Milada Sirova

Summary

Affiliation: Academy of Sciences of the Czech Republic
Country: Czech Republic

Publications

  1. doi request reprint The structure of polymer carriers controls the efficacy of the experimental combination treatment of tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel
    Milada Sirova
    Laboratory of Tumor Immunology, Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, 4, Czech Republic Electronic address
    J Control Release 246:1-11. 2016
  2. ncbi request reprint HPMA copolymer-bound doxorubicin induces immunogenic tumor cell death
    M Sirova
    Division of Immunology and Gnotobiology, Institute of Microbiology ASCR, v v i, Videnska 1083, 142 20 Prague 4, Czech Republic
    Curr Med Chem 20:4815-26. 2013
  3. ncbi request reprint Treatment with HPMA copolymer-based doxorubicin conjugate containing human immunoglobulin induces long-lasting systemic anti-tumour immunity in mice
    Milada Sirova
    Division of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Cancer Immunol Immunother 56:35-47. 2007
  4. doi request reprint Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: efficacy, safety, and immunomodulating activity in murine model
    Milada Sirova
    Laboratory of Tumor Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Videnska 1083, 142 20, Prague 4, Czech Republic
    Pharm Res 27:200-8. 2010
  5. ncbi request reprint Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification
    Petr Chytil
    Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq 2, 162 06 Prague 6, Czech Republic
    J Control Release 115:26-36. 2006
  6. ncbi request reprint Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity
    Tomas Mrkvan
    Department of Immunology and Gnotobiology, Institute of Microbiology ASCR, Prague, Czech Republic
    J Control Release 110:119-29. 2005
  7. doi request reprint Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting
    Tomas Etrych
    Institute of Macromolecular Chemistry AS CR, v v i, Heyrovsky Sq 2, 162 06 Prague 6, Czech Republic
    J Control Release 132:184-92. 2008
  8. ncbi request reprint Drug-HPMA-HuIg conjugates effective against human solid cancer
    Blanka Rihova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Adv Exp Med Biol 519:125-43. 2003
  9. doi request reprint HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release
    Tomas Etrych
    Department of Biomedicinal Polymers, Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
    Mol Pharm 7:1015-26. 2010
  10. doi request reprint The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia
    Barbora Tomalova
    Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic Electronic address
    J Control Release 223:1-10. 2016

Collaborators

Detail Information

Publications15

  1. doi request reprint The structure of polymer carriers controls the efficacy of the experimental combination treatment of tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel
    Milada Sirova
    Laboratory of Tumor Immunology, Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, 4, Czech Republic Electronic address
    J Control Release 246:1-11. 2016
    ....
  2. ncbi request reprint HPMA copolymer-bound doxorubicin induces immunogenic tumor cell death
    M Sirova
    Division of Immunology and Gnotobiology, Institute of Microbiology ASCR, v v i, Videnska 1083, 142 20 Prague 4, Czech Republic
    Curr Med Chem 20:4815-26. 2013
    ..It means that the induction of anti-tumor immunity documented upon treatment of EL4 lymphoma with HPMA-bound Dox conjugates does not rely solely on CRT-mediated cell death, but involves multiple mechanisms. ..
  3. ncbi request reprint Treatment with HPMA copolymer-based doxorubicin conjugate containing human immunoglobulin induces long-lasting systemic anti-tumour immunity in mice
    Milada Sirova
    Division of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Cancer Immunol Immunother 56:35-47. 2007
    ..We propose an effective treatment strategy which eradicates tumours without harming the protective immune anti-cancer responses...
  4. doi request reprint Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: efficacy, safety, and immunomodulating activity in murine model
    Milada Sirova
    Laboratory of Tumor Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Videnska 1083, 142 20, Prague 4, Czech Republic
    Pharm Res 27:200-8. 2010
    ..In vivo efficacy and safety of HPMA-based copolymers armed with doxorubicin via a spacer containing pH-sensitive linkage that can be prepared within a broad range of attached drug contents (1) was tested in murine tumor models...
  5. ncbi request reprint Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification
    Petr Chytil
    Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq 2, 162 06 Prague 6, Czech Republic
    J Control Release 115:26-36. 2006
    ..The highest activity (100% long-term survivors) exhibited polymer-DOX conjugate containing negatively charged GFLG sequences...
  6. ncbi request reprint Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity
    Tomas Mrkvan
    Department of Immunology and Gnotobiology, Institute of Microbiology ASCR, Prague, Czech Republic
    J Control Release 110:119-29. 2005
    ..In other terms, chemotherapy based on conjugates of HPMA copolymer with doxorubicin possesses immunomodulating properties. This finding might also have wider implications for the management of relapsing tumors in human patients...
  7. doi request reprint Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting
    Tomas Etrych
    Institute of Macromolecular Chemistry AS CR, v v i, Heyrovsky Sq 2, 162 06 Prague 6, Czech Republic
    J Control Release 132:184-92. 2008
    ..kg on day 10...
  8. ncbi request reprint Drug-HPMA-HuIg conjugates effective against human solid cancer
    Blanka Rihova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Adv Exp Med Biol 519:125-43. 2003
  9. doi request reprint HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release
    Tomas Etrych
    Department of Biomedicinal Polymers, Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
    Mol Pharm 7:1015-26. 2010
    ..The treatment with the polymer conjugates was devoid of side toxicity. In both models, we achieved complete regression of established tumors accompanied by a durable tumor resistance in most of the cured animals...
  10. doi request reprint The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia
    Barbora Tomalova
    Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic Electronic address
    J Control Release 223:1-10. 2016
    ..On the other hand, the treatment of leukaemia requires a drug conjugate with a long circulation half-life. This would provide an active drug, whilst slowly degrading to excretable fragments. ..
  11. doi request reprint Overcoming immunoescape mechanisms of BCL1 leukemia and induction of CD8+ T-cell-mediated BCL1-specific resistance in mice cured by targeted polymer-bound doxorubicin
    Marek Kovar
    Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
    Cancer Res 68:9875-83. 2008
    ..Finally, we have also shown that elimination of some immunoescape mechanism (e.g., deletion of Treg) can significantly improve the therapeutic outcome of chemotherapy...
  12. ncbi request reprint Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data
    Blanka Rihova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 4, Prague, Czech Republic
    J Control Release 91:1-16. 2003
    ..e. cytostatic and immunomobilizing character of Dox-HPMA conjugates containing a targeting immunoglobulin moiety...
  13. doi request reprint Antitumor activity of IL-2/anti-IL-2 mAb immunocomplexes exerts synergism with that of N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugate due to its low immunosuppressive activity
    Jakub Tomala
    Department of Immunology and Gnotobiology, Institute of Microbiology ASCR, v v i, Prague, Czech Republic
    Int J Cancer 129:2002-12. 2011
    ..Indeed, we demonstrate that the conjugate and IL-2/S4B6 mAb immunocomplexes together have synergistic antitumor activity...
  14. doi request reprint Synergistic effect of EMF-BEMER-type pulsed weak electromagnetic field and HPMA-bound doxorubicin on mouse EL4 T-cell lymphoma
    Blanka Rihova
    Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Vídeňská Prague, Czech Republic
    J Drug Target 19:890-9. 2011
    ....
  15. doi request reprint Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine
    Milada Sirova
    Division of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Videnska 1083, 142 20, Prague, 4, Czech Republic
    J Biomed Mater Res A 102:1982-90. 2014
    ..No adverse tissue responses were induced by the implants. Analysis performed after 4 and 9 weeks indicated areas of foreign body granuloma without formation of a fibrous capsule...