Thian Sze Wong

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. pmc mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
    Wei Gao
    Department of Surgery, The University of Hong Kong and Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    ISRN Otolaryngol 2012:953089. 2012
  2. pmc Hypoxia in head and neck squamous cell carcinoma
    John Zenghong Li
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pok Fu Lam, Hong Kong
    ISRN Otolaryngol 2012:708974. 2012
  3. ncbi request reprint The diagnostic value of methylated DNA in laryngeal squamous cell carcinoma: meta-analysis
    Zhj Li
    Department of Surgery, The University of Hong Kong, Hong Kong Laryngeal Department, Hospital of Otorhinolaryngology, Institute of Otorhinolaryngology, The First Affiliated Hospital Sun Yat sen University, Guangzhou, People s Republic of China Corresponding author Email These authors contributed equally to this study
    Head Neck Oncol 5:15. 2013
  4. doi request reprint Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR China
    Clin Cancer Res 14:2588-92. 2008
  5. doi request reprint Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling
    Thian Sze Wong
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Int J Cancer 123:251-7. 2008
  6. doi request reprint Mature miR-184 and squamous cell carcinoma of the tongue
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong
    ScientificWorldJournal 9:130-2. 2009
  7. ncbi request reprint Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin
    Thian Sze Wong
    Department of Surgery, University of Hong Kong Medical Center, Faculty of Medicine, The University of Hong Kong, China
    Anticancer Res 30:2851-6. 2010
  8. pmc MicroRNA let-7 suppresses nasopharyngeal carcinoma cells proliferation through downregulating c-Myc expression
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    J Cancer Res Clin Oncol 137:415-22. 2011
  9. ncbi request reprint Promoter hypermethylation of high-in-normal 1 gene in primary nasopharyngeal carcinoma
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Hong Kong, SAR China
    Clin Cancer Res 9:3042-6. 2003
  10. ncbi request reprint Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Clin Cancer Res 10:2401-6. 2004

Collaborators

Detail Information

Publications30

  1. pmc mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
    Wei Gao
    Department of Surgery, The University of Hong Kong and Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    ISRN Otolaryngol 2012:953089. 2012
    ..mTOR inhibitor has potential as a single therapeutic agent or in combination with radiation, chemotherapeutic agents, or other targeted therapeutic agents to obtain synergistic repression on head and neck cancer...
  2. pmc Hypoxia in head and neck squamous cell carcinoma
    John Zenghong Li
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pok Fu Lam, Hong Kong
    ISRN Otolaryngol 2012:708974. 2012
    ..We also exploit the molecular mechanisms employed by the HNSCC cells to adapt the hypoxic condition and their tumorigenic role in head and neck, as well as the strategies to overcome hypoxia-induced therapeutic resistance...
  3. ncbi request reprint The diagnostic value of methylated DNA in laryngeal squamous cell carcinoma: meta-analysis
    Zhj Li
    Department of Surgery, The University of Hong Kong, Hong Kong Laryngeal Department, Hospital of Otorhinolaryngology, Institute of Otorhinolaryngology, The First Affiliated Hospital Sun Yat sen University, Guangzhou, People s Republic of China Corresponding author Email These authors contributed equally to this study
    Head Neck Oncol 5:15. 2013
    ..Although intensive efforts had been made on the clinical use of methylation markers for cancer surveillance, the use of methylated DNA in differentiating LSCC patients remains unclear...
  4. doi request reprint Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR China
    Clin Cancer Res 14:2588-92. 2008
    ..The aim of this study was to evaluate the microRNA expression patterns in squamous cell carcinoma (SCC) of the tongue...
  5. doi request reprint Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling
    Thian Sze Wong
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Int J Cancer 123:251-7. 2008
    ..Our results suggested that aberrant reduction of miR-133a and miR-133b was associated with the dysregulation of PKM2 in SCC of tongue...
  6. doi request reprint Mature miR-184 and squamous cell carcinoma of the tongue
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong
    ScientificWorldJournal 9:130-2. 2009
    ..The data suggested that miR-184 is linked to the pathogenesis of tongue SCC. Further studies are warranted to evaluate the use of microRNA-based serological markers in monitoring tongue SCC...
  7. ncbi request reprint Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin
    Thian Sze Wong
    Department of Surgery, University of Hong Kong Medical Center, Faculty of Medicine, The University of Hong Kong, China
    Anticancer Res 30:2851-6. 2010
    ..We hypothesized that suppressing NF-kappaB by curcumin could up-regulate E-cadherin expression in NPC cells...
  8. pmc MicroRNA let-7 suppresses nasopharyngeal carcinoma cells proliferation through downregulating c-Myc expression
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    J Cancer Res Clin Oncol 137:415-22. 2011
    ..This study aimed at evaluating the potential anti-proliferative effects of the microRNA let-7 family in nasopharyngeal carcinoma (NPC) cells. In addition, the association between let-7 suppression and DNA hypermethylation is examined...
  9. ncbi request reprint Promoter hypermethylation of high-in-normal 1 gene in primary nasopharyngeal carcinoma
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Hong Kong, SAR China
    Clin Cancer Res 9:3042-6. 2003
    ..The relationship between HIN-1 promoter methylation and transcription in NPC cell lines was evaluated by reverse transcription-PCR and demethylation agent treatment (5-aza-2-deoxycytidine)...
  10. ncbi request reprint Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Clin Cancer Res 10:2401-6. 2004
    ..This study aims at evaluation of the potential use of methylated gene promoter DNA as a serological tumor marker of primary and potentially salvageable local or nodal recurrent NPC...
  11. ncbi request reprint Differential gene methylation in undifferentiated nasopharyngeal carcinoma
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Hong Kong, P R China
    Int J Oncol 22:869-74. 2003
    ..The results show high frequency of methylation in NPC and the potential of using methylation as peripheral blood tumor marker in screening NPC...
  12. doi request reprint Curcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10
    Raymond King Yin Tsang
    Department of Surgery, The University of Hong Kong, SAR China
    Cancer Invest 30:503-12. 2012
    ..Curcumin treatment on tongue carcinoma cell lines suppressed MMP10 expression at both mRNA and protein levels. Our results suggested that curcumin is a promising inhibitor to tongue cancer cells migration and invasion...
  13. ncbi request reprint Overexpression of Epstein-Barr virus-encoded microRNA-BART7 in undifferentiated nasopharyngeal carcinoma
    Jimmy Yu Wai Chan
    Department of Surgery, The University of Hong Kong, China
    Anticancer Res 32:3201-10. 2012
    ..To validate Epstein-Barr virus BamHI-A rightward transcript 7 microRNA (ebv-miR-BART7) expression in plasma from patients with nasopharyngeal carcinoma (NPC) and explore the oncogenic role of ebv-miR-BART7 in NPC cells...
  14. pmc The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis
    John Zeng Hong Li
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong, SAR, P R China
    Chin J Cancer 35:95. 2016
    ..This study aimed to determine the clinical significance and prognostic value of PDCD4 in solid tumors...
  15. pmc Biomarkers for use in monitoring responses of nasopharyngeal carcinoma cells to ionizing radiation
    Wei Gao
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Sensors (Basel) 12:8832-46. 2012
    ..This review aims to discuss the potential use of biomarkers in monitoring the responsiveness of NPC cells to radiation treatment...
  16. pmc Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma
    Wei Gao
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    J Exp Clin Cancer Res 35:92. 2016
    ..Brain-expressed X-linked (BEX) 4 is a member of BEX family. The functional role of BEX4 in oral squamous cell carcinoma (OSCC) remains unknown...
  17. doi request reprint MicroRNA-138-5p controls sensitivity of nasopharyngeal carcinoma to radiation by targeting EIF4EBP1
    Wei Gao
    Department of Surgery, The University of Hong Kong, Hong Kong, SAR, P R China
    Oncol Rep . 2017
    ..Further studies are warranted to investigate the potential use of miR-138-5p in the clinical management and treatment prediction of NPC patients...
  18. pmc MicroRNA 744-3p promotes MMP-9-mediated metastasis by simultaneously suppressing PDCD4 and PTEN in laryngeal squamous cell carcinoma
    John Zeng Hong Li
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Oncotarget . 2016
    ..Targeting miR-744-3p could be a valuable therapeutic intervention to suppress the aggressiveness of LSCC...
  19. doi request reprint BEX3 contributes to cisplatin chemoresistance in nasopharyngeal carcinoma
    Wei Gao
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    Cancer Med . 2017
    ..In summary, our results indicated a unique functional role of BEX3 in mediating the sensitivity of NPC cells to cisplatin. Targeting or blocking BEX3 activity might be useful in reversing the cisplatin-resistant phenotype in NPC...
  20. ncbi request reprint Anti-cancer effects of curcumin on head and neck cancers
    Wei Gao
    Department of Surgery, The University of Hong Kong
    Anticancer Agents Med Chem 12:1110-6. 2012
    ..Overcoming the poor bioavailability of curcumin in the near future would facilitate its clinical use...
  21. pmc The Efficacy of Triamcinolone Acetonide in Keloid Treatment: A Systematic Review and Meta-analysis
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
    Front Med (Lausanne) 3:71. 2016
    ..Therefore, further evaluation in multi-center RCTs with consistent comparisons and outcome measurements are warrant to reach a consensus on the selection between TAC and different treatment modalities...
  22. pmc Epigenetic dysregulation in laryngeal squamous cell carcinoma
    Thian Sze Wong
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong
    J Oncol 2012:739461. 2012
    ..Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use...
  23. ncbi request reprint High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, SAR China
    Clin Cancer Res 8:433-7. 2002
    ..Death-associated protein (DAP)-kinase gene is frequently inactivated by promoter hypermethylation in cancer. The aim of this study was to evaluate the promoter methylation status of the DAP-kinase gene in nasopharyngeal carcinoma (NPC)...
  24. pmc Transcription regulation of E-cadherin by zinc finger E-box binding homeobox proteins in solid tumors
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
    Biomed Res Int 2014:921564. 2014
    ....
  25. pmc Interactions between E-cadherin and microRNA deregulation in head and neck cancers: the potential interplay
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
    Biomed Res Int 2014:126038. 2014
    ..Increasing evidence suggested that microRNA mediated E-cadherin expression in the head and neck cancers by directly/indirectly targeting the transcription suppressors of E-cadherin, ZEB1 and ZEB2. ..
  26. pmc Long non-coding RNA deregulation in tongue squamous cell carcinoma
    Wei Gao
    Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Kowloon, Hong Kong
    Biomed Res Int 2014:405860. 2014
    ..The deregulated tumorigenic long non-coding RNA (lncRNA) has been reported in several malignancies. However, there is still no comprehensive study on tongue squamous cell carcinoma (SCC)...
  27. doi request reprint Curcumin exerts inhibitory effects on undifferentiated nasopharyngeal carcinoma by inhibiting the expression of miR-125a-5p
    Wei Gao
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    Clin Sci (Lond) 127:571-9. 2014
    ..Curcumin could provide a novel strategy to block miR-125a-5p for miRNA-based gene therapies in NPC. ..
  28. pmc Differential expression of long noncoding RNA in primary and recurrent nasopharyngeal carcinoma
    Wei Gao
    Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong
    Biomed Res Int 2014:404567. 2014
    ..In the present study, we aimed to identify the differentially expressed long noncoding RNA (lncRNA) using data available in the public domain...
  29. doi request reprint A long non-coding RNA signature in glioblastoma multiforme predicts survival
    Xiao Qin Zhang
    Department of Surgery, The University of Hong Kong, Hong Kong
    Neurobiol Dis 58:123-31. 2013
    ..The identification of the prognostic lncRNAs indicates the potential roles of lncRNAs in GBM pathogenesis. This six-lncRNA signature may have clinical implications in the subclassification of GBM. ..
  30. pmc Blockade of MCP-1/CCR4 signaling-induced recruitment of activated regulatory cells evokes an antitumor immune response in head and neck squamous cell carcinoma
    Wei Sun
    Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Oncotarget 7:37714-37727. 2016
    ..Therefore, blocking aTreg cell trafficking in tumors using CCR4-binding agents may be an effective immunotherapy for HNSCC...