of RAS components at the enterocyte BBM, and the rapid inhibition of SGLT1-dependent glucose uptake by luminal AII suggest that AII secretion exerts autocrine control of intestinal glucose transport...
  13. ncbi request reprint Angiotensin II Type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic islet beta-cell function in young Type 2 diabetic mice
    Kwan Yi Chu
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Antioxid Redox Signal 9:869-78. 2007
    ..These data indicate that islet AT1R activation in young diabetic mice can generate progressive islet beta-cell failure through UCP-driven oxidative damage...
  14. ncbi request reprint Expression of sperm Ca2+-activated K+ channels in Xenopus oocytes and their modulation by extracellular ATP
    H C Chan
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin
    FEBS Lett 438:177-82. 1998
    ..These results suggest that sperm possess Ca2+-activated K+ channels which may be involved in the process of sperm activation...
  15. ncbi request reprint The recovery of some components of the renin angiotensin system in the rat pancreas after chronic exposure to hypoxic condition
    S P Ip
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Mol Endocrinol 31:563-71. 2003
    ..The significance of its reversibility and adaptability following chronic hypoxia may be of physiological relevance to the pancreas...
  16. ncbi request reprint Rod-type cyclic nucleotide-gated cation channel is expressed in vascular endothelium and vascular smooth muscle cells
    X Yao
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin N T, Hong Kong
    Cardiovasc Res 41:282-90. 1999
    ..The aim of this study is to examine whether rod-type nucleotide-gated nonselective cation (CNG1) channel, a channel which has been molecularly cloned, is related to the nonselective channels in vascular cells...
  17. pmc Regulation of anion secretion by cyclo-oxygenase and prostanoids in cultured epididymal epithelia from the rat
    P Y Wong
    Department of Physiology, The Chinese University of Hong Kong, Shatin, NT, Hong
    J Physiol 514:809-20. 1999
    ..8. The role of COX in the formation of the epididymal microenvironment and the implication of long term administration of non-steroidal anti-inflammatory drugs (NSAIDs) on male fertility are discussed...
  18. ncbi request reprint Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes
    Kwan Yi Chu
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories
    Diabetes 55:367-74. 2006
    ..Whether islet AT1R activation plays a role in the pathogenesis of human type 2 diabetes remains to be determined...
  19. ncbi request reprint Effect of angiotensin AT1 receptor antagonist on D-galactosamine-induced acute liver injury
    Herman Chan
    Department of Physiology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Exp Pharmacol Physiol 34:985-91. 2007
    ..5%, respectively; P < 0.05). 4. In conclusion, the AT(1)R blocker losartan suppresses GalN-induced liver injury. This may indicate that AT(1)R blockers may have therapeutic potential in the treatment of acute liver injury...
  20. ncbi request reprint In vivo treatment with glucagon-like peptide 1 promotes the graft function of fetal islet-like cell clusters in transplanted mice
    Po Man Suen
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin
    Int J Biochem Cell Biol 38:951-60. 2006
    ..These data indicate that in vivo exendin-4 treatment may enhance the growth and differentiation of fetal mice islet-like cell clusters, thus promoting the functional maturation of the graft after transplantation...
  21. doi request reprint Enantiospecific synthesis of pseudoacarviosin as a potential antidiabetic agent
    Tony K M Shing
    Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Org Lett 10:3145-8. 2008
    ..Pseudoacarviosin 5 has been shown to be a potent inhibitor of alpha-glucosidases, particularly the intestinal mucosal enzymes sucrase and glucoamylase of relevance to blood glucose control...
  22. ncbi request reprint Effects of chronic hypoxia on the circulating and pancreatic renin-angiotensin system
    Siu Po Ip
    Department of Physiology and School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong
    Pancreas 25:296-300. 2002
    ..Our further investigation showed that such a pancreatic RAS could be activated by experimental models of chronic hypoxia and chemically induced pancreatitis. These previous findings formed the basis for the current study...
  23. ncbi request reprint Regulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid body
    Siu Yin Lam
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    J Appl Physiol (1985) 96:809-13. 2004
    ..This may be important in the modulation of cardiopulmonary adaptation in the hypoxic ventilatory response as well as for electrolyte and water homeostasis during chronic hypoxia...
  24. ncbi request reprint Chronic hypoxia activates a local angiotensin-generating system in rat carotid body
    Siu Yin Lam
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Mol Cell Endocrinol 203:147-53. 2003
    ....
  25. ncbi request reprint Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis
    Siu Po Ip
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin N T, Hong Kong, PR China
    Int J Biochem Cell Biol 35:944-54. 2003
    ..All these data suggest that increased activity of pancreatic ACE in chronic hypoxia and acute pancreatitis could have implications for pancreatic physiology and pathophysiology...
  26. ncbi request reprint Saralasin, a nonspecific angiotensin II receptor antagonist, attenuates oxidative stress and tissue injury in cerulein-induced acute pancreatitis
    Siu Po Ip
    Department of Physiology and School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong
    Pancreas 26:224-9. 2003
    ..In the current study we hypothesized that inhibition of this renin-angiotensin system by saralasin, a nonspecific antagonist for angiotensin II receptor, could attenuate the severity of cerulein-induced pancreatitis...
  27. ncbi request reprint PDZ-domain containing-2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells
    P M Suen
    Department of Physiology, The Chinese University of Hong Kong, Hong Kong, China
    Int J Biochem Cell Biol 40:789-803. 2008
    ..Findings from this study will contribute to the development of improved methods for islet transplantation therapy in the treatment of diabetes...
  28. pmc Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, P R China
    Gut 54:1391-5. 2005
    ..Despite the requirement for increased iron delivery for erythropoiesis during hypoxia, there is very little information on how duodenal iron uptake and its transfer to the blood adapts to this condition...
  29. ncbi request reprint Secretin facilitates GABA transmission in the cerebellum
    W H Yung
    Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Neurosci 21:7063-8. 2001
    ..We propose that secretin is released from the somatodendritic region of Purkinje cells and serves as a retrograde messenger modulating GABAergic afferent activity...
  30. ncbi request reprint Differential effects of saralasin and ramiprilat, the inhibitors of renin-angiotensin system, on cerulein-induced acute pancreatitis
    Siu Wai Tsang
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, PR China
    Regul Pept 111:47-53. 2003
    ..These data indicate that administration of saralasin but not ramiprilat could be protective against acute pancreatitis and that activation of pancreatic RAS in acute pancreatitis may play a role in pancreatic tissue injury...
  31. ncbi request reprint The ghrelin system in acinar cells: localization, expression, and regulation in the exocrine pancreas
    Kit Ching Lai
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Pancreas 35:e1-8. 2007
    ..This ghrelin system may play a role in regulating insulin secretion and glucose homeostasis. The aim of the present study was to investigate whether a functional ghrelin system also exists in the exocrine pancreas...
  32. ncbi request reprint A locally generated angiotensin system in rat carotid body
    Siu Yin Lam
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, PR China
    Regul Pept 107:97-103. 2002
    ....
  33. ncbi request reprint Effects of hyperglycemia on angiotensin II receptor type 1 expression and insulin secretion in an INS-1E pancreatic beta-cell line
    Kwan Keung Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong Shatin, Hong Kong, China
    JOP 9:290-9. 2008
    ..The effects of hyperglycemia, a condition observed in diabetes, on angiotensin II type 1 receptor (AT1R) expression and beta-cell secretory function have yet to be explored...
  34. doi request reprint Diabetes mellitus and expression of the enterocyte renin-angiotensin system: implications for control of glucose transport across the brush border membrane
    Tung Po Wong
    School of Biomedical Sciences, Faculty of Medicine, The Chinese Univ of Hong Kong, Shatin, N T, Hong Kong, China
    Am J Physiol Cell Physiol 297:C601-10. 2009
    ....
  35. ncbi request reprint AT1 receptor antagonism ameliorates acute pancreatitis-associated pulmonary injury
    Y C Chan
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Regul Pept 134:46-53. 2006
    ..Thus, the implication is that a blockade of AT1 receptors may have a clinical application for the treatment of AP and, perhaps more importantly, subsequent pulmonary complications...
  36. ncbi request reprint Effect of chronic hypoxia on glutathione status and membrane integrity in the pancreas
    S P Ip
    School of Chinese Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    Pancreatology 2:34-9. 2002
    ..The present study aims at elucidating the antioxidant status in the pancreas during varying degrees of chronic hypoxia...
  37. ncbi request reprint Association of free radicals and the tissue renin-angiotensin system: prospective effects of Rhodiola, a genus of Chinese herb, on hypoxia-induced pancreatic injury
    S P Ip
    School of Chinese Medicine, Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong
    JOP 2:16-25. 2001
    ..Alternatively, it reduces hypoxia-induced oxidative damage by its antioxidant activities. Additional experimental data are required to fully elucidate the mode of action of this herbal drug...
  38. ncbi request reprint Acute pancreatitis: animal models and recent advances in basic research
    Yuk Cheung Chan
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Pancreas 34:1-14. 2007
    ..In this review, commonly used animal models of AP will be critically evaluated. A discussion of recent advances in our knowledge about AP risk factors is also included...
  39. ncbi request reprint Desoxyrhaponticin (3,5-dihydroxy-4'-methoxystilbene 3-O-beta-D-glucoside) inhibits glucose uptake in the intestine and kidney: In vitro and in vivo studies
    Jian Mei Li
    School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Pharmacol Exp Ther 320:38-46. 2007
    ..The in vivo antidiabetic action of this compound can be explained, in part at least, by inhibition of glucose transport in the small intestine and inhibition of glucose reabsorption in the kidney...
  40. ncbi request reprint Angiotensin II in type 2 diabetes mellitus
    Kwan Yi Chu
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Curr Protein Pept Sci 10:75-84. 2009
    ..Therefore, the present review discusses the role of Ang II in particular organs during normal physiological conditions as well as in type 2 diabetes...
  41. ncbi request reprint Expression, immunolocalization, and functional activity of Na+/H+ exchanger isoforms in mouse endometrial epithelium
    X F Wang
    Department of Physiology, The Chinese University of Hong Kong, Shatin, China
    Biol Reprod 68:302-8. 2003
    ..The apically located NHEs may be involved in mediating Na(+) absorption as alternatives of or complementary to epithelial Na(+) channels...
  42. ncbi request reprint Inhibition of intestinal and renal Na+-glucose cotransporter by naringenin
    Jian Mei Li
    School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Int J Biochem Cell Biol 38:985-95. 2006
    ..The possible application of these natural compounds in controlling hyperglycemia warrants further investigations...
  43. ncbi request reprint Pancreatic stem cells: a glimmer of hope for diabetes?
    Po Man Suen
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong Shatin, New Territories, Hong Kong
    JOP 6:422-4. 2005
  44. ncbi request reprint Calcitriol Reduces Hepatic Triglyceride Accumulation and Glucose Output Through Ca2+/CaMKK&#946;/AMPK Activation Under Insulin-Resistant Conditions in Type 2 Diabetes Mellitus
    S Cheng
    Room 609A, Lo Kwee Seong Integrated Biomedical Sciences Building, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Curr Mol Med 16:747-758. 2016
    ..The present study was designed to investigate the effects of calcitriol (the active hormonal metabolite of vitamin D) on hepatic metabolic abnormalities in type 2 diabetes...
  45. pmc The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus
    Po Sing Leung
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Nutrients 8:147. 2016
    ....
  46. ncbi request reprint Eriocalyxin B-induced apoptosis in pancreatic adenocarcinoma cells through thiol-containing antioxidant systems and downstream signalling pathways
    L Li
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shain, New Territories Hong Kong, China
    Curr Mol Med 14:673-89. 2014
    ..Taken together, our results shed important new light on the molecular mechanisms of EriB acting as an apoptogenic agent and its therapeutic potential for pancreatic cancer. ..
  47. pmc Role of reactive oxygen species in brucein D-mediated p38-mitogen-activated protein kinase and nuclear factor-kappaB signalling pathways in human pancreatic adenocarcinoma cells
    S T Lau
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Br J Cancer 102:583-93. 2010
    ..This study investigated the function of reactive oxygen species (ROS) in BD-mediated p38-MAPK and NF-kappaB signalling pathways in PANC-1 cells...
  48. ncbi request reprint Current progress in stem cell research and its potential for islet cell transplantation
    P S Leung
    Lo Kwee Seong Integrated Biomedical Sciences Building, Room 609A, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Curr Mol Med 13:109-25. 2013
    ..Despite good progress, several obstacles remain to be overcome before islet transplantation can be translated into a therapy for human patients, including, but are not limited to, immunogenicity and risk of tumorogenesis...
  49. ncbi request reprint Effects of combining linagliptin treatment with BI-38335, a novel SGLT2 inhibitor, on pancreatic islet function and inflammation in db/db mice
    L Chen
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, China
    Curr Mol Med 12:995-1004. 2012
    ..Collectively, our data show that combined treatment with BI-38335 and linagliptin work, at least in part, synergistically to benefit islet cell function/architecture and insulin resistance, thus improving glycemic control...
  50. doi request reprint Upregulation of ACE2-ANG-(1-7)-Mas axis in jejunal enterocytes of type 1 diabetic rats: implications for glucose transport
    Tung Po Wong
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Am J Physiol Endocrinol Metab 303:E669-81. 2012
    ..Therefore, altered activity of both ACE and ACE2 systems during diabetes will determine the overall rate of glucose transport across the jejunal epithelium...
  51. ncbi request reprint Chronic hypoxia induced down-regulation of angiotensinogen expression in rat epididymis
    P S Leung
    Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong
    Regul Pept 96:143-9. 2001
    ..It was concluded that chronic hypoxia decreases the transcriptional and translational expression of angiotensinogen, and thus local formation of angiotensin II, in the rat epididymis...
  52. pmc The physiology of a local renin-angiotensin system in the pancreas
    Po Sing Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    J Physiol 580:31-7. 2007
    ..Further exploration of this system would probably offer new insights into the pathogenesis of pancreatitis, diabetes, cystic fibrosis and pancreatic cancer formation. New therapeutic targets and strategies might thus be suggested...
  53. ncbi request reprint Involvement of the pancreatic renin-angiotensin system in insulin resistance and the metabolic syndrome
    Po Sing Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Cardiometab Syndr 1:197-203. 2006
    ..This RAS-associated oxidative stress can induce islet cell dysfunction in the pancreas and insulin resistance in peripheral tissues...
  54. ncbi request reprint Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreas
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    J Mol Endocrinol 26:155-64. 2001
    ..The significance of changes in pancreatic RAS could have a potential role in acute pancreatitis, islet transplantation and in different shock states, by causing a further decrease of blood perfusion in the pancreas...
  55. ncbi request reprint Local regulation of anion secretion by pituitary adenylate cyclase-activating polypeptide in human colonic T84 cells
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Cell Biol Int 25:123-9. 2001
    ..Moreover, the regulation of anion secretion by T84 cells may be mediated by locally formed PACAP in an autocrine or paracrine fashion...
  56. ncbi request reprint Angiotensinogen expression by rat epididymis: evidence for an intrinsic, angiotensin-generating system
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, NT, PR China
    Mol Cell Endocrinol 155:115-22. 1999
    ..This epididymal RAS may have paracrine or autocrine roles in mediating the epididymal and sperm functions...
  57. ncbi request reprint Regulated expression of pancreatic renin-angiotensin system in experimental pancreatitis
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, N T, Shatin, Hong Kong
    Mol Cell Endocrinol 166:121-8. 2000
    ..Such an activation of pancreatic RAS and its significance of differential changes in individual RAS components could play a role in the pathophysiology of acute pancreatitis..
  58. doi request reprint The novel roles of glucagon-like peptide-1, angiotensin II, and vitamin D in islet function
    Po Sing Leung
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Adv Exp Med Biol 654:339-61. 2010
    ..Since all of these molecules have biological interactions with pancreatic islets, potential relationships may exist among them and they will also be discussed...
  59. ncbi request reprint Testicular hormonal regulation of the renin-angiotensin system in the rat epididymis
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT
    Life Sci 66:1317-24. 2000
    ....
  60. ncbi request reprint Localization and distribution of pituitary adenylate cyclase-activating polypeptide in the rat epididymis
    P S Leung
    Department of Physiology, Chinese University of Hong Kong, Shatin
    Cell Biol Int 22:193-8. 1998
    ....
  61. doi request reprint Role of oxidative stress in pancreatic inflammation
    Po Sing Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Antioxid Redox Signal 11:135-65. 2009
    ..Emerging evidence indicates that pancreatitis-inducing ROS/RNS generation may be attenuated by targeting ROS/RNS-generating enzymes and upstream mediators...
  62. ncbi request reprint Differential gene expression of angiotensin II receptor subtypes in the epididymides of mature and immature rats
    P S Leung
    Department of Physiology, The Chinese University of Hong Kong, Shatin, NT
    Life Sci 62:461-8. 1998
    ..Type-1 subtype may play a role in regulation of electrolyte and fluid transport in mature rat whereas type-2 subtype may be important in growth and development in the immature rat...
  63. ncbi request reprint A local pancreatic renin-angiotensin system: endocrine and exocrine roles
    Po Sing Leung
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N T, Hong Kong, PR China
    Int J Biochem Cell Biol 35:838-46. 2003
    ..The target for the local pancreatic RAS may provide a new insight into future management of various clinical conditions including islet transplants, diabetes mellitus, pancreatic cancer, pancreatitis and cystic fibrosis...
  64. ncbi request reprint Renin-angiotensin system in the carotid body
    Po Sing Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Int J Biochem Cell Biol 35:847-54. 2003
    ..The regulation of RAS by chronic hypoxia, the significance of its changes and clinical relevance in the carotid body, are also addressed...
  65. ncbi request reprint The renin-angiotensin system and male reproduction: new functions for old hormones
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Mol Endocrinol 30:263-70. 2003
    ..However, it is clear that there are several potential targets for manipulating the activity of the male reproductive system by interfering with the locally generated angiotensin systems...
  66. ncbi request reprint Expression and localization of AT1 receptors in hepatic Kupffer cells: its potential role in regulating a fibrogenic response
    Po Sing Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Regul Pept 116:61-9. 2003
    ..The intimate interaction of angiotensin II with its AT(1) receptor located in the Kupffer cells and its fibrogenic action may represent a regulatory mechanism in the development of liver fibrosis such as inflammation and cirrhosis...
  67. ncbi request reprint Intrinsic angiotensin-generating system: its tissue specific functions and clinical implications
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Panminerva Med 44:93-7. 2002
    ..Future targets for the intervention of the intrinsic RAS, such as at the levels of pancreas, epididymis and carotid body should have clinical implications for the management of their respective functions...
  68. ncbi request reprint The peptide hormone angiotensin II: its new functions in tissues and organs
    Po Sing Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Curr Protein Pept Sci 5:267-73. 2004
    ..The current review is to focus on some of the new functions arising from the locally formed angiotensin II in tissues and organs, with particular attention to its emerging roles in the liver and the pancreas...
  69. ncbi request reprint Pancreatic islet renin angiotensin system: its novel roles in islet function and in diabetes mellitus
    Po Sing Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Pancreas 30:293-8. 2005
    ..Blockade of the RAS could contribute to the development of novel therapeutic strategies in the prevention and treatment of patients with diabetes and in islet transplantation...
  70. ncbi request reprint Local renin-angiotensin system in the pancreas: the significance of changes by chronic hypoxia and acute pancreatitis
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong Shatin, N T, Hong Kong
    JOP 2:3-8. 2001
    ..The significant changes of pancreatic RAS may have clinical relevance to acute pancreatitis and hypoxia-induced injury in the pancreas...
  71. ncbi request reprint Mechanisms of protective effects induced by blockade of the renin-angiotensin system: novel role of the pancreatic islet angiotensin-generating system in Type 2 diabetes
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Diabet Med 24:110-6. 2007
    ....
  72. ncbi request reprint Pancreatic renin-angiotensin system: a novel target for the potential treatment of pancreatic diseases?
    Po Sing Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong Shatin, Hong Kong
    JOP 4:89-91. 2003
  73. ncbi request reprint Androgen dependent expression of AT1 receptor and its regulation of anion secretion in rat epididymis
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Cell Biol Int 26:117-22. 2002
    ..This androgen-dependent expression of AT(1)receptor could have a role in the control of AT(1)receptor-mediated anion secretion and thus fluid secretion by the rat epididymis...
  74. pmc Novel roles of a local angiotensin-generating system in the carotid body
    Po Sing Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, China
    J Physiol 575:4. 2006
  75. ncbi request reprint Role of the RAS in pancreatic cancer
    Sin Ting Lau
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Curr Cancer Drug Targets 11:412-20. 2011
    ..This review critically appraises the current research progress on the role of RAS in pancreatic cancer, and discusses the potential for developing drugs that target RAS for treatment of pancreatic cancer...
  76. ncbi request reprint PGE suppresses excessive anti-IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory disease
    X S Wang
    Department of Pharmacology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Allergy 62:620-7. 2007
    ..Aspirin causes bronchospasm in patients with aspirin exacerbated respiratory disease (AERD). The contribution of mast cells to the increased cysteinyl-leucotrienes (cys-LTs) detected in AERD patients is however not defined...
  77. ncbi request reprint Antioxidant actions of phenolic compounds found in dietary plants on low-density lipoprotein and erythrocytes in vitro
    Rosanna Y Y Lam
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    J Am Coll Nutr 26:233-42. 2007
    ..In the present study, the antioxidant effects of selected phenolic compounds from dietary sources, namely barbaloin, 6-gingerol and rhapontin, were investigated...
  78. doi request reprint PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization
    Kwan Keung Leung
    Department of Physiology, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Stem Cells Dev 18:979-90. 2009
    ..In conclusion, our data suggest that sPDZD2 promotes functional maturation of human fetal PPC-derived ICCs, thus enhancing its transplanting potentials...
  79. ncbi request reprint Intestinal trefoil factor promotes invasion in non-tumorigenic Rat-2 fibroblast cell
    Victor Y W Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Regul Pept 127:87-94. 2005
    ..5-37.8%) in TFF3-transfected cells compared to controls during 48-h incubation. Our results suggested that TFF3 possesses malignant potential through promotion of cell invasiveness and alteration of invasion-related genes...
  80. ncbi request reprint Roles of the renin-angiotensin system and its blockade in pancreatic inflammation
    Po Sing Leung
    Int J Biochem Cell Biol 37:237-8. 2005
  81. ncbi request reprint Regulation and expression of a renin-angiotensin system in human pancreas and pancreatic endocrine tumours
    King Yin Lam
    Department of Pathology, School of Medicine, James Cook University, Queensland, Australia
    Eur J Endocrinol 146:567-72. 2002
    ..The aims of this study were to prove the presence of an intrinsic RAS in the human pancreas and to analyse the role of such an RAS in pancreatic endocrine tumours (PETs)...
  82. ncbi request reprint Isolation and in vitro characterization of pancreatic progenitor cells from the islets of diabetic monkey models
    Chunlin Zou
    Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, PR China
    Int J Biochem Cell Biol 38:973-84. 2006
    ..This study provides a foundation for further characterization of adult pancreatic progenitor cells and autologous transplantation using pancreatic progenitor cells in treating diabetic monkeys...
  83. ncbi request reprint Frontiers in diabetic research
    Po Sing Leung
    Int J Biochem Cell Biol 38:687-8. 2006
  84. doi request reprint Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines
    Sin Ting Lau
    School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Phytother Res 22:477-86. 2008
    ....
  85. ncbi request reprint Ghrelin system in pancreatic AR42J cells: its ligand stimulation evokes calcium signalling through ghrelin receptors
    Jan Kit Ching Lai
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, PR China
    Int J Biochem Cell Biol 37:887-900. 2005
    ..These data suggests the presence of a ghrelin system in pancreatic AR42J cells. In addition, its roles in exocrine function are implicated in the pancreas...
  86. ncbi request reprint High prevalence of RET proto-oncogene activation (RET/PTC) in papillary thyroid carcinomas
    King Yin Lam
    Division of Pathology, School of Medicine, James Cook University, Townsville, Queensland, Australia
    Eur J Endocrinol 147:741-5. 2002
    ..The aim of this study was to investigate the frequency and types of PTC genetic rearrangements in papillary carcinoma in a population of Hong Kong Chinese...
  87. ncbi request reprint Asian-Oceanic Pancreatic Association: conception to actuality
    Yutaka Atomi
    Department of Surgery, Kyorin University School of Medicine, Tokyo, Japan
    Pancreas 31:405-12. 2005
    ..The second scientific meeting will be held during APDW 2007...
  88. ncbi request reprint Secreted PDZD2 exerts concentration-dependent effects on the proliferation of INS-1E cells
    Richard Yam Man Ma
    Department of Biochemistry, The University of Hong Kong, China
    Int J Biochem Cell Biol 38:1015-22. 2006
    ..As a potential mitogen of beta-like cells, sPDZD2 may be useful for the optimization of beta-cell growth and differentiation in vitro...
  89. doi request reprint Diarylheptanoids and a monoterpenoid from the rhizomes of Zingiber officinale: antioxidant and cytoprotective properties
    Qiao Feng Tao
    Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People s Republic of China
    J Nat Prod 71:12-7. 2008
    ..These compounds were subsequently tested on primary cultures of rat hepatocytes exposed to oxidative damage, and definitive cytoprotective actions were found...