Xiao bing Fu

Summary

Affiliation: Wound Healing and Cell Biology Laboratory
Country: China

Publications

  1. ncbi Potentiality of mesenchymal stem cells in regeneration of sweat glands
    Xiaobing Fu
    Wound Healing and Cell Biology Laboratory, Burns Institute, 304th Clinical Department, The General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P R China
    J Surg Res 136:204-8. 2006
  2. doi Migration of bone marrow-derived mesenchymal stem cells induced by tumor necrosis factor-alpha and its possible role in wound healing
    Xiaobing Fu
    Chinese PLA General Hospital, Trauma Center of Postgraduate Medical College, Burn Institute, The First Affiliated Hospital, Beijing, China
    Wound Repair Regen 17:185-91. 2009
  3. pmc Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors
    Yuanguang Meng
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing, 100853, PR China
    BMC Cancer 9:75. 2009
  4. ncbi Advances in wound healing research in China: from antiquity to the present
    X Fu
    Wound Healing Unit, Burn Research Institute, 304th Hospital, Trauma Center of Postgraduate Medical College, Beijing, PR China
    Wound Repair Regen 9:2-10. 2001
  5. ncbi [Different expression of chaperone interacting protein in normal, scar and chronic ulcer tissues and its relationship with wound healing]
    Xiaobing Fu
    Key Research Laboratory of Wound Repair of PLA, 304th Clinical Department, General Hospital of PLA, Beijing, 100037, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 19:127-9. 2005
  6. ncbi [Effects of the nerve, endocrine, and immune factors on the skin repair and regeneration]
    Xiaobing Fu
    The Institute for Basic Research, General Hospital of PLA, Beijing, 100853, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 20:331-5. 2006
  7. ncbi [Enhancing the repair quality of skin injury on porcine after autografting with the bone marrow mesenchymal stem cells]
    Xiao bing Fu
    Key Laboratory of Wound Repair, Burn Institute, 304th Hospital, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 84:920-4. 2004
  8. ncbi Thermal injuries induce gene expression of endogenous c-fos, c-myc and bFGF in burned tissues
    Xiaobing Fu
    Key Research Laboratory of Wound Repair of PLA, Burn Institute, 304th Hospital, Trauma Center of Postgraduate Medical College, Beijing 100037, China
    Chin Med J (Engl) 116:235-8. 2003
  9. pmc Rapid mitogen-activated protein kinase by basic fibroblast growth factor in rat intestine after ischemia/reperfusion injury
    Xiao bing Fu
    Wound Healing and Cell Biology Laboratory, 304 Hospital, Burns Institute, Trauma Center of Postgraduate Medical College, 51 Fu Cheng Road, Beijing 100037, China
    World J Gastroenterol 9:1312-7. 2003
  10. ncbi Engineered growth factors and cutaneous wound healing: success and possible questions in the past 10 years
    Xiaobing Fu
    Wound Healing and Cell Biology Laboratory, Burns Institute, 304th Medical Department 304th Hospital, The General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P R China
    Wound Repair Regen 13:122-30. 2005

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. ncbi Potentiality of mesenchymal stem cells in regeneration of sweat glands
    Xiaobing Fu
    Wound Healing and Cell Biology Laboratory, Burns Institute, 304th Clinical Department, The General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P R China
    J Surg Res 136:204-8. 2006
    ..However, the plasticity of mesenchymal stem cells (MSCs) may offer the hope and potentiality to regenerate sweat glands after severe burn injury...
  2. doi Migration of bone marrow-derived mesenchymal stem cells induced by tumor necrosis factor-alpha and its possible role in wound healing
    Xiaobing Fu
    Chinese PLA General Hospital, Trauma Center of Postgraduate Medical College, Burn Institute, The First Affiliated Hospital, Beijing, China
    Wound Repair Regen 17:185-91. 2009
    ....
  3. pmc Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors
    Yuanguang Meng
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing, 100853, PR China
    BMC Cancer 9:75. 2009
    ..We aimed to reveal the role of Id2 in invasion potential in poorly invasive and estrogen receptor alpha (ERalpha)-positive MCF-7 and SKOV-3 cancer cells...
  4. ncbi Advances in wound healing research in China: from antiquity to the present
    X Fu
    Wound Healing Unit, Burn Research Institute, 304th Hospital, Trauma Center of Postgraduate Medical College, Beijing, PR China
    Wound Repair Regen 9:2-10. 2001
    ..We hope that these works will benefit our foreign colleagues to know our work and enhance the communication among us...
  5. ncbi [Different expression of chaperone interacting protein in normal, scar and chronic ulcer tissues and its relationship with wound healing]
    Xiaobing Fu
    Key Research Laboratory of Wound Repair of PLA, 304th Clinical Department, General Hospital of PLA, Beijing, 100037, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 19:127-9. 2005
    ..To explore the expression characteristics of chaperone interacting protein (CHIP) in normal, scar and chronic ulcer tissues and its relationship with wound healing...
  6. ncbi [Effects of the nerve, endocrine, and immune factors on the skin repair and regeneration]
    Xiaobing Fu
    The Institute for Basic Research, General Hospital of PLA, Beijing, 100853, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 20:331-5. 2006
    ..To investigate the effects of the nerve, endocrine, and immune factors on the process of wound healing and regeneration of the skin after injury and to review the research work in the past years in this area...
  7. ncbi [Enhancing the repair quality of skin injury on porcine after autografting with the bone marrow mesenchymal stem cells]
    Xiao bing Fu
    Key Laboratory of Wound Repair, Burn Institute, 304th Hospital, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 84:920-4. 2004
    ..To explore the effects of bone marrow mesenchymal stem cells (MSCs) on the quality of healing of porcine skin wounds after burn injury so as to provide a new method for clinical skin repair in the future...
  8. ncbi Thermal injuries induce gene expression of endogenous c-fos, c-myc and bFGF in burned tissues
    Xiaobing Fu
    Key Research Laboratory of Wound Repair of PLA, Burn Institute, 304th Hospital, Trauma Center of Postgraduate Medical College, Beijing 100037, China
    Chin Med J (Engl) 116:235-8. 2003
    ....
  9. pmc Rapid mitogen-activated protein kinase by basic fibroblast growth factor in rat intestine after ischemia/reperfusion injury
    Xiao bing Fu
    Wound Healing and Cell Biology Laboratory, 304 Hospital, Burns Institute, Trauma Center of Postgraduate Medical College, 51 Fu Cheng Road, Beijing 100037, China
    World J Gastroenterol 9:1312-7. 2003
    ....
  10. ncbi Engineered growth factors and cutaneous wound healing: success and possible questions in the past 10 years
    Xiaobing Fu
    Wound Healing and Cell Biology Laboratory, Burns Institute, 304th Medical Department 304th Hospital, The General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P R China
    Wound Repair Regen 13:122-30. 2005
    ..a need for exogenous application of growth factors in acute or chronic wounds, and if so, is it safe to use growth factors to promote wound healing? Last, can we achieve perfect wound healing in those wounds treated with growth factors?..
  11. pmc Activation of phosphorylating-p38 mitogen-activated protein kinase and its relationship with localization of intestinal stem cells in rats after ischemia-reperfusion injury
    Xiao bing Fu
    Wound Healing and Cell Biology Laboratory, Institute of Burns, 304 Hospital, Trauma Center of Postgraduate Medical College, 51 Fu Cheng Road, Beijing 100037, China
    World J Gastroenterol 9:2036-9. 2003
    ..To investigate the expression of phosphorylating p38 mitogen-activated protein kinase (MAPK) in rat small intestine after ischemia-reperfusion (I/R) insult and its relationship with the localization of intestinal stem cells...
  12. ncbi Morphological and distribution characteristics of sweat glands in hypertrophic scar and their possible effects on sweat gland regeneration
    Xiao bing Fu
    Laboratory of Wound Healing and Cell Biology, Burns Institute, 304th Clinical Department, General Hospital of PLA, Beijing 100037, China
    Chin Med J (Engl) 118:186-91. 2005
    ....
  13. ncbi [Growth factors and wound healing: review and prospect in recent ten years]
    Xiaobing Fu
    Key Research Laboratory of Wound Repair of PLA, 304th Clinical Department, General Hospital of PLA, Beijing
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:508-12. 2004
    ..To review the current condition of growth factors and their application to clinical treatment of acute and chronic wounds...
  14. ncbi [Characteristics of bFGF and TGF-beta expression in dermal chronic ulcers and hypertrophic scars and their effects on tissue repair]
    X B Fu
    304th Hospital of PLA, Beijing, P R China 100037
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 14:271-4. 2000
    ..To localize the distribution of basic fibroblast growth factor (bFGF) and transforming growth factor-beta(TGF-beta) in tissues from dermal chronic ulcer and hypertrophic scar and to explore their effects on tissue repair...
  15. pmc Enhanced anti-apoptosis and gut epithelium protection function of acidic fibroblast growth factor after cancelling of its mitogenic activity
    Xiao bing Fu
    Wound Healing and Cell Biology Laboratory, Burns Institute, 304 Medical Department, General Hospital of PLA, Trauma Centre of Postgraduate Medical College, 51 Fucheng Road, Beijing 100037, China
    World J Gastroenterol 10:3590-6. 2004
    ..In this study, we identified the source of its anti-apoptosis function with a mutant, aFGF28-154 and observed its effect on reducing gut ischemia and reperfusion injury...
  16. ncbi Expression of oncoproteins c-fos and c-jun in hypertrophic scars and chronic dermal ulcers and their regulation of basic fibroblast growth factor
    X Fu
    Wound Healing Unit, 304th Hospital, Beijing 100037, China
    Chin Med J (Engl) 114:852-6. 2001
    ..To explore the characteristics of oncoprotein expression of c-fos and c-jun in hypertrophic scars and chronic dermal ulcers and their regulation of basic fibroblast growth factor (bFGF)...
  17. ncbi [Epidermal growth factor stimulates tissue repair in skin through skin stem cell activation]
    Xiao bing Fu
    304th Hospital of PLA, Beijing, P R China 100037
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 16:31-5. 2002
    ..To explore the possible mechanisms of skin regeneration through the epidermal stem cells stimulated by epidermal growth factor (EGF)...
  18. ncbi Healing of chronic cutaneous wounds by topical treatment with basic fibroblast growth factor
    Xiaobing Fu
    Wound Healing Unit, 304th Hospital, Beijing 100037, China
    Chin Med J (Engl) 115:331-5. 2002
    ..To evaluate the safety and efficacy of topical application of recombinant bovine basic fibroblast growth factor (rbFGF) on the healing of chronic cutaneous wounds...
  19. doi Mesenchymal stem cells and skin wound repair and regeneration: possibilities and questions
    Xiaobing Fu
    Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical College, General Hospital of PLA, 28 Fu Xing Road, Beijing 100853, PR China
    Cell Tissue Res 335:317-21. 2009
    ..This review focuses mainly on the benefits of MSCs in skin wound healing and tissue regeneration and on the questions that remain to be answered before MSCs can be used in clinical practice...
  20. ncbi Adipose tissue extract enhances skin wound healing
    Xiaobing Fu
    Wound Healing and Cell Biology Laboratory, Institute for Basic Medical Science, Trauma Center of Postgraduate Medical College, PLA General Hospital, Beijing, China
    Wound Repair Regen 15:540-8. 2007
    ..These results may challenge the traditional concept that adipose tissue plays a negative role in wound healing and may offer direct evidence for encouraging the retention of adipose tissue in autologous skin grafting for skin wounds...
  21. ncbi Pseudoepitheliomatous hyperplasia formation after skin injury
    Xiaobing Fu
    Wound Healing and Cell Biology Laboratory, The First Affiliated Hospital 304th Hospital, Beijing, China
    Wound Repair Regen 15:39-46. 2007
    ..SCF and c-Kit might be involved in the epidermal hyperplasia observed in PEH...
  22. ncbi Enhanced wound-healing quality with bone marrow mesenchymal stem cells autografting after skin injury
    Xiaobing Fu
    Wound Healing and Cell Biology Laboratory, Institute for Basic Research, Trauma Center of Postgraduate Medical College, General Hospital of PLA, Beijing, China
    Wound Repair Regen 14:325-35. 2006
    ..Our results indicate that locally delivered bone marrow MSCs can enhance wound healing quality, and may generate de novo intact skin, resulting in perfect skin regeneration after full-thickness injury...
  23. ncbi [Expression characteristics of transforming growth factor-beta1 in human skin at different development stages of gestation]
    Wei Chen
    Key Research Laboratory of Wound Repair, Burns Institute, 304 th Hospital of PLA, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16:206-9. 2004
    ....
  24. ncbi [Gene expression of angiogenesis-related factors in fetal skin at different developmental stages and childhood skin]
    Wei Chen
    Key Research Laboratory of Wound Repair, Burns Institute, 304 th Hospital of PLA, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16:85-9. 2004
    ....
  25. ncbi [Gene expression of extracellular-signal regulated protein kinase 5 and their MAPKK in fetal skin hypertrophic scars]
    Wei Chen
    Key Research Laboratory of Wound Repair, 304th Hopital of PLA, Beijing 100037, China
    Zhonghua Zheng Xing Wai Ke Za Zhi 20:222-4. 2004
    ..To explore the change of gene expression of extracellular-signal regulated protein kinase 5 (ERK5) and its upstream signaling molecule (MEK5) in fetal skin of differentially developmental stages and hypertrophic scars...
  26. ncbi [Study of mechanism on loss of some components from basement membrane in epithelial-interstitial junction in cutaneous pseudoepitheliomatous hyperplasia lesion]
    Du yin Jiang
    Key Laboratory of Wound Repair, 304th Hospital of PLA, Beijing, 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16:36-41. 2004
    ....
  27. pmc Intravenous acid fibroblast growth factor protects intestinal mucosal cells against ischemia-reperfusion injury via regulating Bcl-2/Bax expression
    Wei Chen
    Wound Healing and Cell Biology Laboratory, 304th Hospital, Burns Institute, Trauma Center of Postgraduate Medical College, 51 Fu Cheng Road, Beijing 100037, China
    World J Gastroenterol 11:3419-25. 2005
    ..To detect the effect of acid fibroblast growth factor (aFGF) on apoptosis and gene expression of bax and bcl-2 gene in rat intestine after ischemia/reperfusion (I/R) injury, and to explore the protective mechanisms of aFGF...
  28. ncbi [Effects of basic fibroblast growth factor on the matrix metalloproteinase-2,7 and its tissue inhibitor on deep partial thickness burn wounds in rats]
    Biao Cheng
    Burn Institute of the 304th Hospital, PLA, Beijing 100037, P R China
    Zhonghua Shao Shang Za Zhi 19:336-9. 2003
    ..To observe the changes in matrix metalloproteinase-2,7 (MMP-2,7) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in deep partial thickness burn during the process of wound healing, and the effects of bFGF on wound healing...
  29. ncbi [Oligonucleotide microarrays in the screening of differentially expressed genes in skin of rat fetus in early and late pregnancy ]
    Wei Chen
    State Key Laborary of Trauma Repair, No 304 Hospital of China PLA, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 85:487-9. 2005
  30. ncbi [Characteristics of epidermal growth factor and its receptor expression in dermal chronic ulcers]
    Wei Chen
    304th Hospital of People s Liberation Army, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:600-2. 2003
    ..To investigate the expression and location of epidermal growth factor (EGF) and its receptor (EGFR) in dermal chronic ulcers and normal skin in order to explore their influence on ulcer formation...
  31. pmc Acid fibroblast growth factor reduces rat intestinal mucosal damage caused by ischemia-reperfusion insult
    Wei Chen
    Wound Healing and Cell Biology Laboratory, Burns Institute, 304th Clinical Department, General Hospital of PLA, 51 Fu Cheng Road, Beijing 100037, China
    World J Gastroenterol 11:6477-82. 2005
    ..To detect the effects of acid fibroblast growth factor (aFGF) on apoptosis and proliferation of intestinal epithelial cells in differentiation or proliferation status to explore the protective mechanisms of aFGF...
  32. ncbi [The regulation mechanisms of MMP-1,2 and TIMP-1,2 on wound healing after partial thickness scald]
    Biao Cheng
    Key Laboratory of Wound Repair, 304th Hospital, People s Liberation Army, Beijing 100037, China
    Zhonghua Wai Ke Za Zhi 41:766-9. 2003
    ....
  33. pmc Exogenous acid fibroblast growth factor inhibits ischemia-reperfusion-induced damage in intestinal epithelium via regulating P53 and P21WAF-1 expression
    Wei Chen
    Key Research Laboratory of Wound Repair, Burns Institute, 304 Clinical Department, General Hospital of PLA, 51 Fu Cheng Road, Beijing 100037, China
    World J Gastroenterol 11:6981-7. 2005
    ..To detect the effect of acid fibroblast growth factor (aFGF) on P53 and P21WAF-1 expression in rat intestine after ischemia-reperfusion (I-R) injury in order to explore the protective mechanisms of aFGF...
  34. ncbi [Chemotactic effects of burn rat serum on mesenchymal stem cells derived from different sources]
    Bing Han
    Key Laboratory of Wound Repair and Regeneration of PLA, Burn Institute, First Hospital Affiliated to the PLA General Hospital, Beijing 100037, PR China
    Zhonghua Shao Shang Za Zhi 23:25-8. 2007
    ..To isolate and culture mesenchymal stem cells ( MSC) from different sources and to investigate the chemotactic effects of burn rat serum on MSC derived from different sources...
  35. ncbi Development of gene microarray in screening differently expressed genes in keloid and normal-control skin
    Wei Chen
    Department of Wound Healing, 304th Hospital, Beijing 100037, China
    Chin Med J (Engl) 117:877-81. 2004
    ..Keloid is an intricate lesion that is probably regulated by many genes. In this study, the authors used the technique of complementary DNA (cDNA) microarray to analyse abnormal gene expression in keloids and normal control skins...
  36. ncbi [Characteristics of P38 mitogen-activated protein kinase and c-Jun expression in hypertrophic scar and their effects on scar formation]
    Wei Chen
    Key Research Laboratory of Wound Repair, 304th Hospital of PLA, Beijing, P R China 100037
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 17:379-81. 2003
    ..To observe the protein expression of phosphorylated form of P38 mitogen-activated protein kinase(P38MAPK) and c-Jun in hypertrophic scar skin and to explore their influences on the formation and maturation of hypertrophic scar...
  37. ncbi [Isolation and culture technics of human sweat glands]
    Hai Hong Li
    Key Laboratory of Truama Repair, Clinical Medicine, China PLA No 304 General Hospital, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 85:638-40. 2005
  38. ncbi [Expressive characteristics of epidermal growth factor and its receptor in tissues of fetal and adult intestines]
    Wei Chen
    Key Research Laboratory of Wound Repair, 304th Hospital of PLA, Beijing, P R China, 100037
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 17:289-92. 2003
    ..To explore the expressive characteristics of epidermal growth factor (EGF) and its receptor (EGFR) in tissues of fetal and adult intestines...
  39. ncbi [Experimental study on recombinant human platelet-derived growth factor gel in a diabetic rat model of cutaneous incisal wound healing]
    Tong zhu Sun
    Research Department of Burn Institute, 304th Hospital of People s Liberation Army, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:596-9. 2003
    ..To investigate the effect of recombinant human platelet-derived growth factor (rhPDGF-BB) on cutaneous incisal wound healing in diabetic rats and this factor does-effect relationship...
  40. ncbi [Effects of serum from normal and burned rats on the biological behavior of bone marrow stromal cells]
    Bing Han
    Key Laboratory of Wound Repair, 304th Hospital of People s Liberation Army, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:603-5. 2003
    ..To investigate the effect of serum from normal and burned rats on the biological behaviors of bone marrow stromal cells (BMSCs)...
  41. ncbi [Relationship between epithelial-immunologic cells transdifferentiation and pseudoepitheliomatous granuloma lesion]
    Du yin Jiang
    Key Laboratory of Wound Repair, People s Liberation Army, 304th Hospital of People s Liberation Army, 100037 Beijing, China
    Zhonghua Wai Ke Za Zhi 42:400-5. 2004
    ..The correlation of abnormal transdifferentiation of epithelial cells to immunologic cells and the occurrence of PEG lesion was investigated...
  42. ncbi Analysis of differentially expressed genes in fetal skin of scarless and scar-forming periods of gestational rats
    Wei Chen
    Key Research Laboratory of Wound Repair, Burn Institute, 304th Clinical Department, General Hospital of PLA, Beijing 100037, China
    Chin J Traumatol 9:94-9. 2006
    ....
  43. doi Effects of the Four-Herb Compound ANBP on Wound Healing Promotion in Diabetic Mice
    Qian Hou
    Chinese PLA General Hospital, Beijing, People s Republic of China Chinese PLA 148th Hospital, Zibo, People s Republic of China
    Int J Low Extrem Wounds 14:335-42. 2015
    ..Taken together, our studies revealed that ANBP treatment could accelerate wound healing, promote vascularization, and inhibit inflammation, suggesting the potential clinic application of ANBP for diabetes mellitus and refractory wounds. ..
  44. ncbi [Gene expression of stress activated protein kinase and its MAPKs in hypertrophic scar]
    Wei Chen
    Key Research Laboratory of Wound Repair, 304th Hospital of PLA, Beijing, P R China 100037
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:1-3. 2004
    ..To explore the change of gene expression of stress activated protein kinase (SAPK) and its upstream signal-regulated molecule--mitogen activated protein kinases(MAPKs) (MKK4 and MKK7) in hypertrophic scar and auto-control normal skin...
  45. ncbi [Biologic significance of neurofilament protein expression in scar tissue]
    Biao Cheng
    The Key Laboratory of Wound Repairement, People s Liberation Army, 304 th Hospital, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:715-7. 2003
    ..To investigate the situation of neurofilament protein (NFP) and epidermal growth factor receptor (EGFR) staining in scars and normal human skin, and attempt to explain the etiology of scarring formation...
  46. ncbi [Study in the novel function of adipose tissue on wound healing]
    Xiao bing Fu
    Departmant of Clinical Medicine, 304 Hospital, General Hospital of PLA, Key Laboratory of Trauma Repairment, Beijing 100037, China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:447-8. 2004
  47. ncbi Non-mitogenic acidic fibroblast growth factor reduces intestinal dysfunction induced by ischemia and reperfusion injury in rats
    Hai Hong Li
    Wound Healing and Cell Biology Laboratory, Burns Institute, First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, China
    J Gastroenterol Hepatol 22:363-70. 2007
    ..The purpose of the present study was to explore the effects and mechanisms of wild-type (aFGF) and non-mitogenic aFGF on gut ischemia-reperfusion injury in rats...
  48. ncbi [Effects of acute hypoxia and intermittent hypoxic acclimatization on vascular endothelial growth factor gene expression in HepG2 cells]
    Wei Chen
    Key Research Laboratory of Wound Repair, 304th Hospital of PLA, Beijing 100037, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 21:274-7. 2005
    ....
  49. ncbi Adult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages
    Haihong Li
    Wound Healing and Cell Biology Laboratory, Burns Institute, The First Affiliated Hospital 304th Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, People s Republic of China
    Cell Tissue Res 326:725-36. 2006
    ..We conclude that adult MSCs have the capacity to dock at specific sites, to contribute to wound healing of skin appendages, and to home toward marrow, and that engraftment of bone-marrow-derived cells is a functional event...
  50. pmc Inhibition of p38 mitogen-activated protein kinase may decrease intestinal epithelial cell apoptosis and improve intestinal epithelial barrier function after ischemia- reperfusion injury
    Shu Yun Zheng
    Wound Healing and Cell Biology Laboratory, Burns Institute, 304 Medical Department, The General Hospital of PLA, Trauma Center of Postgraduate Medical College, 51 Fu Cheng Road, Beijing 100037, China
    World J Gastroenterol 11:656-60. 2005
    ..To investigate the role of p38 mitogen-activated protein kinase in rat small intestine after ischemia-reperfusion (I/R) insult and the relationship between activation of p38 MAPK and apoptotic cell death of intestine...
  51. ncbi [Effects of acidi fibroblast growth factor on hepatic and renal functions after intestinal ischemia/reperfusion injury]
    Li xin Weng
    304th Hospital of PLA, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16:19-21. 2004
    ....
  52. ncbi [Effects of fibroblast growth factor-10 on the secretions of transforming growth factor-alpha, platelet-derived growth factor-AB and vascular endothelial growth factor by normal adult human keratinocytes in culture]
    Xiao qing Sun
    304 th Hospital of People s Liberation Army, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16:13-8. 2004
    ....
  53. ncbi [Characteristics and effect of three transforming growth factor-beta isoforms and their receptor(I) on scar formation]
    Wei Chen
    Key Research Laboratory of Wound Repair, 304th Hospital of PLA, Beijing, P R China 100037
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 16:252-5. 2002
    ..To observe the differences in protein contents of three transforming growth factor-beta (TGF-beta) isoforms, beta 1, beta 2, beta 3 and their receptor(I) in hypertrophic scar and normal skin and to explore their influence on scar formation...
  54. ncbi [Redistribution of epidermal stem cells in wound edge in the process of re-epithelialization]
    Jian Fu Li
    Burns Institute of People s Liberation Army, 304th Hospital, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 83:228-31. 2003
    ..To study the redistribution of epidermal stem cells in regenerating wound tissues, and to elucidate the role of epidermal stem cells during wound repair...
  55. ncbi [Effect of exogenous basic fibroblast growth factor on proliferation and migration of endothelial cells of partial thickness scald in rats]
    Biao Cheng
    Key Research Laboratory of Wound Repair, PLA 304th Hospital, Beijing, 100037, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:200-4. 2004
    ..To observe the proliferation and migration of endothelial cells after 30% total burn surface area (TBSA) of deep partial thickness scald, and the effect of basic fibroblast growth factor (bFGF) on angiogenesis during wound healing...
  56. ncbi Therapeutic potential of stem cells in skin repair and regeneration
    Cui ping Zhang
    Wound Healing and Cell Biology Laboratory, Burns Institute, First Affiliated Hospital General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing 100037, China
    Chin J Traumatol 11:209-21. 2008
    ..In this study, we present an overview of the most recent advances in skin repair and regeneration by using stem cells...
  57. ncbi [Construction of eucaryotic expression plasmid carrying the BMP7 gene and expression in mesenchymal stem cells]
    Shu xun Hou
    Department of Orthopeadics, 304th Hospital, People s Liberation Army, Beijing 100037, China
    Zhonghua Wai Ke Za Zhi 41:445-8. 2003
    ..To construct an eucaryotic expression plasmid carrying the BMP7 gene and express in MSCs...
  58. ncbi [Expression of matrix metalloproteinases and their inhibitors in fetal skin and their biological significance]
    Wen Juan Li
    Key Research Laboratory of Wound Repair, First Affiliated Hospital of General Hospital of PLA, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 18:303-6. 2006
    ..To investigate the expression characteristics of matrix metalloproteinases (MMP-2, MMP-3, MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1, TIMP-2) in developing fetal skin and their potential biological significance...
  59. ncbi [Stem cells and wound repair in burns]
    Xiao bing Fu
    Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, the First Affiliated Hospital to the PLA General Hospital, Beijing 100853, P R China
    Zhonghua Shao Shang Za Zhi 24:365-6. 2008
    ..Clinical results show that the use of stem cells therapies has brought new hope for accelerating wound healing with improvement in quality, inducing sweat gland regeneration, and constructing tissue engineering skin, etc...
  60. doi MSCs: Biological characteristics, clinical applications and their outstanding concerns
    Yi Ling Si
    Institute of Basic Medicine Science, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
    Ageing Res Rev 10:93-103. 2011
    ..These interventions might help to establish a new clinical paradigm to turn MSC transplantation into a routine therapy for at least some diseases in the near future...
  61. ncbi [Present status and prospect in the clinical use of adult stem cells in tissue repair and regeneration]
    Xiao bing Fu
    Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, First Hospital Affiliated to the PLA General Hospital, Beijing 100853, China
    Zhonghua Shao Shang Za Zhi 25:241-2. 2009
    ..Meanwhile, I express my personal opinion on their use in the future...
  62. ncbi [The effect of basic fibroblast growth factor on myofibroblasts and its significance on wound healing]
    Biao Cheng
    Burn Institute, 304th Hospital of People s Liberation Army, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 82:1187-91. 2002
    ..To observe the effect of basic fibroblast growth factor (bFGF) on the outcome of myofibroblasts in burn wounds, and to further explore the mechanism of bFGF on wound healing...
  63. doi Regeneration of functional sweat gland-like structures by transplanted differentiated bone marrow mesenchymal stem cells
    Zhiyong Sheng
    Burns Institute, The First Affiliated Hospital, Chinese PLA General Hospital, Trauma Center of Postgraduate Medical College, Beijing 10048, China
    Wound Repair Regen 17:427-35. 2009
    ..This is the first report of successful transplantation of MSCs in regenerating functional sweat glands, which may help solve the problem of depletion of sweat glands in patients surviving extensive deep burns in the future...
  64. doi In vitro constitution and in vivo implantation of engineered skin constructs with sweat glands
    Sha Huang
    Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, PR China
    Biomaterials 31:5520-5. 2010
    ..This engineered skin construct could be used as a promising tool for regeneration of sweat glands in skin repair and a valuable engineered strategy for constitution of appendage-containing engineered skin models...
  65. ncbi Future application of hair follicle stem cells: capable in differentiation into sweat gland cells
    Yao Wang
    School of Medicine, Nankai University, Tianjin 300192, China Wound Healing and Cell Biology Laboratory, Burns Institute, First Affiliated Hospital of General Hospital of Chinese People s Liberation Army, Trauma Centre of Postgraduate Medical College, Beijing 100048, China
    Chin Med J (Engl) 126:3545-52. 2013
    ..In this research, we attempted to direct the HFSCs suffered from the sweat gland cells (SGCs) special differentiation by a co-operative coculture system in vitro...
  66. ncbi [Effects of acute hypoxia and intermittent hypoxic acclimatization on erythropoietin and hypoxia-inducible factor-1alpha gene expression in rat hepatic and renal tissues]
    Wei Chen
    PLA Key Laboratory for Burn and Repair, 304th Hospital, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16:9-12. 2004
    ..To explore the effects of acute hypoxia and intermittent hypoxic acclimatization on gene expression of erythropoietin (EPO) and hypoxia-inducible factor-1alpha (HIF-1alpha) in rat hepatic and renal tissues...
  67. ncbi [Uses of autologous stem cell transplantation in the field of burns and injuries]
    Xiao bing Fu
    Key Laboratory of Wound Repairing, 304 Hospital of PLA, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 84:1332. 2004
  68. ncbi [Strengthening the study of some key points in the management of local wounds after burns and trauma]
    Xiao bing Fu
    Key Laboratory of Wound Repair and Regeneration of PLA, First Hospital Affiliated to the PLA General Hospital, Beijing 100037, PR China
    Zhonghua Shao Shang Za Zhi 23:13-5. 2007
    ..Also, the application of some high-technique methods may help enhancing the wound healing velocity and quality after injury...
  69. ncbi [Identification and cell phenotype transdifferentiation of adipose-derived stem cells]
    Xiao Hong Dong
    Key Research Laboratory for Wound Repair and Regeneration, the 304 Clinical Department, General Hospital of PLA, Beijing, 100037, China
    Zhonghua Zheng Xing Wai Ke Za Zhi 23:151-3. 2007
    ..To investigate the transdifferentiation of the ADSCs to epidermal cells...
  70. ncbi [Study on combined implantation of pig dermis and autologous skin in rats]
    Zhigu Wu
    Research Department of Burn Institute, 304th Hospital, Beijing 100037
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 20:642-5. 2003
    ..8% to 65.9% compared to its original size. The results suggested that the time and the way of autologous skin grafting on xenogenous dermis may influence wound contraction and healing time...
  71. ncbi [Change of gene expression of transforming growth factor-beta1, Smad 2 and Smad 3 in hypertrophic scars skins]
    Wei Chen
    PLA Key Research Laboratory of Wound Repair, 304th Hospital, Beijing 100037, China
    Zhonghua Wai Ke Za Zhi 40:17-9. 2002
    ..To explore the regulatory mechanisms of transforming growth factor-beta1 (TGF-beta1) and two transcriptional factors Smad 2, 3 on hypertrophic scar formation and fetal scarless healing...
  72. doi Microenvironment-evoked cell lineage conversion: Shifting the focus from internal reprogramming to external forcing
    Ji Lin
    Institute of Basic Medicine, Chinese PLA General Hospital, Beijing, PR China
    Ageing Res Rev 12:29-38. 2013
    ..Based on the relatively slight safety and technical issues, we conclude that microenvironment-evoked cell lineage conversion, instead of reprogramming, will be the shifting focus in regenerative medicine...
  73. doi Can hematopoietic stem cells be an alternative source for skin regeneration?
    Xiaobing Fu
    Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical School, Chinese PLA General Hospital, Beijing 100853, PR China
    Ageing Res Rev 8:244-9. 2009
    ..In particular, we focus on the possible use of blood stem cells as an alternative resource for research advances in skin biology...
  74. ncbi Possible pathogenesis of painful intervertebral disc degeneration
    Baogan Peng
    Department of Orthopaedics, 304th Hospital, Beijing, China
    Spine (Phila Pa 1976) 31:560-6. 2006
    ..We collected the specimens of lumbar intervertebral disc (i.e., the symptomatic degenerative disc) from patients with discogenic low back pain to study the histopathologic features and growth factor expressions...
  75. ncbi [Ponderance over tissue regeneration and regenerative medicine]
    Xiao bing Fu
    Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, First Hospital Affiliated to the PLA General Hospital, Beijing 100853, China
    Zhonghua Shao Shang Za Zhi 27:1-2. 2011
    ..Research in the field of tissue regeneration is a new focus in life science and medicine in the 21st century, hereby I express my personal expectations of its research and translational application in the future...
  76. ncbi Differential expression of matrix metalloproteinases and tissue-derived inhibitors of metalloproteinase in fetal and adult skins
    Wei Chen
    Key Research Laboratory of Wound Repair, The First Affiliated Hospital, 301th Hospital of Beijing, 100037 Beijing, China
    Int J Biochem Cell Biol 39:997-1005. 2007
    ....
  77. ncbi The interaction between epidermal growth factor and matrix metalloproteinases induces the development of sweat glands in human fetal skin
    Jianfu Li
    Wound Healing Unit, Burns Institute, 304th Hospital, 51 Fu Cheng Road, Beijing 100037, People s Republic of China
    J Surg Res 106:258-63. 2002
    ..Furthermore, we hope to elucidate the mechanism(s) underlying the induction of epidermal stem cells into sweat gland cells...
  78. ncbi Cutaneous stem cells: something new and something borrowed
    Xiaoyan Sun
    Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical College, Chinese PLA General Hospital, Beijing, China
    Wound Repair Regen 15:775-85. 2007
    ..In this paper, we focus on comparing several kinds of stem cells in the epidermis, signaling influences of the stem cell and its niche in actively self-renewing epithelia, and introducing something new and something borrowed...
  79. ncbi In vivo dedifferentiation of human epidermal cells
    Haihong Li
    Mental Health Center, Shantou University Medical College, Guangdong Province, and Wound Healing and Cell Biology Laboratory, Burns Institute, The First Affiliated Hospital 304th Hospital, Beijing 100037, PR China
    Cell Biol Int 31:1436-41. 2007
    ..The results collectively indicated that some of the differentiated cells in engrafted epidermal sheets dedifferentiated into stem cells or stem cells-like in vivo, which offer us new evidence and insights into the dedifferentiation...
  80. ncbi Ontogeny of expression of transforming growth factor-beta and its receptors and their possible relationship with scarless healing in human fetal skin
    Wei Chen
    Wound Healing and Cell Biology Laboratory, Burns Institute, 304th Hospital, Trauma Center of Postgraduate Medical College, Academy of Military Medicine Sciences, Beijing, People s Republic of China
    Wound Repair Regen 13:68-75. 2005
    ..Lower expression of their receptors in early gestational skins may be a reason for the reduced ability to perceive ligands, ultimately leading to scar-free healing...
  81. ncbi Epidermal stem cells are the source of sweat glands in human fetal skin: evidence of synergetic development of stem cells, sweat glands, growth factors, and matrix metalloproteinases
    Xiaobing Fu
    Wound Healing and Cell Biology Laboratory, Burns Institute, 304 Clinical Department, The General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, People s Republic of China
    Wound Repair Regen 13:102-8. 2005
    ..Epidermal growth factor is one of the main inducers in the development and maturity of sweat gland buds or cells and the local activated MMPs may play an important role in cleaving the major matrix components in the basement membrane...
  82. ncbi Analysis of differentially expressed genes in keloids and normal skin with cDNA microarray
    Wei Chen
    Wound Healing and Cell Biology Laboratory, Burns Institute, 304th Hospital, Trauma Center of Postgraduate Medical College, Beijing 100037, People s Republic of China
    J Surg Res 113:208-16. 2003
    ..We ventured to study the differences of gene expressions between keloids and normal skin with the aid of a cDNA microarray to explore the molecular mechanism underlying keloid formation...
  83. ncbi Expression of epidermal growth factor receptor and related phosphorylation proteins in hypertrophic scars and normal skin
    Biao Cheng
    Burn Institute, 304th Hospital, Trauma Center of Postgraduate Medical College, Beijing 100037, China
    Chin Med J (Engl) 115:1525-8. 2002
    ..To study the potential signal pathway involved in pathogenesis of hypertrophic scar formation...
  84. ncbi Profiling of genes differentially expressed in a rat of early and later gestational ages with high-density oligonucleotide DNA array
    Wei Chen
    Wound Healing and Cell Biology Laboratory, Burns Institute, The First Affiliated Hospital 304 Hospital of the General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, China
    Wound Repair Regen 15:147-55. 2007
    ..Many genes were involved in the phenotypic transition from scarless to scar-forming wound repair during gestation. Further analysis of the obtained genes will help to understand the molecular mechanism of fetal scarless healing...
  85. ncbi [The characteristics of PCNA expression in hypertrophic scars and chronic ulcers and implication of the expression]
    Tongzhu Sun
    304th Hospital of PLA, Beijing 100037, China
    Zhonghua Zheng Xing Wai Ke Za Zhi 18:232-3. 2002
    ..To investigate the characteristics of PCNA expression in hypertrophic scars and chronic ulcers and to discuss its relation to their formation...
  86. ncbi [Proliferating cell nuclear antigen expression in recurrent aphthous ulcer and its significance]
    Peng Sun
    Department of Stomatology, 304th Hospital of People s Liberation Army, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:207-9. 2003
    ..To explore the expression changes of proliferating cell nuclear antigen (PCNA) in oral normal mucosa and recurrent aphthous ulcers(RAU)...
  87. ncbi [The practice of wound healing center construction in China]
    Xiao bing Fu
    Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, First Hospital Affiliated to the PLA General Hospital, Beijing 100853, China
    Zhonghua Shao Shang Za Zhi 27:8-9. 2011
    ..In this paper, we summarize their experience and expect their development in the future...
  88. pmc FHL2 interacts with and acts as a functional repressor of Id2 in human neuroblastoma cells
    Weidong Han
    Department of Molecular Biology, Chinese PLA General Hospital, Beijing 100853, China
    Nucleic Acids Res 37:3996-4009. 2009
    ..Altogether, these results indicate that FHL2 is an important repressor of the oncogenic activity of Id2 in neuroblastoma cells...
  89. doi Acclimatized induction reveals the multipotency of adult human undifferentiated keratinocytes
    Weidong Han
    Institute of Basic Medical Science, Chinese PLA General Hospital, Beijing, People s Republic of China
    Cell Reprogram 12:283-94. 2010
    ..These data indicate that human UKs represent a novel multipotent adult stem cell, and suggest that they may provide an accessible, therapeutically promising cell source for regenerative medicine...
  90. ncbi [Development of hair follicle stem cells related signal transduction in proliferation and differentiation]
    Yongan Xu
    Key Laboratory of Wound Repair, First Affiliated Hospital, Chinese PLA General Hospital, Beijing, 100048, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:161-4. 2010
    ..To introduce the basic research and clinical potential of the hair follicle stem cells related signal transduction in proliferation and differentiation...
  91. pmc Dedifferentiation derived cells exhibit phenotypic and functional characteristics of epidermal stem cells
    Cuiping Zhang
    Wound Healing and Cell Biology Laboratory, Burns Institute, The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, PR China
    J Cell Mol Med 14:1135-45. 2010
    ..This study may also offer a new approach to yield epidermal stem cells for wound repair and regeneration...
  92. doi Naturally derived materials-based cell and drug delivery systems in skin regeneration
    Sha Huang
    Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, Beijing 100853, PR China
    J Control Release 142:149-59. 2010
    ....
  93. ncbi Comparative study of fibronectin gene expression in tissues from hypertrophic scars and diabetic foot ulcers
    Xiaobing Fu
    Wound Healing Unit, Burn Institute, 304th Hospital, Beijing 100037
    Chin Med Sci J 17:90-4. 2002
    ..To explore the expression characteristic of fibronectin gene in hypertrophic scars and diabetic ulcer tissues...
  94. doi Differential induction of LRP16 by liganded and unliganded estrogen receptor alpha in SKOV3 ovarian carcinoma cells
    Liyuan Tian
    Department of Molecular Biology, Institute of Basic Medicine, Chinese PLA General Hospital, Beijing, People s Republic of China
    J Endocrinol 202:167-77. 2009
    ..Our study suggests a novel mechanism of estrogen resistance of ovarian cancer by which estrogen-repressed signaling pathway antagonizes estrogen-activated signaling transduction...
  95. ncbi Review of current progress in the structure and function of Smad proteins
    Wei Chen
    PLA Key Laboratory of Wound Repair, 304th Hospital, Beijing 100037, China
    Chin Med J (Engl) 115:446-50. 2002
    ..To review the recent developments in the structure and function of Smad proteins...
  96. doi Can controlled cellular reprogramming be achieved using microRNAs?
    Xiaoyan Sun
    Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical School, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, PR China
    Ageing Res Rev 9:475-83. 2010
    ....
  97. ncbi Effect of keratinocyte growth factor-2 on proliferation of human adult keratinocytes
    Yinhui Yang
    Trauma Centre, Burn Department, 304th Hospital of PLA, Beijing 100037, China
    Chin J Traumatol 5:342-5. 2002
    ..To investigate the proliferative effect of keratinocyte growth factor (KGF-2) on human adult keratinocytes...
  98. pmc Intradiscal methylene blue injection for the treatment of chronic discogenic low back pain
    Baogan Peng
    Department of Orthopaedics, 304th Hospital, 51 Fucheng Road, 100037, Beijing, China
    Eur Spine J 16:33-8. 2007
    ..0001) after the treatment. The study suggests that the injection of MB into the painful disc may be a very effective alternative for the surgical treatment of chronic discogenic low back pain...
  99. ncbi [Relationship of ectodysplasin gene signaling with development and regeneration of sweat glands]
    Gang Zhou
    Key Research Laboratory of the Wound Repair, the 304th Clinical Department, General Hospital of PLA, Beijing, 100037, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 20:578-81. 2006
    ..To investigate the expression of ectodysplasin (EDA) gene signaling and its relationship with the development and regeneration of sweat glands...
  100. ncbi Long-term mortality of ultrasound structure in patients with venous leg ulcers-healed from one week to twenty years
    Yinhui Yang
    Trauma Centre, Department of Burn, 304th Hospital of PLA, Beijing 100037, China
    Chin Med J (Engl) 115:1819-23. 2002
    ..To obtain information about the quality of scars of healed venous leg ulcers compared with intact skin on the opposite leg by using high-frequency ultrasound...
  101. ncbi Progress of cellular dedifferentiation research
    Hu Xian Liu
    Ceter of Burns Surgery, Xi Jing Hospital, Fourth Military Medical University, Xi an 710032, China
    Chin J Traumatol 9:308-15. 2006
    ..These discoveries open the possibility that researchers might enhance the endogenous regenerative capacity of mammals by inducing cellular dedifferentiation in vivo...