Pingzhang Wang

Summary

Country: China

Publications

  1. doi Novel transcript variants of TRAIL show different activities in activation of NF-κB and apoptosis
    Pingzhang Wang
    Laboratory of Medical Immunology, School of Basic Medical Science, Peking University Health Science Center, No 38 Xueyuan Road, Beijing 100191, PR China
    Life Sci 89:839-46. 2011
  2. ncbi Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex
    Pingzhang Wang
    Chinese National Human Genome Center, Beijing 100176, China
    Sci China C Life Sci 49:265-73. 2006
  3. ncbi Cloning of a novel human caspase-9 splice variant containing only the CARD domain
    Pingzhang Wang
    Chinese National Human Genome Center, Beijing 3 707 North YongChang Road BDA, Beijing 100176, PR China
    Life Sci 79:934-40. 2006
  4. doi Human SBK1 is dysregulated in multiple cancers and promotes survival of ovary cancer SK-OV-3 cells
    Pingzhang Wang
    Chinese National Human Genome Center, 3 707 North YongChang Road BDA, Beijing 100176, People s Republic of China
    Mol Biol Rep 38:3551-9. 2011
  5. doi Molecular cloning and characterization of novel human JNK2 (MAPK9) transcript variants that show different stimulation activities on AP-1
    Pingzhang Wang
    Peking University Center for Human Disease Genomics, Beijing, 100191, P R China
    BMB Rep 43:738-43. 2010
  6. pmc Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site
    Pingzhang Wang
    Chinese National Human Genome Center, 3 707 North YongChang Road BDA, Beijing, PR China
    BMC Genomics 10:518. 2009
  7. pmc The Secreted Form of Transmembrane Protein 98 Promotes the Differentiation of T Helper 1 Cells
    Weiwei Fu
    1 Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    J Interferon Cytokine Res 35:720-33. 2015
  8. doi SUSD2 is frequently downregulated and functions as a tumor suppressor in RCC and lung cancer
    Yingying Cheng
    Peking University Center for Human Disease Genomics, Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China
    Tumour Biol 37:9919-30. 2016
  9. doi Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2
    Xiaolin Wang
    Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China and Peking University Center for Human Disease Genomics, Peking University Health Science Center, Beijing 100191, China
    J Immunol 196:4090-9. 2016
  10. pmc CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma
    Ting Li
    Peking University Center for Human Disease Genomics, Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University Center for Human Disease Genomics, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China
    J Exp Clin Cancer Res 34:122. 2015

Collaborators

Detail Information

Publications22

  1. doi Novel transcript variants of TRAIL show different activities in activation of NF-κB and apoptosis
    Pingzhang Wang
    Laboratory of Medical Immunology, School of Basic Medical Science, Peking University Health Science Center, No 38 Xueyuan Road, Beijing 100191, PR China
    Life Sci 89:839-46. 2011
    ..Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has many transcript variants, but whether they possess distinct function is not completely known. In the present study, we compared the function of these TRAIL variants...
  2. ncbi Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex
    Pingzhang Wang
    Chinese National Human Genome Center, Beijing 100176, China
    Sci China C Life Sci 49:265-73. 2006
    ....
  3. ncbi Cloning of a novel human caspase-9 splice variant containing only the CARD domain
    Pingzhang Wang
    Chinese National Human Genome Center, Beijing 3 707 North YongChang Road BDA, Beijing 100176, PR China
    Life Sci 79:934-40. 2006
    ..This suggests that the procaspase-9-mediated NF-kappaB activation in response to cellular stresses is cell type-specific through an unidentified mechanism...
  4. doi Human SBK1 is dysregulated in multiple cancers and promotes survival of ovary cancer SK-OV-3 cells
    Pingzhang Wang
    Chinese National Human Genome Center, 3 707 North YongChang Road BDA, Beijing 100176, People s Republic of China
    Mol Biol Rep 38:3551-9. 2011
    ....
  5. doi Molecular cloning and characterization of novel human JNK2 (MAPK9) transcript variants that show different stimulation activities on AP-1
    Pingzhang Wang
    Peking University Center for Human Disease Genomics, Beijing, 100191, P R China
    BMB Rep 43:738-43. 2010
    ..Our results further demonstrate that JNK2 isoforms preferentially target different substrates and may regulate the expression of various target genes...
  6. pmc Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site
    Pingzhang Wang
    Chinese National Human Genome Center, 3 707 North YongChang Road BDA, Beijing, PR China
    BMC Genomics 10:518. 2009
    ..This bias leaves a large space to discover novel transcript variants...
  7. pmc The Secreted Form of Transmembrane Protein 98 Promotes the Differentiation of T Helper 1 Cells
    Weiwei Fu
    1 Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    J Interferon Cytokine Res 35:720-33. 2015
    ..Overall, these observations emphasize the characteristics and essential roles of TMEM98 for the first time and will be helpful in further understanding the development of Th1 cells. ..
  8. doi SUSD2 is frequently downregulated and functions as a tumor suppressor in RCC and lung cancer
    Yingying Cheng
    Peking University Center for Human Disease Genomics, Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China
    Tumour Biol 37:9919-30. 2016
    ..Our findings suggested that SUSD2 functions as a tumor suppressor gene (TSG) in RCC and lung cancer. ..
  9. doi Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2
    Xiaolin Wang
    Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China and Peking University Center for Human Disease Genomics, Peking University Health Science Center, Beijing 100191, China
    J Immunol 196:4090-9. 2016
    ..Furthermore, the chemotactic activity of CYTL1 is sensitive to pertussis toxin. All of the above data confirm that CCR2B is a functional receptor of CYTL1. ..
  10. pmc CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma
    Ting Li
    Peking University Center for Human Disease Genomics, Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University Center for Human Disease Genomics, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China
    J Exp Clin Cancer Res 34:122. 2015
    ..1, a locus that harbours a number of tumour suppressor genes. It has been defined as a regulator of cell cycle and division in HeLa cells; however, its roles in tumourigenesis remain poorly studied...
  11. doi VSTM1-v2, a novel soluble glycoprotein, promotes the differentiation and activation of Th17 cells
    Xiaohuan Guo
    Peking University Center for Human Disease Genomics, Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China
    Cell Immunol 278:136-42. 2012
    ..Here, we report a novel soluble protein, VSTM1-v2, which is a classical secretory glycoprotein mainly expressed in immune tissues, and can promote the differentiation and activation of Th17 cells...
  12. doi Human TMEM174 that is highly expressed in kidney tissue activates AP-1 and promotes cell proliferation
    Pingzhang Wang
    Chinese National Human Genome Center, 3 707 North YongChang Road BDA, Beijing 100191, PR China
    Biochem Biophys Res Commun 394:993-9. 2010
    ..The possible mechanism of activation of AP-1 by TMEM174 was further examined. Our results suggest the potential role of TMEM174 in renal development and physiological function...
  13. doi PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2
    Xiaolei Pei
    Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing 100191, China
    J Immunol 192:1878-86. 2014
    ..Taken together, our data collectively suggest that PSMP is a chemoattractant protein acting as a novel CCR2 ligand that may influence inflammation and cancer development. ..
  14. doi Identification of FAM3D as a new endogenous chemotaxis agonist for the formyl peptide receptors
    Xinjian Peng
    Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing 100191, China
    J Cell Sci 129:1831-42. 2016
    ..Taken together, we propose that FAM3D plays a role in gastrointestinal homeostasis and inflammation through its receptors FPR1 and FPR2. ..
  15. doi V‑set and transmembrane domain‑containing 1 is silenced in human hematopoietic malignancy cell lines with promoter methylation and has inhibitory effects on cell growth
    Ting Li
    Peking University Center for Human Disease Genomics, Beijing 100191, P R China
    Mol Med Rep 11:1344-51. 2015
    ..In conclusion, the results of the present study indicated that promoter methylation silenced VSTM1 and negatively regulated cell growth in human hematopoietic malignancy cell lines...
  16. doi Identification of GPR65, a novel regulator of matrix metalloproteinases using high through-put screening
    Hongbo Xu
    Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing, China
    Biochem Biophys Res Commun 436:96-103. 2013
    ..In conclusion, we validate that GPR65 is vital regulatory genes upstream of MMP3, and define a novel mechanism of MMP3 regulation by proton-sensing G-protein-coupled receptors...
  17. ncbi Screening for novel human genes associated with CRE pathway activation with cell microarray
    Linjie Tian
    Chinese National Human Genome Center, Beijing, 3 707 North YongChang Road BDA, Beijing 100176, People s Republic of China
    Genomics 90:28-34. 2007
    ..These results demonstrate the successful combination of cell microarray technology with this reporting system and the potential of this tool to characterize functions of novel genes in a highly parallel format...
  18. doi Electronic Sorting of Immune Cell Subpopulations Based on Highly Plastic Genes
    Pingzhang Wang
    Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China Peking University Center for Human Disease Genomics, Beijing 100191, China and Key Laboratory of Medical Immunology, Ministry of Health, Beijing 100191, China
    J Immunol 197:665-73. 2016
    ..Finally, in human CD4(+) T cells, 747 potential immune cell subpopulations and their candidate signature genes were identified, which provides a useful resource for big data-driven knowledge discoveries. ..
  19. pmc ImmuSort, a database on gene plasticity and electronic sorting for immune cells
    Pingzhang Wang
    1 Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center Key Laboratory of Medical Immunology, Ministry of Health, China Peking University Center for Human Disease Genomics No 38 Xueyuan Road, Beijing, 100191, China 2 Chinese National Human Genome Center at Beijing No 3 707 North YongChang Road, BDA, Beijing, 100176, China
    Sci Rep 5:10370. 2015
    ..A total of 20,283 human and 20,963 mouse genes are available to query in the database. Examples show the distinct advantages of the database. The database URL is http://202.85.212.211/Account/ImmuSort.html. ..
  20. pmc ImmuCo: a database of gene co-expression in immune cells
    Pingzhang Wang
    Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University Health Science Center, No 38 Xueyuan Road, Beijing 100191, China Peking University Center for Human Disease Genomics, No 38 Xueyuan Road, Beijing 100191, China
    Nucleic Acids Res 43:D1133-9. 2015
    ..More than 8.6 × 10(8) and 7.4 × 10(8) probe set combinations are provided for querying each human and mouse cell group, respectively. Sample applications support the distinctive advantages of the database...
  21. doi Epigenetic regulation of reelin expression in multiple myeloma
    Liang Lin
    Key Laboratory of Medical Immunology, Ministry of Health, Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Hematol Oncol . 2016
    ..Together, we established that the methylation status of the promoter proximal cytosine-phospho-guanine dinucleotides determines the expression of RELN in myeloma cells. Copyright © 2016 John Wiley & Sons, Ltd...
  22. pmc CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest
    Wen Pan
    Department of Immunology, Center for Human Disease Genomics, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University, Beijing, China
    Sci Rep 4:6812. 2014
    ..Its growth inhibitory effects can be blocked by sSUSD2-Fc soluble protein. Our results suggest that CSBF/C10orf99 is a novel potential cytokine with tumor suppressor functions...